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Protein

Proline and serine-rich protein 2

Gene

PROSER2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Proline and serine-rich protein 2
Gene namesi
Name:PROSER2
Synonyms:C10orf47
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23728. PROSER2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134910296.

Polymorphism and mutation databases

BioMutaiPROSER2.
DMDMi73620073.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Proline and serine-rich protein 2PRO_0000089792Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81PhosphoserineCombined sources
Modified residuei43 – 431PhosphoserineCombined sources1 Publication
Modified residuei45 – 451PhosphothreonineCombined sources
Modified residuei146 – 1461PhosphothreonineCombined sources
Modified residuei166 – 1661PhosphoserineCombined sources
Modified residuei167 – 1671PhosphothreonineCombined sources
Modified residuei179 – 1791PhosphoserineCombined sources1 Publication
Modified residuei212 – 2121PhosphoserineCombined sources1 Publication
Modified residuei215 – 2151PhosphoserineCombined sources
Modified residuei252 – 2521Omega-N-methylarginine1 Publication
Modified residuei312 – 3121PhosphoserineCombined sources
Modified residuei320 – 3201Dimethylated arginine; alternate1 Publication
Modified residuei320 – 3201Omega-N-methylarginine; alternate1 Publication
Modified residuei400 – 4001PhosphoserineCombined sources

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ86WR7.
MaxQBiQ86WR7.
PaxDbiQ86WR7.
PeptideAtlasiQ86WR7.
PRIDEiQ86WR7.

PTM databases

iPTMnetiQ86WR7.
PhosphoSiteiQ86WR7.

Expressioni

Gene expression databases

BgeeiENSG00000148426.
CleanExiHS_C10orf47.
ExpressionAtlasiQ86WR7. baseline and differential.
GenevisibleiQ86WR7. HS.

Organism-specific databases

HPAiHPA041337.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
POT1Q9NUX52EBI-2880603,EBI-752420

Protein-protein interaction databases

BioGridi129035. 34 interactions.
IntActiQ86WR7. 8 interactions.
STRINGi9606.ENSP00000277570.

Structurei

3D structure databases

ProteinModelPortaliQ86WR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi8 – 4336Ser-richAdd
BLAST
Compositional biasi147 – 254108Pro-richAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IJR6. Eukaryota.
ENOG4111Z7A. LUCA.
GeneTreeiENSGT00440000039611.
HOVERGENiHBG081179.
InParanoidiQ86WR7.
OMAiANGFQSI.
OrthoDBiEOG091G0C4U.
PhylomeDBiQ86WR7.
TreeFamiTF335482.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86WR7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVTHRKSDA SDMNSDTSPS CRLRAFSRGG SLESRSSSSR SRSFTLDDES
60 70 80 90 100
LKYLTHEEKD VLLFFEETID SLDEDFEEPV LCDGGVCCLC SPSLEESTSS
110 120 130 140 150
PSEPEDVIDL VQPAPGAGEA EGLPEGTQAA GPAPAGKEHR KQDAETPPPP
160 170 180 190 200
DPPAPETLLA PPPLPSTPDP PRRELRAPSP PVEHPRLLRS VPTPLVMAQK
210 220 230 240 250
ISERMAGNEA LSPTSPFREG RPGEWRTPAA RGPRSGDPGP GPSHPAQPKA
260 270 280 290 300
PRFPSNIIVT NGAAREPRRT LSRAAVSVQE RRAQVLATIH GHAGAFPAAG
310 320 330 340 350
DAGEGAPGGG SSPERVARGR GLPGPAESLR AGGQAPRGPA LANGFPSAHE
360 370 380 390 400
ALKSAPSSFA PAGKSLCFRP GPALPSTRAR QSFPGPRQPN GAQDWRRADS
410 420 430
LPRPQGITVQ FAGRGSSEEA RREALRKLGL LRESS
Length:435
Mass (Da):45,802
Last modified:August 16, 2005 - v2
Checksum:i223F949909100AA1
GO
Isoform 2 (identifier: Q86WR7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     245-338: Missing.

