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Protein

Proline and serine-rich protein 2

Gene

PROSER2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Proline and serine-rich protein 2
Gene namesi
Name:PROSER2
Synonyms:C10orf47
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23728. PROSER2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148426.
PharmGKBiPA134910296.

Polymorphism and mutation databases

BioMutaiPROSER2.
DMDMi73620073.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000897921 – 435Proline and serine-rich protein 2Add BLAST435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineCombined sources1
Modified residuei43PhosphoserineCombined sources1 Publication1
Modified residuei45PhosphothreonineCombined sources1
Modified residuei146PhosphothreonineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei167PhosphothreonineCombined sources1
Modified residuei179PhosphoserineCombined sources1 Publication1
Modified residuei212PhosphoserineCombined sources1 Publication1
Modified residuei215PhosphoserineCombined sources1
Modified residuei252Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei252Omega-N-methylarginine; alternate1 Publication1
Modified residuei312PhosphoserineCombined sources1
Modified residuei320Dimethylated arginine; alternate1 Publication1
Modified residuei320Omega-N-methylarginine; alternateCombined sources1 Publication1
Modified residuei378Omega-N-methylarginineCombined sources1
Modified residuei400PhosphoserineCombined sources1
Modified residuei414Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ86WR7.
MaxQBiQ86WR7.
PaxDbiQ86WR7.
PeptideAtlasiQ86WR7.
PRIDEiQ86WR7.

PTM databases

iPTMnetiQ86WR7.
PhosphoSitePlusiQ86WR7.

Expressioni

Gene expression databases

BgeeiENSG00000148426.
CleanExiHS_C10orf47.
ExpressionAtlasiQ86WR7. baseline and differential.
GenevisibleiQ86WR7. HS.

Organism-specific databases

HPAiHPA041337.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
POT1Q9NUX52EBI-2880603,EBI-752420

Protein-protein interaction databases

BioGridi129035. 34 interactors.
IntActiQ86WR7. 8 interactors.
STRINGi9606.ENSP00000277570.

Structurei

3D structure databases

ProteinModelPortaliQ86WR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8 – 43Ser-richAdd BLAST36
Compositional biasi147 – 254Pro-richAdd BLAST108

Phylogenomic databases

eggNOGiENOG410IJR6. Eukaryota.
ENOG4111Z7A. LUCA.
GeneTreeiENSGT00440000039611.
HOVERGENiHBG081179.
InParanoidiQ86WR7.
OMAiANGFQSI.
OrthoDBiEOG091G0C4U.
PhylomeDBiQ86WR7.
TreeFamiTF335482.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86WR7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVTHRKSDA SDMNSDTSPS CRLRAFSRGG SLESRSSSSR SRSFTLDDES
60 70 80 90 100
LKYLTHEEKD VLLFFEETID SLDEDFEEPV LCDGGVCCLC SPSLEESTSS
110 120 130 140 150
PSEPEDVIDL VQPAPGAGEA EGLPEGTQAA GPAPAGKEHR KQDAETPPPP
160 170 180 190 200
DPPAPETLLA PPPLPSTPDP PRRELRAPSP PVEHPRLLRS VPTPLVMAQK
210 220 230 240 250
ISERMAGNEA LSPTSPFREG RPGEWRTPAA RGPRSGDPGP GPSHPAQPKA
260 270 280 290 300
PRFPSNIIVT NGAAREPRRT LSRAAVSVQE RRAQVLATIH GHAGAFPAAG
310 320 330 340 350
DAGEGAPGGG SSPERVARGR GLPGPAESLR AGGQAPRGPA LANGFPSAHE
360 370 380 390 400
ALKSAPSSFA PAGKSLCFRP GPALPSTRAR QSFPGPRQPN GAQDWRRADS
410 420 430
LPRPQGITVQ FAGRGSSEEA RREALRKLGL LRESS
Length:435
Mass (Da):45,802
Last modified:August 16, 2005 - v2
Checksum:i223F949909100AA1
GO
Isoform 2 (identifier: Q86WR7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     245-338: Missing.

