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Protein

Protein NLRC5

Gene

NLRC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi228 – 2358ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • RNA polymerase II core promoter sequence-specific DNA binding Source: BHF-UCL

GO - Biological processi

  • defense response to virus Source: UniProtKB
  • innate immune response Source: UniProtKB
  • negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • negative regulation of type I interferon-mediated signaling pathway Source: UniProtKB
  • negative regulation of type I interferon production Source: Reactome
  • positive regulation of interferon-gamma-mediated signaling pathway Source: UniProtKB
  • positive regulation of MHC class I biosynthetic process Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • positive regulation of type I interferon-mediated signaling pathway Source: UniProtKB
  • regulation of kinase activity Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-168928. RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways.
R-HSA-936440. Negative regulators of RIG-I/MDA5 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NLRC5
Alternative name(s):
Caterpiller protein 16.1
Short name:
CLR16.1
Nucleotide-binding oligomerization domain protein 27
Nucleotide-binding oligomerization domain protein 4
Gene namesi
Name:NLRC5
Synonyms:NOD27, NOD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29933. NLRC5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: BHF-UCL
  • nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162397694.

Polymorphism and mutation databases

BioMutaiNLRC5.
DMDMi269849666.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18661866Protein NLRC5PRO_0000296189Add
BLAST

Proteomic databases

EPDiQ86WI3.
MaxQBiQ86WI3.
PaxDbiQ86WI3.
PRIDEiQ86WI3.

Expressioni

Tissue specificityi

Expressed in spleen, thymus, lung, brain, tonsil, heart and prostate.2 Publications

Inductioni

By IFNG/IFN-gamma.1 Publication

Gene expression databases

BgeeiQ86WI3.
CleanExiHS_NLRC5.
ExpressionAtlasiQ86WI3. baseline and differential.
GenevisibleiQ86WI3. HS.

Interactioni

Subunit structurei

Interacts with CHUK and IKBKB; prevents CHUK and IKBKB phosphorylation and inhibits their kinase activity. Interacts with DDX58 and IFIH1; blocks the interaction of MAVS to DDX58.1 Publication

Protein-protein interaction databases

BioGridi123922. 4 interactions.
IntActiQ86WI3. 2 interactions.
STRINGi9606.ENSP00000262510.

Structurei

3D structure databases

ProteinModelPortaliQ86WI3.
SMRiQ86WI3. Positions 1-95, 219-244, 716-1836.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini222 – 539318NACHTPROSITE-ProRule annotationAdd
BLAST
Repeati599 – 62224LRR 1Add
BLAST
Repeati713 – 73725LRR 2Add
BLAST
Repeati741 – 76525LRR 3Add
BLAST
Repeati769 – 79224LRR 4Add
BLAST
Repeati869 – 89224LRR 5Add
BLAST
Repeati897 – 92125LRR 6Add
BLAST
Repeati930 – 95324LRR 7Add
BLAST
Repeati976 – 100025LRR 8Add
BLAST
Repeati1004 – 102623LRR 9Add
BLAST
Repeati1031 – 105828LRR 10Add
BLAST
Repeati1138 – 116124LRR 11Add
BLAST
Repeati1162 – 118423LRR 12Add
BLAST
Repeati1242 – 126524LRR 13Add
BLAST
Repeati1272 – 129423LRR 14Add
BLAST
Repeati1462 – 148827LRR 15Add
BLAST
Repeati1493 – 151624LRR 16Add
BLAST
Repeati1521 – 154424LRR 17Add
BLAST
Repeati1554 – 157724LRR 18Add
BLAST
Repeati1578 – 160023LRR 19Add
BLAST
Repeati1605 – 162824LRR 20Add
BLAST
Repeati1633 – 165624LRR 21Add
BLAST
Repeati1661 – 168424LRR 22Add
BLAST
Repeati1687 – 171428LRR 23Add
BLAST
Repeati1715 – 173925LRR 24Add
BLAST
Repeati1741 – 176222LRR 25Add
BLAST
Repeati1795 – 181824LRR 26Add
BLAST

