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Q86WN1

- FCSD1_HUMAN

UniProt

Q86WN1 - FCSD1_HUMAN

Protein

FCH and double SH3 domains protein 1

Gene

FCHSD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FCH and double SH3 domains protein 1
    Gene namesi
    Name:FCHSD1
    ORF Names:UNQ737/PRO1431
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:25463. FCHSD1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134871859.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 690690FCH and double SH3 domains protein 1PRO_0000278212Add
    BLAST

    Proteomic databases

    MaxQBiQ86WN1.
    PaxDbiQ86WN1.
    PRIDEiQ86WN1.

    PTM databases

    PhosphoSiteiQ86WN1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ86WN1.
    BgeeiQ86WN1.
    CleanExiHS_FCHSD1.
    GenevestigatoriQ86WN1.

    Organism-specific databases

    HPAiHPA043795.

    Interactioni

    Protein-protein interaction databases

    BioGridi124619. 7 interactions.
    IntActiQ86WN1. 5 interactions.
    MINTiMINT-6769031.
    STRINGi9606.ENSP00000399259.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86WN1.
    SMRiQ86WN1. Positions 467-611.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 7564FCHPROSITE-ProRule annotationAdd
    BLAST
    Domaini468 – 52962SH3 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini546 – 60964SH3 2PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili116 – 14934Sequence AnalysisAdd
    BLAST
    Coiled coili354 – 38431Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi610 – 68879Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FCH domain.PROSITE-ProRule annotation
    Contains 2 SH3 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiNOG327979.
    HOGENOMiHOG000046016.
    HOVERGENiHBG063540.
    InParanoidiQ86WN1.
    OMAiKSEHGIF.
    OrthoDBiEOG722J81.
    PhylomeDBiQ86WN1.
    TreeFamiTF324557.

    Family and domain databases

    InterProiIPR001060. FCH_dom.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00611. FCH. 1 hit.
    PF14604. SH3_9. 2 hits.
    [Graphical view]
    SMARTiSM00326. SH3. 2 hits.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 2 hits.
    PROSITEiPS50133. FCH. 1 hit.
    PS50002. SH3. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86WN1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQPPPRKVKP AQEVKLRFLE QLSILQTWQQ READLLEDIR SYSKQRAAIE    50
    REYGQALQKL AGPFLKREGH RSGEMDSRGR TVFGAWRCLL DATVAGGQTR 100
    LQASDRYRDL AGGTGRSAKE QVLRKGTENL QRAQAEVLQS VRELSRSRKL 150
    YGQRERVWAL AQEKAADVQA RLNRSDHGIF HSRTSLQKLS TKLSAQSAQY 200
    SQQLQAARNE YLLNLVATNA HLDHYYQEEL PALLKALVSE LSEHLRDPLT 250
    SLSHTELEAA EVILEHAHRG EQTTSQVSWE QDLKLFLQEP GVFSPTPPQQ 300
    FQPAGTDQVC VLEWGAEGVA GKSGLEKEVQ RLTSRAARDY KIQNHGHRVL 350
    QRLEQRRQQA SEREAPSIEQ RLQEVRESIR RAQVSQVKGA ARLALLQGAG 400
    LDVERWLKPA MTQAQDEVEQ ERRLSEARLS QRDLSPTAED AELSDFEECE 450
    ETGELFEEPA PQALATRALP CPAHVVFRYQ AGREDELTIT EGEWLEVIEE 500
    GDADEWVKAR NQHGEVGFVP ERYLNFPDLS LPESSQDSDN PCGAEPTAFL 550
    AQALYSYTGQ SAEELSFPEG ALIRLLPRAQ DGVDDGFWRG EFGGRVGVFP 600
    SLLVEELLGP PGPPELSDPE QMLPSPSPPS FSPPAPTSVL DGPPAPVLPG 650
    DKALDFPGFL DMMAPRLRPM RPPPPPPAKA PDPGHPDPLT 690
    Length:690
    Mass (Da):76,942
    Last modified:June 1, 2003 - v1
    Checksum:iEEC9583BCB176897
    GO
    Isoform 2 (identifier: Q86WN1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-320: Missing.
         321-348: GKSGLEKEVQRLTSRAARDYKIQNHGHR → MQLAKYQSHSKSCPTVFPPTPVLCLPNQ

    Show »
    Length:370
    Mass (Da):40,685
    Checksum:i099948E9D3A6719E
    GO
    Isoform 3 (identifier: Q86WN1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-76: Missing.
         77-79: SRG → MDS
         481-485: AGRED → GVRMS
         486-690: Missing.

