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Protein

Interferon epsilon

Gene

IFNE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon epsilon
Short name:
IFN-epsilon
Alternative name(s):
Interferon epsilon-1
Gene namesi
Name:IFNE
Synonyms:IFNE1
ORF Names:UNQ360/PRO655
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000184995.7.
HGNCiHGNC:18163. IFNE.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi338376.
OpenTargetsiENSG00000184995.
PharmGKBiPA164720874.

Polymorphism and mutation databases

BioMutaiIFNE.
DMDMi74727686.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000031763122 – 208Interferon epsilonAdd BLAST187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 163By similarity
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ86WN2.
PaxDbiQ86WN2.
PeptideAtlasiQ86WN2.
PRIDEiQ86WN2.

PTM databases

iPTMnetiQ86WN2.
PhosphoSitePlusiQ86WN2.

Expressioni

Tissue specificityi

Endometrium-specific.1 Publication

Developmental stagei

Highly expressed in endometrial epithelial cells in proliferative phase of the menstrual cycle. Levels decrease approximately 10-fold in the secretory phase. Virtually undetectable in samples from postmenopausal women.1 Publication

Inductioni

By estrogens.1 Publication

Gene expression databases

BgeeiENSG00000184995.
GenevisibleiQ86WN2. HS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi130722. 11 interactors.
STRINGi9606.ENSP00000418018.

Structurei

3D structure databases

ProteinModelPortaliQ86WN2.
SMRiQ86WN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JB9C. Eukaryota.
ENOG4111BCG. LUCA.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230501.
InParanoidiQ86WN2.
KOiK05442.
OMAiKMYFRRI.
OrthoDBiEOG091G0R2T.
PhylomeDBiQ86WN2.
TreeFamiTF336177.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR000471. Interferon_alpha/beta/delta.
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiView protein in Pfam
PF00143. Interferon. 1 hit.
PRINTSiPR00266. INTERFERONAB.
SMARTiView protein in SMART
SM00076. IFabd. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00252. INTERFERON_A_B_D. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86WN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIKHFFGTV LVLLASTTIF SLDLKLIIFQ QRQVNQESLK LLNKLQTLSI
60 70 80 90 100
QQCLPHRKNF LLPQKSLSPQ QYQKGHTLAI LHEMLQQIFS LFRANISLDG
110 120 130 140 150
WEENHTEKFL IQLHQQLEYL EALMGLEAEK LSGTLGSDNL RLQVKMYFRR
160 170 180 190 200
IHDYLENQDY STCAWAIVQV EISRCLFFVF SLTEKLSKQG RPLNDMKQEL

TTEFRSPR
Length:208
Mass (Da):24,414
Last modified:June 1, 2003 - v1
Checksum:i65FB861407F14E5F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04963946Q → H. Corresponds to variant dbSNP:rs1125488Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY190045 mRNA. Translation: AAO38686.1.
AY358570 mRNA. Translation: AAQ88933.1.
BC100871 mRNA. Translation: AAI00872.1.
BC100872 mRNA. Translation: AAI00873.1.
BC100873 mRNA. Translation: AAI00874.1.
CCDSiCCDS34997.1.
RefSeqiNP_795372.1. NM_176891.4.
UniGeneiHs.682604.

Genome annotation databases

EnsembliENST00000448696; ENSP00000418018; ENSG00000184995.
GeneIDi338376.
KEGGihsa:338376.
UCSCiuc003zpg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIFNE_HUMAN
AccessioniPrimary (citable) accession number: Q86WN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2003
Last modified: September 27, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families