Sequence similaritiesi

Belongs to the NLRP family.Curated
Contains 26 LRR (leucine-rich) repeats.Curated
Contains 1 NACHT domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG4112B0K. LUCA.
GeneTreeiENSGT00840000129782.
HOVERGENiHBG108194.
InParanoidiQ86WI3.
OMAiIRLWNNP.
OrthoDBiEOG7P5T07.
PhylomeDBiQ86WI3.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.80.10.10. 6 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF12799. LRR_4. 1 hit.
PF13516. LRR_6. 4 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 9 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51450. LRR. 13 hits.
PS50837. NACHT. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86WI3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPVGLQLGN KNLWSCLVRL LTKDPEWLNA KMKFFLPNTD LDSRNETLDP
60 70 80 90 100
EQRVILQLNK LHVQGSDTWQ SFIHCVCMQL EVPLDLEVLL LSTFGYDDGF
110 120 130 140 150
TSQLGAEGKS QPESQLHHGL KRPHQSCGSS PRRKQCKKQQ LELAKKYLQL
160 170 180 190 200
LRTSAQQRYR SQIPGSGQPH AFHQVYVPPI LRRATASLDT PEGAIMGDVK
210 220 230 240 250
VEDGADVSIS DLFNTRVNKG PRVTVLLGKA GMGKTTLAHR LCQKWAEGHL
260 270 280 290 300
NCFQALFLFE FRQLNLITRF LTPSELLFDL YLSPESDHDT VFQYLEKNAD
310 320 330 340 350
QVLLIFDGLD EALQPMGPDG PGPVLTLFSH LCNGTLLPGC RVMATSRPGK
360 370 380 390 400
LPACLPAEAA MVHMLGFDGP RVEEYVNHFF SAQPSREGAL VELQTNGRLR
410 420 430 440 450
SLCAVPALCQ VACLCLHHLL PDHAPGQSVA LLPNMTQLYM QMVLALSPPG
460 470 480 490 500
HLPTSSLLDL GEVALRGLET GKVIFYAKDI APPLIAFGAT HSLLTSFCVC
510 520 530 540 550
TGPGHQQTGY AFTHLSLQEF LAALHLMASP KVNKDTLTQY VTLHSRWVQR
560 570 580 590 600
TKARLGLSDH LPTFLAGLAS CTCRPFLSHL AQGNEDCVGA KQAAVVQVLK
610 620 630 640 650
KLATRKLTGP KVVELCHCVD ETQEPELASL TAQSLPYQLP FHNFPLTCTD
660 670 680 690 700
LATLTNILEH REAPIHLDFD GCPLEPHCPE ALVGCGQIEN LSFKSRKCGD
710 720 730 740 750
AFAEALSRSL PTMGRLQMLG LAGSKITARG ISHLVKALPL CPQLKEVSFR
760 770 780 790 800
DNQLSDQVVL NIVEVLPHLP RLRKLDLSSN SICVSTLLCL ARVAVTCPTV
810 820 830 840 850
RMLQAREADL IFLLSPPTET TAELQRAPDL QESDGQRKGA QSRSLTLRLQ
860 870 880 890 900
KCQLQVHDAE ALIALLQEGP HLEEVDLSGN QLEDEGCRLM AEAASQLHIA
910 920 930 940 950
RKLDLSNNGL SVAGVHCVLR AVSACWTLAE LHISLQHKTV IFMFAQEPEE
960 970 980 990 1000
QKGPQERAAF LDSLMLQMPS ELPLSSRRMR LTHCGLQEKH LEQLCKALGG
1010 1020 1030 1040 1050
SCHLGHLHLD FSGNALGDEG AARLAQLLPG LGALQSLNLS ENGLSLDAVL
1060 1070 1080 1090 1100
GLVRCFSTLQ WLFRLDISFE SQHILLRGDK TSRDMWATGS LPDFPAAAKF
1110 1120 1130 1140 1150
LGFRQRCIPR SLCLSECPLE PPSLTRLCAT LKDCPGPLEL QLSCEFLSDQ
1160 1170 1180 1190 1200
SLETLLDCLP QLPQLSLLQL SQTGLSPKSP FLLANTLSLC PRVKKVDLRS
1210 1220 1230 1240 1250
LHHATLHFRS NEEEEGVCCG RFTGCSLSQE HVESLCWLLS KCKDLSQVDL
1260 1270 1280 1290 1300
SANLLGDSGL RCLLECLPQV PISGLLDLSH NSISQESALY LLETLPSCPR
1310 1320 1330 1340 1350
VREASVNLGS EQSFRIHFSR EDQAGKTLRL SECSFRPEHV SRLATGLSKS
1360 1370 1380 1390 1400
LQLTELTLTQ CCLGQKQLAI LLSLVGRPAG LFSLRVQEPW ADRARVLSLL
1410 1420 1430 1440 1450
EVCAQASGSV TEISISETQQ QLCVQLEFPR QEENPEAVAL RLAHCDLGAH
1460 1470 1480 1490 1500
HSLLVGQLME TCARLQQLSL SQVNLCEDDD ASSLLLQSLL LSLSELKTFR
1510 1520 1530 1540 1550
LTSSCVSTEG LAHLASGLGH CHHLEELDLS NNQFDEEGTK ALMRALEGKW
1560 1570 1580 1590 1600
MLKRLDLSHL LLNSSTLALL THRLSQMTCL QSLRLNRNSI GDVGCCHLSE
1610 1620 1630 1640 1650
ALRAATSLEE LDLSHNQIGD AGVQHLATIL PGLPELRKID LSGNSISSAG
1660 1670 1680 1690 1700
GVQLAESLVL CRRLEELMLG CNALGDPTAL GLAQELPQHL RVLHLPFSHL
1710 1720 1730 1740 1750
GPGGALSLAQ ALDGSPHLEE ISLAENNLAG GVLRFCMELP LLRQIDLVSC
1760 1770 1780 1790 1800
KIDNQTAKLL TSSFTSCPAL EVILLSWNLL GDEAAAELAQ VLPQMGRLKR
1810 1820 1830 1840 1850
VDLEKNQITA LGAWLLAEGL AQGSSIQVIR LWNNPIPCDM AQHLKSQEPR
1860
LDFAFFDNQP QAPWGT
Length:1,866
Mass (Da):204,595
Last modified:November 24, 2009 - v3
Checksum:i4E3BDED8E1624967
GO
Isoform 2 (identifier: Q86WI3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1307-1328: NLGSEQSFRIHFSREDQAGKTL → KCLGSWHVWAPCFPRPFSLQPGL
     1329-1866: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:1,329
Mass (Da):146,203
Checksum:i88549300F78231D0
GO
Isoform 3 (identifier: Q86WI3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     721-1866: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:720
Mass (Da):79,324
Checksum:i88BA764FA11781C7
GO
Isoform 4 (identifier: Q86WI3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1221-1249: Missing.

