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Protein

Lipoma HMGIC fusion partner-like 1 protein

Gene

LHFPL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-31566-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoma HMGIC fusion partner-like 1 protein
Gene namesi
Name:LHFPL1
ORF Names:UNQ5824/PRO19643
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:6587. LHFPL1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi340596.
OpenTargetsiENSG00000182508.
PharmGKBiPA30359.

Polymorphism and mutation databases

BioMutaiLHFPL1.
DMDMi74714099.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000024476021 – 220Lipoma HMGIC fusion partner-like 1 proteinAdd BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi153N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86WI0.
PRIDEiQ86WI0.

Expressioni

Tissue specificityi

Widely expressed. Expressed at high levels in lung, thymus, skeletal muscle, colon and ovary.1 Publication

Gene expression databases

BgeeiENSG00000182508.
CleanExiHS_LHFPL1.
GenevisibleiQ86WI0. HS.

Organism-specific databases

HPAiHPA003029.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361036.

Structurei

3D structure databases

ProteinModelPortaliQ86WI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LHFP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4026. Eukaryota.
ENOG410XSUB. LUCA.
GeneTreeiENSGT00550000074479.
HOGENOMiHOG000007007.
HOVERGENiHBG080585.
InParanoidiQ86WI0.
OMAiKPVMLVE.
OrthoDBiEOG091G10EV.
PhylomeDBiQ86WI0.
TreeFamiTF321143.

Family and domain databases

InterProiIPR019372. Lipome_HGMIC_fus_partner-like.
[Graphical view]
PfamiPF10242. L_HMGIC_fpl. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86WI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSSLTMVGT LWAFLSLVTA VTSSTSYFLP YWLFGSQMGK PVSFSTFRRC
60 70 80 90 100
NYPVRGEGHS LIMVEECGRY ASFNAIPSLA WQMCTVVTGA GCALLLLVAL
110 120 130 140 150
AAVLGCCMEE LISRMMGRCM GAAQFVGGLL ISSGCALYPL GWNSPEIMQT
160 170 180 190 200
CGNVSNQFQL GTCRLGWAYY CAGGGAAAAM LICTWLSCFA GRNPKPVILV
210 220
ESIMRNTNSY AMELDHCLKP
Length:220
Mass (Da):23,777
Last modified:June 1, 2003 - v1
Checksum:i6BD3E610319E0CF2
GO
Isoform 2 (identifier: Q86WI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-161: Missing.

Note: No experimental confirmation available.
Show »
Length:187
Mass (Da):20,253
Checksum:iA035C06E3888D1EE
GO
Isoform 3 (identifier: Q86WI0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-179: Missing.

Note: No experimental confirmation available.
Show »
Length:41
Mass (Da):4,697
Checksum:i221F0030D75AAF1F
GO

Sequence cautioni

The sequence AAQ88575 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0196161 – 179Missing in isoform 3. 1 PublicationAdd BLAST179
Alternative sequenceiVSP_019617129 – 161Missing in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY217350 mRNA. Translation: AAO60107.1.
AY358208 mRNA. Translation: AAQ88575.1. Different initiation.
AK289946 mRNA. Translation: BAF82635.1.
BC100785 mRNA. Translation: AAI00786.1.
BC100786 mRNA. Translation: AAI00787.1.
BC100787 mRNA. Translation: AAI00788.1.
CCDSiCCDS14562.1. [Q86WI0-1]
RefSeqiNP_835469.1. NM_178175.3. [Q86WI0-1]
XP_011529245.1. XM_011530943.2.
XP_011529246.1. XM_011530944.2. [Q86WI0-1]
XP_011529248.1. XM_011530946.2. [Q86WI0-2]
XP_016884974.1. XM_017029485.1.
UniGeneiHs.297420.

Genome annotation databases

EnsembliENST00000371968; ENSP00000361036; ENSG00000182508. [Q86WI0-1]
GeneIDi340596.
KEGGihsa:340596.
UCSCiuc004epq.4. human. [Q86WI0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY217350 mRNA. Translation: AAO60107.1.
AY358208 mRNA. Translation: AAQ88575.1. Different initiation.
AK289946 mRNA. Translation: BAF82635.1.
BC100785 mRNA. Translation: AAI00786.1.
BC100786 mRNA. Translation: AAI00787.1.
BC100787 mRNA. Translation: AAI00788.1.
CCDSiCCDS14562.1. [Q86WI0-1]
RefSeqiNP_835469.1. NM_178175.3. [Q86WI0-1]
XP_011529245.1. XM_011530943.2.
XP_011529246.1. XM_011530944.2. [Q86WI0-1]
XP_011529248.1. XM_011530946.2. [Q86WI0-2]
XP_016884974.1. XM_017029485.1.
UniGeneiHs.297420.

3D structure databases

ProteinModelPortaliQ86WI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000361036.

Polymorphism and mutation databases

BioMutaiLHFPL1.
DMDMi74714099.

Proteomic databases

PaxDbiQ86WI0.
PRIDEiQ86WI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371968; ENSP00000361036; ENSG00000182508. [Q86WI0-1]
GeneIDi340596.
KEGGihsa:340596.
UCSCiuc004epq.4. human. [Q86WI0-1]

Organism-specific databases

CTDi340596.
DisGeNETi340596.
GeneCardsiLHFPL1.
HGNCiHGNC:6587. LHFPL1.
HPAiHPA003029.
MIMi300566. gene.
neXtProtiNX_Q86WI0.
OpenTargetsiENSG00000182508.
PharmGKBiPA30359.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4026. Eukaryota.
ENOG410XSUB. LUCA.
GeneTreeiENSGT00550000074479.
HOGENOMiHOG000007007.
HOVERGENiHBG080585.
InParanoidiQ86WI0.
OMAiKPVMLVE.
OrthoDBiEOG091G10EV.
PhylomeDBiQ86WI0.
TreeFamiTF321143.

Enzyme and pathway databases

BioCyciZFISH:G66-31566-MONOMER.

Miscellaneous databases

GeneWikiiLHFPL1.
GenomeRNAii340596.
PROiQ86WI0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182508.
CleanExiHS_LHFPL1.
GenevisibleiQ86WI0. HS.

Family and domain databases

InterProiIPR019372. Lipome_HGMIC_fus_partner-like.
[Graphical view]
PfamiPF10242. L_HMGIC_fpl. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLHPL1_HUMAN
AccessioniPrimary (citable) accession number: Q86WI0
Secondary accession number(s): A8K1N1
, Q496M9, Q496N0, Q6UXU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.