Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibrocystin-L

Gene

PKHD1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • receptor activity Source: UniProtKB

GO - Biological processi

  • immune response Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrocystin-L
Alternative name(s):
Polycystic kidney and hepatic disease 1-like protein 1
Short name:
PKHD1-like protein 1
Gene namesi
Name:PKHD1L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:20313. PKHD1L1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 42104190ExtracellularSequence analysisAdd
BLAST
Transmembranei4211 – 423121HelicalSequence analysisAdd
BLAST
Topological domaini4232 – 424312CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • extracellular space Source: UniProtKB
  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134950222.

Polymorphism and mutation databases

BioMutaiPKHD1L1.
DMDMi269849629.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 42434223Fibrocystin-LPRO_0000318572Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi122 – 1221O-linked (GalNAc...)Sequence analysis
Glycosylationi445 – 4451O-linked (GalNAc...)Sequence analysis
Glycosylationi1803 – 18031O-linked (GalNAc...)Sequence analysis
Glycosylationi1839 – 18391O-linked (GalNAc...)Sequence analysis
Glycosylationi2320 – 23201O-linked (GalNAc...)Sequence analysis
Glycosylationi3736 – 37361O-linked (GalNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86WI1.
PeptideAtlasiQ86WI1.
PRIDEiQ86WI1.

PTM databases

iPTMnetiQ86WI1.
PhosphoSiteiQ86WI1.

Expressioni

Tissue specificityi

Ubiquitous. Expressed in spleen and thymus as well as in activated T-cells and B-lymphoblasts.1 Publication

Gene expression databases

BgeeiENSG00000205038.
CleanExiHS_PKHD1L1.
ExpressionAtlasiQ86WI1. baseline and differential.
GenevisibleiQ86WI1. HS.

Organism-specific databases

HPAiHPA044458.

Interactioni

Protein-protein interaction databases

DIPiDIP-59023N.
STRINGi9606.ENSP00000367655.

Structurei

3D structure databases

ProteinModelPortaliQ86WI1.
SMRiQ86WI1. Positions 1157-1297, 2001-2152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 12999IPT/TIG 1Add
BLAST
Domaini146 – 255110IPT/TIG 2Add
BLAST
Domaini270 – 36192IPT/TIG 3Add
BLAST
Domaini1067 – 115185IPT/TIG 4Add
BLAST
Domaini1155 – 123480IPT/TIG 5Add
BLAST
Domaini1240 – 132283IPT/TIG 6Add
BLAST
Domaini1330 – 1469140IPT/TIG 7Add
BLAST
Domaini1566 – 164984IPT/TIG 8Add
BLAST
Domaini1659 – 174385IPT/TIG 9Add
BLAST
Domaini1749 – 182880IPT/TIG 10Add
BLAST
Domaini1831 – 191080IPT/TIG 11Add
BLAST
Domaini1916 – 199782IPT/TIG 12Add
BLAST
Domaini1999 – 208587IPT/TIG 13Add
BLAST
Domaini2091 – 217686IPT/TIG 14Add
BLAST
Domaini2184 – 2304121G8 1PROSITE-ProRule annotationAdd
BLAST
Repeati2508 – 253023PbH1 1Add
BLAST
Repeati2566 – 258823PbH1 2Add
BLAST
Repeati2665 – 268723PbH1 3Add
BLAST
Repeati2733 – 275624PbH1 4Add
BLAST
Domaini3036 – 3174139G8 2PROSITE-ProRule annotationAdd
BLAST
Repeati3293 – 331523PbH1 5Add
BLAST
Repeati3355 – 337723PbH1 6Add
BLAST
Repeati3416 – 343823PbH1 7Add
BLAST
Repeati3471 – 349323PbH1 8Add
BLAST
Repeati3527 – 354822PbH1 9Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4188 – 420013Poly-SerAdd
BLAST

Sequence similaritiesi

Contains 2 G8 domains.PROSITE-ProRule annotation
Contains 14 IPT/TIG domains.Curated
Contains 9 PbH1 repeats.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEIF. Eukaryota.
ENOG410XQ01. LUCA.
GeneTreeiENSGT00780000121902.
HOGENOMiHOG000010311.
HOVERGENiHBG099795.
InParanoidiQ86WI1.
OMAiGRSGICW.
OrthoDBiEOG091G000V.
PhylomeDBiQ86WI1.
TreeFamiTF329582.