Note: No experimental confirmation available.
Show »
Length:341
Mass (Da):36,412
Checksum:i3D8C3F662BAFA6F9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti323P → R in AAH48800 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023097412A → V.1 PublicationCorresponds to variant rs12253554dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014955245 – 338Missing in isoform 2. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138898 Genomic DNA. Translation: CAH73460.1.
AL138898 Genomic DNA. Translation: CAH73461.1.
AL138898 Genomic DNA. Translation: CAH73462.1.
AL138898 Genomic DNA. Translation: CAH73463.1. Sequence problems.
CH471072 Genomic DNA. Translation: EAW86336.1.
CH471072 Genomic DNA. Translation: EAW86339.1.
BC017269 mRNA. Translation: AAH17269.1.
BC029134 mRNA. Translation: AAH29134.2.
BC048800 mRNA. Translation: AAH48800.1.
CCDSiCCDS7085.1. [Q86WR7-1]
RefSeqiNP_694988.3. NM_153256.3. [Q86WR7-1]
XP_011517740.1. XM_011519438.2. [Q86WR7-1]
XP_016871517.1. XM_017016028.1. [Q86WR7-1]
UniGeneiHs.435775.

Genome annotation databases

EnsembliENST00000277570; ENSP00000277570; ENSG00000148426. [Q86WR7-1]
ENST00000622831; ENSP00000484913; ENSG00000148426. [Q86WR7-2]
GeneIDi254427.
KEGGihsa:254427.
UCSCiuc001ikx.3. human. [Q86WR7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138898 Genomic DNA. Translation: CAH73460.1.
AL138898 Genomic DNA. Translation: CAH73461.1.
AL138898 Genomic DNA. Translation: CAH73462.1.
AL138898 Genomic DNA. Translation: CAH73463.1. Sequence problems.
CH471072 Genomic DNA. Translation: EAW86336.1.
CH471072 Genomic DNA. Translation: EAW86339.1.
BC017269 mRNA. Translation: AAH17269.1.
BC029134 mRNA. Translation: AAH29134.2.
BC048800 mRNA. Translation: AAH48800.1.
CCDSiCCDS7085.1. [Q86WR7-1]
RefSeqiNP_694988.3. NM_153256.3. [Q86WR7-1]
XP_011517740.1. XM_011519438.2. [Q86WR7-1]
XP_016871517.1. XM_017016028.1. [Q86WR7-1]
UniGeneiHs.435775.

3D structure databases

ProteinModelPortaliQ86WR7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129035. 34 interactors.
IntActiQ86WR7. 8 interactors.
STRINGi9606.ENSP00000277570.

PTM databases

iPTMnetiQ86WR7.
PhosphoSitePlusiQ86WR7.

Polymorphism and mutation databases

BioMutaiPROSER2.
DMDMi73620073.

Proteomic databases

EPDiQ86WR7.
MaxQBiQ86WR7.
PaxDbiQ86WR7.
PeptideAtlasiQ86WR7.
PRIDEiQ86WR7.

Protocols and materials databases

DNASUi254427.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000277570; ENSP00000277570; ENSG00000148426. [Q86WR7-1]
ENST00000622831; ENSP00000484913; ENSG00000148426. [Q86WR7-2]
GeneIDi254427.
KEGGihsa:254427.
UCSCiuc001ikx.3. human. [Q86WR7-1]

Organism-specific databases

CTDi254427.
GeneCardsiPROSER2.
H-InvDBHIX0008641.
HGNCiHGNC:23728. PROSER2.
HPAiHPA041337.
neXtProtiNX_Q86WR7.
OpenTargetsiENSG00000148426.
PharmGKBiPA134910296.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJR6. Eukaryota.
ENOG4111Z7A. LUCA.
GeneTreeiENSGT00440000039611.
HOVERGENiHBG081179.
InParanoidiQ86WR7.
OMAiANGFQSI.
OrthoDBiEOG091G0C4U.
PhylomeDBiQ86WR7.
TreeFamiTF335482.

Miscellaneous databases

GenomeRNAii254427.
PROiQ86WR7.

Gene expression databases

BgeeiENSG00000148426.
CleanExiHS_C10orf47.
ExpressionAtlasiQ86WR7. baseline and differential.
GenevisibleiQ86WR7. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiPRSR2_HUMAN
AccessioniPrimary (citable) accession number: Q86WR7
Secondary accession number(s): D3DRR8
, Q5W0J9, Q5W0K0, Q5W0K1, Q5W0K2, Q6PJC8, Q8N317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: November 2, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.