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Protein

Amphoterin-induced protein 3

Gene

AMIGO3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Amphoterin-induced protein 3
Alternative name(s):
AMIGO-3
Alivin-3
Gene namesi
Name:AMIGO3Imported
Synonyms:ALI3By similarity, KIAA1851Imported
ORF Names:UNQ6084/PRO20089
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24075. AMIGO3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 383364ExtracellularSequence analysisAdd
BLAST
Transmembranei384 – 40421HelicalSequence analysisAdd
BLAST
Topological domaini405 – 504100CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672627.

Polymorphism and mutation databases

BioMutaiAMIGO3.
DMDMi68052343.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 504485Amphoterin-induced protein 3Sequence analysisPRO_0000014513Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 40PROSITE-ProRule annotation
Disulfide bondi38 ↔ 47PROSITE-ProRule annotation
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence analysis
Disulfide bondi223 ↔ 251PROSITE-ProRule annotation
Disulfide bondi225 ↔ 273PROSITE-ProRule annotation
Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence analysis
Disulfide bondi300 ↔ 352PROSITE-ProRule annotation
Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence analysis
Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence analysis
Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ86WK7.
PRIDEiQ86WK7.

PTM databases

iPTMnetiQ86WK7.
PhosphoSiteiQ86WK7.

Expressioni

Gene expression databases

CleanExiHS_AMIGO3.
GenevisibleiQ86WK7. HS.

Organism-specific databases

HPAiHPA026673.

Interactioni

Subunit structurei

Binds AMIGO1 or AMIGO2.By similarity

Protein-protein interaction databases

BioGridi132150. 15 interactions.
STRINGi9606.ENSP00000323096.

Structurei

3D structure databases

ProteinModelPortaliQ86WK7.
SMRiQ86WK7. Positions 32-369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 6137LRRNTAdd
BLAST
Repeati62 – 8322LRR 1Add
BLAST
Repeati86 – 10722LRR 2Add
BLAST
Repeati110 – 13324LRR 3Add
BLAST
Repeati134 – 15522LRR 4Add
BLAST
Repeati158 – 17821LRR 5Add
BLAST
Repeati184 – 20724LRR 6Add
BLAST
Domaini219 – 27557LRRCTAdd
BLAST
Domaini277 – 37094Ig-like C2-typeSequence analysisAdd
BLAST

Sequence similaritiesi

Contains 6 LRR (leucine-rich) repeats.Sequence analysis
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGMJ. Eukaryota.
ENOG410YSS0. LUCA.
GeneTreeiENSGT00530000063545.
HOGENOMiHOG000231327.
HOVERGENiHBG080231.
InParanoidiQ86WK7.
OMAiVCLATGP.
OrthoDBiEOG7C8GHP.
PhylomeDBiQ86WK7.
TreeFamiTF326838.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR031283. AMIGO.
IPR031285. AMIGO3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PANTHERiPTHR24368. PTHR24368. 1 hit.
PTHR24368:SF62. PTHR24368:SF62. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86WK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWLVLLGTL LCMLRVGLGT PDSEGFPPRA LHNCPYKCIC AADLLSCTGL
60 70 80 90 100
GLQDVPAELP AATADLDLSH NALQRLRPGW LAPLFQLRAL HLDHNELDAL
110 120 130 140 150
GRGVFVNASG LRLLDLSSNT LRALGRHDLD GLGALEKLLL FNNRLVHLDE
160 170 180 190 200
HAFHGLRALS HLYLGCNELA SFSFDHLHGL SATHLLTLDL SSNRLGHISV
210 220 230 240 250
PELAALPAFL KNGLYLHNNP LPCDCRLYHL LQRWHQRGLS AVRDFAREYV
260 270 280 290 300
CLAFKVPASR VRFFQHSRVF ENCSSAPALG LERPEEHLYA LVGRSLRLYC
310 320 330 340 350
NTSVPAMRIA WVSPQQELLR APGSRDGSIA VLADGSLAIG NVQEQHAGLF
360 370 380 390 400
VCLATGPRLH HNQTHEYNVS VHFPRPEPEA FNTGFTTLLG CAVGLVLVLL
410 420 430 440 450
YLFAPPCRCC RRACRCRRWP QTPSPLQELS AQSSVLSTTP PDAPSRKASV
460 470 480 490 500
HKHVVFLEPG RRGLNGRVQL AVAEEFDLYN PGGLQLKAGS ESASSIGSEG

PMTT
Length:504
Mass (Da):55,250
Last modified:June 1, 2003 - v1
Checksum:i92044CA180BD34FA
GO

Sequence cautioni

The sequence BAB47480.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237003 mRNA. Translation: AAO48944.1.
AB058754 mRNA. Translation: BAB47480.1. Different initiation.
AY358134 mRNA. Translation: AAQ88501.1.
BC101363 mRNA. Translation: AAI01364.1.
BC101364 mRNA. Translation: AAI01365.1.
CCDSiCCDS33759.1.
RefSeqiNP_942015.1. NM_198722.2.
UniGeneiHs.567903.

Genome annotation databases

EnsembliENST00000320431; ENSP00000323096; ENSG00000176020.
GeneIDi386724.
KEGGihsa:386724.
UCSCiuc003cxj.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237003 mRNA. Translation: AAO48944.1.
AB058754 mRNA. Translation: BAB47480.1. Different initiation.
AY358134 mRNA. Translation: AAQ88501.1.
BC101363 mRNA. Translation: AAI01364.1.
BC101364 mRNA. Translation: AAI01365.1.
CCDSiCCDS33759.1.
RefSeqiNP_942015.1. NM_198722.2.
UniGeneiHs.567903.

3D structure databases

ProteinModelPortaliQ86WK7.
SMRiQ86WK7. Positions 32-369.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132150. 15 interactions.
STRINGi9606.ENSP00000323096.

PTM databases

iPTMnetiQ86WK7.
PhosphoSiteiQ86WK7.

Polymorphism and mutation databases

BioMutaiAMIGO3.
DMDMi68052343.

Proteomic databases

PaxDbiQ86WK7.
PRIDEiQ86WK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320431; ENSP00000323096; ENSG00000176020.
GeneIDi386724.
KEGGihsa:386724.
UCSCiuc003cxj.4. human.

Organism-specific databases

CTDi386724.
GeneCardsiAMIGO3.
HGNCiHGNC:24075. AMIGO3.
HPAiHPA026673.
MIMi615691. gene.
neXtProtiNX_Q86WK7.
PharmGKBiPA142672627.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGMJ. Eukaryota.
ENOG410YSS0. LUCA.
GeneTreeiENSGT00530000063545.
HOGENOMiHOG000231327.
HOVERGENiHBG080231.
InParanoidiQ86WK7.
OMAiVCLATGP.
OrthoDBiEOG7C8GHP.
PhylomeDBiQ86WK7.
TreeFamiTF326838.

Miscellaneous databases

GenomeRNAii386724.
NextBioi101050.
PROiQ86WK7.
SOURCEiSearch...

Gene expression databases

CleanExiHS_AMIGO3.
GenevisibleiQ86WK7. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR031283. AMIGO.
IPR031285. AMIGO3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PANTHERiPTHR24368. PTHR24368. 1 hit.
PTHR24368:SF62. PTHR24368:SF62. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats."
    Kuja-Panula J., Kiiltomaeki M., Yamashiro T., Rouhiainen A., Rauvala H.
    J. Cell Biol. 160:963-973(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryonic kidney1 Publication.
  2. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiAMGO3_HUMAN
AccessioniPrimary (citable) accession number: Q86WK7
Secondary accession number(s): Q494V6, Q96JH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.