Family and domain databases

Gene3Di2.60.40.10. 14 hits.
3.90.182.10. 1 hit.
InterProiIPR008972. Cupredoxin.
IPR019316. G8_domain.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR011658. PA14_dom.
IPR006626. PbH1.
IPR011050. Pectin_lyase_fold/virulence.
IPR029927. PKHDL1.
[Graphical view]
PANTHERiPTHR11915:SF330. PTHR11915:SF330. 1 hit.
PfamiPF10162. G8. 2 hits.
PF07691. PA14. 1 hit.
PF01833. TIG. 14 hits.
[Graphical view]
SMARTiSM01225. G8. 2 hits.
SM00429. IPT. 14 hits.
SM00758. PA14. 1 hit.
SM00710. PbH1. 10 hits.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF51126. SSF51126. 2 hits.
SSF81296. SSF81296. 14 hits.
PROSITEiPS51484. G8. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86WI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHLWLLGIW GLCGLLLCAA DPSTDGSQII PKVTEIIPKY GSINGATRLT
60 70 80 90 100
IRGEGFSQAN QFNYGVDNAE LGNSVQLISS FQSITCDVEK DASHSTQITC
110 120 130 140 150
YTRAMPEDSY TVRVSVDGVP VTENNTCKGH INSWECTFNA KSFRTPTIRS
160 170 180 190 200
ITPLSGTPGT LITIQGRIFT DVYGSNIALS SNGKNVRILR VYIGGMPCEL
210 220 230 240 250
LIPQSDNLYG LKLDHPNGDM GSMVCKTTGT FIGHHNVSFI LDNDYGRSFP
260 270 280 290 300
QKMAYFVSSL NKIAMFQTYA EVTMIFPSQG SIRGGTTLTI SGRFFDQTDF
310 320 330 340 350
PVRVLVGGEP CDILNVTENS ICCKTPPKPH ILKTVYPGGR GLKLEVWNNS
360 370 380 390 400
RPIRLEEILE YNEKTPGYMG ASWVDSASYI WLMEQDTFVA RFSGFLVAPD
410 420 430 440 450
SDVYRFYIKG DDRYAIYFSQ TGLPEDKVRI AYHSANANSY FSSPTQRSDD
460 470 480 490 500
IHLQKGKEYY IEILLQEYRL SAFVDVGLYQ YRNVYTEQQT GDAVNEEQVI
510 520 530 540 550
KSQSTILQEV QVITLENWET TNAINEVQKI KVTSPCVEAN SCSLYQYRLI
560 570 580 590 600
YNMEKTVFLP ADASEFILQS ALNDLWSIKP DTVQVIRTQN PQSYVYMVTF
610 620 630 640 650
ISTRGDFDLL GYEVVEGNNV TLDITEQTKG KPNLETFTLN WDGIASKPLT
660 670 680 690 700
LWSSEAEFQG AVEEMVSTKC PPQIANFEEG FVVKYFRDYE TDFNLEHINR
710 720 730 740 750
GQKTAETDAY CGRYSLKNPA VLFDSADVKP NRRPYGDILL FPYNQLCLAY
760 770 780 790 800
KGFLANYIGL KFQYQDNSKI TRSTDTQFTY NFAYGNNWTY TCIDLLDLVR
810 820 830 840 850
TKYTGTNVSL QRISLHKASE SQSFYVDVVY IGHTSTISTL DEMPKRRLPA
860 870 880 890 900
LANKGIFLEH FQVNQTKTNG PTMTNQYSVT MTSYNCSYNI PMMAVSFGQI
910 920 930 940 950
ITHETENEFV YRGNNWPGES KIHIQRIQAA SPPLSGSFDI QAYGHILKGL
960 970 980 990 1000
PAAVSAADLQ FALQSLEGMG RISVTREGTC AGYAWNIKWR STCGKQNLLQ
1010 1020 1030 1040 1050
INDSNIIGEK ANMTVTRIKE GGLFRQHVLG DLLRTPSQQP QVEVYVNGIP
1060 1070 1080 1090 1100
AKCSGDCGFT WDSNITPLVL AISPSQGSYE EGTILTIVGS GFSPSSAVTV
1110 1120 1130 1140 1150
SVGPVGCSLL SVDEKELKCQ ILNGSAGHAP VAVSMADVGL AQNVGGEEFY
1160 1170 1180 1190 1200
FVYQSQISHI WPDSGSIAGG TLLTLSGFGF NENSKVLVGN ETCNVIEGDL
1210 1220 1230 1240 1250
NRITCRTPKK TEGTVDISVT TNGFQATARD AFSYNCLQTP IITDFSPKVR
1260 1270 1280 1290 1300
TILGEVNLTI KGYNFGNELT QNMAVYVGGK TCQILHWNFT DIRCLLPKLS
1310 1320 1330 1340 1350
PGKHDIYVEV RNWGFASTRD KLNSSIQYVL EVTSMFPQRG SLFGGTEITI
1360 1370 1380 1390 1400
RGFGFSTIPA ENTVLLGSIP CNVTSSSENV IKCILHSTGN IFRITNNGKD
1410 1420 1430 1440 1450
SVHGLGYAWS PPVLNVSVGD TVAWHWQTHP FLRGIGYRIF SVSSPGSVIY
1460 1470 1480 1490 1500
DGKGFTSGRQ KSTSGSFSYQ FTSPGIHYYS SGYVDEAHSI FLQGVINVLP
1510 1520 1530 1540 1550
AETRHIPLHL FVGRSEATYA YGGPENLHLG SSVAGCLATE PLCSLNNTRV
1560 1570 1580 1590 1600
KNSKRLLFEV SSCFSPSISN ITPSTGTVNE LITIIGHGFS NLPWANKVTI
1610 1620 1630 1640 1650
GSYPCVVEES SEDSITCHID PQNSMDVGIR ETVTLTVYNL GTAINTLSNE
1660 1670 1680 1690 1700
FDRRFVLLPN IDLVLPNAGS TTGMTSVTIK GSGFAVSSAG VKVLMGHFPC
1710 1720 1730 1740 1750
KVLSVNYTAI ECETSPAAQQ LVDVDLLIHG VPAQCQGNCT FSYLESITPY
1760 1770 1780 1790 1800
ITGVFPNSVI GSVKVLIEGE GLGTVLEDIA VFIGNQQFRA IEVNENNITA
1810 1820 1830 1840 1850
LVTPLPVGHH SVSVVVGSKG LALGNLTVSS PPVASLSPTS GSIGGGTTLV
1860 1870 1880 1890 1900
ITGNGFYPGN TTVTIGDEPC QIISINPNEV YCRTPAGTTG MVDVKIFVNT
1910 1920 1930 1940 1950
IAYPPLLFTY ALEDTPFLRG IIPSRGPPGT EIEITGSNFG FEILEISVMI
1960 1970 1980 1990 2000
NNIQCNVTMA NDSVVQCIVG DHAGGTFPVM MHHKTKGSAM STVVFEYPLN
2010 2020 2030 2040 2050
IQNINPSQGS FGGGQTMTVT GTGFNPQNSI ILVCGSECAI DRLRSDYTTL
2060 2070 2080 2090 2100
LCEIPSNNGT GAEQACEVSV VNGKDLSQSM TPFTYAVSLT PLITAVSPKR
2110 2120 2130 2140 2150
GSTAGGTRLT VVGSGFSENM EDVHITIAEA KCDVEYSNKT HIICMTDAHT
2160 2170 2180 2190 2200
LSGWAPVCVH IRGVGMAKLD NADFLYVDAW SSNFSWGGKS PPEEGSLVVI
2210 2220 2230 2240 2250
TKGQTILLDQ STPILKMLLI QGGTLIFDEA DIELQAENIL ITDGGVLQIG
2260 2270 2280 2290 2300
TETSPFQHKA VITLHGHLRS PELPVYGAKT LAVREGILDL HGVPVPVTWT
2310 2320 2330 2340 2350
RLAHTAKAGE RILILQEAVT WKPGDNIVIA STGHRHSQGE NEKMTIASVS
2360 2370 2380 2390 2400
ADGINITLSN PLNYTHLGIT VTLPDGTLFE ARAEVGILTR NILIRGSDNV
2410 2420 2430 2440 2450
EWNNKIPACP DGFDTGEFAT QTCLQGKFGE EIGSDQFGGC VMFHAPVPGA
2460 2470 2480 2490 2500
NMVTGRIEYV EVFHAGQAFR LGRYPIHWHL LGDLQFKSYV RGCAIHQAYN
2510 2520 2530 2540 2550
RAVTIHNTHH LLVERNIIYD IKGGAFFIED GIEHGNILQY NLAVFVQQST
2560 2570 2580 2590 2600
SLLNDDVTPA AFWVTNPNNT IRHNAVAGGT HFGFWYRMNN HPDGPSYDRN
2610 2620 2630 2640 2650
ICQKRVPLGE FFNNTVHSQG WFGMWIFEEY FPMQTGSCTS TVPAPAIFNS
2660 2670 2680 2690 2700
LTTWNCQKGA EWVNGGALQF HNFVMVNNYE AGIETKRILA PYVGGWGETN
2710 2720 2730 2740 2750
GAVIKNAKIV GHLDELGMGS AFCTAKGLVL PFSEGLTVSS VHFMNFDRPN
