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Protein

Coiled-coil domain-containing protein 25

Gene

CCDC25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 25
Gene namesi
Name:CCDC25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147419.16
HGNCiHGNC:25591 CCDC25
neXtProtiNX_Q86WR0

Pathology & Biotechi

Organism-specific databases

DisGeNETi55246
OpenTargetsiENSG00000147419
PharmGKBiPA142672183

Polymorphism and mutation databases

BioMutaiCCDC25
DMDMi94707504

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002334041 – 208Coiled-coil domain-containing protein 25Add BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23N6-acetyllysineCombined sources1
Modified residuei204PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ86WR0
MaxQBiQ86WR0
PaxDbiQ86WR0
PeptideAtlasiQ86WR0
PRIDEiQ86WR0

PTM databases

iPTMnetiQ86WR0
PhosphoSitePlusiQ86WR0

Expressioni

Gene expression databases

BgeeiENSG00000147419
CleanExiHS_CCDC25
ExpressionAtlasiQ86WR0 baseline and differential
GenevisibleiQ86WR0 HS

Organism-specific databases

HPAiHPA023256

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120537, 13 interactors
IntActiQ86WR0, 5 interactors
STRINGi9606.ENSP00000348933

Structurei

3D structure databases

ProteinModelPortaliQ86WR0
SMRiQ86WR0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili117 – 187Sequence analysisAdd BLAST71

Sequence similaritiesi

Belongs to the CCDC25 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3272 Eukaryota
ENOG410Z5JK LUCA
GeneTreeiENSGT00390000004380
HOGENOMiHOG000041378
HOVERGENiHBG057190
InParanoidiQ86WR0
OMAiDVWFHVH
OrthoDBiEOG091G0LS0
PhylomeDBiQ86WR0
TreeFamiTF300013

Family and domain databases

InterProiView protein in InterPro
IPR008532 DUF814
PfamiView protein in Pfam
PF05670 DUF814, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86WR0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVFYFTSSSV NSSAYTIYMG KDKYENEDLI KHGWPEDIWF HVDKLSSAHV
60 70 80 90 100
YLRLHKGENI EDIPKEVLMD CAHLVKANSI QGCKMNNVNV VYTPWSNLKK
110 120 130 140 150
TADMDVGQIG FHRQKDVKIV TVEKKVNEIL NRLEKTKVER FPDLAAEKEC
160 170 180 190 200
RDREERNEKK AQIQEMKKRE KEEMKKKREM DELRSYSSLM KVENMSSNQD

GNDSDEFM
Length:208
Mass (Da):24,479
Last modified:May 2, 2006 - v2
Checksum:i8EA9E0FFD84494B6
GO
Isoform 2 (identifier: Q86WR0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Show »
Length:140
Mass (Da):16,474
Checksum:i0434DFDC5DBAC16E
GO

Sequence cautioni

The sequence BAA91857 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0560461 – 68Missing in isoform 2. 2 PublicationsAdd BLAST68

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001715 mRNA Translation: BAA91857.1 Different initiation.
AK027900 mRNA Translation: BAB55442.1
AK292875 mRNA Translation: BAF85564.1
AC013643 Genomic DNA No translation available.
AC104997 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63539.1
BC032588 mRNA Translation: AAH32588.1
BC049197 mRNA Translation: AAH49197.2
BC065295 mRNA Translation: AAH65295.1
CCDSiCCDS6062.2 [Q86WR0-1]
CCDS78323.1 [Q86WR0-2]
RefSeqiNP_001291458.1, NM_001304529.1
NP_001291459.1, NM_001304530.1
NP_001291461.1, NM_001304532.1 [Q86WR0-2]
NP_060716.2, NM_018246.2
XP_011542872.1, XM_011544570.2 [Q86WR0-2]
XP_011542873.1, XM_011544571.2 [Q86WR0-2]
UniGeneiHs.445512

Genome annotation databases

EnsembliENST00000356537; ENSP00000348933; ENSG00000147419 [Q86WR0-1]
ENST00000522915; ENSP00000428000; ENSG00000147419 [Q86WR0-2]
GeneIDi55246
KEGGihsa:55246
UCSCiuc003xgc.4 human [Q86WR0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCCD25_HUMAN
AccessioniPrimary (citable) accession number: Q86WR0
Secondary accession number(s): Q0P663, Q96SI2, Q9NV98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: May 23, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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