Reviewed,
UniProtKB/Swiss-Prot Q86WN2 (IFNE_HUMAN)
Last modified
February 9, 2010.
Version 61.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Interferon epsilon Short name=IFN-epsilon Alternative name(s): Interferon epsilon-1 | ||||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 208 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Subcellular location | Secreted Potential. |
| Tissue specificity | Expressed in prostate cancer cell line PC-3, amnion-derived WISH cells, SK-MEL28 melanoma cells and Daudi cells and very weakly in MCF-7 human breast cancer cells. Not detected in Namalwa cells (Burkitt's lymphoma) or in Jurkat (T) cells. Ref.1 |
| Sequence similarities | Belongs to the alpha/beta interferon family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Antiviral defense |
| Cellular component | Secreted |
| Coding sequence diversity | Polymorphism |
| Domain | Signal |
| Molecular function | Cytokine |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | defense response Inferred from electronic annotation. Source: InterPro response to virusInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | extracellular space Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | cytokine activity Inferred from electronic annotation. Source: UniProtKB-KW cytokine receptor bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 21 | 21 | Potential | ||||||||
| Chain | 22 – 208 | 187 | Interferon epsilon | PRO_0000317631 | |||||||
Amino acid modifications | |||||||||||
| Glycosylation | 95 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 104 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 53 ↔ 163 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 46 | 1 | Q → H: dbSNP rs1125488. | VAR_049639 | |||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of the type I interferon locus and identification of novel genes." Hardy M.P., Owczarek C.M., Jermiin L.S., Ejdebaeck M., Hertzog P.J. Genomics 84:331-345(2004) [PubMed: 15233997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. |
| [2] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY190045 mRNA. Translation: AAO38686.1. AY358570 mRNA. Translation: AAQ88933.1. BC100871 mRNA. Translation: AAI00872.1. BC100872 mRNA. Translation: AAI00873.1. BC100873 mRNA. Translation: AAI00874.1. |
| IPI | IPI00329100. |
| RefSeq | NP_795372.1. |
| UniGene | Hs.682604 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1B5L based on UniProtKB P56828. |
| SMR | Q86WN2. Positions 22-187. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q86WN2. |
Genome annotation databases | |
| Ensembl | ENST00000448696; ENSP00000418018; ENSG00000184995; Homo sapiens. [Genome view] |
| GeneID | 338376. |
| KEGG | hsa:338376. |
| UCSC | uc003zpg.1. human. |
Organism-specific databases | |
| CTD | 338376. |
| GeneCards | GC09M021470. |
| HGNC | HGNC:18163. IFNE. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | maNOG19917. |
| HOVERGEN | Q86WN2. |
| InParanoid | Q86WN2. |
| PhylomeDB | Q86WN2. |
Gene expression databases | |
| Genevestigator | Q86WN2. |
Family and domain databases | |
| InterPro | IPR009079. 4_helix_cytokine-like_core. IPR000471. IInterferon_alpha/beta/delta. [Graphical view] |
| PANTHER | PTHR11691. Interferon_abd. 1 hit. |
| Pfam | PF00143. Interferon. 1 hit. [Graphical view] |
| PRINTS | PR00266. INTERFERONAB. |
| SMART | SM00076. IFabd. 1 hit. [Graphical view] |
| PROSITE | PS00252. INTERFERON_A_B_D. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 96956. |
Entry information
| Entry name | IFNE_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q86WN2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 9 Human chromosome 9: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

Clusters with


