ID   IFNE_HUMAN              Reviewed;         208 AA.
AC   Q86WN2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   09-FEB-2010, entry version 61.
DE   RecName: Full=Interferon epsilon;
DE            Short=IFN-epsilon;
DE   AltName: Full=Interferon epsilon-1;
DE   Flags: Precursor;
GN   Name=IFNE; Synonyms=IFNE1; ORFNames=UNQ360/PRO655;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=15233997; DOI=10.1016/j.ygeno.2004.03.003;
RA   Hardy M.P., Owczarek C.M., Jermiin L.S., Ejdebaeck M., Hertzog P.J.;
RT   "Characterization of the type I interferon locus and identification of
RT   novel genes.";
RL   Genomics 84:331-345(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- TISSUE SPECIFICITY: Expressed in prostate cancer cell line PC-3,
CC       amnion-derived WISH cells, SK-MEL28 melanoma cells and Daudi cells
CC       and very weakly in MCF-7 human breast cancer cells. Not detected
CC       in Namalwa cells (Burkitt's lymphoma) or in Jurkat (T) cells.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family.
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DR   EMBL; AY190045; AAO38686.1; -; mRNA.
DR   EMBL; AY358570; AAQ88933.1; -; mRNA.
DR   EMBL; BC100871; AAI00872.1; -; mRNA.
DR   EMBL; BC100872; AAI00873.1; -; mRNA.
DR   EMBL; BC100873; AAI00874.1; -; mRNA.
DR   IPI; IPI00329100; -.
DR   RefSeq; NP_795372.1; -.
DR   UniGene; Hs.682604; -.
DR   HSSP; P56828; 1B5L.
DR   SMR; Q86WN2; 22-187.
DR   STRING; Q86WN2; -.
DR   Ensembl; ENST00000448696; ENSP00000418018; ENSG00000184995; Homo sapiens.
DR   GeneID; 338376; -.
DR   KEGG; hsa:338376; -.
DR   UCSC; uc003zpg.1; human.
DR   CTD; 338376; -.
DR   GeneCards; GC09M021470; -.
DR   HGNC; HGNC:18163; IFNE.
DR   eggNOG; maNOG19917; -.
DR   HOVERGEN; Q86WN2; -.
DR   InParanoid; Q86WN2; -.
DR   PhylomeDB; Q86WN2; -.
DR   NextBio; 96956; -.
DR   Genevestigator; Q86WN2; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005126; F:cytokine receptor binding; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   GO; GO:0009615; P:response to virus; IEA:UniProtKB-KW.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; IInterferon_alpha/beta/delta.
DR   PANTHER; PTHR11691; Interferon_abd; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   2: Evidence at transcript level;
KW   Antiviral defense; Complete proteome; Cytokine; Disulfide bond;
KW   Glycoprotein; Polymorphism; Secreted; Signal.
FT   SIGNAL        1     21       Potential.
FT   CHAIN        22    208       Interferon epsilon.
FT                                /FTId=PRO_0000317631.
FT   CARBOHYD     95     95       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    104    104       N-linked (GlcNAc...) (Potential).
FT   DISULFID     53    163       By similarity.
FT   VARIANT      46     46       Q -> H (in dbSNP:rs1125488).
FT                                /FTId=VAR_049639.
SQ   SEQUENCE   208 AA;  24414 MW;  65FB861407F14E5F CRC64;
     MIIKHFFGTV LVLLASTTIF SLDLKLIIFQ QRQVNQESLK LLNKLQTLSI QQCLPHRKNF
     LLPQKSLSPQ QYQKGHTLAI LHEMLQQIFS LFRANISLDG WEENHTEKFL IQLHQQLEYL
     EALMGLEAEK LSGTLGSDNL RLQVKMYFRR IHDYLENQDY STCAWAIVQV EISRCLFFVF
     SLTEKLSKQG RPLNDMKQEL TTEFRSPR
//