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Q86WK9 (MPRA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Membrane progestin receptor alpha

Short name=mPR alpha
Alternative name(s):
Progestin and adipoQ receptor family member 7
Progestin and adipoQ receptor family member VII
Gene names
Name:PAQR7
Synonyms:MRPA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Steroid membrane receptor. Binds progesterone in vitro. May be involved in oocyte maturation. Ref.1

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Expressed in a wide range of tissues including ovary, testis, placenta, uterus and bladder. Ref.1 Ref.2

Sequence similarities

Belongs to the ADIPOR family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Membrane progestin receptor alpha
PRO_0000218835

Regions

Topological domain1 – 7272Cytoplasmic Potential
Transmembrane73 – 9321Helical; Name=1; Potential
Topological domain94 – 10310Extracellular Potential
Transmembrane104 – 12421Helical; Name=2; Potential
Topological domain125 – 13713Cytoplasmic Potential
Transmembrane138 – 15821Helical; Name=3; Potential
Topological domain159 – 16911Extracellular Potential
Transmembrane170 – 19021Helical; Name=4; Potential
Topological domain191 – 23747Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=5; Potential
Topological domain259 – 27618Extracellular Potential
Transmembrane277 – 29721Helical; Name=6; Potential
Topological domain298 – 31619Cytoplasmic Potential
Transmembrane317 – 33721Helical; Name=7; Potential
Topological domain338 – 3469Extracellular Potential

Natural variations

Natural variant2271V → M. Ref.5
Corresponds to variant rs55948644 [ dbSNP | Ensembl ].
VAR_060999
Natural variant2721G → R.
Corresponds to variant rs6689014 [ dbSNP | Ensembl ].
VAR_048204

Sequences

Sequence LengthMass (Da)Tools
Q86WK9 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 7D12639DD4756501

FASTA34639,719
        10         20         30         40         50         60 
MAMAQKLSHL LPSLRQVIQE PQLSLQPEPV FTVDRAEVPP LFWKPYIYAG YRPLHQTWRF 

        70         80         90        100        110        120 
YFRTLFQQHN EAVNVWTHLL AALVLLLRLA LFVETVDFWG DPHALPLFII VLASFTYLSF 

       130        140        150        160        170        180 
SALAHLLQAK SEFWHYSFFF LDYVGVAVYQ FGSALAHFYY AIEPAWHAQV QAVFLPMAAF 

       190        200        210        220        230        240 
LAWLSCIGSC YNKYIQKPGL LGRTCQEVPS VLAYALDISP VVHRIFVSSD PTTDDPALLY 

       250        260        270        280        290        300 
HKCQVVFFLL AAAFFSTFMP ERWFPGSCHV FGQGHQLFHI FLVLCTLAQL EAVALDYEAR 

       310        320        330        340 
RPIYEPLHTH WPHNFSGLFL LTVGSSILTA FLLSQLVQRK LDQKTK 

« Hide

References

« Hide 'large scale' references
[1]"Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor."
Zhu Y., Bond J., Thomas P.
Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Testis.
[2]"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-227.
Tissue: Duodenum and Uterus.
[6]"The further redefining of steroid-mediated signaling."
Hammes S.R.
Proc. Natl. Acad. Sci. U.S.A. 100:2168-2170(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF313620 mRNA. Translation: AAO47233.1.
AY424285 mRNA. Translation: AAR08373.1.
AL033528 Genomic DNA. Translation: CAM12867.1.
CH471059 Genomic DNA. Translation: EAX07862.1.
BC034015 mRNA. Translation: AAH34015.1.
BC042298 mRNA. No translation available.
CCDSCCDS267.1.
RefSeqNP_848509.1. NM_178422.5.
XP_005245802.1. XM_005245745.1.
XP_005245803.1. XM_005245746.1.
XP_006710459.1. XM_006710396.1.
UniGeneHs.523652.

3D structure databases

ProteinModelPortalQ86WK9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127887. 2 interactions.
STRING9606.ENSP00000363414.

PTM databases

PhosphoSiteQ86WK9.

Polymorphism databases

DMDM51316435.

Proteomic databases

MaxQBQ86WK9.
PaxDbQ86WK9.
PRIDEQ86WK9.

Protocols and materials databases

DNASU164091.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000374296; ENSP00000363414; ENSG00000182749.
GeneID164091.
KEGGhsa:164091.
UCSCuc001bkx.3. human.

Organism-specific databases

CTD164091.
GeneCardsGC01M026187.
HGNCHGNC:23146. PAQR7.
HPAHPA046936.
MIM607779. gene.
neXtProtNX_Q86WK9.
PharmGKBPA142671200.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1272.
HOGENOMHOG000230872.
HOVERGENHBG052504.
InParanoidQ86WK9.
OMARRPIYEP.
OrthoDBEOG7SN8D2.
PhylomeDBQ86WK9.
TreeFamTF319738.

Gene expression databases

BgeeQ86WK9.
CleanExHS_PAQR7.
GenevestigatorQ86WK9.

Family and domain databases

InterProIPR004254. HlyIII-related.
[Graphical view]
PANTHERPTHR20855. PTHR20855. 1 hit.
PfamPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi164091.
NextBio88433.
PROQ86WK9.
SOURCESearch...

Entry information

Entry nameMPRA_HUMAN
AccessionPrimary (citable) accession number: Q86WK9
Secondary accession number(s): A2A2D3, Q5XKF9, Q86VE4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM