Reviewed,
UniProtKB/Swiss-Prot Q86WN2 (IFNE1_HUMAN)
Last modified
November 25, 2008.
Version 46.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Interferon epsilon-1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 208 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Subcellular location | SecretedPotential. |
| Tissue specificity | Expressed in prostate cancer cell line PC-3, amnion-derived WISH cells, SK-MEL28 melanoma cells and Daudi cells and very weakly in MCF-7 human breast cancer cells. Not detected in Namalwa cells (Burkitt's lymphoma) or in Jurkat (T) cells. |
| Sequence similarities | Belongs to the alpha/beta interferon family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Antiviral defense |
| Cellular component | Secreted |
| Domain | Signal |
| Molecular function | Cytokine |
| PTM | Glycoprotein |
Gene Ontology (GO) | |
| Biological process | defense response Inferred from electronic annotation. Source: InterPro response to virusInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | extracellular space Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | hematopoietin/interferon-class (D200-domain) cytokine receptor binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 21 | 21 | Potential | ||||||||
| Chain | 22 – 208 | 187 | Interferon epsilon-1 | PRO_0000317631 | |||||||
Amino acid modifications | |||||||||||
| Glycosylation | 95 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 104 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 53 ↔ 163 | By similarity | |||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of the type I interferon locus and identification of novel genes." Hardy M.P., Owczarek C.M., Jermiin L.S., Ejdebaeck M., Hertzog P.J. Genomics 84:331-345(2004) [PubMed: 15233997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. |
| [2] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| AY190045 mRNA. Translation: AAO38686.1. AY358570 mRNA. Translation: AAQ88933.1. BC100871 mRNA. Translation: AAI00872.1. BC100872 mRNA. Translation: AAI00873.1. BC100873 mRNA. Translation: AAI00874.1. | |
| RefSeq | NP_795372.1. |
| UniGene | Hs.682604 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1B5L based on UniProtKB P56828. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSG00000184995. Homo sapiens. [Contig view] |
| GeneID | 338376. |
| KEGG | hsa:338376. |
Organism-specific databases | |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q86WN2. |
| HOVERGEN | Q86WN2. |
Gene expression databases | |
| ArrayExpress | Q86WN2. |
Family and domain databases | |
| InterPro | IPR012351. 4_helix_cytokine_core. IPR000471. Interferon_abd. [Graphical view] |
| Gene3D | G3DSA:1.20.1250.10. 4_helix_cytokine_core. 1 hit. |
| PANTHER | PTHR11691. Interferon_abd. 1 hit. |
| Pfam | PF00143. Interferon. 1 hit. [Graphical view] |
| PRINTS | PR00266. INTERFERONAB. |
| ProDom | PD000550. Interferon_abd. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00076. IFabd. 1 hit. [Graphical view] |
| PROSITE | PS00252. INTERFERON_A_B_D. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | Q86WN2. |
| NextBio | 96956. |
Entry information
| Entry name | IFNE1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q86WN2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 9 Human chromosome 9: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

Clusters with


