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Protein

Tetratricopeptide repeat protein 30A

Gene

TTC30A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Enzyme and pathway databases

BioCyciZFISH:G66-33927-MONOMER.
ReactomeiR-HSA-5620924. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 30A
Short name:
TPR repeat protein 30A
Gene namesi
Name:TTC30A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25853. TTC30A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Organism-specific databases

DisGeNETi92104.
OpenTargetsiENSG00000197557.
PharmGKBiPA145147829.

Polymorphism and mutation databases

BioMutaiTTC30A.
DMDMi224471874.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003332001 – 665Tetratricopeptide repeat protein 30AAdd BLAST665

Proteomic databases

EPDiQ86WT1.
MaxQBiQ86WT1.
PaxDbiQ86WT1.
PeptideAtlasiQ86WT1.
PRIDEiQ86WT1.

PTM databases

iPTMnetiQ86WT1.
PhosphoSitePlusiQ86WT1.

Expressioni

Gene expression databases

BgeeiENSG00000197557.
CleanExiHS_TTC30A.
GenevisibleiQ86WT1. HS.

Organism-specific databases

HPAiHPA051714.
HPA052100.
HPA052487.

Interactioni

Protein-protein interaction databases

BioGridi124908. 22 interactors.
IntActiQ86WT1. 17 interactors.
STRINGi9606.ENSP00000347915.

Structurei

3D structure databases

ProteinModelPortaliQ86WT1.
SMRiQ86WT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 44TPR 1Add BLAST34
Repeati45 – 78TPR 2Add BLAST34
Repeati154 – 187TPR 3Add BLAST34
Repeati189 – 221TPR 4Add BLAST33
Repeati393 – 424TPR 5Add BLAST32
Repeati425 – 457TPR 6Add BLAST33
Repeati459 – 492TPR 7Add BLAST34
Repeati544 – 577TPR 8Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili508 – 535Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi326 – 329Poly-Leu4

Sequence similaritiesi

Belongs to the TTC30/dfy-1/fleer family.Curated
Contains 8 TPR repeats.Curated

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4340. Eukaryota.
ENOG410XNQ1. LUCA.
GeneTreeiENSGT00390000010116.
HOGENOMiHOG000258608.
HOVERGENiHBG061770.
InParanoidiQ86WT1.
KOiK19683.
OMAiINKYEDL.
OrthoDBiEOG091G03OT.
PhylomeDBiQ86WT1.
TreeFamiTF314592.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 6 hits.
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86WT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLSGAQIP DGEFTALVYR LIRDARYAEA VQLLGRELQR SPRSRAGLSL
60 70 80 90 100
LGYCYYRLQE FALAAECYEQ LGQLHPELEQ YRLYQAQALY KACLYPEATR
110 120 130 140 150
VAFLLLDNPA YHSRVLRLQA AIKYSEGDLP GSRSLVEQLL SGEGGEESGG
160 170 180 190 200
DNETDGQVNL GCLLYKEGQY EAACSKFSAT LQASGYQPDL SYNLALAYYS
210 220 230 240 250
SRQYASALKH IAEIIERGIR QHPELGVGMT TEGFDVRSVG NTLVLHQTAL
260 270 280 290 300
VEAFNLKAAI EYQLRNYEVA QETLTDMPPR AEEELDPVTL HNQALMNMDA
310 320 330 340 350
RPTEGFEKLQ FLLQQNPFPP ETFGNLLLLY CKYEYFDLAA DVLAENAHLT
360 370 380 390 400
YKFLTPYLYD FLDALITCQT APEEAFIKLD GLAGMLTEQL RRLTKQVQEA
410 420 430 440 450
RHNRDDEAIK KAVNEYDETM EKYIPVLMAQ AKIYWNLENY PMVEKVFRKS
460 470 480 490 500
VEFCNDHDVW KLNVAHVLFM QENKYKEAIG FYEPIVKKHY DNILNVSAIV
510 520 530 540 550
LANLCVSYIM TSQNEEAEEL MRKIEKEEEQ LSYDDPNRKM YHLCIVNLVI
560 570 580 590 600
GTLYCAKGNY EFGISRVIKS LEPYNKKLGT DTWYYAKRCF LSLLENMSKH
610 620 630 640 650
MIVIHDSVIQ ECVQFLGHCE LYGTNIPAVI EQPLEEERMH VGKNTVTDES
660
RQLKALIYEI IGWNK
Length:665
Mass (Da):76,136
Last modified:March 3, 2009 - v3
Checksum:i567FD2C26CC48435
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti279P → H in BAF85084 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054660446V → I.3 PublicationsCorresponds to variant rs28630685dbSNPEnsembl.1
Natural variantiVAR_043123577K → R.1 PublicationCorresponds to variant rs17854236dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292395 mRNA. Translation: BAF85084.1.
AC073834 Genomic DNA. No translation available.
CH471058 Genomic DNA. Translation: EAX11053.1.
BC042848 mRNA. Translation: AAH42848.1.
BC048006 mRNA. Translation: AAH48006.2.
CCDSiCCDS2276.1.
RefSeqiNP_689488.3. NM_152275.3.
UniGeneiHs.128384.

Genome annotation databases

EnsembliENST00000355689; ENSP00000347915; ENSG00000197557.
GeneIDi92104.
KEGGihsa:92104.
UCSCiuc002ulo.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292395 mRNA. Translation: BAF85084.1.
AC073834 Genomic DNA. No translation available.
CH471058 Genomic DNA. Translation: EAX11053.1.
BC042848 mRNA. Translation: AAH42848.1.
BC048006 mRNA. Translation: AAH48006.2.
CCDSiCCDS2276.1.
RefSeqiNP_689488.3. NM_152275.3.
UniGeneiHs.128384.

3D structure databases

ProteinModelPortaliQ86WT1.
SMRiQ86WT1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124908. 22 interactors.
IntActiQ86WT1. 17 interactors.
STRINGi9606.ENSP00000347915.

PTM databases

iPTMnetiQ86WT1.
PhosphoSitePlusiQ86WT1.

Polymorphism and mutation databases

BioMutaiTTC30A.
DMDMi224471874.

Proteomic databases

EPDiQ86WT1.
MaxQBiQ86WT1.
PaxDbiQ86WT1.
PeptideAtlasiQ86WT1.
PRIDEiQ86WT1.

Protocols and materials databases

DNASUi92104.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355689; ENSP00000347915; ENSG00000197557.
GeneIDi92104.
KEGGihsa:92104.
UCSCiuc002ulo.4. human.

Organism-specific databases

CTDi92104.
DisGeNETi92104.
GeneCardsiTTC30A.
HGNCiHGNC:25853. TTC30A.
HPAiHPA051714.
HPA052100.
HPA052487.
neXtProtiNX_Q86WT1.
OpenTargetsiENSG00000197557.
PharmGKBiPA145147829.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4340. Eukaryota.
ENOG410XNQ1. LUCA.
GeneTreeiENSGT00390000010116.
HOGENOMiHOG000258608.
HOVERGENiHBG061770.
InParanoidiQ86WT1.
KOiK19683.
OMAiINKYEDL.
OrthoDBiEOG091G03OT.
PhylomeDBiQ86WT1.
TreeFamiTF314592.

Enzyme and pathway databases

BioCyciZFISH:G66-33927-MONOMER.
ReactomeiR-HSA-5620924. Intraflagellar transport.

Miscellaneous databases

GenomeRNAii92104.
PROiQ86WT1.

Gene expression databases

BgeeiENSG00000197557.
CleanExiHS_TTC30A.
GenevisibleiQ86WT1. HS.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 6 hits.
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTT30A_HUMAN
AccessioniPrimary (citable) accession number: Q86WT1
Secondary accession number(s): A8K8N0, Q8IVP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 3, 2009
Last modified: November 30, 2016
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.