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Protein

F-BAR and double SH3 domains protein 1

Gene

FCHSD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
F-BAR and double SH3 domains protein 1
Gene namesi
Name:FCHSD1
ORF Names:UNQ737/PRO1431
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:25463. FCHSD1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134871859.

Polymorphism and mutation databases

BioMutaiFCHSD1.
DMDMi74714119.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 690690F-BAR and double SH3 domains protein 1PRO_0000278212Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei444 – 4441Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ86WN1.
PaxDbiQ86WN1.
PRIDEiQ86WN1.

PTM databases

PhosphoSiteiQ86WN1.

Expressioni

Gene expression databases

BgeeiQ86WN1.
CleanExiHS_FCHSD1.
ExpressionAtlasiQ86WN1. baseline and differential.
GenevisibleiQ86WN1. HS.

Organism-specific databases

HPAiHPA043795.

Interactioni

Protein-protein interaction databases

BioGridi124619. 10 interactions.
IntActiQ86WN1. 5 interactions.
MINTiMINT-6769031.
STRINGi9606.ENSP00000399259.

Structurei

3D structure databases

ProteinModelPortaliQ86WN1.
SMRiQ86WN1. Positions 467-534, 550-611.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 282271F-BARPROSITE-ProRule annotationAdd
BLAST
Domaini468 – 52962SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini546 – 60964SH3 2PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili116 – 14934Sequence AnalysisAdd
BLAST
Coiled coili354 – 38431Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi610 – 68879Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 F-BAR domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG327979.
GeneTreeiENSGT00510000046732.
HOGENOMiHOG000046016.
HOVERGENiHBG063540.
InParanoidiQ86WN1.
OMAiKSEHGIF.
OrthoDBiEOG722J81.
PhylomeDBiQ86WN1.
TreeFamiTF324557.

Family and domain databases

InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view]
SMARTiSM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS51741. F_BAR. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86WN1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQPPPRKVKP AQEVKLRFLE QLSILQTWQQ READLLEDIR SYSKQRAAIE
60 70 80 90 100
REYGQALQKL AGPFLKREGH RSGEMDSRGR TVFGAWRCLL DATVAGGQTR
110 120 130 140 150
LQASDRYRDL AGGTGRSAKE QVLRKGTENL QRAQAEVLQS VRELSRSRKL
160 170 180 190 200
YGQRERVWAL AQEKAADVQA RLNRSDHGIF HSRTSLQKLS TKLSAQSAQY
210 220 230 240 250
SQQLQAARNE YLLNLVATNA HLDHYYQEEL PALLKALVSE LSEHLRDPLT
260 270 280 290 300
SLSHTELEAA EVILEHAHRG EQTTSQVSWE QDLKLFLQEP GVFSPTPPQQ
310 320 330 340 350
FQPAGTDQVC VLEWGAEGVA GKSGLEKEVQ RLTSRAARDY KIQNHGHRVL
360 370 380 390 400
QRLEQRRQQA SEREAPSIEQ RLQEVRESIR RAQVSQVKGA ARLALLQGAG
410 420 430 440 450
LDVERWLKPA MTQAQDEVEQ ERRLSEARLS QRDLSPTAED AELSDFEECE
460 470 480 490 500
ETGELFEEPA PQALATRALP CPAHVVFRYQ AGREDELTIT EGEWLEVIEE
510 520 530 540 550
GDADEWVKAR NQHGEVGFVP ERYLNFPDLS LPESSQDSDN PCGAEPTAFL
560 570 580 590 600
AQALYSYTGQ SAEELSFPEG ALIRLLPRAQ DGVDDGFWRG EFGGRVGVFP
610 620 630 640 650
SLLVEELLGP PGPPELSDPE QMLPSPSPPS FSPPAPTSVL DGPPAPVLPG
660 670 680 690
DKALDFPGFL DMMAPRLRPM RPPPPPPAKA PDPGHPDPLT
Length:690
Mass (Da):76,942
Last modified:June 1, 2003 - v1
Checksum:iEEC9583BCB176897
GO
Isoform 2 (identifier: Q86WN1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-320: Missing.
     321-348: GKSGLEKEVQRLTSRAARDYKIQNHGHR → MQLAKYQSHSKSCPTVFPPTPVLCLPNQ

Show »
Length:370
Mass (Da):40,685
Checksum:i099948E9D3A6719E
GO
Isoform 3 (identifier: Q86WN1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.
     77-79: SRG → MDS
     481-485: AGRED → GVRMS
     486-690: Missing.

