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Protein

Amphoterin-induced protein 3

Gene

AMIGO3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Amphoterin-induced protein 3
Alternative name(s):
AMIGO-3
Alivin-3
Gene namesi
Name:AMIGO3Imported
Synonyms:ALI3By similarity, KIAA1851Imported
ORF Names:UNQ6084/PRO20089
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000176020.8
HGNCiHGNC:24075 AMIGO3
MIMi615691 gene
neXtProtiNX_Q86WK7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 383ExtracellularSequence analysisAdd BLAST364
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Topological domaini405 – 504CytoplasmicSequence analysisAdd BLAST100

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi386724
PharmGKBiPA142672627

Polymorphism and mutation databases

BioMutaiAMIGO3
DMDMi68052343

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001451320 – 504Amphoterin-induced protein 3Sequence analysisAdd BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 40PROSITE-ProRule annotation
Disulfide bondi38 ↔ 47PROSITE-ProRule annotation
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi223 ↔ 251PROSITE-ProRule annotation
Disulfide bondi225 ↔ 273PROSITE-ProRule annotation
Glycosylationi272N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi300 ↔ 352PROSITE-ProRule annotation
Glycosylationi301N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ86WK7
PRIDEiQ86WK7

PTM databases

iPTMnetiQ86WK7
PhosphoSitePlusiQ86WK7

Expressioni

Gene expression databases

BgeeiENSG00000176020
CleanExiHS_AMIGO3
GenevisibleiQ86WK7 HS

Organism-specific databases

HPAiHPA026673

Interactioni

Subunit structurei

Binds AMIGO1 or AMIGO2.By similarity

Protein-protein interaction databases

BioGridi132150, 15 interactors
STRINGi9606.ENSP00000323096

Structurei

3D structure databases

ProteinModelPortaliQ86WK7
SMRiQ86WK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 61LRRNTAdd BLAST37
Repeati62 – 83LRR 1Add BLAST22
Repeati86 – 107LRR 2Add BLAST22
Repeati110 – 133LRR 3Add BLAST24
Repeati134 – 155LRR 4Add BLAST22
Repeati158 – 178LRR 5Add BLAST21
Repeati184 – 207LRR 6Add BLAST24
Domaini219 – 275LRRCTAdd BLAST57
Domaini277 – 370Ig-like C2-typeSequence analysisAdd BLAST94

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGMJ Eukaryota
ENOG410YSS0 LUCA
GeneTreeiENSGT00530000063545
HOGENOMiHOG000231327
HOVERGENiHBG080231
InParanoidiQ86WK7
KOiK22529
OMAiLYLGCNE
OrthoDBiEOG091G09BC
PhylomeDBiQ86WK7
TreeFamiTF326838

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR031283 AMIGO
IPR031285 AMIGO3
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PANTHERiPTHR24368 PTHR24368, 1 hit
PTHR24368:SF62 PTHR24368:SF62, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 6 hits
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86WK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWLVLLGTL LCMLRVGLGT PDSEGFPPRA LHNCPYKCIC AADLLSCTGL
60 70 80 90 100
GLQDVPAELP AATADLDLSH NALQRLRPGW LAPLFQLRAL HLDHNELDAL
110 120 130 140 150
GRGVFVNASG LRLLDLSSNT LRALGRHDLD GLGALEKLLL FNNRLVHLDE
160 170 180 190 200
HAFHGLRALS HLYLGCNELA SFSFDHLHGL SATHLLTLDL SSNRLGHISV
210 220 230 240 250
PELAALPAFL KNGLYLHNNP LPCDCRLYHL LQRWHQRGLS AVRDFAREYV
260 270 280 290 300
CLAFKVPASR VRFFQHSRVF ENCSSAPALG LERPEEHLYA LVGRSLRLYC
310 320 330 340 350
NTSVPAMRIA WVSPQQELLR APGSRDGSIA VLADGSLAIG NVQEQHAGLF
360 370 380 390 400
VCLATGPRLH HNQTHEYNVS VHFPRPEPEA FNTGFTTLLG CAVGLVLVLL
410 420 430 440 450
YLFAPPCRCC RRACRCRRWP QTPSPLQELS AQSSVLSTTP PDAPSRKASV
460 470 480 490 500
HKHVVFLEPG RRGLNGRVQL AVAEEFDLYN PGGLQLKAGS ESASSIGSEG

PMTT
Length:504
Mass (Da):55,250
Last modified:June 1, 2003 - v1
Checksum:i92044CA180BD34FA
GO

Sequence cautioni

The sequence BAB47480 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237003 mRNA Translation: AAO48944.1
AB058754 mRNA Translation: BAB47480.1 Different initiation.
AY358134 mRNA Translation: AAQ88501.1
BC101363 mRNA Translation: AAI01364.1
BC101364 mRNA Translation: AAI01365.1
CCDSiCCDS33759.1
RefSeqiNP_942015.1, NM_198722.2
UniGeneiHs.567903

Genome annotation databases

EnsembliENST00000320431; ENSP00000323096; ENSG00000176020
GeneIDi386724
KEGGihsa:386724
UCSCiuc003cxj.4 human

Similar proteinsi

Entry informationi

Entry nameiAMGO3_HUMAN
AccessioniPrimary (citable) accession number: Q86WK7
Secondary accession number(s): Q494V6, Q96JH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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