Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q86WI0 (LHPL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipoma HMGIC fusion partner-like 1 protein
Gene names
Name:LHFPL1
ORF Names:UNQ5824/PRO19643
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Widely expressed. Expressed at high levels in lung, thymus, skeletal muscle, colon and ovary. Ref.1

Sequence similarities

Belongs to the LHFP family.

Sequence caution

The sequence AAQ88575.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainSignal
Transmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86WI0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86WI0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     129-161: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q86WI0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-179: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 220200Lipoma HMGIC fusion partner-like 1 protein
PRO_0000244760

Regions

Transmembrane86 – 10621Helical; Potential
Transmembrane122 – 14221Helical; Potential
Transmembrane165 – 18521Helical; Potential

Amino acid modifications

Glycosylation1531N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 179179Missing in isoform 3.
VSP_019616
Alternative sequence129 – 16133Missing in isoform 2.
VSP_019617

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 6BD3E610319E0CF2

FASTA22023,777
        10         20         30         40         50         60 
MRSSLTMVGT LWAFLSLVTA VTSSTSYFLP YWLFGSQMGK PVSFSTFRRC NYPVRGEGHS 

        70         80         90        100        110        120 
LIMVEECGRY ASFNAIPSLA WQMCTVVTGA GCALLLLVAL AAVLGCCMEE LISRMMGRCM 

       130        140        150        160        170        180 
GAAQFVGGLL ISSGCALYPL GWNSPEIMQT CGNVSNQFQL GTCRLGWAYY CAGGGAAAAM 

       190        200        210        220 
LICTWLSCFA GRNPKPVILV ESIMRNTNSY AMELDHCLKP 

« Hide

Isoform 2 [UniParc].

Checksum: A035C06E3888D1EE
Show »

FASTA18720,253
Isoform 3 [UniParc].

Checksum: 221F0030D75AAF1F
Show »

FASTA414,697

References

« Hide 'large scale' references
[1]"Isolation, tissue distribution and prokaryotic expression of a novel human X-linked gene LHFPL1."
Huang C., Guo J., Liu S., Shan Y., Wu S., Cai Y., Yu L.
DNA Seq. 15:299-302(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Tissue: Brain.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Hippocampus.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY217350 mRNA. Translation: AAO60107.1.
AY358208 mRNA. Translation: AAQ88575.1. Different initiation.
AK289946 mRNA. Translation: BAF82635.1.
BC100785 mRNA. Translation: AAI00786.1.
BC100786 mRNA. Translation: AAI00787.1.
BC100787 mRNA. Translation: AAI00788.1.
CCDSCCDS14562.1. [Q86WI0-1]
RefSeqNP_835469.1. NM_178175.3. [Q86WI0-1]
XP_005262185.1. XM_005262128.1.
UniGeneHs.297420.

3D structure databases

ProteinModelPortalQ86WI0.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ86WI0.

Polymorphism databases

DMDM74714099.

Proteomic databases

PRIDEQ86WI0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000371968; ENSP00000361036; ENSG00000182508. [Q86WI0-1]
ENST00000536453; ENSP00000444573; ENSG00000182508. [Q86WI0-2]
GeneID340596.
KEGGhsa:340596.
UCSCuc004epp.3. human. [Q86WI0-1]
uc010nqb.3. human. [Q86WI0-2]

Organism-specific databases

CTD340596.
GeneCardsGC0XM111873.
HGNCHGNC:6587. LHFPL1.
HPAHPA003029.
MIM300566. gene.
neXtProtNX_Q86WI0.
PharmGKBPA30359.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG310245.
HOGENOMHOG000007007.
HOVERGENHBG080585.
InParanoidQ86WI0.
OMAEAFFESH.
OrthoDBEOG7TF7BG.
PhylomeDBQ86WI0.
TreeFamTF321143.

Gene expression databases

BgeeQ86WI0.
CleanExHS_LHFPL1.
GenevestigatorQ86WI0.

Family and domain databases

InterProIPR019372. Lipome_HGMIC_fus_partner-like.
[Graphical view]
PfamPF10242. L_HGMIC_fpl. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiLHFPL1.
GenomeRNAi340596.
NextBio97979.
PROQ86WI0.
SOURCESearch...

Entry information

Entry nameLHPL1_HUMAN
AccessionPrimary (citable) accession number: Q86WI0
Secondary accession number(s): A8K1N1 expand/collapse secondary AC list , Q496M9, Q496N0, Q6UXU2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM