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Q86WN2 (IFNE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon epsilon

Short name=IFN-epsilon
Alternative name(s):
Interferon epsilon-1
Gene names
Name:IFNE
Synonyms:IFNE1
ORF Names:UNQ360/PRO655
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections By similarity.

Subcellular location

Secreted Probable.

Tissue specificity

Endometrium-specific. Ref.4

Developmental stage

Highly expressed in endometrial epithelial cells in proliferative phase of the menstrual cycle. Levels decrease approximately 10-fold in the secretory phase. Virtually undetectable in samples from postmenopausal women. Ref.4

Induction

By estrogens Probable. Ref.4

Sequence similarities

Belongs to the alpha/beta interferon family.

Ontologies

Keywords
   Biological processAntiviral defense
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processB cell differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

B cell proliferation

Inferred from Biological aspect of Ancestor. Source: RefGenome

T cell activation involved in immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

adaptive immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytokine-mediated signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

defense response to bacterium

Inferred from sequence or structural similarity. Source: UniProtKB

defense response to virus

Inferred from sequence or structural similarity. Source: UniProtKB

humoral immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

innate immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

natural killer cell activation involved in immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of peptidyl-serine phosphorylation of STAT protein

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of MHC class I biosynthetic process

Inferred from Biological aspect of Ancestor. Source: RefGenome

response to exogenous dsRNA

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentextracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functioncytokine activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

type I interferon receptor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 208187Interferon epsilon
PRO_0000317631

Amino acid modifications

Glycosylation951N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Disulfide bond53 ↔ 163 By similarity

Natural variations

Natural variant461Q → H.
Corresponds to variant rs1125488 [ dbSNP | Ensembl ].
VAR_049639

Sequences

Sequence LengthMass (Da)Tools
Q86WN2 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 65FB861407F14E5F

FASTA20824,414
        10         20         30         40         50         60 
MIIKHFFGTV LVLLASTTIF SLDLKLIIFQ QRQVNQESLK LLNKLQTLSI QQCLPHRKNF 

        70         80         90        100        110        120 
LLPQKSLSPQ QYQKGHTLAI LHEMLQQIFS LFRANISLDG WEENHTEKFL IQLHQQLEYL 

       130        140        150        160        170        180 
EALMGLEAEK LSGTLGSDNL RLQVKMYFRR IHDYLENQDY STCAWAIVQV EISRCLFFVF 

       190        200 
SLTEKLSKQG RPLNDMKQEL TTEFRSPR 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the type I interferon locus and identification of novel genes."
Hardy M.P., Owczarek C.M., Jermiin L.S., Ejdebaeck M., Hertzog P.J.
Genomics 84:331-345(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Interferon-epsilon protects the female reproductive tract from viral and bacterial infection."
Fung K.Y., Mangan N.E., Cumming H., Horvat J.C., Mayall J.R., Stifter S.A., De Weerd N., Roisman L.C., Rossjohn J., Robertson S.A., Schjenken J.E., Parker B., Gargett C.E., Nguyen H.P., Carr D.J., Hansbro P.M., Hertzog P.J.
Science 339:1088-1092(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY190045 mRNA. Translation: AAO38686.1.
AY358570 mRNA. Translation: AAQ88933.1.
BC100871 mRNA. Translation: AAI00872.1.
BC100872 mRNA. Translation: AAI00873.1.
BC100873 mRNA. Translation: AAI00874.1.
RefSeqNP_795372.1. NM_176891.4.
UniGeneHs.682604.

3D structure databases

ProteinModelPortalQ86WN2.
SMRQ86WN2. Positions 36-188.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid130722. 1 interaction.
STRING9606.ENSP00000418018.

PTM databases

PhosphoSiteQ86WN2.

Polymorphism databases

DMDM74727686.

Proteomic databases

PRIDEQ86WN2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000448696; ENSP00000418018; ENSG00000184995.
GeneID338376.
KEGGhsa:338376.
UCSCuc003zpg.3. human.

Organism-specific databases

CTD338376.
GeneCardsGC09M021480.
HGNCHGNC:18163. IFNE.
HPAHPA041028.
MIM615223. gene.
neXtProtNX_Q86WN2.
PharmGKBPA164720874.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44880.
HOGENOMHOG000230501.
InParanoidQ86WN2.
KOK05442.
OMAILHEMLQ.
OrthoDBEOG7MH10X.
PhylomeDBQ86WN2.
TreeFamTF336177.

Gene expression databases

BgeeQ86WN2.
GenevestigatorQ86WN2.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERPTHR11691. PTHR11691. 1 hit.
PfamPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSPR00266. INTERFERONAB.
SMARTSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi338376.
NextBio96956.
PROQ86WN2.
SOURCESearch...

Entry information

Entry nameIFNE_HUMAN
AccessionPrimary (citable) accession number: Q86WN2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2003
Last modified: March 19, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM