ID   IFNE_HUMAN              Reviewed;         208 AA.
AC   Q86WN2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   24-JAN-2024, entry version 154.
DE   RecName: Full=Interferon epsilon;
DE            Short=IFN-epsilon;
DE   AltName: Full=Interferon epsilon-1;
DE   Flags: Precursor;
GN   Name=IFNE; Synonyms=IFNE1; ORFNames=UNQ360/PRO655;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15233997; DOI=10.1016/j.ygeno.2004.03.003;
RA   Hardy M.P., Owczarek C.M., Jermiin L.S., Ejdebaeck M., Hertzog P.J.;
RT   "Characterization of the type I interferon locus and identification of
RT   novel genes.";
RL   Genomics 84:331-345(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   INDUCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=23449591; DOI=10.1126/science.1233321;
RA   Fung K.Y., Mangan N.E., Cumming H., Horvat J.C., Mayall J.R., Stifter S.A.,
RA   De Weerd N., Roisman L.C., Rossjohn J., Robertson S.A., Schjenken J.E.,
RA   Parker B., Gargett C.E., Nguyen H.P., Carr D.J., Hansbro P.M.,
RA   Hertzog P.J.;
RT   "Interferon-epsilon protects the female reproductive tract from viral and
RT   bacterial infection.";
RL   Science 339:1088-1092(2013).
CC   -!- FUNCTION: Type I interferon required for maintaining basal levels of
CC       IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7
CC       and ISG15, in the female reproductive tract. Directly mediates
CC       protection against viral and bacterial genital infections (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Endometrium-specific.
CC       {ECO:0000269|PubMed:23449591}.
CC   -!- DEVELOPMENTAL STAGE: Highly expressed in endometrial epithelial cells
CC       in proliferative phase of the menstrual cycle. Levels decrease
CC       approximately 10-fold in the secretory phase. Virtually undetectable in
CC       samples from postmenopausal women. {ECO:0000269|PubMed:23449591}.
CC   -!- INDUCTION: By estrogens. {ECO:0000305|PubMed:23449591}.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR   EMBL; AY190045; AAO38686.1; -; mRNA.
DR   EMBL; AY358570; AAQ88933.1; -; mRNA.
DR   EMBL; BC100871; AAI00872.1; -; mRNA.
DR   EMBL; BC100872; AAI00873.1; -; mRNA.
DR   EMBL; BC100873; AAI00874.1; -; mRNA.
DR   CCDS; CCDS34997.1; -.
DR   RefSeq; NP_795372.1; NM_176891.4.
DR   AlphaFoldDB; Q86WN2; -.
DR   SMR; Q86WN2; -.
DR   BioGRID; 130722; 31.
DR   ComplexPortal; CPX-6008; Interferon epsilon receptor-ligand complex.
DR   IntAct; Q86WN2; 9.
DR   STRING; 9606.ENSP00000418018; -.
DR   GlyCosmos; Q86WN2; 2 sites, No reported glycans.
DR   GlyGen; Q86WN2; 2 sites.
DR   iPTMnet; Q86WN2; -.
DR   PhosphoSitePlus; Q86WN2; -.
DR   BioMuta; IFNE; -.
DR   DMDM; 74727686; -.
DR   MassIVE; Q86WN2; -.
DR   PaxDb; 9606-ENSP00000418018; -.
DR   PeptideAtlas; Q86WN2; -.
DR   ProteomicsDB; 70184; -.
DR   Antibodypedia; 24882; 162 antibodies from 21 providers.
DR   DNASU; 338376; -.
DR   Ensembl; ENST00000448696.4; ENSP00000418018.2; ENSG00000184995.7.
DR   GeneID; 338376; -.
DR   KEGG; hsa:338376; -.
DR   MANE-Select; ENST00000448696.4; ENSP00000418018.2; NM_176891.5; NP_795372.1.
DR   UCSC; uc003zpg.4; human.
DR   AGR; HGNC:18163; -.
DR   CTD; 338376; -.
DR   DisGeNET; 338376; -.
DR   GeneCards; IFNE; -.
DR   HGNC; HGNC:18163; IFNE.
DR   HPA; ENSG00000184995; Tissue enhanced (esophagus).
DR   MIM; 615223; gene.
DR   neXtProt; NX_Q86WN2; -.
DR   OpenTargets; ENSG00000184995; -.
DR   PharmGKB; PA164720874; -.
DR   VEuPathDB; HostDB:ENSG00000184995; -.
DR   eggNOG; ENOG502S65R; Eukaryota.
DR   GeneTree; ENSGT01000000214430; -.
DR   HOGENOM; CLU_109427_1_0_1; -.
DR   InParanoid; Q86WN2; -.
DR   OMA; QQCLPHR; -.
DR   OrthoDB; 5358931at2759; -.
DR   PhylomeDB; Q86WN2; -.
DR   TreeFam; TF336177; -.
DR   PathwayCommons; Q86WN2; -.
DR   SignaLink; Q86WN2; -.
DR   BioGRID-ORCS; 338376; 11 hits in 1136 CRISPR screens.
DR   GenomeRNAi; 338376; -.
DR   Pharos; Q86WN2; Tbio.
DR   PRO; PR:Q86WN2; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q86WN2; Protein.
DR   Bgee; ENSG00000184995; Expressed in stromal cell of endometrium and 59 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR   GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR   GO; GO:0098586; P:cellular response to virus; NAS:ComplexPortal.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; ISS:UniProtKB.
DR   GO; GO:0051607; P:defense response to virus; ISS:UniProtKB.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR   GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0060337; P:type I interferon-mediated signaling pathway; NAS:ComplexPortal.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   PANTHER; PTHR11691:SF8; INTERFERON EPSILON; 1.
DR   PANTHER; PTHR11691; TYPE I INTERFERON; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
DR   Genevisible; Q86WN2; HS.
PE   2: Evidence at transcript level;
KW   Antiviral defense; Cytokine; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..208
FT                   /note="Interferon epsilon"
FT                   /id="PRO_0000317631"
FT   CARBOHYD        95
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        104
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        53..163
FT                   /evidence="ECO:0000250"
FT   VARIANT         46
FT                   /note="Q -> H (in dbSNP:rs1125488)"
FT                   /id="VAR_049639"
SQ   SEQUENCE   208 AA;  24414 MW;  65FB861407F14E5F CRC64;
     MIIKHFFGTV LVLLASTTIF SLDLKLIIFQ QRQVNQESLK LLNKLQTLSI QQCLPHRKNF
     LLPQKSLSPQ QYQKGHTLAI LHEMLQQIFS LFRANISLDG WEENHTEKFL IQLHQQLEYL
     EALMGLEAEK LSGTLGSDNL RLQVKMYFRR IHDYLENQDY STCAWAIVQV EISRCLFFVF
     SLTEKLSKQG RPLNDMKQEL TTEFRSPR
//