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Protein

E3 ubiquitin-protein ligase TRIM69

Gene

TRIM69

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri41 – 8242RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • ligase activity Source: UniProtKB-KW
  • ubiquitin-protein transferase activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM69 (EC:6.3.2.-)
Alternative name(s):
RFP-like domain-containing protein trimless
RING finger protein 36
Tripartite motif-containing protein 69
Gene namesi
Name:TRIM69
Synonyms:RNF36
ORF Names:HSD-34, HSD34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:17857. TRIM69.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • nuclear speck Source: UniProtKB
  • nucleus Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi61 – 611C → A: Loss of E3 ubiquitin-protein ligase activity; when associated with A-64. 1 Publication
Mutagenesisi64 – 641C → A: Loss of E3 ubiquitin-protein ligase activity; when associated with A-61. 1 Publication

Organism-specific databases

PharmGKBiPA162407010.

Polymorphism and mutation databases

BioMutaiTRIM69.
DMDMi229462760.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500E3 ubiquitin-protein ligase TRIM69PRO_0000278236Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei341 – 3411PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated. Phosphorylation is necessary for nuclear localization (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ86WT6.
PeptideAtlasiQ86WT6.
PRIDEiQ86WT6.
TopDownProteomicsiQ86WT6-2. [Q86WT6-2]

PTM databases

iPTMnetiQ86WT6.
PhosphoSiteiQ86WT6.

Expressioni

Gene expression databases

BgeeiQ86WT6.
CleanExiHS_TRIM69.
ExpressionAtlasiQ86WT6. baseline and differential.
GenevisibleiQ86WT6. HS.

Organism-specific databases

HPAiHPA028894.

Interactioni

Subunit structurei

Interacts with PML.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ASNSP082433EBI-749955,EBI-722989
ATP5G1P054963EBI-749955,EBI-10194585
DVL1Q86TH33EBI-749955,EBI-10185025
FAM110AQ9BQ893EBI-749955,EBI-1752811
FKBP1BP681063EBI-749955,EBI-6693977
HAUS1Q96CS23EBI-749955,EBI-2514791
IYDQ6PHW03EBI-749955,EBI-10253668
KRT17F5GWP83EBI-749955,EBI-10177711
LARP1BQ659C43EBI-749955,EBI-3940258
MAGEA4Q1RN333EBI-749955,EBI-10194128
NEK8Q86SG63EBI-749955,EBI-1752987
PPP1R18Q6NYC83EBI-749955,EBI-2557469
RECKQ6P9E23EBI-749955,EBI-10253121
RSPH14Q9UHP63EBI-749955,EBI-748350
SF1Q156373EBI-749955,EBI-744603
SF3A3Q128743EBI-749955,EBI-1051880
SYNE4Q8N2053EBI-749955,EBI-7131783
TRIM44Q96DX73EBI-749955,EBI-8787399
ZNF483Q6P0883EBI-749955,EBI-10196963

Protein-protein interaction databases

BioGridi126654. 36 interactions.
IntActiQ86WT6. 22 interactions.
MINTiMINT-1465642.
STRINGi9606.ENSP00000332284.

Structurei

Secondary structure

1
500
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi144 – 1485Combined sources
Helixi153 – 260108Combined sources
Helixi266 – 2716Combined sources
Helixi273 – 28715Combined sources
Helixi298 – 3014Combined sources
Helixi305 – 31814Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NQJX-ray2.15A/B/C143-321[»]
ProteinModelPortaliQ86WT6.
SMRiQ86WT6. Positions 28-104, 114-496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini305 – 500196B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 152152Necessary for nuclear localizationBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili161 – 25595Sequence analysisAdd
BLAST

Domaini

The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity and for nuclear localization and aggregation.

