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Q86WU2

- LDHD_HUMAN

UniProt

Q86WU2 - LDHD_HUMAN

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Protein
Probable D-lactate dehydrogenase, mitochondrial
Gene
LDHD
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

(R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+.

Cofactori

FAD By similarity.By similarity

GO - Molecular functioni

  1. D-lactate dehydrogenase (cytochrome) activity Source: UniProtKB-EC
  2. UDP-N-acetylmuramate dehydrogenase activity Source: InterPro
  3. flavin adenine dinucleotide binding Source: InterPro
  4. protein binding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciMetaCyc:HS15490-MONOMER.
ReactomeiREACT_118595. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable D-lactate dehydrogenase, mitochondrial (EC:1.1.2.4)
Short name:
DLD
Short name:
Lactate dehydrogenase D
Gene namesi
Name:LDHD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:19708. LDHD.

Subcellular locationi

Mitochondrion By similarity By similarity

GO - Cellular componenti

  1. mitochondrial inner membrane Source: Ensembl
  2. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134917525.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 507Probable D-lactate dehydrogenase, mitochondrialPRO_0000262952
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei36 – 361N6-acetyllysine By similarity
Modified residuei315 – 3151N6-acetyllysine By similarity
Modified residuei358 – 3581N6-acetyllysine; alternate By similarity
Modified residuei358 – 3581N6-succinyllysine; alternate By similarity
Modified residuei445 – 4451N6-acetyllysine By similarity
Modified residuei472 – 4721N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ86WU2.
PaxDbiQ86WU2.
PRIDEiQ86WU2.

PTM databases

PhosphoSiteiQ86WU2.

Expressioni

Tissue specificityi

Expressed moderately in heart and liver and at lower levels in skeletal muscle and kidney.1 Publication

Gene expression databases

ArrayExpressiQ86WU2.
BgeeiQ86WU2.
CleanExiHS_LDHD.
GenevestigatoriQ86WU2.

Organism-specific databases

HPAiHPA041766.
HPA048639.

Interactioni

Subunit structurei

Interacts with CSRP3.1 Publication

Protein-protein interaction databases

BioGridi128242. 4 interactions.
STRINGi9606.ENSP00000300051.

Structurei

3D structure databases

ProteinModelPortaliQ86WU2.
SMRiQ86WU2. Positions 27-507.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 265204FAD-binding PCMH-type
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0277.
HOGENOMiHOG000230995.
HOVERGENiHBG066407.
InParanoidiQ86WU2.
KOiK00102.
OMAiNCLVAPT.
OrthoDBiEOG7QNVKV.
PhylomeDBiQ86WU2.
TreeFamiTF314122.

Family and domain databases

Gene3Di1.10.45.10. 1 hit.
3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR016164. FAD-linked_Oxase-like_C.
IPR004113. FAD-linked_oxidase_C.
IPR006094. Oxid_FAD_bind_N.
IPR016171. Vanillyl_alc_oxidase_C-sub2.
[Graphical view]
PfamiPF02913. FAD-oxidase_C. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view]
SUPFAMiSSF55103. SSF55103. 1 hit.
SSF56176. SSF56176. 2 hits.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q86WU2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MARLLRSATW ELFPWRGYCS QKAKGELCRD FVEALKAVVG GSHVSTAAVV    50
REQHGRDESV HRCEPPDAVV WPQNVEQVSR LAALCYRQGV PIIPFGTGTG 100
LEGGVCAVQG GVCVNLTHMD RILELNQEDF SVVVEPGVTR KALNAHLRDS 150
GLWFPVDPGA DASLCGMAAT GASGTNAVRY GTMRDNVLNL EVVLPDGRLL 200
HTAGRGRHFR FGFWPEIPHH TAWYSPCVSL GRRKSAAGYN LTGLFVGSEG 250
TLGLITATTL RLHPAPEATV AATCAFPSVQ AAVDSTVHIL QAAVPVARIE 300
FLDEVMMDAC NRYSKLNCLV APTLFLEFHG SQQALEEQLQ RTEEIVQQNG 350
ASDFSWAKEA EERSRLWTAR HNAWYAALAT RPGCKGYSTD VCVPISRLPE 400
IVVQTKEDLN ASGLTGSIVG HVGDGNFHCI LLVNPDDAEE LGRVKAFAEQ 450
LGRRALALHG TCTGEHGIGM GKRQLLQEEV GAVGVETMRQ LKAVLDPQGL 500
MNPGKVL 507

Note: No experimental confirmation available.

Length:507
Mass (Da):54,871
Last modified:June 1, 2003 - v1
Checksum:i5625743709939182
GO
Isoform 21 Publication (identifier: Q86WU2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-233: Missing.

Show »
Length:484
Mass (Da):52,144
Checksum:iFF9C9F939CB4BDC3
GO

Sequence cautioni

The sequence AAM50322.1 differs from that shown. Reason: Frameshift at several positions.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti233 – 2331R → K.
Corresponds to variant rs11644820 [ dbSNP | Ensembl ].
VAR_029561

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei211 – 23323Missing in isoform 2. 1 Publication
VSP_052253Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti323 – 3231T → I in AAM50322. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY092767 mRNA. Translation: AAM50322.1. Frameshift.
BC040279 mRNA. Translation: AAH40279.1.
BC047902 mRNA. Translation: AAH47902.1.
CCDSiCCDS10913.1. [Q86WU2-1]
CCDS45529.1. [Q86WU2-2]
RefSeqiNP_705690.2. NM_153486.3. [Q86WU2-1]
NP_919417.1. NM_194436.2. [Q86WU2-2]
UniGeneiHs.380929.

Genome annotation databases

EnsembliENST00000300051; ENSP00000300051; ENSG00000166816. [Q86WU2-1]
ENST00000450168; ENSP00000417011; ENSG00000166816. [Q86WU2-2]
GeneIDi197257.
KEGGihsa:197257.
UCSCiuc002fdm.3. human. [Q86WU2-1]
uc002fdn.3. human. [Q86WU2-2]

Polymorphism databases

DMDMi74727712.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY092767 mRNA. Translation: AAM50322.1 . Frameshift.
BC040279 mRNA. Translation: AAH40279.1 .
BC047902 mRNA. Translation: AAH47902.1 .
CCDSi CCDS10913.1. [Q86WU2-1 ]
CCDS45529.1. [Q86WU2-2 ]
RefSeqi NP_705690.2. NM_153486.3. [Q86WU2-1 ]
NP_919417.1. NM_194436.2. [Q86WU2-2 ]
UniGenei Hs.380929.

3D structure databases

ProteinModelPortali Q86WU2.
SMRi Q86WU2. Positions 27-507.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128242. 4 interactions.
STRINGi 9606.ENSP00000300051.

Chemistry

BindingDBi Q86WU2.

PTM databases

PhosphoSitei Q86WU2.

Polymorphism databases

DMDMi 74727712.

Proteomic databases

MaxQBi Q86WU2.
PaxDbi Q86WU2.
PRIDEi Q86WU2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000300051 ; ENSP00000300051 ; ENSG00000166816 . [Q86WU2-1 ]
ENST00000450168 ; ENSP00000417011 ; ENSG00000166816 . [Q86WU2-2 ]
GeneIDi 197257.
KEGGi hsa:197257.
UCSCi uc002fdm.3. human. [Q86WU2-1 ]
uc002fdn.3. human. [Q86WU2-2 ]

Organism-specific databases

CTDi 197257.
GeneCardsi GC16M075145.
HGNCi HGNC:19708. LDHD.
HPAi HPA041766.
HPA048639.
MIMi 607490. gene.
neXtProti NX_Q86WU2.
PharmGKBi PA134917525.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0277.
HOGENOMi HOG000230995.
HOVERGENi HBG066407.
InParanoidi Q86WU2.
KOi K00102.
OMAi NCLVAPT.
OrthoDBi EOG7QNVKV.
PhylomeDBi Q86WU2.
TreeFami TF314122.

Enzyme and pathway databases

BioCyci MetaCyc:HS15490-MONOMER.
Reactomei REACT_118595. Mitochondrial protein import.

Miscellaneous databases

GenomeRNAii 197257.
NextBioi 89620.
PROi Q86WU2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q86WU2.
Bgeei Q86WU2.
CleanExi HS_LDHD.
Genevestigatori Q86WU2.

Family and domain databases

Gene3Di 1.10.45.10. 1 hit.
3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProi IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR016164. FAD-linked_Oxase-like_C.
IPR004113. FAD-linked_oxidase_C.
IPR006094. Oxid_FAD_bind_N.
IPR016171. Vanillyl_alc_oxidase_C-sub2.
[Graphical view ]
Pfami PF02913. FAD-oxidase_C. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view ]
SUPFAMi SSF55103. SSF55103. 1 hit.
SSF56176. SSF56176. 2 hits.
PROSITEi PS51387. FAD_PCMH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of putative mammalian D-lactate dehydrogenase enzymes."
    Flick M.J., Konieczny S.F.
    Biochem. Biophys. Res. Commun. 295:910-916(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH CSRP3, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Colon.

Entry informationi

Entry nameiLDHD_HUMAN
AccessioniPrimary (citable) accession number: Q86WU2
Secondary accession number(s): Q8IZK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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