Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q86WN2

- IFNE_HUMAN

UniProt

Q86WN2 - IFNE_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Interferon epsilon

Gene

IFNE

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity).By similarity

GO - Molecular functioni

  1. cytokine activity Source: RefGenome
  2. type I interferon receptor binding Source: RefGenome

GO - Biological processi

  1. adaptive immune response Source: RefGenome
  2. B cell differentiation Source: RefGenome
  3. B cell proliferation Source: RefGenome
  4. cytokine-mediated signaling pathway Source: RefGenome
  5. defense response to bacterium Source: UniProtKB
  6. defense response to virus Source: UniProtKB
  7. humoral immune response Source: RefGenome
  8. innate immune response Source: RefGenome
  9. natural killer cell activation involved in immune response Source: RefGenome
  10. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
  11. regulation of MHC class I biosynthetic process Source: RefGenome
  12. response to exogenous dsRNA Source: RefGenome
  13. T cell activation involved in immune response Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon epsilon
Short name:
IFN-epsilon
Alternative name(s):
Interferon epsilon-1
Gene namesi
Name:IFNE
Synonyms:IFNE1
ORF Names:UNQ360/PRO655
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:18163. IFNE.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular space Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164720874.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 208187Interferon epsilonPRO_0000317631Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 163By similarity
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ86WN2.

PTM databases

PhosphoSiteiQ86WN2.

Expressioni

Tissue specificityi

Endometrium-specific.1 Publication

Developmental stagei

Highly expressed in endometrial epithelial cells in proliferative phase of the menstrual cycle. Levels decrease approximately 10-fold in the secretory phase. Virtually undetectable in samples from postmenopausal women.1 Publication

Inductioni

By estrogens.1 Publication

Gene expression databases

BgeeiQ86WN2.
GenevestigatoriQ86WN2.

Organism-specific databases

HPAiHPA041028.

Interactioni

Protein-protein interaction databases

BioGridi130722. 1 interaction.
STRINGi9606.ENSP00000418018.

Structurei

3D structure databases

ProteinModelPortaliQ86WN2.
SMRiQ86WN2. Positions 36-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44880.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230501.
InParanoidiQ86WN2.
KOiK05442.
OMAiILHEMLQ.
OrthoDBiEOG7MH10X.
PhylomeDBiQ86WN2.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86WN2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIIKHFFGTV LVLLASTTIF SLDLKLIIFQ QRQVNQESLK LLNKLQTLSI
60 70 80 90 100
QQCLPHRKNF LLPQKSLSPQ QYQKGHTLAI LHEMLQQIFS LFRANISLDG
110 120 130 140 150
WEENHTEKFL IQLHQQLEYL EALMGLEAEK LSGTLGSDNL RLQVKMYFRR
160 170 180 190 200
IHDYLENQDY STCAWAIVQV EISRCLFFVF SLTEKLSKQG RPLNDMKQEL

TTEFRSPR
Length:208
Mass (Da):24,414
Last modified:June 1, 2003 - v1
Checksum:i65FB861407F14E5F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461Q → H.
Corresponds to variant rs1125488 [ dbSNP | Ensembl ].
VAR_049639

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY190045 mRNA. Translation: AAO38686.1.
AY358570 mRNA. Translation: AAQ88933.1.
BC100871 mRNA. Translation: AAI00872.1.
BC100872 mRNA. Translation: AAI00873.1.
BC100873 mRNA. Translation: AAI00874.1.
CCDSiCCDS34997.1.
RefSeqiNP_795372.1. NM_176891.4.
UniGeneiHs.682604.

Genome annotation databases

EnsembliENST00000448696; ENSP00000418018; ENSG00000184995.
GeneIDi338376.
KEGGihsa:338376.
UCSCiuc003zpg.3. human.

Polymorphism databases

DMDMi74727686.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY190045 mRNA. Translation: AAO38686.1 .
AY358570 mRNA. Translation: AAQ88933.1 .
BC100871 mRNA. Translation: AAI00872.1 .
BC100872 mRNA. Translation: AAI00873.1 .
BC100873 mRNA. Translation: AAI00874.1 .
CCDSi CCDS34997.1.
RefSeqi NP_795372.1. NM_176891.4.
UniGenei Hs.682604.

3D structure databases

ProteinModelPortali Q86WN2.
SMRi Q86WN2. Positions 36-188.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 130722. 1 interaction.
STRINGi 9606.ENSP00000418018.

PTM databases

PhosphoSitei Q86WN2.

Polymorphism databases

DMDMi 74727686.

Proteomic databases

PRIDEi Q86WN2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000448696 ; ENSP00000418018 ; ENSG00000184995 .
GeneIDi 338376.
KEGGi hsa:338376.
UCSCi uc003zpg.3. human.

Organism-specific databases

CTDi 338376.
GeneCardsi GC09M021480.
HGNCi HGNC:18163. IFNE.
HPAi HPA041028.
MIMi 615223. gene.
neXtProti NX_Q86WN2.
PharmGKBi PA164720874.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44880.
GeneTreei ENSGT00760000119150.
HOGENOMi HOG000230501.
InParanoidi Q86WN2.
KOi K05442.
OMAi ILHEMLQ.
OrthoDBi EOG7MH10X.
PhylomeDBi Q86WN2.
TreeFami TF336177.

Miscellaneous databases

GenomeRNAii 338376.
NextBioi 96956.
PROi Q86WN2.
SOURCEi Search...

Gene expression databases

Bgeei Q86WN2.
Genevestigatori Q86WN2.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view ]
PANTHERi PTHR11691. PTHR11691. 1 hit.
Pfami PF00143. Interferon. 1 hit.
[Graphical view ]
PRINTSi PR00266. INTERFERONAB.
SMARTi SM00076. IFabd. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the type I interferon locus and identification of novel genes."
    Hardy M.P., Owczarek C.M., Jermiin L.S., Ejdebaeck M., Hertzog P.J.
    Genomics 84:331-345(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: INDUCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiIFNE_HUMAN
AccessioniPrimary (citable) accession number: Q86WN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3