Note: No experimental confirmation available.
Show »
Length:341
Mass (Da):36,412
Checksum:i3D8C3F662BAFA6F9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti323 – 3231P → R in AAH48800 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti412 – 4121A → V.1 Publication
Corresponds to variant rs12253554 [ dbSNP | Ensembl ].
VAR_023097

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei245 – 33894Missing in isoform 2. 1 PublicationVSP_014955Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138898 Genomic DNA. Translation: CAH73460.1.
AL138898 Genomic DNA. Translation: CAH73461.1.
AL138898 Genomic DNA. Translation: CAH73462.1.
AL138898 Genomic DNA. Translation: CAH73463.1. Sequence problems.
CH471072 Genomic DNA. Translation: EAW86336.1.
CH471072 Genomic DNA. Translation: EAW86339.1.
BC017269 mRNA. Translation: AAH17269.1.
BC029134 mRNA. Translation: AAH29134.2.
BC048800 mRNA. Translation: AAH48800.1.
CCDSiCCDS7085.1. [Q86WR7-1]
RefSeqiNP_694988.3. NM_153256.3. [Q86WR7-1]
XP_011517740.1. XM_011519438.2. [Q86WR7-1]
UniGeneiHs.435775.

Genome annotation databases

EnsembliENST00000277570; ENSP00000277570; ENSG00000148426. [Q86WR7-1]
ENST00000622831; ENSP00000484913; ENSG00000148426. [Q86WR7-2]
GeneIDi254427.
KEGGihsa:254427.
UCSCiuc001ikx.3. human. [Q86WR7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138898 Genomic DNA. Translation: CAH73460.1.
AL138898 Genomic DNA. Translation: CAH73461.1.
AL138898 Genomic DNA. Translation: CAH73462.1.
AL138898 Genomic DNA. Translation: CAH73463.1. Sequence problems.
CH471072 Genomic DNA. Translation: EAW86336.1.
CH471072 Genomic DNA. Translation: EAW86339.1.
BC017269 mRNA. Translation: AAH17269.1.
BC029134 mRNA. Translation: AAH29134.2.
BC048800 mRNA. Translation: AAH48800.1.
CCDSiCCDS7085.1. [Q86WR7-1]
RefSeqiNP_694988.3. NM_153256.3. [Q86WR7-1]
XP_011517740.1. XM_011519438.2. [Q86WR7-1]
UniGeneiHs.435775.

3D structure databases

ProteinModelPortaliQ86WR7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129035. 34 interactions.
IntActiQ86WR7. 8 interactions.
STRINGi9606.ENSP00000277570.

PTM databases

iPTMnetiQ86WR7.
PhosphoSiteiQ86WR7.

Polymorphism and mutation databases

BioMutaiPROSER2.
DMDMi73620073.

Proteomic databases

EPDiQ86WR7.
MaxQBiQ86WR7.
PaxDbiQ86WR7.
PeptideAtlasiQ86WR7.
PRIDEiQ86WR7.

Protocols and materials databases

DNASUi254427.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000277570; ENSP00000277570; ENSG00000148426. [Q86WR7-1]
ENST00000622831; ENSP00000484913; ENSG00000148426. [Q86WR7-2]
GeneIDi254427.
KEGGihsa:254427.
UCSCiuc001ikx.3. human. [Q86WR7-1]

Organism-specific databases

CTDi254427.
GeneCardsiPROSER2.
H-InvDBHIX0008641.
HGNCiHGNC:23728. PROSER2.
HPAiHPA041337.
neXtProtiNX_Q86WR7.
PharmGKBiPA134910296.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJR6. Eukaryota.
ENOG4111Z7A. LUCA.
GeneTreeiENSGT00440000039611.
HOVERGENiHBG081179.
InParanoidiQ86WR7.
OMAiANGFQSI.
OrthoDBiEOG091G0C4U.
PhylomeDBiQ86WR7.
TreeFamiTF335482.

Miscellaneous databases

GenomeRNAii254427.
PROiQ86WR7.

Gene expression databases

BgeeiENSG00000148426.
CleanExiHS_C10orf47.
ExpressionAtlasiQ86WR7. baseline and differential.
GenevisibleiQ86WR7. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiPRSR2_HUMAN
AccessioniPrimary (citable) accession number: Q86WR7
Secondary accession number(s): D3DRR8
, Q5W0J9, Q5W0K0, Q5W0K1, Q5W0K2, Q6PJC8, Q8N317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: September 7, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.