Reviewed, UniProtKB/Swiss-Prot Q86WN2 (IFNE_HUMAN)

Names and origin

Protein names

Recommended name:
    Interferon epsilon
Alternative name(s):
    Interferon epsilon-1

Gene names

Name:	IFNE
Synonyms:	IFNE1
ORF Names:	UNQ360/PRO655

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Secreted Potential.
Tissue specificity	Expressed in prostate cancer cell line PC-3, amnion-derived WISH cells, SK-MEL28 melanoma cells and Daudi cells and very weakly in MCF-7 human breast cancer cells. Not detected in Namalwa cells (Burkitt's lymphoma) or in Jurkat (T) cells. Ref.1
Sequence similarities	Belongs to the alpha/beta interferon family.

Ontologies

Keywords
Biological process	Antiviral defense
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	defense response Inferred from electronic annotation. Source: InterPro response to virus Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytokine activity Inferred from electronic annotation. Source: UniProtKB-KW hematopoietin/interferon-class (D200-domain) cytokine receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 208	187	Interferon epsilon		PRO_0000317631
Amino acid modifications
	Glycosylation	95	1	N-linked (GlcNAc...) Potential
	Glycosylation	104	1	N-linked (GlcNAc...) Potential
	Disulfide bond	53 ↔ 163		By similarity
Natural variations
	Natural variant	46	1	Q → H: dbSNP rs1125488.		VAR_049639

Sequences

	Sequence		Length	Mass (Da)
	Q86WN2-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 65FB861407F14E5F	FASTA	208	24,414
	10 20 30 40 50 60 MIIKHFFGTV LVLLASTTIF SLDLKLIIFQ QRQVNQESLK LLNKLQTLSI QQCLPHRKNF 70 80 90 100 110 120 LLPQKSLSPQ QYQKGHTLAI LHEMLQQIFS LFRANISLDG WEENHTEKFL IQLHQQLEYL 130 140 150 160 170 180 EALMGLEAEK LSGTLGSDNL RLQVKMYFRR IHDYLENQDY STCAWAIVQV EISRCLFFVF 190 200 SLTEKLSKQG RPLNDMKQEL TTEFRSPR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the type I interferon locus and identification of novel genes." Hardy M.P., Owczarek C.M., Jermiin L.S., Ejdebaeck M., Hertzog P.J. Genomics 84:331-345(2004) [PubMed: 15233997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY190045 mRNA. Translation: AAO38686.1. AY358570 mRNA. Translation: AAQ88933.1. BC100871 mRNA. Translation: AAI00872.1. BC100872 mRNA. Translation: AAI00873.1. BC100873 mRNA. Translation: AAI00874.1.
IPI	IPI00329100.
RefSeq	NP_795372.1.
UniGene	Hs.682604
3D structure databases
HSSP	HSSP built from PDB template 1B5L based on UniProtKB P56828.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000184995. Homo sapiens. [Contig view]
GeneID	338376.
KEGG	hsa:338376.
Organism-specific databases
GeneCards	GC09M021470.
HGNC	HGNC:18163. IFNE.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q86WN2.
HOVERGEN	Q86WN2.
OMA	Q86WN2. RIHDYLE.
Gene expression databases
ArrayExpress	Q86WN2.
Bgee	Q86WN2.
Family and domain databases
InterPro	IPR012351. 4_helix_cytokine_core. IPR000471. IInterferon_alpha/beta/delta. [Graphical view]
Gene3D	G3DSA:1.20.1250.10. 4_helix_cytokine_core. 1 hit.
PANTHER	PTHR11691. Interferon_abd. 1 hit.
Pfam	PF00143. Interferon. 1 hit. [Graphical view]
PRINTS	PR00266. INTERFERONAB.
ProDom	PD000550. Interferon_abd. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00076. IFabd. 1 hit. [Graphical view]
PROSITE	PS00252. INTERFERON_A_B_D. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	96956.

Entry information

Entry name

IFNE_HUMAN

Accession

Primary (citable) accession number: Q86WN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)