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Q86WR0

- CCD25_HUMAN

UniProt

Q86WR0 - CCD25_HUMAN

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Protein
Coiled-coil domain-containing protein 25
Gene
CCDC25
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 25
Gene namesi
Name:CCDC25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:25591. CCDC25.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672183.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Coiled-coil domain-containing protein 25
PRO_0000233404Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231N6-acetyllysine1 Publication
Modified residuei204 – 2041Phosphoserine5 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ86WR0.
PaxDbiQ86WR0.
PRIDEiQ86WR0.

PTM databases

PhosphoSiteiQ86WR0.

Expressioni

Gene expression databases

ArrayExpressiQ86WR0.
BgeeiQ86WR0.
CleanExiHS_CCDC25.
GenevestigatoriQ86WR0.

Organism-specific databases

HPAiHPA023256.

Interactioni

Protein-protein interaction databases

BioGridi120537. 2 interactions.
IntActiQ86WR0. 1 interaction.
MINTiMINT-3058321.

Structurei

3D structure databases

ProteinModelPortaliQ86WR0.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili117 – 18771 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the CCDC25 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG288654.
HOGENOMiHOG000041378.
HOVERGENiHBG057190.
InParanoidiQ86WR0.
OMAiIRWGWPE.
OrthoDBiEOG7PVWQT.
PhylomeDBiQ86WR0.
TreeFamiTF300013.

Family and domain databases

InterProiIPR008532. DUF814.
[Graphical view]
PfamiPF05670. DUF814. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86WR0-1 [UniParc]FASTAAdd to Basket

« Hide

MVFYFTSSSV NSSAYTIYMG KDKYENEDLI KHGWPEDIWF HVDKLSSAHV    50
YLRLHKGENI EDIPKEVLMD CAHLVKANSI QGCKMNNVNV VYTPWSNLKK 100
TADMDVGQIG FHRQKDVKIV TVEKKVNEIL NRLEKTKVER FPDLAAEKEC 150
RDREERNEKK AQIQEMKKRE KEEMKKKREM DELRSYSSLM KVENMSSNQD 200
GNDSDEFM 208
Length:208
Mass (Da):24,479
Last modified:May 2, 2006 - v2
Checksum:i8EA9E0FFD84494B6
GO

Sequence cautioni

The sequence BAA91857.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001715 mRNA. Translation: BAA91857.1. Different initiation.
AK027900 mRNA. Translation: BAB55442.1.
BC049197 mRNA. Translation: AAH49197.2.
BC065295 mRNA. Translation: AAH65295.1.
CCDSiCCDS6062.2.
RefSeqiNP_060716.2. NM_018246.2.
XP_005273620.1. XM_005273563.2.
UniGeneiHs.445512.

Genome annotation databases

EnsembliENST00000356537; ENSP00000348933; ENSG00000147419.
GeneIDi55246.
KEGGihsa:55246.
UCSCiuc003xgc.3. human.

Polymorphism databases

DMDMi94707504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001715 mRNA. Translation: BAA91857.1 . Different initiation.
AK027900 mRNA. Translation: BAB55442.1 .
BC049197 mRNA. Translation: AAH49197.2 .
BC065295 mRNA. Translation: AAH65295.1 .
CCDSi CCDS6062.2.
RefSeqi NP_060716.2. NM_018246.2.
XP_005273620.1. XM_005273563.2.
UniGenei Hs.445512.

3D structure databases

ProteinModelPortali Q86WR0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120537. 2 interactions.
IntActi Q86WR0. 1 interaction.
MINTi MINT-3058321.

PTM databases

PhosphoSitei Q86WR0.

Polymorphism databases

DMDMi 94707504.

Proteomic databases

MaxQBi Q86WR0.
PaxDbi Q86WR0.
PRIDEi Q86WR0.

Protocols and materials databases

DNASUi 55246.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356537 ; ENSP00000348933 ; ENSG00000147419 .
GeneIDi 55246.
KEGGi hsa:55246.
UCSCi uc003xgc.3. human.

Organism-specific databases

CTDi 55246.
GeneCardsi GC08M027590.
HGNCi HGNC:25591. CCDC25.
HPAi HPA023256.
neXtProti NX_Q86WR0.
PharmGKBi PA142672183.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG288654.
HOGENOMi HOG000041378.
HOVERGENi HBG057190.
InParanoidi Q86WR0.
OMAi IRWGWPE.
OrthoDBi EOG7PVWQT.
PhylomeDBi Q86WR0.
TreeFami TF300013.

Miscellaneous databases

GeneWikii Coiled-Coil_Domain_Containing_Protein_%E2%80%93_25.
GenomeRNAii 55246.
NextBioi 59292.
PROi Q86WR0.

Gene expression databases

ArrayExpressi Q86WR0.
Bgeei Q86WR0.
CleanExi HS_CCDC25.
Genevestigatori Q86WR0.

Family and domain databases

InterProi IPR008532. DUF814.
[Graphical view ]
Pfami PF05670. DUF814. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retinoblastoma and Teratocarcinoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retinoblastoma and Uterus.
  3. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCCD25_HUMAN
AccessioniPrimary (citable) accession number: Q86WR0
Secondary accession number(s): Q96SI2, Q9NV98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: September 3, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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