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Protein
Submitted name:

Mutant receptor type protein tyrosine phosphatase K

Gene

PTPRK

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseSAAS annotation, ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Mutant receptor type protein tyrosine phosphatase KImported (EC:3.1.3.48Imported)
Gene namesi
Name:PTPRKImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei754 – 775HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34019.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_500430413728 – 1440Sequence analysisAdd BLAST1413

Proteomic databases

PaxDbiQ86WJ2.
PRIDEiQ86WJ2.

Expressioni

Gene expression databases

GenevisibleiQ86WJ2. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357196.

Structurei

3D structure databases

ProteinModelPortaliQ86WJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 194MAMInterPro annotationAdd BLAST161
Domaini196 – 281Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST86
Domaini294 – 389Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini392 – 488Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini491 – 595Fibronectin type-IIIInterPro annotationAdd BLAST105
Domaini888 – 1142Tyrosine-protein phosphataseInterPro annotationAdd BLAST255
Domaini1062 – 1133TYR_PHOSPHATASE_2InterPro annotationAdd BLAST72
Domaini1174 – 1436Tyrosine-protein phosphataseInterPro annotationAdd BLAST263
Domaini1350 – 1427TYR_PHOSPHATASE_2InterPro annotationAdd BLAST78

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
HOVERGENiHBG062785.

Family and domain databases

CDDicd00063. FN3. 2 hits.
cd06263. MAM. 1 hit.
Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 1 hit.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86WJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTTAAAALP AFVALLLLSP WPLLGSAQGQ FSAGGCTFDD GPGACDYHQD
60 70 80 90 100
LYDDFEWVHV SAQEPHYLPP EMPQGSYMIV DSSDHDPGEK ARLQLPTMKE
110 120 130 140 150
NDTHCIDFSY LLYSQKGLNP GTLNILVRVN KGPLANPIWN VTGFTGRDWL
160 170 180 190 200
RAELAVSTFW PNEYQVIFEA EVSGGRSGYI AIDDIQVLSY PCDKSPHFLR
210 220 230 240 250
LGDVEVNAGQ NATFQCIATG RDAVHNKLWL QRRNGEDIPV AQTKNINHRR
260 270 280 290 300
FAASFRLQEV TKTDQDLYRC VTQSERGSGV SNFAQLIVRE PPRPIAPPQL
310 320 330 340 350
LGVGPTYLLI QLNANSIIGD GPIILKEVEY RMTSGSWTET HAVNAPTYKL
360 370 380 390 400
WHLDPDTEYE IRVLLTRPGE GGTGLPGPPL ITRTKCAEPM RTPKTLKIAE
410 420 430 440 450
IQARRIAVDW ESLGYNITRC HTFNVTICYH YFRGHNESKA DCLDMDPKAP
460 470 480 490 500
QHVVNHLPPY TNVSLKMILT NPEGRKESEE TIIQTDEDVP GPVPVKSLQG
510 520 530 540 550
TSFENKIFLN WKEPLDPNGI ITQYEISYSS IRSFDPAVPV AGPPQTVSNL
560 570 580 590 600
WNSTHHVFMH LHPGTTYQFF IRASTVKGFG PATAINVTTN ISAPTLPDYE
610 620 630 640 650
GVDASLNETA TTITVLLRPA QAKGAPISAY QIVVEELHPH RTKREAGAME
660 670 680 690 700
CYQVPVTYQN AMSGGAPYYF AAELPPRNLP EPAPFTVGDN RTYQGFWNPP
710 720 730 740 750
LAPRKGYNIY FQAMSSVEKE TKTQCVRIAT KAAATEEPEV IPDPAKQTDR
760 770 780 790 800
VVKIAGISAG ILVFILLLLV VILIVKKSKL AKKRKDAMGN TRQEMTHMVN
810 820 830 840 850
AMDRSYADQS TLHAEDPLSI TFMDQHNFSP RYENHSATAE SSRLLDVPRY
860 870 880 890 900
LCEGTESPYQ TGQLHPAIRV ADLLQHINLM KTSDSYGFKE EYESFFEGQS
910 920 930 940 950
ASWDVAKKDQ NRAKNRYGNI IAYDHSRVIL QPVEDDPSSD YINANYIDGY
960 970 980 990 1000
QRPSHYIATQ GPVHETVYDF WRMIWQEQSA CIVMVTNLVE VGRVKCYKYW
1010 1020 1030 1040 1050
PDDTEVYGDF KVTCVEMEPL AEYVVRTFTL ERRGYNEIRE VKQFHFTGWP
1060 1070 1080 1090 1100
DHGVPYHATG LLSFIRRVKL SNPPSAGPIV VHCSAGAGRT GCYIVIDIML
1110 1120 1130 1140 1150
DMAEREGVVD IYNCVKALRS RRINMVQTEE QYIFIHDAIL EACLCGETAI
1160 1170 1180 1190 1200
PVCEFKAAYF DMIRIDSQTN SSHLKDEFQT LNSVTPRLQA EDCSIACLPR
1210 1220 1230 1240 1250
NHDKNRFMDM LPPDRCLPFL ITIDGESSNY INAALMDSYR QPAAFIVTQY
1260 1270 1280 1290 1300
PLPNTVKDFW RLVYDYGCTS IVMLNEVDLS QGCPQYWPEE GMLRYGPIQV
1310 1320 1330 1340 1350
ECMSCSMDCD VINRIFRICN LTRPQEGYLM VQQFQYLGWA SHREVPGSKR
1360 1370 1380 1390 1400
SFLKLILQVE KWQEECEEGE GRTIIHCLNG GGRSGMFCAI GIVVEMVKRQ
1410 1420 1430 1440
NVVDVFHAVK TLRNSKPNMV EAPEQYRFCY DVALEYLESS
Length:1,440
Mass (Da):162,272
Last modified:June 1, 2003 - v1
Checksum:iB140BC621878586A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533875 mRNA. Translation: AAO49502.1.
RefSeqiNP_002835.2. NM_002844.3.
UniGeneiHs.155919.

Genome annotation databases

GeneIDi5796.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533875 mRNA. Translation: AAO49502.1.
RefSeqiNP_002835.2. NM_002844.3.
UniGeneiHs.155919.

3D structure databases

ProteinModelPortaliQ86WJ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000357196.

Proteomic databases

PaxDbiQ86WJ2.
PRIDEiQ86WJ2.

Protocols and materials databases

DNASUi5796.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5796.

Organism-specific databases

CTDi5796.
PharmGKBiPA34019.

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
HOVERGENiHBG062785.

Miscellaneous databases

ChiTaRSiPTPRK. human.
GenomeRNAii5796.

Gene expression databases

GenevisibleiQ86WJ2. HS.

Family and domain databases

CDDicd00063. FN3. 2 hits.
cd06263. MAM. 1 hit.
Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 1 hit.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ86WJ2_HUMAN
AccessioniPrimary (citable) accession number: Q86WJ2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.