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Q86WN2

- IFNE_HUMAN

UniProt

Q86WN2 - IFNE_HUMAN

Protein

Interferon epsilon

Gene

IFNE

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections By similarity.By similarity

    GO - Molecular functioni

    1. cytokine activity Source: RefGenome
    2. type I interferon receptor binding Source: RefGenome

    GO - Biological processi

    1. adaptive immune response Source: RefGenome
    2. B cell differentiation Source: RefGenome
    3. B cell proliferation Source: RefGenome
    4. cytokine-mediated signaling pathway Source: RefGenome
    5. defense response to bacterium Source: UniProtKB
    6. defense response to virus Source: UniProtKB
    7. humoral immune response Source: RefGenome
    8. innate immune response Source: RefGenome
    9. natural killer cell activation involved in immune response Source: RefGenome
    10. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
    11. regulation of MHC class I biosynthetic process Source: RefGenome
    12. response to exogenous dsRNA Source: RefGenome
    13. T cell activation involved in immune response Source: RefGenome

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon epsilon
    Short name:
    IFN-epsilon
    Alternative name(s):
    Interferon epsilon-1
    Gene namesi
    Name:IFNE
    Synonyms:IFNE1
    ORF Names:UNQ360/PRO655
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:18163. IFNE.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164720874.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 208187Interferon epsilonPRO_0000317631Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi53 ↔ 163By similarity
    Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ86WN2.

    PTM databases

    PhosphoSiteiQ86WN2.

    Expressioni

    Tissue specificityi

    Endometrium-specific.1 Publication

    Developmental stagei

    Highly expressed in endometrial epithelial cells in proliferative phase of the menstrual cycle. Levels decrease approximately 10-fold in the secretory phase. Virtually undetectable in samples from postmenopausal women.1 Publication

    Inductioni

    By estrogens.1 Publication

    Gene expression databases

    BgeeiQ86WN2.
    GenevestigatoriQ86WN2.

    Organism-specific databases

    HPAiHPA041028.

    Interactioni

    Protein-protein interaction databases

    BioGridi130722. 1 interaction.
    STRINGi9606.ENSP00000418018.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86WN2.
    SMRiQ86WN2. Positions 36-188.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha/beta interferon family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44880.
    HOGENOMiHOG000230501.
    InParanoidiQ86WN2.
    KOiK05442.
    OMAiILHEMLQ.
    OrthoDBiEOG7MH10X.
    PhylomeDBiQ86WN2.
    TreeFamiTF336177.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view]
    PANTHERiPTHR11691. PTHR11691. 1 hit.
    PfamiPF00143. Interferon. 1 hit.
    [Graphical view]
    PRINTSiPR00266. INTERFERONAB.
    SMARTiSM00076. IFabd. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q86WN2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIIKHFFGTV LVLLASTTIF SLDLKLIIFQ QRQVNQESLK LLNKLQTLSI    50
    QQCLPHRKNF LLPQKSLSPQ QYQKGHTLAI LHEMLQQIFS LFRANISLDG 100
    WEENHTEKFL IQLHQQLEYL EALMGLEAEK LSGTLGSDNL RLQVKMYFRR 150
    IHDYLENQDY STCAWAIVQV EISRCLFFVF SLTEKLSKQG RPLNDMKQEL 200
    TTEFRSPR 208
    Length:208
    Mass (Da):24,414
    Last modified:June 1, 2003 - v1
    Checksum:i65FB861407F14E5F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti46 – 461Q → H.
    Corresponds to variant rs1125488 [ dbSNP | Ensembl ].
    VAR_049639

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY190045 mRNA. Translation: AAO38686.1.
    AY358570 mRNA. Translation: AAQ88933.1.
    BC100871 mRNA. Translation: AAI00872.1.
    BC100872 mRNA. Translation: AAI00873.1.
    BC100873 mRNA. Translation: AAI00874.1.
    CCDSiCCDS34997.1.
    RefSeqiNP_795372.1. NM_176891.4.
    UniGeneiHs.682604.

    Genome annotation databases

    EnsembliENST00000448696; ENSP00000418018; ENSG00000184995.
    GeneIDi338376.
    KEGGihsa:338376.
    UCSCiuc003zpg.3. human.

    Polymorphism databases

    DMDMi74727686.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY190045 mRNA. Translation: AAO38686.1 .
    AY358570 mRNA. Translation: AAQ88933.1 .
    BC100871 mRNA. Translation: AAI00872.1 .
    BC100872 mRNA. Translation: AAI00873.1 .
    BC100873 mRNA. Translation: AAI00874.1 .
    CCDSi CCDS34997.1.
    RefSeqi NP_795372.1. NM_176891.4.
    UniGenei Hs.682604.

    3D structure databases

    ProteinModelPortali Q86WN2.
    SMRi Q86WN2. Positions 36-188.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130722. 1 interaction.
    STRINGi 9606.ENSP00000418018.

    PTM databases

    PhosphoSitei Q86WN2.

    Polymorphism databases

    DMDMi 74727686.

    Proteomic databases

    PRIDEi Q86WN2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000448696 ; ENSP00000418018 ; ENSG00000184995 .
    GeneIDi 338376.
    KEGGi hsa:338376.
    UCSCi uc003zpg.3. human.

    Organism-specific databases

    CTDi 338376.
    GeneCardsi GC09M021480.
    HGNCi HGNC:18163. IFNE.
    HPAi HPA041028.
    MIMi 615223. gene.
    neXtProti NX_Q86WN2.
    PharmGKBi PA164720874.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44880.
    HOGENOMi HOG000230501.
    InParanoidi Q86WN2.
    KOi K05442.
    OMAi ILHEMLQ.
    OrthoDBi EOG7MH10X.
    PhylomeDBi Q86WN2.
    TreeFami TF336177.

    Miscellaneous databases

    GenomeRNAii 338376.
    NextBioi 96956.
    PROi Q86WN2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q86WN2.
    Genevestigatori Q86WN2.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view ]
    PANTHERi PTHR11691. PTHR11691. 1 hit.
    Pfami PF00143. Interferon. 1 hit.
    [Graphical view ]
    PRINTSi PR00266. INTERFERONAB.
    SMARTi SM00076. IFabd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the type I interferon locus and identification of novel genes."
      Hardy M.P., Owczarek C.M., Jermiin L.S., Ejdebaeck M., Hertzog P.J.
      Genomics 84:331-345(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: INDUCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiIFNE_HUMAN
    AccessioniPrimary (citable) accession number: Q86WN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3