Note: No experimental confirmation available.
Show »
Length:1,837
Mass (Da):201,300
Checksum:i3DEED7B4B9E094E2
GO
Isoform 5 (identifier: Q86WI3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1221-1249: Missing.
     1385-1385: R → S
     1386-1866: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:1,356
Mass (Da):148,956
Checksum:iF6BE709CA4115698
GO
Isoform 6 (identifier: Q86WI3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1501-1551: LTSSCVSTEG...LMRALEGKWM → IQSSQDPGRL...LPPLGGAGLV
     1552-1866: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:1,551
Mass (Da):170,417
Checksum:i4F701C542D352429
GO

Sequence cautioni

The sequence BAB55096.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB55098.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB85008.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti808 – 8103ADL → RTI in AAO59377 (PubMed:12615073).Curated
Sequence conflicti808 – 8103ADL → RTI in ABO40479 (Ref. 2) Curated
Sequence conflicti1411 – 14111T → A in BAB55096 (PubMed:14702039).Curated
Sequence conflicti1411 – 14111T → A in BAB55098 (PubMed:14702039).Curated
Sequence conflicti1715 – 17151S → F in BAB55096 (PubMed:14702039).Curated
Sequence conflicti1715 – 17151S → F in BAB55098 (PubMed:14702039).Curated
Sequence conflicti1794 – 17941Q → K in AAO59377 (PubMed:12615073).Curated
Sequence conflicti1794 – 17941Q → K in ABO40479 (Ref. 2) Curated
Sequence conflicti1794 – 17941Q → K in AAH63566 (PubMed:15489334).Curated
Sequence conflicti1803 – 18031L → P in BAB55096 (PubMed:14702039).Curated
Sequence conflicti1803 – 18031L → P in BAB55098 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti210 – 2101S → L.
Corresponds to variant rs16965150 [ dbSNP | Ensembl ].
VAR_034607
Natural varianti361 – 3611M → I in a breast cancer sample; somatic mutation. 1 Publication
VAR_036388
Natural varianti453 – 4531P → L.1 Publication
Corresponds to variant rs9938543 [ dbSNP | Ensembl ].
VAR_034608
Natural varianti500 – 5001C → R.1 Publication
Corresponds to variant rs28438857 [ dbSNP | Ensembl ].
VAR_034609
Natural varianti833 – 8331S → N.
Corresponds to variant rs35534915 [ dbSNP | Ensembl ].
VAR_034610
Natural varianti907 – 9071N → D.3 Publications
Corresponds to variant rs1672867 [ dbSNP | Ensembl ].
VAR_060589
Natural varianti1105 – 11051Q → K.2 Publications
Corresponds to variant rs289723 [ dbSNP | Ensembl ].
VAR_034611
Natural varianti1455 – 14551V → A.
Corresponds to variant rs7190199 [ dbSNP | Ensembl ].
VAR_034612
Natural varianti1466 – 14661Q → R.
Corresponds to variant rs7185320 [ dbSNP | Ensembl ].
VAR_034613

