Q86WR7 (CJ047_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C10orf47

Gene names

Name:

C10orf47

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	435 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Methylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86WR7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86WR7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     245-338: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 435	435	Uncharacterized protein C10orf47		PRO_0000089792
Regions
	Compositional bias	8 – 43	36	Ser-rich
	Compositional bias	147 – 254	108	Pro-rich
Amino acid modifications
	Modified residue	41	1	Phosphoserine Ref.5
	Modified residue	43	1	Phosphoserine Ref.4 Ref.7 Ref.8 Ref.9
	Modified residue	146	1	Phosphothreonine Ref.8
	Modified residue	167	1	Phosphothreonine Ref.8
	Modified residue	179	1	Phosphoserine Ref.4 Ref.6 Ref.7 Ref.8
	Modified residue	212	1	Phosphoserine Ref.4 Ref.7 Ref.8 Ref.9
	Modified residue	215	1	Phosphoserine Ref.7 Ref.8
	Modified residue	252	1	Omega-N-methylarginine Ref.4
	Modified residue	320	1	Dimethylated arginine; alternate Ref.4
	Modified residue	320	1	Omega-N-methylarginine; alternate Ref.4
Natural variations
	Alternative sequence	245 – 338	94	Missing in isoform 2.		VSP_014955
	Natural variant	412	1	A → V. Ref.3 Corresponds to variant rs12253554 [ dbSNP | Ensembl ].		VAR_023097
Experimental info
	Sequence conflict	323	1	P → R in AAH48800. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 16, 2005. Version 2. Checksum: 223F949909100AA1	FASTA	435	45,802
	10 20 30 40 50 60 MPVTHRKSDA SDMNSDTSPS CRLRAFSRGG SLESRSSSSR SRSFTLDDES LKYLTHEEKD 70 80 90 100 110 120 VLLFFEETID SLDEDFEEPV LCDGGVCCLC SPSLEESTSS PSEPEDVIDL VQPAPGAGEA 130 140 150 160 170 180 EGLPEGTQAA GPAPAGKEHR KQDAETPPPP DPPAPETLLA PPPLPSTPDP PRRELRAPSP 190 200 210 220 230 240 PVEHPRLLRS VPTPLVMAQK ISERMAGNEA LSPTSPFREG RPGEWRTPAA RGPRSGDPGP 250 260 270 280 290 300 GPSHPAQPKA PRFPSNIIVT NGAAREPRRT LSRAAVSVQE RRAQVLATIH GHAGAFPAAG 310 320 330 340 350 360 DAGEGAPGGG SSPERVARGR GLPGPAESLR AGGQAPRGPA LANGFPSAHE ALKSAPSSFA 370 380 390 400 410 420 PAGKSLCFRP GPALPSTRAR QSFPGPRQPN GAQDWRRADS LPRPQGITVQ FAGRGSSEEA 430 RREALRKLGL LRESS
	Isoform 2 [UniParc]. Checksum: 3D8C3F662BAFA6F9	FASTA	341	36,412
	10 20 30 40 50 60 MPVTHRKSDA SDMNSDTSPS CRLRAFSRGG SLESRSSSSR SRSFTLDDES LKYLTHEEKD 70 80 90 100 110 120 VLLFFEETID SLDEDFEEPV LCDGGVCCLC SPSLEESTSS PSEPEDVIDL VQPAPGAGEA 130 140 150 160 170 180 EGLPEGTQAA GPAPAGKEHR KQDAETPPPP DPPAPETLLA PPPLPSTPDP PRRELRAPSP 190 200 210 220 230 240 PVEHPRLLRS VPTPLVMAQK ISERMAGNEA LSPTSPFREG RPGEWRTPAA RGPRSGDPGP 250 260 270 280 290 300 GPSHPALANG FPSAHEALKS APSSFAPAGK SLCFRPGPAL PSTRARQSFP GPRQPNGAQD 310 320 330 340 WRRADSLPRP QGITVQFAGR GSSEEARREA LRKLGLLRES S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-412. Tissue: Blood and Kidney.
[4]	Bienvenut W.V., Dozynkiewicz M., Norman J.C. Submitted (JAN-2010) to UniProtKB Cited for: PROTEIN SEQUENCE OF 41-52; 174-186; 190-218; 250-268; 319-330; 338-364; 381-387; 398-414 AND 428-435, PHOSPHORYLATION AT SER-43; SER-179 AND SER-212, METHYLATION AT ARG-252 AND ARG-320, MASS SPECTROMETRY. Tissue: Ovarian carcinoma.
[5]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43; SER-179; SER-212 AND SER-215, MASS SPECTROMETRY. Tissue: Platelet.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43; THR-146; THR-167; SER-179; SER-212 AND SER-215, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43 AND SER-212, MASS SPECTROMETRY. Tissue: Leukemic T-cell.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL138898 Genomic DNA. Translation: CAH73460.1. AL138898 Genomic DNA. Translation: CAH73461.1. AL138898 Genomic DNA. Translation: CAH73462.1. AL138898 Genomic DNA. Translation: CAH73463.1. Sequence problems. CH471072 Genomic DNA. Translation: EAW86336.1. CH471072 Genomic DNA. Translation: EAW86339.1. BC017269 mRNA. Translation: AAH17269.1. BC029134 mRNA. Translation: AAH29134.2. BC048800 mRNA. Translation: AAH48800.1.
IPI	IPI00329115. IPI00873200.
RefSeq	NP_694988.3. NM_153256.3.
UniGene	Hs.435775.
3D structure databases
ProteinModelPortal	Q86WR7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86WR7. 4 interactions.
PTM databases
PhosphoSite	Q86WR7.
Polymorphism databases
DMDM	73620073.
Proteomic databases
PRIDE	Q86WR7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000277570; ENSP00000277570; ENSG00000148426.
GeneID	254427.
KEGG	hsa:254427.
NMPDR	fig|9606.3.peg.3548.
UCSC	uc001ikx.1. human.
Organism-specific databases
CTD	254427.
GeneCards	GC10P011905.
HGNC	HGNC:23728. C10orf47.
HPA	HPA041337.
neXtProt	NX_Q86WR7.
PharmGKB	PA134910296.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00440000039611.
HOVERGEN	HBG081179.
InParanoid	Q86WR7.
OMA	QFAGRGS.
PhylomeDB	Q86WR7.
Gene expression databases
ArrayExpress	Q86WR7.
Bgee	Q86WR7.
CleanEx	HS_C10orf47.
Genevestigator	Q86WR7.
GermOnline	ENSG00000148426. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	92347.

Entry information

Entry name

CJ047_HUMAN

Accession

Primary (citable) accession number: Q86WR7
Secondary accession number(s): D3DRR8 , Q5W0J9, Q5W0K0, Q5W0K1, Q5W0K2, Q6PJC8, Q8N317

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	August 16, 2005
Last modified:	January 25, 2012
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.