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Protein

Vasculin

Gene

GPBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a GC-rich promoter-specific transactivating transcription factor.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Vasculin
Alternative name(s):
GC-rich promoter-binding protein 1
Vascular wall-linked protein
Gene namesi
Name:GPBP1
Synonyms:GPBP, SSH6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:29520. GPBP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671714.

Polymorphism and mutation databases

BioMutaiGPBP1.
DMDMi74714120.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473VasculinPRO_0000324110Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491PhosphoserineCombined sources
Modified residuei274 – 2741PhosphoserineBy similarity
Modified residuei276 – 2761PhosphoserineBy similarity
Modified residuei322 – 3221PhosphoserineCombined sources
Modified residuei381 – 3811PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ86WP2.
PaxDbiQ86WP2.
PeptideAtlasiQ86WP2.
PRIDEiQ86WP2.

PTM databases

iPTMnetiQ86WP2.
PhosphoSiteiQ86WP2.

Expressioni

Tissue specificityi

Widely expressed. Some isoforms may be specifically expressed in veins and arteries (at protein level). Isoform 4 is widely expressed. Isoform 1, isoform 2 and isoform 3 may be specifically expressed in vascular smooth muscle cells.2 Publications

Gene expression databases

BgeeiENSG00000062194.
CleanExiHS_GPBP1.
ExpressionAtlasiQ86WP2. baseline and differential.
GenevisibleiQ86WP2. HS.

Organism-specific databases

HPAiHPA037772.
HPA037773.
HPA072377.

Interactioni

Subunit structurei

Interacts with GTF2B, GTF2F2, RNA polymerase II and TBP.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
C20orf195Q9BVV23EBI-10300058,EBI-744935
PLEKHF2Q9H8W43EBI-2349758,EBI-742388

Protein-protein interaction databases

BioGridi122378. 27 interactions.
IntActiQ86WP2. 13 interactions.
MINTiMINT-4716328.
STRINGi9606.ENSP00000264779.

Structurei

3D structure databases

ProteinModelPortaliQ86WP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasculin family.Curated

Phylogenomic databases

eggNOGiENOG410IJH3. Eukaryota.
ENOG410Y09K. LUCA.
GeneTreeiENSGT00420000029753.
HOGENOMiHOG000049182.
HOVERGENiHBG056980.
InParanoidiQ86WP2.
PhylomeDBiQ86WP2.
TreeFamiTF332220.

Family and domain databases

InterProiIPR028128. Vasculin_fam.
[Graphical view]
PfamiPF15337. Vasculin. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86WP2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQHDFAPAW LNFPTPPSST KSSLNFEKHS ENFAWTENRY DVNRRRHNSS
60 70 80 90 100
DGFDSAIGRP NGGNFGRKEK NGWRTHGRNG TENINHRGGY HGGSSRSRSS
110 120 130 140 150
IFHAGKSQGL HENNIPDNET GRKEDKRERK QFEAEDFPSL NPEYEREPNH
160 170 180 190 200
NKSLAAGVWE YPPNPKSRAP RMLVIKKGNT KDLQLSGFPV VGNLPSQPVK
210 220 230 240 250
NGTGPSVYKG LVPKPAAPPT KPTQWKSQTK ENKVGTSFPH ESTFGVGNFN
260 270 280 290 300
AFKSTAKNFS PSTNSVKECN RSNSSSPVDK LNQQPRLTKL TRMRTDKKSE
310 320 330 340 350
FLKALKRDRV EEEHEDESRA GSEKDDDSFN LHNSNSTHQE RDINRNFDEN
360 370 380 390 400
EIPQENGNAS VISQQIIRSS TFPQTDVLSS SLEAEHRLLK EMGWQEDSEN
410 420 430 440 450
DETCAPLTED EMREFQVISE QLQKNGLRKN GILKNGLICD FKFGPWKNST
460 470
FKPTTENDDT ETSSSDTSDD DDV
Length:473
Mass (Da):53,339
Last modified:June 1, 2003 - v1
Checksum:i932A7681860622C4
GO
Isoform 2 (identifier: Q86WP2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: T → TKVLTSSL

Show »
Length:480
Mass (Da):54,068
Checksum:i5CDD94AF77BA000F
GO
Isoform 3 (identifier: Q86WP2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: T → TKVLTSSL
     269-283: Missing.

Note: No experimental confirmation available.
Show »
Length:465
Mass (Da):52,437
Checksum:iDCB1357E3D0DC49A
GO
Isoform 4 (identifier: Q86WP2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.