Show »
Length:409
Mass (Da):46,070
Checksum:i71A68B030C0F6CE6
GO

Sequence cautioni

The sequence BAA92232.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti344 – 3441N → K.
Corresponds to variant rs3749760 [ dbSNP | Ensembl ].
VAR_030692
Natural varianti681 – 6811P → L.
Corresponds to variant rs32957 [ dbSNP | Ensembl ].
VAR_030693

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 320320Missing in isoform 2. 1 PublicationVSP_023160Add
BLAST
Alternative sequencei1 – 7676Missing in isoform 3. 1 PublicationVSP_023161Add
BLAST
Alternative sequencei77 – 793SRG → MDS in isoform 3. 1 PublicationVSP_023162
Alternative sequencei321 – 34828GKSGL…NHGHR → MQLAKYQSHSKSCPTVFPPT PVLCLPNQ in isoform 2. 1 PublicationVSP_023163Add
BLAST
Alternative sequencei481 – 4855AGRED → GVRMS in isoform 3. 1 PublicationVSP_023164
Alternative sequencei486 – 690205Missing in isoform 3. 1 PublicationVSP_023165Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY217346 mRNA. Translation: AAO45099.1.
AY358478 mRNA. Translation: AAQ88842.1.
AK000007 mRNA. Translation: BAA92232.1. Different initiation.
AC008781 Genomic DNA. No translation available.
AC022420 Genomic DNA. No translation available.
BC047016 mRNA. Translation: AAH47016.1.
CCDSiCCDS47295.1. [Q86WN1-1]
RefSeqiNP_258260.1. NM_033449.2. [Q86WN1-1]
UniGeneiHs.591257.

Genome annotation databases

EnsembliENST00000435817; ENSP00000399259; ENSG00000197948.
ENST00000522126; ENSP00000427796; ENSG00000197948. [Q86WN1-3]
GeneIDi89848.
KEGGihsa:89848.
UCSCiuc003llk.3. human. [Q86WN1-1]
uc010jgg.3. human. [Q86WN1-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY217346 mRNA. Translation: AAO45099.1.
AY358478 mRNA. Translation: AAQ88842.1.
AK000007 mRNA. Translation: BAA92232.1. Different initiation.
AC008781 Genomic DNA. No translation available.
AC022420 Genomic DNA. No translation available.
BC047016 mRNA. Translation: AAH47016.1.
CCDSiCCDS47295.1. [Q86WN1-1]
RefSeqiNP_258260.1. NM_033449.2. [Q86WN1-1]
UniGeneiHs.591257.

3D structure databases

ProteinModelPortaliQ86WN1.
SMRiQ86WN1. Positions 467-534, 550-611.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124619. 10 interactions.
IntActiQ86WN1. 5 interactions.
MINTiMINT-6769031.
STRINGi9606.ENSP00000399259.

PTM databases

PhosphoSiteiQ86WN1.

Polymorphism and mutation databases

BioMutaiFCHSD1.
DMDMi74714119.

Proteomic databases

MaxQBiQ86WN1.
PaxDbiQ86WN1.
PRIDEiQ86WN1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000435817; ENSP00000399259; ENSG00000197948.
ENST00000522126; ENSP00000427796; ENSG00000197948. [Q86WN1-3]
GeneIDi89848.
KEGGihsa:89848.
UCSCiuc003llk.3. human. [Q86WN1-1]
uc010jgg.3. human. [Q86WN1-2]

Organism-specific databases

CTDi89848.
GeneCardsiGC05M141018.
HGNCiHGNC:25463. FCHSD1.
HPAiHPA043795.
neXtProtiNX_Q86WN1.
PharmGKBiPA134871859.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG327979.
GeneTreeiENSGT00510000046732.
HOGENOMiHOG000046016.
HOVERGENiHBG063540.
InParanoidiQ86WN1.
OMAiKSEHGIF.
OrthoDBiEOG722J81.
PhylomeDBiQ86WN1.
TreeFamiTF324557.

Miscellaneous databases

GeneWikiiFCHSD1.
GenomeRNAii89848.
NextBioi76338.
PROiQ86WN1.

Gene expression databases

BgeeiQ86WN1.
CleanExiHS_FCHSD1.
ExpressionAtlasiQ86WN1. baseline and differential.
GenevisibleiQ86WN1. HS.

Family and domain databases

InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view]
SMARTiSM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS51741. F_BAR. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Shan Y.X., Yu L.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Spleen.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Blood.
  6. "Identification and characterization of human FCHSD1 and FCHSD2 genes in silico."
    Katoh M., Katoh M.
    Int. J. Mol. Med. 13:749-754(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-444, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiFCSD1_HUMAN
AccessioniPrimary (citable) accession number: Q86WN1
Secondary accession number(s): Q6UX75, Q86Y77, Q9NXX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.