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Q86WU2 (LDHD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable D-lactate dehydrogenase, mitochondrial

Short name=DLD
Short name=Lactate dehydrogenase D
EC=1.1.2.4
Gene names
Name:LDHD
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

(R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+.

Cofactor

FAD By similarity. UniProtKB P39976

Subunit structure

Interacts with CSRP3. Ref.1

Subcellular location

Mitochondrion By similarity UniProtKB Q7TNG8.

Tissue specificity

Expressed moderately in heart and liver and at lower levels in skeletal muscle and kidney. Ref.1

Sequence similarities

Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

Contains 1 FAD-binding PCMH-type domain.

Sequence caution

The sequence AAM50322.1 differs from that shown. Reason: Frameshift at several positions.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.2 (identifier: Q86WU2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 Ref.1 (identifier: Q86WU2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     211-233: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 507Probable D-lactate dehydrogenase, mitochondrialPRO_0000262952

Regions

Domain62 – 265204FAD-binding PCMH-type

Amino acid modifications

Modified residue361N6-acetyllysine By similarity
Modified residue3151N6-acetyllysine By similarity
Modified residue3581N6-acetyllysine; alternate By similarity
Modified residue3581N6-succinyllysine; alternate By similarity
Modified residue4451N6-acetyllysine By similarity
Modified residue4721N6-acetyllysine By similarity

Natural variations

Alternative sequence211 – 23323Missing in isoform 2. Ref.1
VSP_052253
Natural variant2331R → K.
Corresponds to variant rs11644820 [ dbSNP | Ensembl ].
VAR_029561

Experimental info

Sequence conflict3231T → I in AAM50322. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 5625743709939182

FASTA50754,871
        10         20         30         40         50         60 
MARLLRSATW ELFPWRGYCS QKAKGELCRD FVEALKAVVG GSHVSTAAVV REQHGRDESV 

        70         80         90        100        110        120 
HRCEPPDAVV WPQNVEQVSR LAALCYRQGV PIIPFGTGTG LEGGVCAVQG GVCVNLTHMD 

       130        140        150        160        170        180 
RILELNQEDF SVVVEPGVTR KALNAHLRDS GLWFPVDPGA DASLCGMAAT GASGTNAVRY 

       190        200        210        220        230        240 
GTMRDNVLNL EVVLPDGRLL HTAGRGRHFR FGFWPEIPHH TAWYSPCVSL GRRKSAAGYN 

       250        260        270        280        290        300 
LTGLFVGSEG TLGLITATTL RLHPAPEATV AATCAFPSVQ AAVDSTVHIL QAAVPVARIE 

       310        320        330        340        350        360 
FLDEVMMDAC NRYSKLNCLV APTLFLEFHG SQQALEEQLQ RTEEIVQQNG ASDFSWAKEA 

       370        380        390        400        410        420 
EERSRLWTAR HNAWYAALAT RPGCKGYSTD VCVPISRLPE IVVQTKEDLN ASGLTGSIVG 

       430        440        450        460        470        480 
HVGDGNFHCI LLVNPDDAEE LGRVKAFAEQ LGRRALALHG TCTGEHGIGM GKRQLLQEEV 

       490        500 
GAVGVETMRQ LKAVLDPQGL MNPGKVL 

« Hide

Isoform 2 [UniParc].

Checksum: FF9C9F939CB4BDC3
Show »

FASTA48452,144

References

« Hide 'large scale' references
[1]"Identification of putative mammalian D-lactate dehydrogenase enzymes."
Flick M.J., Konieczny S.F.
Biochem. Biophys. Res. Commun. 295:910-916(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH CSRP3, TISSUE SPECIFICITY.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain and Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY092767 mRNA. Translation: AAM50322.1. Frameshift.
BC040279 mRNA. Translation: AAH40279.1.
BC047902 mRNA. Translation: AAH47902.1.
RefSeqNP_705690.2. NM_153486.3.
NP_919417.1. NM_194436.2.
UniGeneHs.380929.

3D structure databases

ProteinModelPortalQ86WU2.
SMRQ86WU2. Positions 27-507.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128242. 4 interactions.
STRING9606.ENSP00000300051.

Chemistry

BindingDBQ86WU2.

PTM databases

PhosphoSiteQ86WU2.

Polymorphism databases

DMDM74727712.

Proteomic databases

PaxDbQ86WU2.
PRIDEQ86WU2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000300051; ENSP00000300051; ENSG00000166816. [Q86WU2-1]
ENST00000450168; ENSP00000417011; ENSG00000166816. [Q86WU2-2]
GeneID197257.
KEGGhsa:197257.
UCSCuc002fdm.3. human. [Q86WU2-1]
uc002fdn.3. human. [Q86WU2-2]

Organism-specific databases

CTD197257.
GeneCardsGC16M075145.
HGNCHGNC:19708. LDHD.
HPAHPA041766.
HPA048639.
MIM607490. gene.
neXtProtNX_Q86WU2.
PharmGKBPA134917525.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0277.
HOGENOMHOG000230995.
HOVERGENHBG066407.
InParanoidQ86WU2.
KOK00102.
OMAGQGFEWA.
OrthoDBEOG7QNVKV.
PhylomeDBQ86WU2.
TreeFamTF314122.

Enzyme and pathway databases

BioCycMetaCyc:HS15490-MONOMER.
ReactomeREACT_17015. Metabolism of proteins.

Gene expression databases

ArrayExpressQ86WU2.
BgeeQ86WU2.
CleanExHS_LDHD.
GenevestigatorQ86WU2.

Family and domain databases

Gene3D1.10.45.10. 1 hit.
3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR016164. FAD-linked_Oxase-like_C.
IPR004113. FAD-linked_oxidase_C.
IPR006094. Oxid_FAD_bind_N.
IPR016171. Vanillyl_alc_oxidase_C-sub2.
[Graphical view]
PfamPF02913. FAD-oxidase_C. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view]
SUPFAMSSF55103. SSF55103. 1 hit.
SSF56176. SSF56176. 2 hits.
PROSITEPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi197257.
NextBio89620.
PROQ86WU2.
SOURCESearch...

Entry information

Entry nameLDHD_HUMAN
AccessionPrimary (citable) accession number: Q86WU2
Secondary accession number(s): Q8IZK5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2003
Last modified: March 19, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM