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Protein
Submitted name:

Hyperpolarization activated cyclic nucleotide-gated potassium channel

Gene

HCN1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation, Voltage-gated channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Submitted name:
Hyperpolarization activated cyclic nucleotide-gated potassium channelImported
Gene namesi
Name:HCN1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei143 – 167HelicalSequence analysisAdd BLAST25
Transmembranei372 – 397HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA77

PTM / Processingi

Proteomic databases

PeptideAtlasiQ86WJ6
PRIDEiQ86WJ6

Expressioni

Gene expression databases

GenevisibleiQ86WJ6 HS

Structurei

3D structure databases

ProteinModelPortaliQ86WJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini475 – 572Cyclic nucleotide-bindingInterPro annotationAdd BLAST98

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0498 Eukaryota
ENOG410XPSE LUCA
HOVERGENiHBG039489
KOiK04954

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di1.20.120.350, 1 hit
2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR018488 cNMP-bd_CS
IPR000595 cNMP-bd_dom
IPR005821 Ion_trans_dom
IPR013621 Ion_trans_N
IPR030169 K/Na_HCN1
IPR003938 K_chnl_volt-dep_EAG/ELK/ERG
IPR014710 RmlC-like_jellyroll
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10217:SF373 PTHR10217:SF373, 1 hit
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00520 Ion_trans, 1 hit
PF08412 Ion_trans_N, 1 hit
PRINTSiPR01463 EAGCHANLFMLY
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS00888 CNMP_BINDING_1, 1 hit
PS50042 CNMP_BINDING_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q86WJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGGGKPNSS SNSRDDGNSV FPAKASATGA GPAAAEKRLG TPPGGGGAGA
60 70 80 90 100
KEHGNSVCFK VDGGGGGGGG GGGGEEPAGG FEDAEGPRRQ YGFMQRQFTS
110 120 130 140 150
MLQPGVNKFS LRMFGSQKAV EKEQERVKTA GFWIIHPYSD FRFYWDLIML
160 170 180 190 200
IMMVGNLVII PVGITFFTEQ TTTPWIIFNV ASDTVFLLDL IMNFRTGTVN
210 220 230 240 250
EDSSEIILDP KVIKMNYLKS WSVVDFISSI PVDYIFLIVE KGMDSEVYKT
260 270 280 290 300
ARALRIVRFT KILSLLRLLR LSRLIRYIHQ WEEIFHMTYD LASAVVRIFN
310 320 330 340 350
LIGMMLLLCH WDGCLQFLVP LLQDFPPDCW VSLNEMVNDS WGKQYSYALF
360 370 380 390 400
KAMSHMLCIG YGAQAPVSMS DLWITMLSMI VGATCYAMFV GHATALIQSL
410 420 430 440 450
DSSRRQYQEK YKQVEQYMSF HKLPADMRQK IHDYYEHRYQ GKIFDEENIL
460 470 480 490 500
NELNDPLRGE IVNFNCRKLV ATMPLFANAD PNFVTAMLSK LRFEVFQPGD
510 520 530 540 550
YIVREGAVGK KMYFIQHGVA GVITKSSKEM KLTDGSYFGE ICLLTKGRRT
560 570 580 590 600
ASVRADTYCR LYSLSVDNFN EVPEEYPMMR RAFETVAIDR LDRIGKKNSI
610 620 630 640 650
LLQKFQKDLN TGVFNNQENE ILKQIVKHDR EMVQAIAPIN YPQMTTLNSA
660 670 680 690 700
SSTTTPTSRM RTQSPPVYTA TSLSHSNLHS PSPSTQTPQP SAILSPCSYT
710 720 730 740 750
TAVCSPPVQS PLAARTFHYA SPTASQLSLM QQQPQQQVQQ SQPPQTQPQQ
760 770 780 790 800
PSPQPQTPGS STPKNEVHKS TQALHNTNLT REVRPLSASQ PSLPHEVPTL
810 820 830 840 850
ISRPHPTVGE SLASIPQPVT AVPGTGLQAG GRSTVPQRVT LFRQMSSGAI
860 870 880 890
PPNRGVPPAP PPPAAALPRE SSSVLNTDPD AEKPRFASNL
Length:890
Mass (Da):98,614
Last modified:June 1, 2003 - v1
Checksum:i49517252B5E4D03C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF488549 mRNA Translation: AAO49469.1
RefSeqiNP_066550.2, NM_021072.3
UniGeneiHs.353176

Genome annotation databases

GeneIDi348980
KEGGihsa:348980

Similar proteinsi

Entry informationi

Entry nameiQ86WJ6_HUMAN
AccessioniPrimary (citable) accession number: Q86WJ6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health