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Q86WN1

- FCSD1_HUMAN

UniProt

Q86WN1 - FCSD1_HUMAN

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Protein
FCH and double SH3 domains protein 1
Gene
FCHSD1, UNQ737/PRO1431
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
FCH and double SH3 domains protein 1
Gene namesi
Name:FCHSD1
ORF Names:UNQ737/PRO1431
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:25463. FCHSD1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134871859.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 690690FCH and double SH3 domains protein 1
PRO_0000278212Add
BLAST

Proteomic databases

MaxQBiQ86WN1.
PaxDbiQ86WN1.
PRIDEiQ86WN1.

PTM databases

PhosphoSiteiQ86WN1.

Expressioni

Gene expression databases

ArrayExpressiQ86WN1.
BgeeiQ86WN1.
CleanExiHS_FCHSD1.
GenevestigatoriQ86WN1.

Organism-specific databases

HPAiHPA043795.

Interactioni

Protein-protein interaction databases

BioGridi124619. 7 interactions.
IntActiQ86WN1. 5 interactions.
MINTiMINT-6769031.
STRINGi9606.ENSP00000399259.

Structurei

3D structure databases

ProteinModelPortaliQ86WN1.
SMRiQ86WN1. Positions 467-611.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 7564FCH
Add
BLAST
Domaini468 – 52962SH3 1
Add
BLAST
Domaini546 – 60964SH3 2
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili116 – 14934 Reviewed prediction
Add
BLAST
Coiled coili354 – 38431 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi610 – 68879Pro-rich
Add
BLAST

Sequence similaritiesi

Contains 1 FCH domain.
Contains 2 SH3 domains.

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG327979.
HOGENOMiHOG000046016.
HOVERGENiHBG063540.
InParanoidiQ86WN1.
OMAiKSEHGIF.
OrthoDBiEOG722J81.
PhylomeDBiQ86WN1.
TreeFamiTF324557.

Family and domain databases

InterProiIPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view]
SMARTiSM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS50133. FCH. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86WN1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQPPPRKVKP AQEVKLRFLE QLSILQTWQQ READLLEDIR SYSKQRAAIE    50
REYGQALQKL AGPFLKREGH RSGEMDSRGR TVFGAWRCLL DATVAGGQTR 100
LQASDRYRDL AGGTGRSAKE QVLRKGTENL QRAQAEVLQS VRELSRSRKL 150
YGQRERVWAL AQEKAADVQA RLNRSDHGIF HSRTSLQKLS TKLSAQSAQY 200
SQQLQAARNE YLLNLVATNA HLDHYYQEEL PALLKALVSE LSEHLRDPLT 250
SLSHTELEAA EVILEHAHRG EQTTSQVSWE QDLKLFLQEP GVFSPTPPQQ 300
FQPAGTDQVC VLEWGAEGVA GKSGLEKEVQ RLTSRAARDY KIQNHGHRVL 350
QRLEQRRQQA SEREAPSIEQ RLQEVRESIR RAQVSQVKGA ARLALLQGAG 400
LDVERWLKPA MTQAQDEVEQ ERRLSEARLS QRDLSPTAED AELSDFEECE 450
ETGELFEEPA PQALATRALP CPAHVVFRYQ AGREDELTIT EGEWLEVIEE 500
GDADEWVKAR NQHGEVGFVP ERYLNFPDLS LPESSQDSDN PCGAEPTAFL 550
AQALYSYTGQ SAEELSFPEG ALIRLLPRAQ DGVDDGFWRG EFGGRVGVFP 600
SLLVEELLGP PGPPELSDPE QMLPSPSPPS FSPPAPTSVL DGPPAPVLPG 650
DKALDFPGFL DMMAPRLRPM RPPPPPPAKA PDPGHPDPLT 690
Length:690
Mass (Da):76,942
Last modified:June 1, 2003 - v1
Checksum:iEEC9583BCB176897
GO
Isoform 2 (identifier: Q86WN1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-320: Missing.
     321-348: GKSGLEKEVQRLTSRAARDYKIQNHGHR → MQLAKYQSHSKSCPTVFPPTPVLCLPNQ

Show »
Length:370
Mass (Da):40,685
Checksum:i099948E9D3A6719E
GO
Isoform 3 (identifier: Q86WN1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.
     77-79: SRG → MDS
     481-485: AGRED → GVRMS
     486-690: Missing.