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri41 – 8242RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG410XWXM. LUCA.
GeneTreeiENSGT00760000118838.
HOVERGENiHBG001357.
InParanoidiQ86WT6.
KOiK12034.
OMAiFFTEELT.
OrthoDBiEOG72RMXQ.
PhylomeDBiQ86WT6.
TreeFamiTF342569.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86WT6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVSTNPSSN IDPGDYVEMN DSITHLPSKV VIQDITMELH CPLCNDWFRD
60 70 80 90 100
PLMLSCGHNF CEACIQDFWR LQAKETFCPE CKMLCQYNNC TFNPVLDKLV
110 120 130 140 150
EKIKKLPLLK GHPQCPEHGE NLKLFSKPDG KLICFQCKDA RLSVGQSKEF
160 170 180 190 200
LQISDAVHFF TEELAIQQGQ LETTLKELQT LRNMQKEAIA AHKENKLHLQ
210 220 230 240 250
QHVSMEFLKL HQFLHSKEKD ILTELREEGK ALNEEMELNL SQLQEQCLLA
260 270 280 290 300
KDMLVSIQAK TEQQNSFDFL KDITTLLHSL EQGMKVLATR ELISRKLNLG
310 320 330 340 350
QYKGPIQYMV WREMQDTLCP GLSPLTLDPK TAHPNLVLSK SQTSVWHGDI
360 370 380 390 400
KKIMPDDPER FDSSVAVLGS RGFTSGKWYW EVEVAKKTKW TVGVVRESII
410 420 430 440 450
RKGSCPLTPE QGFWLLRLRN QTDLKALDLP SFSLTLTNNL DKVGIYLDYE
460 470 480 490 500
GGQLSFYNAK TMTHIYTFSN TFMEKLYPYF CPCLNDGGEN KEPLHILHPQ
Length:500
Mass (Da):57,419
Last modified:May 5, 2009 - v2
Checksum:iE9957652895213B3
GO
Isoform 2 (identifier: Q86WT6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-161: Missing.

Show »
Length:341
Mass (Da):39,254
Checksum:i36DF6708DB5DBF7B
GO
Isoform 3 (identifier: Q86WT6-3) [UniParc]FASTAAdd to basket

Also known as: Trimless alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-204: Missing.

Show »
Length:296
Mass (Da):34,033
Checksum:iFD94B8F14B04945B
GO
Isoform 4 (identifier: Q86WT6-4) [UniParc]FASTAAdd to basket

Also known as: Trimless beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-204: Missing.
     255-271: Missing.

Show »
Length:279
Mass (Da):32,068
Checksum:i732E356FEF439FF9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti469 – 4691S → G in AAQ75551 (Ref. 3) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121D → N.
Corresponds to variant rs2444007 [ dbSNP | Ensembl ].
VAR_057226
Natural varianti15 – 151D → N.1 Publication
Corresponds to variant rs2470911 [ dbSNP | Ensembl ].
VAR_057227
Natural varianti31 – 311V → A.
Corresponds to variant rs3759880 [ dbSNP | Ensembl ].
VAR_030704
Natural varianti104 – 1041K → R.
Corresponds to variant rs17588988 [ dbSNP | Ensembl ].
VAR_057228
Natural varianti161 – 1611T → M.1 Publication
Corresponds to variant rs3100139 [ dbSNP | Ensembl ].
VAR_057229
Natural varianti190 – 1901A → V.
Corresponds to variant rs3759880 [ dbSNP | Ensembl ].
VAR_057230

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 204204Missing in isoform 3 and isoform 4. 1 PublicationVSP_023200Add
BLAST
Alternative sequencei3 – 161159Missing in isoform 2. 1 PublicationVSP_023201Add
BLAST
Alternative sequencei255 – 27117Missing in isoform 4. 1 PublicationVSP_023202Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302088 mRNA. Translation: AAL55810.1.
AF302089 mRNA. Translation: AAL55811.1.
DQ232883 mRNA. Translation: ABB18376.1.
AY305385 mRNA. Translation: AAQ75551.1.
AC122108 Genomic DNA. No translation available.
BC024199 mRNA. Translation: AAH24199.1. Different termination.
BC033314 mRNA. Translation: AAH33314.1.
BC047945 mRNA. Translation: AAH47945.1.
CCDSiCCDS10114.1. [Q86WT6-2]
CCDS32220.1. [Q86WT6-1]
CCDS73719.1. [Q86WT6-3]
CCDS76746.1. [Q86WT6-4]
RefSeqiNP_001288073.1. NM_001301144.1. [Q86WT6-3]
NP_001288074.1. NM_001301145.1. [Q86WT6-4]
NP_001288075.1. NM_001301146.1.
NP_542783.2. NM_080745.4. [Q86WT6-2]
NP_892030.3. NM_182985.4. [Q86WT6-1]
UniGeneiHs.745248.

