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Protein

Nuclear receptor 2C2-associated protein

Gene

NR2C2AP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes.1 Publication

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-383280. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor 2C2-associated protein
Alternative name(s):
TR4 orphan receptor-associated 16 kDa protein
Gene namesi
Name:NR2C2AP
Synonyms:TRA16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30763. NR2C2AP.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162398172.

Polymorphism and mutation databases

BioMutaiNR2C2AP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 139139Nuclear receptor 2C2-associated proteinPRO_0000295585Add
BLAST

Proteomic databases

EPDiQ86WQ0.
MaxQBiQ86WQ0.
PaxDbiQ86WQ0.
PeptideAtlasiQ86WQ0.
PRIDEiQ86WQ0.
TopDownProteomicsiQ86WQ0-1. [Q86WQ0-1]

PTM databases

PhosphoSiteiQ86WQ0.

Expressioni

Tissue specificityi

Expressed in all tissues examined, with highest expression in heart, skeletal muscle and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000184162.
CleanExiHS_NR2C2AP.
ExpressionAtlasiQ86WQ0. baseline and differential.
GenevisibleiQ86WQ0. HS.

Organism-specific databases

HPAiHPA042054.
HPA055653.

Interactioni

Subunit structurei

Interacts with NR2C2/TR4.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RELQ048643EBI-10260040,EBI-307352
SLC16A3O154273EBI-10260040,EBI-7600166
TCF4P158843EBI-10260040,EBI-533224

Protein-protein interaction databases

BioGridi125987. 6 interactions.
IntActiQ86WQ0. 3 interactions.
STRINGi9606.ENSP00000332823.

Structurei

3D structure databases

ProteinModelPortaliQ86WQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NR2C2AP family.Curated

Phylogenomic databases

eggNOGiENOG410IX85. Eukaryota.
ENOG4111V3C. LUCA.
GeneTreeiENSGT00390000017748.
HOGENOMiHOG000237373.
HOVERGENiHBG054782.
InParanoidiQ86WQ0.
OMAiNEETCWN.
OrthoDBiEOG091G0SPL.
PhylomeDBiQ86WQ0.
TreeFamiTF300180.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR033601. NR2C2AP.
[Graphical view]
PANTHERiPTHR31535. PTHR31535. 1 hit.
SUPFAMiSSF49785. SSF49785. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86WQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTHSLVCPET VSRVSSVLNR NTRQFGKKHL FDQDEETCWN SDQGPSQWVT
60 70 80 90 100
LEFPQLIRVS QLQIQFQGGF SSRRGCLEGS QGTQALHKIV DFYPEDNNSL
110 120 130
QTFPIPAAEV DRLKVTFEDA TDFFGRVVIY HLRVLGEKV
Length:139
Mass (Da):15,876
Last modified:June 1, 2003 - v1
Checksum:iD7BA1228FE9AA66E
GO
Isoform 2 (identifier: Q86WQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-139: V → GTNRDPCRDLHYRAKLGEPRTHPRNLNFP

Note: No experimental confirmation available.
Show »
Length:167
Mass (Da):19,191
Checksum:iD7749875A19619F8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei139 – 1391V → GTNRDPCRDLHYRAKLGEPR THPRNLNFP in isoform 2. 1 PublicationVSP_056072

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY101377 mRNA. Translation: AAM48286.1.
AK301426 mRNA. Translation: BAG62954.1.
AC003110 Genomic DNA. No translation available.
BC057837 mRNA. Translation: AAH57837.1.
CCDSiCCDS32967.1. [Q86WQ0-1]
CCDS74316.1. [Q86WQ0-2]
RefSeqiNP_001287874.1. NM_001300945.1. [Q86WQ0-2]
NP_795361.1. NM_176880.5. [Q86WQ0-1]
UniGeneiHs.708153.
Hs.732708.

Genome annotation databases

EnsembliENST00000331552; ENSP00000332823; ENSG00000184162. [Q86WQ0-1]
ENST00000420605; ENSP00000402756; ENSG00000184162. [Q86WQ0-2]
GeneIDi126382.
KEGGihsa:126382.
UCSCiuc002nlx.4. human. [Q86WQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY101377 mRNA. Translation: AAM48286.1.
AK301426 mRNA. Translation: BAG62954.1.
AC003110 Genomic DNA. No translation available.
BC057837 mRNA. Translation: AAH57837.1.
CCDSiCCDS32967.1. [Q86WQ0-1]
CCDS74316.1. [Q86WQ0-2]
RefSeqiNP_001287874.1. NM_001300945.1. [Q86WQ0-2]
NP_795361.1. NM_176880.5. [Q86WQ0-1]
UniGeneiHs.708153.
Hs.732708.

3D structure databases

ProteinModelPortaliQ86WQ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125987. 6 interactions.
IntActiQ86WQ0. 3 interactions.
STRINGi9606.ENSP00000332823.

PTM databases

PhosphoSiteiQ86WQ0.

Polymorphism and mutation databases

BioMutaiNR2C2AP.

Proteomic databases

EPDiQ86WQ0.
MaxQBiQ86WQ0.
PaxDbiQ86WQ0.
PeptideAtlasiQ86WQ0.
PRIDEiQ86WQ0.
TopDownProteomicsiQ86WQ0-1. [Q86WQ0-1]

Protocols and materials databases

DNASUi126382.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331552; ENSP00000332823; ENSG00000184162. [Q86WQ0-1]
ENST00000420605; ENSP00000402756; ENSG00000184162. [Q86WQ0-2]
GeneIDi126382.
KEGGihsa:126382.
UCSCiuc002nlx.4. human. [Q86WQ0-1]

Organism-specific databases

CTDi126382.
GeneCardsiNR2C2AP.
HGNCiHGNC:30763. NR2C2AP.
HPAiHPA042054.
HPA055653.
MIMi608719. gene.
neXtProtiNX_Q86WQ0.
PharmGKBiPA162398172.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX85. Eukaryota.
ENOG4111V3C. LUCA.
GeneTreeiENSGT00390000017748.
HOGENOMiHOG000237373.
HOVERGENiHBG054782.
InParanoidiQ86WQ0.
OMAiNEETCWN.
OrthoDBiEOG091G0SPL.
PhylomeDBiQ86WQ0.
TreeFamiTF300180.

Enzyme and pathway databases

ReactomeiR-HSA-383280. Nuclear Receptor transcription pathway.

Miscellaneous databases

GenomeRNAii126382.
PROiQ86WQ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184162.
CleanExiHS_NR2C2AP.
ExpressionAtlasiQ86WQ0. baseline and differential.
GenevisibleiQ86WQ0. HS.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR033601. NR2C2AP.
[Graphical view]
PANTHERiPTHR31535. PTHR31535. 1 hit.
SUPFAMiSSF49785. SSF49785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNR2CA_HUMAN
AccessioniPrimary (citable) accession number: Q86WQ0
Secondary accession number(s): A6NGP7, B4DW92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.