Show »
Length:302
Mass (Da):33,830
Checksum:i7C4DB60FB19008EC
GO

Sequence cautioni

The sequence AAH00267 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH70132 differs from that shown.Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence BAB15013 differs from that shown. Reason: Frameshift at position 291. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271R → G in AAH70132 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti122 – 1221R → G.
Corresponds to variant rs1862171 [ dbSNP | Ensembl ].
VAR_039654

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 171171Missing in isoform 4. 1 PublicationVSP_032135Add
BLAST
Alternative sequencei20 – 201T → TKVLTSSL in isoform 2 and isoform 3. 2 PublicationsVSP_032136
Alternative sequencei269 – 28315Missing in isoform 3. 1 PublicationVSP_032137Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY226828 mRNA. Translation: AAO34124.1.
AL136844 mRNA. Translation: CAB66778.1.
AL161991 mRNA. Translation: CAB82324.2.
AC034244 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54965.1.
CH471123 Genomic DNA. Translation: EAW54966.1.
BC000267 mRNA. Translation: AAH00267.1. Different initiation.
BC070132 mRNA. Translation: AAH70132.1. Sequence problems.
BC113004 mRNA. Translation: AAI13005.1.
AK024807 mRNA. Translation: BAB15013.1. Frameshift.
CCDSiCCDS34162.1. [Q86WP2-1]
CCDS47211.1. [Q86WP2-2]
CCDS47212.2. [Q86WP2-3]
CCDS56368.1. [Q86WP2-4]
PIRiT47146.
RefSeqiNP_001120707.2. NM_001127235.2. [Q86WP2-3]
NP_001120708.1. NM_001127236.2. [Q86WP2-2]
NP_001190175.1. NM_001203246.1. [Q86WP2-4]
NP_075064.1. NM_022913.3. [Q86WP2-1]
UniGeneiHs.444279.

Genome annotation databases

EnsembliENST00000264779; ENSP00000264779; ENSG00000062194. [Q86WP2-2]
ENST00000506184; ENSP00000421202; ENSG00000062194. [Q86WP2-1]
ENST00000511209; ENSP00000422337; ENSG00000062194. [Q86WP2-3]
ENST00000514387; ENSP00000421709; ENSG00000062194. [Q86WP2-4]
GeneIDi65056.
KEGGihsa:65056.
UCSCiuc003jrh.5. human. [Q86WP2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY226828 mRNA. Translation: AAO34124.1.
AL136844 mRNA. Translation: CAB66778.1.
AL161991 mRNA. Translation: CAB82324.2.
AC034244 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54965.1.
CH471123 Genomic DNA. Translation: EAW54966.1.
BC000267 mRNA. Translation: AAH00267.1. Different initiation.
BC070132 mRNA. Translation: AAH70132.1. Sequence problems.
BC113004 mRNA. Translation: AAI13005.1.
AK024807 mRNA. Translation: BAB15013.1. Frameshift.
CCDSiCCDS34162.1. [Q86WP2-1]
CCDS47211.1. [Q86WP2-2]
CCDS47212.2. [Q86WP2-3]
CCDS56368.1. [Q86WP2-4]
PIRiT47146.
RefSeqiNP_001120707.2. NM_001127235.2. [Q86WP2-3]
NP_001120708.1. NM_001127236.2. [Q86WP2-2]
NP_001190175.1. NM_001203246.1. [Q86WP2-4]
NP_075064.1. NM_022913.3. [Q86WP2-1]
UniGeneiHs.444279.

3D structure databases

ProteinModelPortaliQ86WP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122378. 27 interactions.
IntActiQ86WP2. 13 interactions.
MINTiMINT-4716328.
STRINGi9606.ENSP00000264779.

PTM databases

iPTMnetiQ86WP2.
PhosphoSiteiQ86WP2.

Polymorphism and mutation databases

BioMutaiGPBP1.
DMDMi74714120.

Proteomic databases

MaxQBiQ86WP2.
PaxDbiQ86WP2.
PeptideAtlasiQ86WP2.
PRIDEiQ86WP2.

Protocols and materials databases

DNASUi65056.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264779; ENSP00000264779; ENSG00000062194. [Q86WP2-2]
ENST00000506184; ENSP00000421202; ENSG00000062194. [Q86WP2-1]
ENST00000511209; ENSP00000422337; ENSG00000062194. [Q86WP2-3]
ENST00000514387; ENSP00000421709; ENSG00000062194. [Q86WP2-4]
GeneIDi65056.
KEGGihsa:65056.
UCSCiuc003jrh.5. human. [Q86WP2-1]

Organism-specific databases

CTDi65056.
GeneCardsiGPBP1.
HGNCiHGNC:29520. GPBP1.
HPAiHPA037772.
HPA037773.
HPA072377.
MIMi608412. gene.
neXtProtiNX_Q86WP2.
PharmGKBiPA142671714.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJH3. Eukaryota.
ENOG410Y09K. LUCA.
GeneTreeiENSGT00420000029753.
HOGENOMiHOG000049182.
HOVERGENiHBG056980.
InParanoidiQ86WP2.
PhylomeDBiQ86WP2.
TreeFamiTF332220.

Miscellaneous databases

ChiTaRSiGPBP1. human.
GeneWikiiGPBP1.
GenomeRNAii65056.
PROiQ86WP2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000062194.
CleanExiHS_GPBP1.
ExpressionAtlasiQ86WP2. baseline and differential.
GenevisibleiQ86WP2. HS.

Family and domain databases

InterProiIPR028128. Vasculin_fam.
[Graphical view]
PfamiPF15337. Vasculin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPBP1_HUMAN
AccessioniPrimary (citable) accession number: Q86WP2
Secondary accession number(s): A6NKW3
, Q6NSH6, Q9H0D4, Q9H785, Q9NSN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.