Genome annotation databases

EnsembliENST00000329464; ENSP00000332284; ENSG00000185880. [Q86WT6-1]
ENST00000338264; ENSP00000342922; ENSG00000185880. [Q86WT6-2]
ENST00000558329; ENSP00000453332; ENSG00000185880. [Q86WT6-4]
ENST00000559390; ENSP00000453177; ENSG00000185880. [Q86WT6-1]
ENST00000560442; ENSP00000453549; ENSG00000185880. [Q86WT6-3]
ENST00000618398; ENSP00000479720; ENSG00000278211. [Q86WT6-2]
ENST00000631740; ENSP00000488341; ENSG00000278211. [Q86WT6-4]
ENST00000633106; ENSP00000488084; ENSG00000278211. [Q86WT6-3]
GeneIDi140691.
KEGGihsa:140691.
UCSCiuc001zuf.3. human. [Q86WT6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302088 mRNA. Translation: AAL55810.1.
AF302089 mRNA. Translation: AAL55811.1.
DQ232883 mRNA. Translation: ABB18376.1.
AY305385 mRNA. Translation: AAQ75551.1.
AC122108 Genomic DNA. No translation available.
BC024199 mRNA. Translation: AAH24199.1. Different termination.
BC033314 mRNA. Translation: AAH33314.1.
BC047945 mRNA. Translation: AAH47945.1.
CCDSiCCDS10114.1. [Q86WT6-2]
CCDS32220.1. [Q86WT6-1]
CCDS73719.1. [Q86WT6-3]
CCDS76746.1. [Q86WT6-4]
RefSeqiNP_001288073.1. NM_001301144.1. [Q86WT6-3]
NP_001288074.1. NM_001301145.1. [Q86WT6-4]
NP_001288075.1. NM_001301146.1.
NP_542783.2. NM_080745.4. [Q86WT6-2]
NP_892030.3. NM_182985.4. [Q86WT6-1]
UniGeneiHs.745248.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NQJX-ray2.15A/B/C143-321[»]
ProteinModelPortaliQ86WT6.
SMRiQ86WT6. Positions 28-104, 114-496.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126654. 36 interactions.
IntActiQ86WT6. 22 interactions.
MINTiMINT-1465642.
STRINGi9606.ENSP00000332284.

PTM databases

iPTMnetiQ86WT6.
PhosphoSiteiQ86WT6.

Polymorphism and mutation databases

BioMutaiTRIM69.
DMDMi229462760.

Proteomic databases

PaxDbiQ86WT6.
PeptideAtlasiQ86WT6.
PRIDEiQ86WT6.
TopDownProteomicsiQ86WT6-2. [Q86WT6-2]

Protocols and materials databases

DNASUi140691.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329464; ENSP00000332284; ENSG00000185880. [Q86WT6-1]
ENST00000338264; ENSP00000342922; ENSG00000185880. [Q86WT6-2]
ENST00000558329; ENSP00000453332; ENSG00000185880. [Q86WT6-4]
ENST00000559390; ENSP00000453177; ENSG00000185880. [Q86WT6-1]
ENST00000560442; ENSP00000453549; ENSG00000185880. [Q86WT6-3]
ENST00000618398; ENSP00000479720; ENSG00000278211. [Q86WT6-2]
ENST00000631740; ENSP00000488341; ENSG00000278211. [Q86WT6-4]
ENST00000633106; ENSP00000488084; ENSG00000278211. [Q86WT6-3]
GeneIDi140691.
KEGGihsa:140691.
UCSCiuc001zuf.3. human. [Q86WT6-1]

Organism-specific databases

CTDi140691.
GeneCardsiTRIM69.
HGNCiHGNC:17857. TRIM69.
HPAiHPA028894.
MIMi616017. gene.
neXtProtiNX_Q86WT6.
PharmGKBiPA162407010.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG410XWXM. LUCA.
GeneTreeiENSGT00760000118838.
HOVERGENiHBG001357.
InParanoidiQ86WT6.
KOiK12034.
OMAiFFTEELT.
OrthoDBiEOG72RMXQ.
PhylomeDBiQ86WT6.
TreeFamiTF342569.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii140691.
PROiQ86WT6.
SOURCEiSearch...

Gene expression databases

BgeeiQ86WT6.
CleanExiHS_TRIM69.
ExpressionAtlasiQ86WT6. baseline and differential.
GenevisibleiQ86WT6. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TRIMLESS defines a new class of RFP-like domain containing proteins."
    Merla G., Zanaria E., Cairo S., Meroni G., Reymond A.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
  2. Corcoran M., Lerner M., Sangfelt O., Grander D.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "A new spermatogenesis related gene."
    Fan M.M., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS ASN-15 AND MET-161.
    Tissue: Brain and Testis.
  6. "Characterisation of human RING finger protein TRIM69, a novel testis E3 ubiquitin ligase and its subcellular localisation."
    Han Y., Li R., Gao J., Miao S., Wang L.
    Biochem. Biophys. Res. Commun. 429:6-11(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION, MUTAGENESIS OF CYS-61 AND CYS-64.

Entry informationi

Entry nameiTRI69_HUMAN
AccessioniPrimary (citable) accession number: Q86WT6
Secondary accession number(s): A8MX03
, Q309B0, Q4G1A5, Q6W897, Q8IYY3, Q8WY16, Q8WY17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 5, 2009
Last modified: July 6, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.