Show »
Length:409
Mass (Da):46,070
Checksum:i71A68B030C0F6CE6
GO

Sequence cautioni

The sequence BAA92232.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti344 – 3441N → K.
Corresponds to variant rs3749760 [ dbSNP | Ensembl ].
VAR_030692
Natural varianti681 – 6811P → L.
Corresponds to variant rs32957 [ dbSNP | Ensembl ].
VAR_030693

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 320320Missing in isoform 2.
VSP_023160Add
BLAST
Alternative sequencei1 – 7676Missing in isoform 3.
VSP_023161Add
BLAST
Alternative sequencei77 – 793SRG → MDS in isoform 3.
VSP_023162
Alternative sequencei321 – 34828GKSGL…NHGHR → MQLAKYQSHSKSCPTVFPPT PVLCLPNQ in isoform 2.
VSP_023163Add
BLAST
Alternative sequencei481 – 4855AGRED → GVRMS in isoform 3.
VSP_023164
Alternative sequencei486 – 690205Missing in isoform 3.
VSP_023165Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY217346 mRNA. Translation: AAO45099.1.
AY358478 mRNA. Translation: AAQ88842.1.
AK000007 mRNA. Translation: BAA92232.1. Different initiation.
AC008781 Genomic DNA. No translation available.
AC022420 Genomic DNA. No translation available.
BC047016 mRNA. Translation: AAH47016.1.
CCDSiCCDS47295.1. [Q86WN1-1]
RefSeqiNP_258260.1. NM_033449.2. [Q86WN1-1]
UniGeneiHs.591257.

Genome annotation databases

EnsembliENST00000435817; ENSP00000399259; ENSG00000197948. [Q86WN1-1]
ENST00000522126; ENSP00000427796; ENSG00000197948. [Q86WN1-3]
GeneIDi89848.
KEGGihsa:89848.
UCSCiuc003llk.3. human. [Q86WN1-1]
uc010jgg.3. human. [Q86WN1-2]

Polymorphism databases

DMDMi74714119.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY217346 mRNA. Translation: AAO45099.1 .
AY358478 mRNA. Translation: AAQ88842.1 .
AK000007 mRNA. Translation: BAA92232.1 . Different initiation.
AC008781 Genomic DNA. No translation available.
AC022420 Genomic DNA. No translation available.
BC047016 mRNA. Translation: AAH47016.1 .
CCDSi CCDS47295.1. [Q86WN1-1 ]
RefSeqi NP_258260.1. NM_033449.2. [Q86WN1-1 ]
UniGenei Hs.591257.

3D structure databases

ProteinModelPortali Q86WN1.
SMRi Q86WN1. Positions 467-611.
ModBasei Search...

Protein-protein interaction databases

BioGridi 124619. 7 interactions.
IntActi Q86WN1. 5 interactions.
MINTi MINT-6769031.
STRINGi 9606.ENSP00000399259.

PTM databases

PhosphoSitei Q86WN1.

Polymorphism databases

DMDMi 74714119.

Proteomic databases

MaxQBi Q86WN1.
PaxDbi Q86WN1.
PRIDEi Q86WN1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000435817 ; ENSP00000399259 ; ENSG00000197948 . [Q86WN1-1 ]
ENST00000522126 ; ENSP00000427796 ; ENSG00000197948 . [Q86WN1-3 ]
GeneIDi 89848.
KEGGi hsa:89848.
UCSCi uc003llk.3. human. [Q86WN1-1 ]
uc010jgg.3. human. [Q86WN1-2 ]

Organism-specific databases

CTDi 89848.
GeneCardsi GC05M141018.
HGNCi HGNC:25463. FCHSD1.
HPAi HPA043795.
neXtProti NX_Q86WN1.
PharmGKBi PA134871859.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327979.
HOGENOMi HOG000046016.
HOVERGENi HBG063540.
InParanoidi Q86WN1.
OMAi KSEHGIF.
OrthoDBi EOG722J81.
PhylomeDBi Q86WN1.
TreeFami TF324557.

Miscellaneous databases

GeneWikii FCHSD1.
GenomeRNAii 89848.
NextBioi 76338.
PROi Q86WN1.

Gene expression databases

ArrayExpressi Q86WN1.
Bgeei Q86WN1.
CleanExi HS_FCHSD1.
Genevestigatori Q86WN1.

Family and domain databases

InterProi IPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00611. FCH. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view ]
SMARTi SM00326. SH3. 2 hits.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 2 hits.
PROSITEi PS50133. FCH. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Shan Y.X., Yu L.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Spleen.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Blood.
  6. "Identification and characterization of human FCHSD1 and FCHSD2 genes in silico."
    Katoh M., Katoh M.
    Int. J. Mol. Med. 13:749-754(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiFCSD1_HUMAN
AccessioniPrimary (citable) accession number: Q86WN1
Secondary accession number(s): Q6UX75, Q86Y77, Q9NXX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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