Q86WN2 (IFNE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interferon epsilon
Short name=IFN-epsilon

Alternative name(s):
Interferon epsilon-1

Gene names

Name:	IFNE
Synonyms:	IFNE1
ORF Names:	UNQ360/PRO655

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted Potential.
Tissue specificity	Expressed in prostate cancer cell line PC-3, amnion-derived WISH cells, melanoma cell line SK-MEL-28, cell line Daudi and very weakly in MCF-7 human breast cancer cells. Not detected in cell lines Namalwa (Burkitt's lymphoma) and Jurkat (T-cell). Ref.1
Sequence similarities	Belongs to the alpha/beta interferon family.

Ontologies

Keywords
Biological process	Antiviral defense
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to virus Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 208	187	Interferon epsilon		PRO_0000317631
Amino acid modifications
	Glycosylation	95	1	N-linked (GlcNAc...) Potential
	Glycosylation	104	1	N-linked (GlcNAc...) Potential
	Disulfide bond	53 ↔ 163		By similarity
Natural variations
	Natural variant	46	1	Q → H. Corresponds to variant rs1125488 [ dbSNP | Ensembl ].		VAR_049639

Sequences

	Sequence		Length	Mass (Da)
	Q86WN2 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 65FB861407F14E5F	FASTA	208	24,414
	10 20 30 40 50 60 MIIKHFFGTV LVLLASTTIF SLDLKLIIFQ QRQVNQESLK LLNKLQTLSI QQCLPHRKNF 70 80 90 100 110 120 LLPQKSLSPQ QYQKGHTLAI LHEMLQQIFS LFRANISLDG WEENHTEKFL IQLHQQLEYL 130 140 150 160 170 180 EALMGLEAEK LSGTLGSDNL RLQVKMYFRR IHDYLENQDY STCAWAIVQV EISRCLFFVF 190 200 SLTEKLSKQG RPLNDMKQEL TTEFRSPR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the type I interferon locus and identification of novel genes." Hardy M.P., Owczarek C.M., Jermiin L.S., Ejdebaeck M., Hertzog P.J. Genomics 84:331-345(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY190045 mRNA. Translation: AAO38686.1. AY358570 mRNA. Translation: AAQ88933.1. BC100871 mRNA. Translation: AAI00872.1. BC100872 mRNA. Translation: AAI00873.1. BC100873 mRNA. Translation: AAI00874.1.
IPI	IPI00329100.
RefSeq	NP_795372.1. NM_176891.4.
UniGene	Hs.682604.
3D structure databases
HSSP	HSSP built from PDB template 1B5L based on UniProtKB P56828.
ProteinModelPortal	Q86WN2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000418018.
PTM databases
PhosphoSite	Q86WN2.
Polymorphism databases
DMDM	74727686.
Proteomic databases
PRIDE	Q86WN2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000448696; ENSP00000418018; ENSG00000184995.
GeneID	338376.
KEGG	hsa:338376.
UCSC	uc003zpg.3. human.
Organism-specific databases
CTD	338376.
GeneCards	GC09M021480.
HGNC	HGNC:18163. IFNE.
HPA	HPA041028.
neXtProt	NX_Q86WN2.
PharmGKB	PA164720874.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG44880.
HOGENOM	HOG000230501.
InParanoid	Q86WN2.
KO	K05442.
OMA	ILHEMLQ.
OrthoDB	EOG4KKZ45.
PhylomeDB	Q86WN2.
Gene expression databases
Bgee	Q86WN2.
Genevestigator	Q86WN2.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR000471. Interferon_alpha/beta/delta. [Graphical view]
PANTHER	PTHR11691. PTHR11691. 1 hit.
Pfam	PF00143. Interferon. 1 hit. [Graphical view]
PRINTS	PR00266. INTERFERONAB.
SMART	SM00076. IFabd. 1 hit. [Graphical view]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
PROSITE	PS00252. INTERFERON_A_B_D. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	338376.
NextBio	96956.

Entry information

Entry name

IFNE_HUMAN

Accession

Primary (citable) accession number: Q86WN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.