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Q86WK9

- MPRA_HUMAN

UniProt

Q86WK9 - MPRA_HUMAN

Protein

Membrane progestin receptor alpha

Gene

PAQR7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Steroid membrane receptor. Binds progesterone in vitro. May be involved in oocyte maturation.1 Publication

    GO - Molecular functioni

    1. steroid binding Source: RefGenome
    2. steroid hormone receptor activity Source: RefGenome

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. oogenesis Source: UniProtKB-KW
    3. response to steroid hormone Source: RefGenome
    4. steroid hormone mediated signaling pathway Source: GOC

    Keywords - Molecular functioni

    Developmental protein, Receptor

    Keywords - Biological processi

    Differentiation, Oogenesis

    Keywords - Ligandi

    Lipid-binding, Steroid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Membrane progestin receptor alpha
    Short name:
    mPR alpha
    Alternative name(s):
    Progestin and adipoQ receptor family member 7
    Progestin and adipoQ receptor family member VII
    Gene namesi
    Name:PAQR7
    Synonyms:MRPA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:23146. PAQR7.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671200.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Membrane progestin receptor alphaPRO_0000218835Add
    BLAST

    Proteomic databases

    MaxQBiQ86WK9.
    PaxDbiQ86WK9.
    PRIDEiQ86WK9.

    PTM databases

    PhosphoSiteiQ86WK9.

    Expressioni

    Tissue specificityi

    Expressed in a wide range of tissues including ovary, testis, placenta, uterus and bladder.2 Publications

    Gene expression databases

    BgeeiQ86WK9.
    CleanExiHS_PAQR7.
    GenevestigatoriQ86WK9.

    Organism-specific databases

    HPAiHPA046936.

    Interactioni

    Protein-protein interaction databases

    BioGridi127887. 2 interactions.
    STRINGi9606.ENSP00000363414.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86WK9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7272CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini94 – 10310ExtracellularSequence Analysis
    Topological domaini125 – 13713CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 16911ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini191 – 23747CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27618ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini298 – 31619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini338 – 3469ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei73 – 9321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei170 – 19021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei317 – 33721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ADIPOR family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1272.
    HOGENOMiHOG000230872.
    HOVERGENiHBG052504.
    InParanoidiQ86WK9.
    OMAiRRPIYEP.
    OrthoDBiEOG7SN8D2.
    PhylomeDBiQ86WK9.
    TreeFamiTF319738.

    Family and domain databases

    InterProiIPR004254. HlyIII-related.
    [Graphical view]
    PANTHERiPTHR20855. PTHR20855. 1 hit.
    PfamiPF03006. HlyIII. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q86WK9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMAQKLSHL LPSLRQVIQE PQLSLQPEPV FTVDRAEVPP LFWKPYIYAG    50
    YRPLHQTWRF YFRTLFQQHN EAVNVWTHLL AALVLLLRLA LFVETVDFWG 100
    DPHALPLFII VLASFTYLSF SALAHLLQAK SEFWHYSFFF LDYVGVAVYQ 150
    FGSALAHFYY AIEPAWHAQV QAVFLPMAAF LAWLSCIGSC YNKYIQKPGL 200
    LGRTCQEVPS VLAYALDISP VVHRIFVSSD PTTDDPALLY HKCQVVFFLL 250
    AAAFFSTFMP ERWFPGSCHV FGQGHQLFHI FLVLCTLAQL EAVALDYEAR 300
    RPIYEPLHTH WPHNFSGLFL LTVGSSILTA FLLSQLVQRK LDQKTK 346
    Length:346
    Mass (Da):39,719
    Last modified:June 1, 2003 - v1
    Checksum:i7D12639DD4756501
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti227 – 2271V → M.1 Publication
    Corresponds to variant rs55948644 [ dbSNP | Ensembl ].
    VAR_060999
    Natural varianti272 – 2721G → R.
    Corresponds to variant rs6689014 [ dbSNP | Ensembl ].
    VAR_048204

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF313620 mRNA. Translation: AAO47233.1.
    AY424285 mRNA. Translation: AAR08373.1.
    AL033528 Genomic DNA. Translation: CAM12867.1.
    CH471059 Genomic DNA. Translation: EAX07862.1.
    BC034015 mRNA. Translation: AAH34015.1.
    BC042298 mRNA. No translation available.
    CCDSiCCDS267.1.
    RefSeqiNP_848509.1. NM_178422.5.
    XP_005245802.1. XM_005245745.1.
    XP_005245803.1. XM_005245746.1.
    XP_006710459.1. XM_006710396.1.
    UniGeneiHs.523652.

    Genome annotation databases

    EnsembliENST00000374296; ENSP00000363414; ENSG00000182749.
    GeneIDi164091.
    KEGGihsa:164091.
    UCSCiuc001bkx.3. human.

    Polymorphism databases

    DMDMi51316435.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF313620 mRNA. Translation: AAO47233.1 .
    AY424285 mRNA. Translation: AAR08373.1 .
    AL033528 Genomic DNA. Translation: CAM12867.1 .
    CH471059 Genomic DNA. Translation: EAX07862.1 .
    BC034015 mRNA. Translation: AAH34015.1 .
    BC042298 mRNA. No translation available.
    CCDSi CCDS267.1.
    RefSeqi NP_848509.1. NM_178422.5.
    XP_005245802.1. XM_005245745.1.
    XP_005245803.1. XM_005245746.1.
    XP_006710459.1. XM_006710396.1.
    UniGenei Hs.523652.

    3D structure databases

    ProteinModelPortali Q86WK9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127887. 2 interactions.
    STRINGi 9606.ENSP00000363414.

    PTM databases

    PhosphoSitei Q86WK9.

    Polymorphism databases

    DMDMi 51316435.

    Proteomic databases

    MaxQBi Q86WK9.
    PaxDbi Q86WK9.
    PRIDEi Q86WK9.

    Protocols and materials databases

    DNASUi 164091.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374296 ; ENSP00000363414 ; ENSG00000182749 .
    GeneIDi 164091.
    KEGGi hsa:164091.
    UCSCi uc001bkx.3. human.

    Organism-specific databases

    CTDi 164091.
    GeneCardsi GC01M026187.
    HGNCi HGNC:23146. PAQR7.
    HPAi HPA046936.
    MIMi 607779. gene.
    neXtProti NX_Q86WK9.
    PharmGKBi PA142671200.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1272.
    HOGENOMi HOG000230872.
    HOVERGENi HBG052504.
    InParanoidi Q86WK9.
    OMAi RRPIYEP.
    OrthoDBi EOG7SN8D2.
    PhylomeDBi Q86WK9.
    TreeFami TF319738.

    Miscellaneous databases

    GenomeRNAii 164091.
    NextBioi 88433.
    PROi Q86WK9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q86WK9.
    CleanExi HS_PAQR7.
    Genevestigatori Q86WK9.

    Family and domain databases

    InterProi IPR004254. HlyIII-related.
    [Graphical view ]
    PANTHERi PTHR20855. PTHR20855. 1 hit.
    Pfami PF03006. HlyIII. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor."
      Zhu Y., Bond J., Thomas P.
      Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Testis.
    2. "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
      Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
      J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-227.
      Tissue: Duodenum and Uterus.
    6. "The further redefining of steroid-mediated signaling."
      Hammes S.R.
      Proc. Natl. Acad. Sci. U.S.A. 100:2168-2170(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiMPRA_HUMAN
    AccessioniPrimary (citable) accession number: Q86WK9
    Secondary accession number(s): A2A2D3, Q5XKF9, Q86VE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3