    Show »
    Length:409
    Mass (Da):46,070
    Checksum:i71A68B030C0F6CE6
    GO

    Sequence cautioni

    The sequence BAA92232.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti344 – 3441N → K.
    Corresponds to variant rs3749760 [ dbSNP | Ensembl ].
    VAR_030692
    Natural varianti681 – 6811P → L.
    Corresponds to variant rs32957 [ dbSNP | Ensembl ].
    VAR_030693

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 320320Missing in isoform 2. 1 PublicationVSP_023160Add
    BLAST
    Alternative sequencei1 – 7676Missing in isoform 3. 1 PublicationVSP_023161Add
    BLAST
    Alternative sequencei77 – 793SRG → MDS in isoform 3. 1 PublicationVSP_023162
    Alternative sequencei321 – 34828GKSGL…NHGHR → MQLAKYQSHSKSCPTVFPPT PVLCLPNQ in isoform 2. 1 PublicationVSP_023163Add
    BLAST
    Alternative sequencei481 – 4855AGRED → GVRMS in isoform 3. 1 PublicationVSP_023164
    Alternative sequencei486 – 690205Missing in isoform 3. 1 PublicationVSP_023165Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY217346 mRNA. Translation: AAO45099.1.
    AY358478 mRNA. Translation: AAQ88842.1.
    AK000007 mRNA. Translation: BAA92232.1. Different initiation.
    AC008781 Genomic DNA. No translation available.
    AC022420 Genomic DNA. No translation available.
    BC047016 mRNA. Translation: AAH47016.1.
    CCDSiCCDS47295.1. [Q86WN1-1]
    RefSeqiNP_258260.1. NM_033449.2. [Q86WN1-1]
    UniGeneiHs.591257.

    Genome annotation databases

    EnsembliENST00000435817; ENSP00000399259; ENSG00000197948. [Q86WN1-1]
    ENST00000522126; ENSP00000427796; ENSG00000197948. [Q86WN1-3]
    GeneIDi89848.
    KEGGihsa:89848.
    UCSCiuc003llk.3. human. [Q86WN1-1]
    uc010jgg.3. human. [Q86WN1-2]

    Polymorphism databases

    DMDMi74714119.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY217346 mRNA. Translation: AAO45099.1 .
    AY358478 mRNA. Translation: AAQ88842.1 .
    AK000007 mRNA. Translation: BAA92232.1 . Different initiation.
    AC008781 Genomic DNA. No translation available.
    AC022420 Genomic DNA. No translation available.
    BC047016 mRNA. Translation: AAH47016.1 .
    CCDSi CCDS47295.1. [Q86WN1-1 ]
    RefSeqi NP_258260.1. NM_033449.2. [Q86WN1-1 ]
    UniGenei Hs.591257.

    3D structure databases

    ProteinModelPortali Q86WN1.
    SMRi Q86WN1. Positions 467-611.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124619. 7 interactions.
    IntActi Q86WN1. 5 interactions.
    MINTi MINT-6769031.
    STRINGi 9606.ENSP00000399259.

    PTM databases

    PhosphoSitei Q86WN1.

    Polymorphism databases

    DMDMi 74714119.

    Proteomic databases

    MaxQBi Q86WN1.
    PaxDbi Q86WN1.
    PRIDEi Q86WN1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000435817 ; ENSP00000399259 ; ENSG00000197948 . [Q86WN1-1 ]
    ENST00000522126 ; ENSP00000427796 ; ENSG00000197948 . [Q86WN1-3 ]
    GeneIDi 89848.
    KEGGi hsa:89848.
    UCSCi uc003llk.3. human. [Q86WN1-1 ]
    uc010jgg.3. human. [Q86WN1-2 ]

    Organism-specific databases

    CTDi 89848.
    GeneCardsi GC05M141018.
    HGNCi HGNC:25463. FCHSD1.
    HPAi HPA043795.
    neXtProti NX_Q86WN1.
    PharmGKBi PA134871859.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327979.
    HOGENOMi HOG000046016.
    HOVERGENi HBG063540.
    InParanoidi Q86WN1.
    OMAi KSEHGIF.
    OrthoDBi EOG722J81.
    PhylomeDBi Q86WN1.
    TreeFami TF324557.

    Miscellaneous databases

    GeneWikii FCHSD1.
    GenomeRNAii 89848.
    NextBioi 76338.
    PROi Q86WN1.

    Gene expression databases

    ArrayExpressi Q86WN1.
    Bgeei Q86WN1.
    CleanExi HS_FCHSD1.
    Genevestigatori Q86WN1.

    Family and domain databases

    InterProi IPR001060. FCH_dom.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00611. FCH. 1 hit.
    PF14604. SH3_9. 2 hits.
    [Graphical view ]
    SMARTi SM00326. SH3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 2 hits.
    PROSITEi PS50133. FCH. 1 hit.
    PS50002. SH3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Shan Y.X., Yu L.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Spleen.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Blood.
    6. "Identification and characterization of human FCHSD1 and FCHSD2 genes in silico."
      Katoh M., Katoh M.
      Int. J. Mol. Med. 13:749-754(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiFCSD1_HUMAN
    AccessioniPrimary (citable) accession number: Q86WN1
    Secondary accession number(s): Q6UX75, Q86Y77, Q9NXX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3