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Q86WN1 (FCSD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
FCH and double SH3 domains protein 1
Gene names
Name:FCHSD1
ORF Names:UNQ737/PRO1431
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length690 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 FCH domain.

Contains 2 SH3 domains.

Sequence caution

The sequence BAA92232.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Repeat
SH3 domain
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86WN1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86WN1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-320: Missing.
     321-348: GKSGLEKEVQRLTSRAARDYKIQNHGHR → MQLAKYQSHSKSCPTVFPPTPVLCLPNQ
Isoform 3 (identifier: Q86WN1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.
     77-79: SRG → MDS
     481-485: AGRED → GVRMS
     486-690: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 690690FCH and double SH3 domains protein 1
PRO_0000278212

Regions

Domain12 – 7564FCH
Domain468 – 52962SH3 1
Domain546 – 60964SH3 2
Coiled coil116 – 14934 Potential
Coiled coil354 – 38431 Potential
Compositional bias610 – 68879Pro-rich

Natural variations

Alternative sequence1 – 320320Missing in isoform 2.
VSP_023160
Alternative sequence1 – 7676Missing in isoform 3.
VSP_023161
Alternative sequence77 – 793SRG → MDS in isoform 3.
VSP_023162
Alternative sequence321 – 34828GKSGL…NHGHR → MQLAKYQSHSKSCPTVFPPT PVLCLPNQ in isoform 2.
VSP_023163
Alternative sequence481 – 4855AGRED → GVRMS in isoform 3.
VSP_023164
Alternative sequence486 – 690205Missing in isoform 3.
VSP_023165
Natural variant3441N → K.
Corresponds to variant rs3749760 [ dbSNP | Ensembl ].
VAR_030692
Natural variant6811P → L.
Corresponds to variant rs32957 [ dbSNP | Ensembl ].
VAR_030693

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: EEC9583BCB176897

FASTA69076,942
        10         20         30         40         50         60 
MQPPPRKVKP AQEVKLRFLE QLSILQTWQQ READLLEDIR SYSKQRAAIE REYGQALQKL 

        70         80         90        100        110        120 
AGPFLKREGH RSGEMDSRGR TVFGAWRCLL DATVAGGQTR LQASDRYRDL AGGTGRSAKE 

       130        140        150        160        170        180 
QVLRKGTENL QRAQAEVLQS VRELSRSRKL YGQRERVWAL AQEKAADVQA RLNRSDHGIF 

       190        200        210        220        230        240 
HSRTSLQKLS TKLSAQSAQY SQQLQAARNE YLLNLVATNA HLDHYYQEEL PALLKALVSE 

       250        260        270        280        290        300 
LSEHLRDPLT SLSHTELEAA EVILEHAHRG EQTTSQVSWE QDLKLFLQEP GVFSPTPPQQ 

       310        320        330        340        350        360 
FQPAGTDQVC VLEWGAEGVA GKSGLEKEVQ RLTSRAARDY KIQNHGHRVL QRLEQRRQQA 

       370        380        390        400        410        420 
SEREAPSIEQ RLQEVRESIR RAQVSQVKGA ARLALLQGAG LDVERWLKPA MTQAQDEVEQ 

       430        440        450        460        470        480 
ERRLSEARLS QRDLSPTAED AELSDFEECE ETGELFEEPA PQALATRALP CPAHVVFRYQ 

       490        500        510        520        530        540 
AGREDELTIT EGEWLEVIEE GDADEWVKAR NQHGEVGFVP ERYLNFPDLS LPESSQDSDN 

       550        560        570        580        590        600 
PCGAEPTAFL AQALYSYTGQ SAEELSFPEG ALIRLLPRAQ DGVDDGFWRG EFGGRVGVFP 

       610        620        630        640        650        660 
SLLVEELLGP PGPPELSDPE QMLPSPSPPS FSPPAPTSVL DGPPAPVLPG DKALDFPGFL 

       670        680        690 
DMMAPRLRPM RPPPPPPAKA PDPGHPDPLT 

« Hide

Isoform 2 [UniParc].

Checksum: 099948E9D3A6719E
Show »

FASTA37040,685
Isoform 3 [UniParc].

Checksum: 71A68B030C0F6CE6
Show »

FASTA40946,070

References

« Hide 'large scale' references
[1]Shan Y.X., Yu L.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Spleen.
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Blood.
[6]"Identification and characterization of human FCHSD1 and FCHSD2 genes in silico."
Katoh M., Katoh M.
Int. J. Mol. Med. 13:749-754(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY217346 mRNA. Translation: AAO45099.1.
AY358478 mRNA. Translation: AAQ88842.1.
AK000007 mRNA. Translation: BAA92232.1. Different initiation.
AC008781 Genomic DNA. No translation available.
AC022420 Genomic DNA. No translation available.
BC047016 mRNA. Translation: AAH47016.1.
CCDSCCDS47295.1. [Q86WN1-1]
RefSeqNP_258260.1. NM_033449.2. [Q86WN1-1]
UniGeneHs.591257.

3D structure databases

ProteinModelPortalQ86WN1.
SMRQ86WN1. Positions 467-611.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124619. 7 interactions.
IntActQ86WN1. 5 interactions.
MINTMINT-6769031.
STRING9606.ENSP00000399259.

PTM databases

PhosphoSiteQ86WN1.

Polymorphism databases

DMDM74714119.

Proteomic databases

MaxQBQ86WN1.
PaxDbQ86WN1.
PRIDEQ86WN1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000435817; ENSP00000399259; ENSG00000197948. [Q86WN1-1]
ENST00000522126; ENSP00000427796; ENSG00000197948. [Q86WN1-3]
GeneID89848.
KEGGhsa:89848.
UCSCuc003llk.3. human. [Q86WN1-1]
uc010jgg.3. human. [Q86WN1-2]

Organism-specific databases

CTD89848.
GeneCardsGC05M141018.
HGNCHGNC:25463. FCHSD1.
HPAHPA043795.
neXtProtNX_Q86WN1.
PharmGKBPA134871859.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG327979.
HOGENOMHOG000046016.
HOVERGENHBG063540.
InParanoidQ86WN1.
OMAKSEHGIF.
OrthoDBEOG722J81.
PhylomeDBQ86WN1.
TreeFamTF324557.

Gene expression databases

ArrayExpressQ86WN1.
BgeeQ86WN1.
CleanExHS_FCHSD1.
GenevestigatorQ86WN1.

Family and domain databases

InterProIPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00611. FCH. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view]
SMARTSM00326. SH3. 2 hits.
[Graphical view]
SUPFAMSSF50044. SSF50044. 2 hits.
PROSITEPS50133. FCH. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiFCHSD1.
GenomeRNAi89848.
NextBio76338.
PROQ86WN1.

Entry information

Entry nameFCSD1_HUMAN
AccessionPrimary (citable) accession number: Q86WN1
Secondary accession number(s): Q6UX75, Q86Y77, Q9NXX8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM