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Q86WK9

- MPRA_HUMAN

UniProt

Q86WK9 - MPRA_HUMAN

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Protein

Membrane progestin receptor alpha

Gene

PAQR7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Steroid membrane receptor. Binds progesterone in vitro. May be involved in oocyte maturation.1 Publication

GO - Molecular functioni

  1. steroid binding Source: RefGenome
  2. steroid hormone receptor activity Source: RefGenome

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. oogenesis Source: UniProtKB-KW
  3. response to steroid hormone Source: RefGenome
  4. steroid hormone mediated signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Differentiation, Oogenesis

Keywords - Ligandi

Lipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane progestin receptor alpha
Short name:
mPR alpha
Alternative name(s):
Progestin and adipoQ receptor family member 7
Progestin and adipoQ receptor family member VII
Gene namesi
Name:PAQR7
Synonyms:MRPA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:23146. PAQR7.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7272CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei73 – 9321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini94 – 10310ExtracellularSequence Analysis
Transmembranei104 – 12421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini125 – 13713CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini159 – 16911ExtracellularSequence AnalysisAdd
BLAST
Transmembranei170 – 19021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini191 – 23747CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini259 – 27618ExtracellularSequence AnalysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini298 – 31619CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei317 – 33721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini338 – 3469ExtracellularSequence Analysis

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671200.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Membrane progestin receptor alphaPRO_0000218835Add
BLAST

Proteomic databases

MaxQBiQ86WK9.
PaxDbiQ86WK9.
PRIDEiQ86WK9.

PTM databases

PhosphoSiteiQ86WK9.

Expressioni

Tissue specificityi

Expressed in a wide range of tissues including ovary, testis, placenta, uterus and bladder.2 Publications

Gene expression databases

BgeeiQ86WK9.
CleanExiHS_PAQR7.
GenevestigatoriQ86WK9.

Organism-specific databases

HPAiHPA046936.

Interactioni

Protein-protein interaction databases

BioGridi127887. 2 interactions.
STRINGi9606.ENSP00000363414.

Structurei

3D structure databases

ProteinModelPortaliQ86WK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1272.
GeneTreeiENSGT00530000062965.
HOGENOMiHOG000230872.
HOVERGENiHBG052504.
InParanoidiQ86WK9.
OMAiRRPIYEP.
OrthoDBiEOG7SN8D2.
PhylomeDBiQ86WK9.
TreeFamiTF319738.

Family and domain databases

InterProiIPR004254. HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86WK9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAMAQKLSHL LPSLRQVIQE PQLSLQPEPV FTVDRAEVPP LFWKPYIYAG
60 70 80 90 100
YRPLHQTWRF YFRTLFQQHN EAVNVWTHLL AALVLLLRLA LFVETVDFWG
110 120 130 140 150
DPHALPLFII VLASFTYLSF SALAHLLQAK SEFWHYSFFF LDYVGVAVYQ
160 170 180 190 200
FGSALAHFYY AIEPAWHAQV QAVFLPMAAF LAWLSCIGSC YNKYIQKPGL
210 220 230 240 250
LGRTCQEVPS VLAYALDISP VVHRIFVSSD PTTDDPALLY HKCQVVFFLL
260 270 280 290 300
AAAFFSTFMP ERWFPGSCHV FGQGHQLFHI FLVLCTLAQL EAVALDYEAR
310 320 330 340
RPIYEPLHTH WPHNFSGLFL LTVGSSILTA FLLSQLVQRK LDQKTK
Length:346
Mass (Da):39,719
Last modified:June 1, 2003 - v1
Checksum:i7D12639DD4756501
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti227 – 2271V → M.1 Publication
Corresponds to variant rs55948644 [ dbSNP | Ensembl ].
VAR_060999
Natural varianti272 – 2721G → R.
Corresponds to variant rs6689014 [ dbSNP | Ensembl ].
VAR_048204

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313620 mRNA. Translation: AAO47233.1.
AY424285 mRNA. Translation: AAR08373.1.
AL033528 Genomic DNA. Translation: CAM12867.1.
CH471059 Genomic DNA. Translation: EAX07862.1.
BC034015 mRNA. Translation: AAH34015.1.
BC042298 mRNA. No translation available.
CCDSiCCDS267.1.
RefSeqiNP_848509.1. NM_178422.5.
XP_005245802.1. XM_005245745.1.
XP_005245803.1. XM_005245746.1.
XP_006710459.1. XM_006710396.1.
UniGeneiHs.523652.

Genome annotation databases

EnsembliENST00000374296; ENSP00000363414; ENSG00000182749.
GeneIDi164091.
KEGGihsa:164091.
UCSCiuc001bkx.3. human.

Polymorphism databases

DMDMi51316435.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313620 mRNA. Translation: AAO47233.1 .
AY424285 mRNA. Translation: AAR08373.1 .
AL033528 Genomic DNA. Translation: CAM12867.1 .
CH471059 Genomic DNA. Translation: EAX07862.1 .
BC034015 mRNA. Translation: AAH34015.1 .
BC042298 mRNA. No translation available.
CCDSi CCDS267.1.
RefSeqi NP_848509.1. NM_178422.5.
XP_005245802.1. XM_005245745.1.
XP_005245803.1. XM_005245746.1.
XP_006710459.1. XM_006710396.1.
UniGenei Hs.523652.

3D structure databases

ProteinModelPortali Q86WK9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127887. 2 interactions.
STRINGi 9606.ENSP00000363414.

PTM databases

PhosphoSitei Q86WK9.

Polymorphism databases

DMDMi 51316435.

Proteomic databases

MaxQBi Q86WK9.
PaxDbi Q86WK9.
PRIDEi Q86WK9.

Protocols and materials databases

DNASUi 164091.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374296 ; ENSP00000363414 ; ENSG00000182749 .
GeneIDi 164091.
KEGGi hsa:164091.
UCSCi uc001bkx.3. human.

Organism-specific databases

CTDi 164091.
GeneCardsi GC01M026187.
HGNCi HGNC:23146. PAQR7.
HPAi HPA046936.
MIMi 607779. gene.
neXtProti NX_Q86WK9.
PharmGKBi PA142671200.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1272.
GeneTreei ENSGT00530000062965.
HOGENOMi HOG000230872.
HOVERGENi HBG052504.
InParanoidi Q86WK9.
OMAi RRPIYEP.
OrthoDBi EOG7SN8D2.
PhylomeDBi Q86WK9.
TreeFami TF319738.

Miscellaneous databases

ChiTaRSi PAQR7. human.
GenomeRNAii 164091.
NextBioi 88433.
PROi Q86WK9.
SOURCEi Search...

Gene expression databases

Bgeei Q86WK9.
CleanExi HS_PAQR7.
Genevestigatori Q86WK9.

Family and domain databases

InterProi IPR004254. HlyIII-related.
[Graphical view ]
PANTHERi PTHR20855. PTHR20855. 1 hit.
Pfami PF03006. HlyIII. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor."
    Zhu Y., Bond J., Thomas P.
    Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
    Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
    J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-227.
    Tissue: Duodenum and Uterus.
  6. "The further redefining of steroid-mediated signaling."
    Hammes S.R.
    Proc. Natl. Acad. Sci. U.S.A. 100:2168-2170(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiMPRA_HUMAN
AccessioniPrimary (citable) accession number: Q86WK9
Secondary accession number(s): A2A2D3, Q5XKF9, Q86VE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3