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Q86WR0

- CCD25_HUMAN

UniProt

Q86WR0 - CCD25_HUMAN

Protein

Coiled-coil domain-containing protein 25

Gene

CCDC25

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (02 May 2006)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil domain-containing protein 25
    Gene namesi
    Name:CCDC25
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:25591. CCDC25.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672183.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 208208Coiled-coil domain-containing protein 25PRO_0000233404Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei23 – 231N6-acetyllysine1 Publication
    Modified residuei204 – 2041Phosphoserine5 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ86WR0.
    PaxDbiQ86WR0.
    PRIDEiQ86WR0.

    PTM databases

    PhosphoSiteiQ86WR0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ86WR0.
    BgeeiQ86WR0.
    CleanExiHS_CCDC25.
    GenevestigatoriQ86WR0.

    Organism-specific databases

    HPAiHPA023256.

    Interactioni

    Protein-protein interaction databases

    BioGridi120537. 3 interactions.
    IntActiQ86WR0. 1 interaction.
    MINTiMINT-3058321.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86WR0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili117 – 18771Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCDC25 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG288654.
    HOGENOMiHOG000041378.
    HOVERGENiHBG057190.
    InParanoidiQ86WR0.
    OMAiIRWGWPE.
    OrthoDBiEOG7PVWQT.
    PhylomeDBiQ86WR0.
    TreeFamiTF300013.

    Family and domain databases

    InterProiIPR008532. DUF814.
    [Graphical view]
    PfamiPF05670. DUF814. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86WR0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVFYFTSSSV NSSAYTIYMG KDKYENEDLI KHGWPEDIWF HVDKLSSAHV    50
    YLRLHKGENI EDIPKEVLMD CAHLVKANSI QGCKMNNVNV VYTPWSNLKK 100
    TADMDVGQIG FHRQKDVKIV TVEKKVNEIL NRLEKTKVER FPDLAAEKEC 150
    RDREERNEKK AQIQEMKKRE KEEMKKKREM DELRSYSSLM KVENMSSNQD 200
    GNDSDEFM 208
    Length:208
    Mass (Da):24,479
    Last modified:May 2, 2006 - v2
    Checksum:i8EA9E0FFD84494B6
    GO
    Isoform 2 (identifier: Q86WR0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-68: Missing.

    Show »
    Length:140
    Mass (Da):16,474
    Checksum:i0434DFDC5DBAC16E
    GO

    Sequence cautioni

    The sequence BAA91857.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6868Missing in isoform 2. 2 PublicationsVSP_056046Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001715 mRNA. Translation: BAA91857.1. Different initiation.
    AK027900 mRNA. Translation: BAB55442.1.
    AK292875 mRNA. Translation: BAF85564.1.
    AC013643 Genomic DNA. No translation available.
    AC104997 Genomic DNA. No translation available.
    CH471080 Genomic DNA. Translation: EAW63539.1.
    BC032588 mRNA. Translation: AAH32588.1.
    BC049197 mRNA. Translation: AAH49197.2.
    BC065295 mRNA. Translation: AAH65295.1.
    CCDSiCCDS6062.2.
    RefSeqiNP_060716.2. NM_018246.2.
    XP_005273620.1. XM_005273563.2.
    UniGeneiHs.445512.

    Genome annotation databases

    EnsembliENST00000356537; ENSP00000348933; ENSG00000147419.
    ENST00000522915; ENSP00000428000; ENSG00000147419.
    GeneIDi55246.
    KEGGihsa:55246.
    UCSCiuc003xgc.3. human.

    Polymorphism databases

    DMDMi94707504.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001715 mRNA. Translation: BAA91857.1 . Different initiation.
    AK027900 mRNA. Translation: BAB55442.1 .
    AK292875 mRNA. Translation: BAF85564.1 .
    AC013643 Genomic DNA. No translation available.
    AC104997 Genomic DNA. No translation available.
    CH471080 Genomic DNA. Translation: EAW63539.1 .
    BC032588 mRNA. Translation: AAH32588.1 .
    BC049197 mRNA. Translation: AAH49197.2 .
    BC065295 mRNA. Translation: AAH65295.1 .
    CCDSi CCDS6062.2.
    RefSeqi NP_060716.2. NM_018246.2.
    XP_005273620.1. XM_005273563.2.
    UniGenei Hs.445512.

    3D structure databases

    ProteinModelPortali Q86WR0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120537. 3 interactions.
    IntActi Q86WR0. 1 interaction.
    MINTi MINT-3058321.

    PTM databases

    PhosphoSitei Q86WR0.

    Polymorphism databases

    DMDMi 94707504.

    Proteomic databases

    MaxQBi Q86WR0.
    PaxDbi Q86WR0.
    PRIDEi Q86WR0.

    Protocols and materials databases

    DNASUi 55246.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356537 ; ENSP00000348933 ; ENSG00000147419 .
    ENST00000522915 ; ENSP00000428000 ; ENSG00000147419 .
    GeneIDi 55246.
    KEGGi hsa:55246.
    UCSCi uc003xgc.3. human.

    Organism-specific databases

    CTDi 55246.
    GeneCardsi GC08M027590.
    HGNCi HGNC:25591. CCDC25.
    HPAi HPA023256.
    neXtProti NX_Q86WR0.
    PharmGKBi PA142672183.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG288654.
    HOGENOMi HOG000041378.
    HOVERGENi HBG057190.
    InParanoidi Q86WR0.
    OMAi IRWGWPE.
    OrthoDBi EOG7PVWQT.
    PhylomeDBi Q86WR0.
    TreeFami TF300013.

    Miscellaneous databases

    GeneWikii Coiled-Coil_Domain_Containing_Protein_%E2%80%93_25.
    GenomeRNAii 55246.
    NextBioi 59292.
    PROi Q86WR0.

    Gene expression databases

    ArrayExpressi Q86WR0.
    Bgeei Q86WR0.
    CleanExi HS_CCDC25.
    Genevestigatori Q86WR0.

    Family and domain databases

    InterProi IPR008532. DUF814.
    [Graphical view ]
    Pfami PF05670. DUF814. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Retinoblastoma, Teratocarcinoma and Trachea.
    2. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Retinoblastoma and Uterus.
    5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCCD25_HUMAN
    AccessioniPrimary (citable) accession number: Q86WR0
    Secondary accession number(s): Q0P663, Q96SI2, Q9NV98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3