Q86WK9 (MPRA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Membrane progestin receptor alpha
Short name=mPR alpha

Alternative name(s):
Progestin and adipoQ receptor family member 7
Progestin and adipoQ receptor family member VII

Gene names

Name:	PAQR7
Synonyms:	MRPA

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Steroid membrane receptor. Binds progesterone in vitro. May be involved in oocyte maturation. Ref.1
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Expressed in a wide range of tissues including ovary, testis, placenta, uterus and bladder. Ref.1 Ref.2
Sequence similarities	Belongs to the ADIPOR family.

Ontologies

Keywords
Biological process	Differentiation Oogenesis
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Lipid-binding Steroid-binding
Molecular function	Developmental protein Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW oogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	steroid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Membrane progestin receptor alpha		PRO_0000218835
Regions
	Topological domain	1 – 72	72	Cytoplasmic Potential
	Transmembrane	73 – 93	21	Helical; Name=1; Potential
	Topological domain	94 – 103	10	Extracellular Potential
	Transmembrane	104 – 124	21	Helical; Name=2; Potential
	Topological domain	125 – 137	13	Cytoplasmic Potential
	Transmembrane	138 – 158	21	Helical; Name=3; Potential
	Topological domain	159 – 169	11	Extracellular Potential
	Transmembrane	170 – 190	21	Helical; Name=4; Potential
	Topological domain	191 – 237	47	Cytoplasmic Potential
	Transmembrane	238 – 258	21	Helical; Name=5; Potential
	Topological domain	259 – 276	18	Extracellular Potential
	Transmembrane	277 – 297	21	Helical; Name=6; Potential
	Topological domain	298 – 316	19	Cytoplasmic Potential
	Transmembrane	317 – 337	21	Helical; Name=7; Potential
	Topological domain	338 – 346	9	Extracellular Potential
Natural variations
	Natural variant	227	1	V → M. Ref.5 Corresponds to variant rs55948644 [ dbSNP | Ensembl ].		VAR_060999
	Natural variant	272	1	G → R. Corresponds to variant rs6689014 [ dbSNP | Ensembl ].		VAR_048204

Sequences

	Sequence		Length	Mass (Da)
	Q86WK9 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 7D12639DD4756501	FASTA	346	39,719
	10 20 30 40 50 60 MAMAQKLSHL LPSLRQVIQE PQLSLQPEPV FTVDRAEVPP LFWKPYIYAG YRPLHQTWRF 70 80 90 100 110 120 YFRTLFQQHN EAVNVWTHLL AALVLLLRLA LFVETVDFWG DPHALPLFII VLASFTYLSF 130 140 150 160 170 180 SALAHLLQAK SEFWHYSFFF LDYVGVAVYQ FGSALAHFYY AIEPAWHAQV QAVFLPMAAF 190 200 210 220 230 240 LAWLSCIGSC YNKYIQKPGL LGRTCQEVPS VLAYALDISP VVHRIFVSSD PTTDDPALLY 250 260 270 280 290 300 HKCQVVFFLL AAAFFSTFMP ERWFPGSCHV FGQGHQLFHI FLVLCTLAQL EAVALDYEAR 310 320 330 340 RPIYEPLHTH WPHNFSGLFL LTVGSSILTA FLLSQLVQRK LDQKTK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor." Zhu Y., Bond J., Thomas P. Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Tissue: Testis.
[2]	"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif." Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D. J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-227. Tissue: Duodenum and Uterus.
[6]	"The further redefining of steroid-mediated signaling." Hammes S.R. Proc. Natl. Acad. Sci. U.S.A. 100:2168-2170(2003) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF313620 mRNA. Translation: AAO47233.1. AY424285 mRNA. Translation: AAR08373.1. AL033528 Genomic DNA. Translation: CAM12867.1. CH471059 Genomic DNA. Translation: EAX07862.1. BC034015 mRNA. Translation: AAH34015.1. BC042298 mRNA. No translation available.
IPI	IPI00328879.
RefSeq	NP_848509.1. NM_178422.5.
UniGene	Hs.523652.
3D structure databases
ProteinModelPortal	Q86WK9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000363414.
PTM databases
PhosphoSite	Q86WK9.
Polymorphism databases
DMDM	51316435.
Proteomic databases
PaxDb	Q86WK9.
PRIDE	Q86WK9.
Protocols and materials databases
DNASU	164091.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000374296; ENSP00000363414; ENSG00000182749.
GeneID	164091.
KEGG	hsa:164091.
UCSC	uc001bkx.3. human.
Organism-specific databases
CTD	164091.
GeneCards	GC01M026187.
HGNC	HGNC:23146. PAQR7.
HPA	HPA046936.
MIM	607779. gene.
neXtProt	NX_Q86WK9.
PharmGKB	PA142671200.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1272.
HOGENOM	HOG000230872.
HOVERGEN	HBG052504.
InParanoid	Q86WK9.
OMA	RRPIYEP.
OrthoDB	EOG4BVRV0.
PhylomeDB	Q86WK9.
Gene expression databases
Bgee	Q86WK9.
CleanEx	HS_PAQR7.
Genevestigator	Q86WK9.
GermOnline	ENSG00000182749. Homo sapiens.
Family and domain databases
InterPro	IPR004254. HlyIII-related. [Graphical view]
PANTHER	PTHR20855. PTHR20855. 1 hit.
Pfam	PF03006. HlyIII. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	164091.
NextBio	88433.
SOURCE	Search...

Entry information

Entry name

MPRA_HUMAN

Accession

Primary (citable) accession number: Q86WK9
Secondary accession number(s): A2A2D3, Q5XKF9, Q86VE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	June 1, 2003
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.