2760 2770 2780 2790 2800
CVALGVTSIS GVCNDRCGGW SAKFVDVQYS HTPNKAGFRW EHEMVMIDVD
2810 2820 2830 2840 2850
GSLTGHKGHT VIPHSSLLDP SHCTQEAEWS IGFPGSVCDA SVSFHRLAFN
2860 2870 2880 2890 2900
QPSPVSLLEK DVVLSDSFGT SIIPFQKKRL THMSGWMALI PNANHINWYF
2910 2920 2930 2940 2950
KGVDHITNIS YTSTFYGFKE EDYVIISHNF TQNPDMFNII DMRNGSSNPL
2960 2970 2980 2990 3000
NWNTSKNGDW HLEANTSTLY YLVSGRNDLH QSQLISGNLD PDVKDVVINF
3010 3020 3030 3040 3050
QAYCCILQDC FPVHPPSRKP IPKKRPATYN LWSNDSFWQS SRENNYTVPH
3060 3070 3080 3090 3100
PGANVIIPEG TWIVADIDMP SMERLIIWGV LELEDKYNVG AAESSYREVV
3110 3120 3130 3140 3150
LNATYISLQG GRLIGGWEDN PFKGDLKIVL RGNHTTQDWA LPEGPNQGAK
3160 3170 3180 3190 3200
VLGVFGELDL HGIPHSIYKT KLSETAFAGS KVLSLMDAVD WQEGEEIVIT
3210 3220 3230 3240 3250
TTSYDFHQTE TRSIVKILHD HKILILNDSL SYTHFAEKYH VPGTGESYTL
3260 3270 3280 3290 3300
AADVGILSRN IKIVGEDYPG WSEDSFGARV LVGSFTENMM TFKGNARISN
3310 3320 3330 3340 3350
VEFYHSGQEG FRDSTDPRYA VTFLNLGQIQ EHGSSYIRGC AFHHGFSPAI
3360 3370 3380 3390 3400
GVFGTDGLDI DDNIIHFTVG EGIRIWGNAN RVRGNLIALS VWPGTYQNRK
3410 3420 3430 3440 3450
DLSSTLWHAA IEINRGTNTV LQNNVVAGFG RAGYRIDGEP CPGQFNPVEK
3460 3470 3480 3490 3500
WFDNEAHGGL YGIYMNQDGL PGCSLIQGFT IWTCWDYGIY FQTTESVHIY
3510 3520 3530 3540 3550
NVTLVDNGMA IFPMIYMPAA ISHKISSKNV QIKSSLIVGS SPGFNCSDVL
3560 3570 3580 3590 3600
TNDDPNIELT AAHRSPRSPS GGRSGICWPT FASAHNMAPR KPHAGIMSYN
3610 3620 3630 3640 3650
AISGLLDISG STFVGFKNVC SGETNVIFIT NPLNEDLQHP IHVKNIKLVD
3660 3670 3680 3690 3700
TTEQSKIFIH RPDISKVNPS DCVDMVCDAK RKSFLRDIDG SFLGNAGSVI
3710 3720 3730 3740 3750
PQAEYEWDGN SQVGIGDYRI PKAMLTFLNG SRIPVTEKAP HKGIIRDSTC
3760 3770 3780 3790 3800
KYLPEWQSYQ CFGMEYAMMV IESLDPDTET RRLSPVAIMG NGYVDLINGP
3810 3820 3830 3840 3850
QDHGWCAGYT CQRRLSLFHS IVALNKSYEV YFTGTSPQNL RLMLLNVDHN
3860 3870 3880 3890 3900
KAVLVGIFFS TLQRLDVYVN NLLVCPKTTI WNAQQKHCEL NNHLYKDQFL
3910 3920 3930 3940 3950
PNLDSTVLGE NYFDGTYQML YLLVKGTIPV EIHTATVIFV SFQLSVATED
3960 3970 3980 3990 4000
DFYTSHNLVK NLALFLKIPS DKIRISKIRG KSLRRKRSMG FIIEIEIGDP
4010 4020 4030 4040 4050
PIQFISNGTT GQMQLSELQE IAGSLGQAVI LGNISSILGF NISSMSITNP
4060 4070 4080 4090 4100
LPSPSDSGWI KVTAQPVERS AFPVHHVAFV SSLLVITQPV AAQPGQPFPQ
4110 4120 4130 4140 4150
QPSVKATDSD GNCVSVGITA LTLRAILKDS NNNQVNGLSG NTTIPFSSCW
4160 4170 4180 4190 4200
ANYTDLTPLR TGKNYKIEFI LDNVVGVESR TFSLLAESVS SSGSSSSSNS
4210 4220 4230 4240
KASTVGTYAQ IMTVVISCLV GRMWLLEIFM AAVSTLNITL RSY
Length:4,243
Mass (Da):465,734
Last modified:November 24, 2009 - v2
Checksum:iA3A50CA85C5DA500
GO

Sequence cautioni

The sequence AAH93096 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4061 – 40611K → N in CAB63761 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti373 – 3731W → C.
Corresponds to variant rs16879428 [ dbSNP | Ensembl ].
VAR_038760
Natural varianti440 – 4401Y → H.
Corresponds to variant rs964307 [ dbSNP | Ensembl ].
VAR_038761
Natural varianti923 – 9231H → R.
Corresponds to variant rs4735133 [ dbSNP | Ensembl ].
VAR_038762
Natural varianti943 – 9431Y → H.
Corresponds to variant rs16879534 [ dbSNP | Ensembl ].
VAR_038763
Natural varianti957 – 9571A → E.
Corresponds to variant rs35375999 [ dbSNP | Ensembl ].
VAR_038764
Natural varianti1192 – 11921T → A.
Corresponds to variant rs10093885 [ dbSNP | Ensembl ].
VAR_038765
Natural varianti1514 – 15141R → S.
Corresponds to variant rs1673408 [ dbSNP | Ensembl ].
VAR_038766
Natural varianti1539 – 15391T → R.
Corresponds to variant rs7820062 [ dbSNP | Ensembl ].
VAR_038767
Natural varianti1965 – 19651V → L.1 Publication
Corresponds to variant rs1673407 [ dbSNP | Ensembl ].
VAR_038768
Natural varianti3050 – 30501H → Q.
Corresponds to variant rs1783147 [ dbSNP | Ensembl ].
VAR_038769
Natural varianti3080 – 30801V → I.
Corresponds to variant rs10441509 [ dbSNP | Ensembl ].
VAR_038770
Natural varianti3411 – 34111I → V.
Corresponds to variant rs16879659 [ dbSNP | Ensembl ].
VAR_038771
Natural varianti3607 – 36071D → E.
Corresponds to variant rs9774677 [ dbSNP | Ensembl ].
VAR_038772
Natural varianti3862 – 38621L → F.
Corresponds to variant rs16879693 [ dbSNP | Ensembl ].
VAR_038773
Natural varianti4220 – 42201V → I.
Corresponds to variant rs1783174 [ dbSNP | Ensembl ].
VAR_038774

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY219181 mRNA. Translation: AAO60072.1.
AC021001 Genomic DNA. No translation available.
AC021237 Genomic DNA. No translation available.
BC093096 mRNA. Translation: AAH93096.1. Sequence problems.
AL133640 mRNA. Translation: CAB63761.1.
CCDSiCCDS47911.1.
PIRiT43498.
RefSeqiNP_803875.2. NM_177531.4.
UniGeneiHs.170128.

Genome annotation databases

EnsembliENST00000378402; ENSP00000367655; ENSG00000205038.
GeneIDi93035.
KEGGihsa:93035.
UCSCiuc003yne.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY219181 mRNA. Translation: AAO60072.1.
AC021001 Genomic DNA. No translation available.
AC021237 Genomic DNA. No translation available.
BC093096 mRNA. Translation: AAH93096.1. Sequence problems.
AL133640 mRNA. Translation: CAB63761.1.
CCDSiCCDS47911.1.
PIRiT43498.
RefSeqiNP_803875.2. NM_177531.4.
UniGeneiHs.170128.

3D structure databases

ProteinModelPortaliQ86WI1.
SMRiQ86WI1. Positions 1157-1297, 2001-2152.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59023N.
STRINGi9606.ENSP00000367655.

PTM databases

iPTMnetiQ86WI1.
PhosphoSiteiQ86WI1.

Polymorphism and mutation databases

BioMutaiPKHD1L1.
DMDMi269849629.

Proteomic databases

PaxDbiQ86WI1.
PeptideAtlasiQ86WI1.
PRIDEiQ86WI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378402; ENSP00000367655; ENSG00000205038.
GeneIDi93035.
KEGGihsa:93035.
UCSCiuc003yne.4. human.

Organism-specific databases

CTDi93035.
GeneCardsiPKHD1L1.
H-InvDBHIX0034733.
HIX0201302.
HGNCiHGNC:20313. PKHD1L1.
HPAiHPA044458.
MIMi607843. gene.
neXtProtiNX_Q86WI1.
PharmGKBiPA134950222.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEIF. Eukaryota.
ENOG410XQ01. LUCA.
GeneTreeiENSGT00780000121902.
HOGENOMiHOG000010311.
HOVERGENiHBG099795.
InParanoidiQ86WI1.
OMAiGRSGICW.
OrthoDBiEOG091G000V.
PhylomeDBiQ86WI1.
TreeFamiTF329582.

Miscellaneous databases

ChiTaRSiPKHD1L1. human.
GenomeRNAii93035.
PROiQ86WI1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205038.
CleanExiHS_PKHD1L1.
ExpressionAtlasiQ86WI1. baseline and differential.
GenevisibleiQ86WI1. HS.

Family and domain databases

Gene3Di2.60.40.10. 14 hits.
3.90.182.10. 1 hit.
InterProiIPR008972. Cupredoxin.
IPR019316. G8_domain.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR011658. PA14_dom.
IPR006626. PbH1.
IPR011050. Pectin_lyase_fold/virulence.
IPR029927. PKHDL1.
[Graphical view]
PANTHERiPTHR11915:SF330. PTHR11915:SF330. 1 hit.
PfamiPF10162. G8. 2 hits.
PF07691. PA14. 1 hit.
PF01833. TIG. 14 hits.
[Graphical view]
SMARTiSM01225. G8. 2 hits.
SM00429. IPT. 14 hits.
SM00758. PA14. 1 hit.
SM00710. PbH1. 10 hits.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF51126. SSF51126. 2 hits.
SSF81296. SSF81296. 14 hits.
PROSITEiPS51484. G8. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKHL1_HUMAN
AccessioniPrimary (citable) accession number: Q86WI1
Secondary accession number(s): Q567P2, Q9UF27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 24, 2009
Last modified: September 7, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.