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Q86WI0

- LHPL1_HUMAN

UniProt

Q86WI0 - LHPL1_HUMAN

Protein

Lipoma HMGIC fusion partner-like 1 protein

Gene

LHFPL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipoma HMGIC fusion partner-like 1 protein
    Gene namesi
    Name:LHFPL1
    ORF Names:UNQ5824/PRO19643
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:6587. LHFPL1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30359.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 220200Lipoma HMGIC fusion partner-like 1 proteinPRO_0000244760Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ86WI0.

    PTM databases

    PhosphoSiteiQ86WI0.

    Expressioni

    Tissue specificityi

    Widely expressed. Expressed at high levels in lung, thymus, skeletal muscle, colon and ovary.1 Publication

    Gene expression databases

    BgeeiQ86WI0.
    CleanExiHS_LHFPL1.
    GenevestigatoriQ86WI0.

    Organism-specific databases

    HPAiHPA003029.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86WI0.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei86 – 10621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei122 – 14221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LHFP family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG310245.
    HOGENOMiHOG000007007.
    HOVERGENiHBG080585.
    InParanoidiQ86WI0.
    OMAiEAFFESH.
    OrthoDBiEOG7TF7BG.
    PhylomeDBiQ86WI0.
    TreeFamiTF321143.

    Family and domain databases

    InterProiIPR019372. Lipome_HGMIC_fus_partner-like.
    [Graphical view]
    PfamiPF10242. L_HGMIC_fpl. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86WI0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRSSLTMVGT LWAFLSLVTA VTSSTSYFLP YWLFGSQMGK PVSFSTFRRC    50
    NYPVRGEGHS LIMVEECGRY ASFNAIPSLA WQMCTVVTGA GCALLLLVAL 100
    AAVLGCCMEE LISRMMGRCM GAAQFVGGLL ISSGCALYPL GWNSPEIMQT 150
    CGNVSNQFQL GTCRLGWAYY CAGGGAAAAM LICTWLSCFA GRNPKPVILV 200
    ESIMRNTNSY AMELDHCLKP 220
    Length:220
    Mass (Da):23,777
    Last modified:June 1, 2003 - v1
    Checksum:i6BD3E610319E0CF2
    GO
    Isoform 2 (identifier: Q86WI0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         129-161: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:187
    Mass (Da):20,253
    Checksum:iA035C06E3888D1EE
    GO
    Isoform 3 (identifier: Q86WI0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-179: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:41
    Mass (Da):4,697
    Checksum:i221F0030D75AAF1F
    GO

    Sequence cautioni

    The sequence AAQ88575.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 179179Missing in isoform 3. 1 PublicationVSP_019616Add
    BLAST
    Alternative sequencei129 – 16133Missing in isoform 2. 1 PublicationVSP_019617Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY217350 mRNA. Translation: AAO60107.1.
    AY358208 mRNA. Translation: AAQ88575.1. Different initiation.
    AK289946 mRNA. Translation: BAF82635.1.
    BC100785 mRNA. Translation: AAI00786.1.
    BC100786 mRNA. Translation: AAI00787.1.
    BC100787 mRNA. Translation: AAI00788.1.
    CCDSiCCDS14562.1. [Q86WI0-1]
    RefSeqiNP_835469.1. NM_178175.3. [Q86WI0-1]
    XP_005262185.1. XM_005262128.1.
    UniGeneiHs.297420.

    Genome annotation databases

    EnsembliENST00000371968; ENSP00000361036; ENSG00000182508. [Q86WI0-1]
    GeneIDi340596.
    KEGGihsa:340596.
    UCSCiuc004epp.3. human. [Q86WI0-1]
    uc010nqb.3. human. [Q86WI0-2]

    Polymorphism databases

    DMDMi74714099.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY217350 mRNA. Translation: AAO60107.1 .
    AY358208 mRNA. Translation: AAQ88575.1 . Different initiation.
    AK289946 mRNA. Translation: BAF82635.1 .
    BC100785 mRNA. Translation: AAI00786.1 .
    BC100786 mRNA. Translation: AAI00787.1 .
    BC100787 mRNA. Translation: AAI00788.1 .
    CCDSi CCDS14562.1. [Q86WI0-1 ]
    RefSeqi NP_835469.1. NM_178175.3. [Q86WI0-1 ]
    XP_005262185.1. XM_005262128.1.
    UniGenei Hs.297420.

    3D structure databases

    ProteinModelPortali Q86WI0.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q86WI0.

    Polymorphism databases

    DMDMi 74714099.

    Proteomic databases

    PRIDEi Q86WI0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371968 ; ENSP00000361036 ; ENSG00000182508 . [Q86WI0-1 ]
    GeneIDi 340596.
    KEGGi hsa:340596.
    UCSCi uc004epp.3. human. [Q86WI0-1 ]
    uc010nqb.3. human. [Q86WI0-2 ]

    Organism-specific databases

    CTDi 340596.
    GeneCardsi GC0XM111873.
    HGNCi HGNC:6587. LHFPL1.
    HPAi HPA003029.
    MIMi 300566. gene.
    neXtProti NX_Q86WI0.
    PharmGKBi PA30359.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG310245.
    HOGENOMi HOG000007007.
    HOVERGENi HBG080585.
    InParanoidi Q86WI0.
    OMAi EAFFESH.
    OrthoDBi EOG7TF7BG.
    PhylomeDBi Q86WI0.
    TreeFami TF321143.

    Miscellaneous databases

    GeneWikii LHFPL1.
    GenomeRNAii 340596.
    NextBioi 97979.
    PROi Q86WI0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q86WI0.
    CleanExi HS_LHFPL1.
    Genevestigatori Q86WI0.

    Family and domain databases

    InterProi IPR019372. Lipome_HGMIC_fus_partner-like.
    [Graphical view ]
    Pfami PF10242. L_HGMIC_fpl. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, tissue distribution and prokaryotic expression of a novel human X-linked gene LHFPL1."
      Huang C., Guo J., Liu S., Shan Y., Wu S., Cai Y., Yu L.
      DNA Seq. 15:299-302(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Hippocampus.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).

    Entry informationi

    Entry nameiLHPL1_HUMAN
    AccessioniPrimary (citable) accession number: Q86WI0
    Secondary accession number(s): A8K1N1
    , Q496M9, Q496N0, Q6UXU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3