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Q86WH2 (RASF3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras association domain-containing protein 3
Gene names
Name:RASSF3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length238 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasm. Cytoplasmcytoskeleton. Note: Localized to microtubules in vascular endothelial cells. Ref.4

Tissue specificity

Widely expressed. Ref.3

Sequence similarities

Contains 1 Ras-associating domain.

Contains 1 SARAH domain.

Caution

Was termed (Ref.1) RASSF5.

Binary interactions

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86WH2-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86WH2-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     74-90: NSNGIYTGFIKVQMELC → STPASSQTGNIHSTCVW
     91-238: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 238237Ras association domain-containing protein 3
PRO_0000240396

Regions

Domain79 – 186108Ras-associating
Domain187 – 23448SARAH

Amino acid modifications

Modified residue21N-acetylserine Ref.5

Natural variations

Alternative sequence74 – 9017NSNGI…QMELC → STPASSQTGNIHSTCVW in isoform 2.
VSP_019353
Alternative sequence91 – 238148Missing in isoform 2.
VSP_019354
Natural variant2321R → H. Ref.3
Corresponds to variant rs74098110 [ dbSNP | Ensembl ].
VAR_026724

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (A) [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 2C8AD10649259811

FASTA23827,562
        10         20         30         40         50         60 
MSSGYSSLEE DAEDFFFTAR TSFFRRAPQG KPRSGQQDVE KEKETHSYLS KEEIKEKVHK 

        70         80         90        100        110        120 
YNLAVTDKLK MTLNSNGIYT GFIKVQMELC KPPQTSPNSG KLSPSSNGCM NTLHISSTNT 

       130        140        150        160        170        180 
VGEVIEALLK KFLVTESPAK FALYKRCHRE DQVYACKLSD REHPLYLRLV AGPRTDTLSF 

       190        200        210        220        230 
VLREHEIGEW EAFSLPELQN FLRILDKEED EQLQNLKRRY TAYRQKLEEA LREVWKPD 

« Hide

Isoform 2 (B) [UniParc].

Checksum: EEFFEA9B843855E2
Show »

FASTA9010,265

References

« Hide 'large scale' references
[1]"RASSF5 is transcriptionally inactivated by an epigenetic mechanism in ovarian cancers."
Burbee D.G., White M.A., Miller D.S., Minna J.D., Muller C.Y.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1."
Tommasi S., Dammann R., Jin S.-G., Zhang X.-F., Avruch J., Pfeifer G.P.
Oncogene 21:2713-2720(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, VARIANT HIS-232.
[4]"Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes."
Fujita H., Fukuhara S., Sakurai A., Yamagishi A., Kamioka Y., Nakaoka Y., Masuda M., Mochizuki N.
J. Biol. Chem. 280:5022-5031(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[5]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY217662 mRNA. Translation: AAO61687.1.
AY217663 mRNA. Translation: AAO61688.1.
BC100951 mRNA. Translation: AAI00952.1.
BC100949 mRNA. Translation: AAI00950.1.
CCDSCCDS8969.1. [Q86WH2-1]
RefSeqNP_835463.1. NM_178169.3. [Q86WH2-1]
UniGeneHs.643605.

3D structure databases

ProteinModelPortalQ86WH2.
SMRQ86WH2. Positions 52-185, 189-233.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129534. 5 interactions.
IntActQ86WH2. 22 interactions.
STRING9606.ENSP00000336616.

PTM databases

PhosphoSiteQ86WH2.

Polymorphism databases

DMDM74714093.

Proteomic databases

MaxQBQ86WH2.
PaxDbQ86WH2.
PRIDEQ86WH2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000283172; ENSP00000283172; ENSG00000153179. [Q86WH2-2]
ENST00000336061; ENSP00000336616; ENSG00000153179. [Q86WH2-1]
ENST00000542104; ENSP00000443021; ENSG00000153179. [Q86WH2-1]
GeneID283349.
KEGGhsa:283349.
UCSCuc001ssd.3. human. [Q86WH2-1]

Organism-specific databases

CTD283349.
GeneCardsGC12P065004.
HGNCHGNC:14271. RASSF3.
HPACAB034035.
HPA038469.
MIM607019. gene.
neXtProtNX_Q86WH2.
PharmGKBPA34247.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG257702.
HOGENOMHOG000013025.
HOVERGENHBG054362.
InParanoidQ86WH2.
KOK09852.
OMANEIVACH.
OrthoDBEOG7TF796.
PhylomeDBQ86WH2.
TreeFamTF319243.

Gene expression databases

ArrayExpressQ86WH2.
BgeeQ86WH2.
CleanExHS_RASSF3.
GenevestigatorQ86WH2.

Family and domain databases

InterProIPR000159. