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Protein

Coiled-coil domain-containing protein 25

Gene

CCDC25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 25
Gene namesi
Name:CCDC25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:25591. CCDC25.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672183.

Polymorphism and mutation databases

BioMutaiCCDC25.
DMDMi94707504.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Coiled-coil domain-containing protein 25PRO_0000233404Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231N6-acetyllysine1 Publication
Modified residuei204 – 2041Phosphoserine6 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ86WR0.
PaxDbiQ86WR0.
PRIDEiQ86WR0.

PTM databases

PhosphoSiteiQ86WR0.

Expressioni

Gene expression databases

BgeeiQ86WR0.
CleanExiHS_CCDC25.
ExpressionAtlasiQ86WR0. baseline and differential.
GenevestigatoriQ86WR0.

Organism-specific databases

HPAiHPA023256.
HPA053047.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FLJ13057Q53SE73EBI-2690264,EBI-10172181
TRIM23P364063EBI-2690264,EBI-740098

Protein-protein interaction databases

BioGridi120537. 10 interactions.
IntActiQ86WR0. 4 interactions.
MINTiMINT-3058321.

Structurei

3D structure databases

ProteinModelPortaliQ86WR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili117 – 18771Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the CCDC25 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG288654.
GeneTreeiENSGT00390000004380.
HOGENOMiHOG000041378.
HOVERGENiHBG057190.
InParanoidiQ86WR0.
OMAiPGQVAYH.
OrthoDBiEOG7PVWQT.
PhylomeDBiQ86WR0.
TreeFamiTF300013.

Family and domain databases

InterProiIPR008532. DUF814.
[Graphical view]
PfamiPF05670. DUF814. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86WR0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVFYFTSSSV NSSAYTIYMG KDKYENEDLI KHGWPEDIWF HVDKLSSAHV
60 70 80 90 100
YLRLHKGENI EDIPKEVLMD CAHLVKANSI QGCKMNNVNV VYTPWSNLKK
110 120 130 140 150
TADMDVGQIG FHRQKDVKIV TVEKKVNEIL NRLEKTKVER FPDLAAEKEC
160 170 180 190 200
RDREERNEKK AQIQEMKKRE KEEMKKKREM DELRSYSSLM KVENMSSNQD

GNDSDEFM
Length:208
Mass (Da):24,479
Last modified:May 2, 2006 - v2
Checksum:i8EA9E0FFD84494B6
GO
Isoform 2 (identifier: Q86WR0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Show »
Length:140
Mass (Da):16,474
Checksum:i0434DFDC5DBAC16E
GO

Sequence cautioni

The sequence BAA91857.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6868Missing in isoform 2. 2 PublicationsVSP_056046Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001715 mRNA. Translation: BAA91857.1. Different initiation.
AK027900 mRNA. Translation: BAB55442.1.
AK292875 mRNA. Translation: BAF85564.1.
AC013643 Genomic DNA. No translation available.
AC104997 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63539.1.
BC032588 mRNA. Translation: AAH32588.1.
BC049197 mRNA. Translation: AAH49197.2.
BC065295 mRNA. Translation: AAH65295.1.
CCDSiCCDS6062.2. [Q86WR0-1]
RefSeqiNP_060716.2. NM_018246.2.
UniGeneiHs.445512.

Genome annotation databases

EnsembliENST00000356537; ENSP00000348933; ENSG00000147419. [Q86WR0-1]
ENST00000522915; ENSP00000428000; ENSG00000147419. [Q86WR0-2]
GeneIDi55246.
KEGGihsa:55246.
UCSCiuc003xgc.3. human. [Q86WR0-1]

Polymorphism and mutation databases

BioMutaiCCDC25.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001715 mRNA. Translation: BAA91857.1. Different initiation.
AK027900 mRNA. Translation: BAB55442.1.
AK292875 mRNA. Translation: BAF85564.1.
AC013643 Genomic DNA. No translation available.
AC104997 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63539.1.
BC032588 mRNA. Translation: AAH32588.1.
BC049197 mRNA. Translation: AAH49197.2.
BC065295 mRNA. Translation: AAH65295.1.
CCDSiCCDS6062.2. [Q86WR0-1]
RefSeqiNP_060716.2. NM_018246.2.
UniGeneiHs.445512.

3D structure databases

ProteinModelPortaliQ86WR0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120537. 10 interactions.
IntActiQ86WR0. 4 interactions.
MINTiMINT-3058321.

PTM databases

PhosphoSiteiQ86WR0.

Polymorphism and mutation databases

BioMutaiCCDC25.
DMDMi94707504.

Proteomic databases

MaxQBiQ86WR0.
PaxDbiQ86WR0.
PRIDEiQ86WR0.

Protocols and materials databases

DNASUi55246.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356537; ENSP00000348933; ENSG00000147419. [Q86WR0-1]
ENST00000522915; ENSP00000428000; ENSG00000147419. [Q86WR0-2]
GeneIDi55246.
KEGGihsa:55246.
UCSCiuc003xgc.3. human. [Q86WR0-1]

Organism-specific databases

CTDi55246.
GeneCardsiGC08M027590.
HGNCiHGNC:25591. CCDC25.
HPAiHPA023256.
HPA053047.
neXtProtiNX_Q86WR0.
PharmGKBiPA142672183.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG288654.
GeneTreeiENSGT00390000004380.
HOGENOMiHOG000041378.
HOVERGENiHBG057190.
InParanoidiQ86WR0.
OMAiPGQVAYH.
OrthoDBiEOG7PVWQT.
PhylomeDBiQ86WR0.
TreeFamiTF300013.

Miscellaneous databases

GeneWikiiCoiled-Coil_Domain_Containing_Protein_%E2%80%93_25.
GenomeRNAii55246.
NextBioi59292.
PROiQ86WR0.

Gene expression databases

BgeeiQ86WR0.
CleanExiHS_CCDC25.
ExpressionAtlasiQ86WR0. baseline and differential.
GenevestigatoriQ86WR0.

Family and domain databases

InterProiIPR008532. DUF814.
[Graphical view]
PfamiPF05670. DUF814. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Retinoblastoma, Teratocarcinoma and Trachea.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Retinoblastoma and Uterus.
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCCD25_HUMAN
AccessioniPrimary (citable) accession number: Q86WR0
Secondary accession number(s): Q0P663, Q96SI2, Q9NV98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: April 29, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.