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei721 – 18661146Missing in isoform 3. 1 PublicationVSP_027150Add
BLAST
Alternative sequencei1221 – 124929Missing in isoform 4 and isoform 5. 2 PublicationsVSP_027151Add
BLAST
Alternative sequencei1307 – 132822NLGSE…AGKTL → KCLGSWHVWAPCFPRPFSLQ PGL in isoform 2. 1 PublicationVSP_027152Add
BLAST
Alternative sequencei1329 – 1866538Missing in isoform 2. 1 PublicationVSP_027153Add
BLAST
Alternative sequencei1385 – 13851R → S in isoform 5. 1 PublicationVSP_027154
Alternative sequencei1386 – 1866481Missing in isoform 5. 1 PublicationVSP_027155Add
BLAST
Alternative sequencei1501 – 155151LTSSC…EGKWM → IQSSQDPGRLLPDLLPFDPH QADLQLCEHRGPRPPGIWSG PLPPLGGAGLV in isoform 6. 1 PublicationVSP_027156Add
BLAST
Alternative sequencei1552 – 1866315Missing in isoform 6. 1 PublicationVSP_027157Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF389420 mRNA. Translation: AAO59377.1.
EF452236 mRNA. Translation: ABO40479.1.
AK074133 mRNA. Translation: BAB84959.1.
AK074182 mRNA. Translation: BAB85008.1. Different initiation.
AC009090 Genomic DNA. No translation available.
AC023825 Genomic DNA. No translation available.
AK090439 mRNA. Translation: BAC03420.1.
BC050527 mRNA. Translation: AAH50527.1.
BC063566 mRNA. Translation: AAH63566.1.
AK027414 mRNA. Translation: BAB55096.1. Different initiation.
AK027416 mRNA. Translation: BAB55098.1. Different initiation.
CCDSiCCDS10773.1. [Q86WI3-1]
RefSeqiNP_115582.4. NM_032206.4. [Q86WI3-1]
XP_005256250.1. XM_005256193.1. [Q86WI3-1]
XP_005256251.1. XM_005256194.2. [Q86WI3-1]
XP_005256254.1. XM_005256197.1. [Q86WI3-4]
XP_006721360.1. XM_006721297.1. [Q86WI3-1]
XP_011521675.1. XM_011523373.1. [Q86WI3-1]
UniGeneiHs.528836.

Genome annotation databases

EnsembliENST00000262510; ENSP00000262510; ENSG00000140853. [Q86WI3-1]
ENST00000436936; ENSP00000389739; ENSG00000140853. [Q86WI3-1]
ENST00000539144; ENSP00000441727; ENSG00000140853. [Q86WI3-4]
ENST00000539881; ENSP00000441679; ENSG00000140853. [Q86WI3-3]
GeneIDi84166.
KEGGihsa:84166.
UCSCiuc010ccq.2. human. [Q86WI3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF389420 mRNA. Translation: AAO59377.1.
EF452236 mRNA. Translation: ABO40479.1.
AK074133 mRNA. Translation: BAB84959.1.
AK074182 mRNA. Translation: BAB85008.1. Different initiation.
AC009090 Genomic DNA. No translation available.
AC023825 Genomic DNA. No translation available.
AK090439 mRNA. Translation: BAC03420.1.
BC050527 mRNA. Translation: AAH50527.1.
BC063566 mRNA. Translation: AAH63566.1.
AK027414 mRNA. Translation: BAB55096.1. Different initiation.
AK027416 mRNA. Translation: BAB55098.1. Different initiation.
CCDSiCCDS10773.1. [Q86WI3-1]
RefSeqiNP_115582.4. NM_032206.4. [Q86WI3-1]
XP_005256250.1. XM_005256193.1. [Q86WI3-1]
XP_005256251.1. XM_005256194.2. [Q86WI3-1]
XP_005256254.1. XM_005256197.1. [Q86WI3-4]
XP_006721360.1. XM_006721297.1. [Q86WI3-1]
XP_011521675.1. XM_011523373.1. [Q86WI3-1]
UniGeneiHs.528836.

