Q86WK7 (AMGO3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Amphoterin-induced protein 3

Alternative name(s):
AMIGO-3
Alivin-3

Gene names

Name:	AMIGO3
Synonyms:	ALI3, KIAA1851
ORF Names:	UNQ6084/PRO20089

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain By similarity. UniProtKB Q80ZD5
Subunit structure	Binds AMIGO1 or AMIGO2 By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the immunoglobulin superfamily. AMIGO family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 6 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain.
Sequence caution	The sequence BAB47480.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Domain	Immunoglobulin domain Leucine-rich repeat Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	heterophilic cell-cell adhesion Inferred from sequence or structural similarity Ref.1. Source: UniProtKB
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 504	485	Amphoterin-induced protein 3		PRO_0000014513
Regions
	Topological domain	20 – 383	364	Extracellular Potential
	Transmembrane	384 – 404	21	Helical; Potential
	Topological domain	405 – 504	100	Cytoplasmic Potential
	Domain	25 – 61	37	LRRNT
	Repeat	62 – 83	22	LRR 1
	Repeat	86 – 107	22	LRR 2
	Repeat	110 – 133	24	LRR 3
	Repeat	134 – 155	22	LRR 4
	Repeat	158 – 178	21	LRR 5
	Repeat	184 – 207	24	LRR 6
	Domain	219 – 275	57	LRRCT
	Domain	277 – 370	94	Ig-like C2-type
Amino acid modifications
	Glycosylation	107	1	N-linked (GlcNAc...) Potential
	Glycosylation	272	1	N-linked (GlcNAc...) Potential
	Glycosylation	301	1	N-linked (GlcNAc...) Potential
	Glycosylation	362	1	N-linked (GlcNAc...) Potential
	Glycosylation	368	1	N-linked (GlcNAc...) Potential
	Disulfide bond	300 ↔ 352		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q86WK7 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 92044CA180BD34FA	FASTA	504	55,250
	10 20 30 40 50 60 MTWLVLLGTL LCMLRVGLGT PDSEGFPPRA LHNCPYKCIC AADLLSCTGL GLQDVPAELP 70 80 90 100 110 120 AATADLDLSH NALQRLRPGW LAPLFQLRAL HLDHNELDAL GRGVFVNASG LRLLDLSSNT 130 140 150 160 170 180 LRALGRHDLD GLGALEKLLL FNNRLVHLDE HAFHGLRALS HLYLGCNELA SFSFDHLHGL 190 200 210 220 230 240 SATHLLTLDL SSNRLGHISV PELAALPAFL KNGLYLHNNP LPCDCRLYHL LQRWHQRGLS 250 260 270 280 290 300 AVRDFAREYV CLAFKVPASR VRFFQHSRVF ENCSSAPALG LERPEEHLYA LVGRSLRLYC 310 320 330 340 350 360 NTSVPAMRIA WVSPQQELLR APGSRDGSIA VLADGSLAIG NVQEQHAGLF VCLATGPRLH 370 380 390 400 410 420 HNQTHEYNVS VHFPRPEPEA FNTGFTTLLG CAVGLVLVLL YLFAPPCRCC RRACRCRRWP 430 440 450 460 470 480 QTPSPLQELS AQSSVLSTTP PDAPSRKASV HKHVVFLEPG RRGLNGRVQL AVAEEFDLYN 490 500 PGGLQLKAGS ESASSIGSEG PMTT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats." Kuja-Panula J., Kiiltomaeki M., Yamashiro T., Rouhiainen A., Rauvala H. J. Cell Biol. 160:963-973(2003) [PubMed: 12629050] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryonic kidney.
[2]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed: 11347906] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY237003 mRNA. Translation: AAO48944.1. AB058754 mRNA. Translation: BAB47480.1. Different initiation. AY358134 mRNA. Translation: AAQ88501.1. BC101363 mRNA. Translation: AAI01364.1. BC101364 mRNA. Translation: AAI01365.1.
IPI	IPI00552093.
RefSeq	NP_942015.1. NM_198722.2.
UniGene	Hs.567903.
3D structure databases
ProteinModelPortal	Q86WK7.
SMR	Q86WK7. Positions 7-274, 281-369.
ModBase	Search...
Protein-protein interaction databases
STRING	Q86WK7.
Polymorphism databases
DMDM	68052343.
Proteomic databases
PRIDE	Q86WK7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000320431; ENSP00000323096; ENSG00000176020.
GeneID	386724.
KEGG	hsa:386724.
UCSC	uc003cxj.1. human.
Organism-specific databases
CTD	386724.
GeneCards	GC03M049729.
H-InvDB	HIX0077816. HIX0077905.
HGNC	HGNC:24075. AMIGO3.
HPA	HPA026673.
neXtProt	NX_Q86WK7.
PharmGKB	PA142672627.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00530000063545.
HOGENOM	HBG716121.
HOVERGEN	HBG080231.
InParanoid	Q86WK7.
OMA	SHNALQR.
OrthoDB	EOG4DBTDR.
PhylomeDB	Q86WK7.
Gene expression databases
ArrayExpress	Q86WK7.
CleanEx	HS_AMIGO3.
Genevestigator	Q86WK7.
GermOnline	ENSG00000176020. Homo sapiens.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR001611. Leu-rich_rpt. IPR000372. LRR-contain_N. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
SMART	SM00409. IG. 1 hit. SM00013. LRRNT. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. PS51450. LRR. 5 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	101050.

Entry information

Entry name

AMGO3_HUMAN

Accession

Primary (citable) accession number: Q86WK7
Secondary accession number(s): Q494V6, Q96JH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.