3D structure databases

ProteinModelPortaliQ86WI3.
SMRiQ86WI3. Positions 1-95, 219-244, 716-1836.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123922. 4 interactions.
IntActiQ86WI3. 2 interactions.
STRINGi9606.ENSP00000262510.

Polymorphism and mutation databases

BioMutaiNLRC5.
DMDMi269849666.

Proteomic databases

EPDiQ86WI3.
MaxQBiQ86WI3.
PaxDbiQ86WI3.
PRIDEiQ86WI3.

Protocols and materials databases

DNASUi84166.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262510; ENSP00000262510; ENSG00000140853. [Q86WI3-1]
ENST00000436936; ENSP00000389739; ENSG00000140853. [Q86WI3-1]
ENST00000539144; ENSP00000441727; ENSG00000140853. [Q86WI3-4]
ENST00000539881; ENSP00000441679; ENSG00000140853. [Q86WI3-3]
GeneIDi84166.
KEGGihsa:84166.
UCSCiuc010ccq.2. human. [Q86WI3-1]

Organism-specific databases

CTDi84166.
GeneCardsiNLRC5.
HGNCiHGNC:29933. NLRC5.
MIMi613537. gene.
neXtProtiNX_Q86WI3.
PharmGKBiPA162397694.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG4112B0K. LUCA.
GeneTreeiENSGT00840000129782.
HOVERGENiHBG108194.
InParanoidiQ86WI3.
OMAiIRLWNNP.
OrthoDBiEOG7P5T07.
PhylomeDBiQ86WI3.

Enzyme and pathway databases

ReactomeiR-HSA-168928. RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways.
R-HSA-936440. Negative regulators of RIG-I/MDA5 signaling.

Miscellaneous databases

ChiTaRSiNLRC5. human.
GeneWikiiNLRC5.
GenomeRNAii84166.
NextBioi73516.
PROiQ86WI3.
SOURCEiSearch...

Gene expression databases

BgeeiQ86WI3.
CleanExiHS_NLRC5.
ExpressionAtlasiQ86WI3. baseline and differential.
GenevisibleiQ86WI3. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.80.10.10. 6 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF12799. LRR_4. 1 hit.
PF13516. LRR_6. 4 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 9 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51450. LRR. 13 hits.
PS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product."
    Dowds T.A., Masumoto J., Chen F.F., Ogura Y., Inohara N., Nunez G.
    Biochem. Biophys. Res. Commun. 302:575-580(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-907.
  2. Kronos K.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-907.
  3. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 850-1866 (ISOFORM 6), VARIANTS ASP-907 AND LYS-1105.
    Tissue: Spleen.
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
    Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
    DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 274-1866 (ISOFORM 2), VARIANTS LEU-453 AND ARG-500.
    Tissue: Spleen.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 971-1385 (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1030-1866, VARIANT LYS-1105.
    Tissue: Brain and Ovary.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1067-1866 (ISOFORM 4).
  8. "NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways."
    Cui J., Zhu L., Xia X., Wang H.Y., Legras X., Hong J., Ji J., Shen P., Zheng S., Chen Z.J., Wang R.F.
    Cell 141:483-496(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH CHUK; DDX58; IFIH1 AND IKBKB.
  9. "The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses."
    Kuenzel S., Till A., Winkler M., Hasler R., Lipinski S., Jung S., Grotzinger J., Fickenscher H., Schreiber S., Rosenstiel P.
    J. Immunol. 184:1990-2000(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  10. "CATERPILLER: a novel gene family important in immunity, cell death, and diseases."
    Ting J.P.-Y., Davis B.K.
    Annu. Rev. Immunol. 23:387-414(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  11. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-361.

Entry informationi

Entry nameiNLRC5_HUMAN
AccessioniPrimary (citable) accession number: Q86WI3
Secondary accession number(s): B5MEF1
, C9JMD8, Q6P4A6, Q86VM7, Q8NF42, Q8TEE2, Q8TEJ1, Q969L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: November 24, 2009
Last modified: May 11, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Supposed to contain a CARD domain at the N-terminus (PubMed:20434986). However, this domain is not detected by Pfam, PROSITE or SMART. Has a weak similarity with a DAPIN domain.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.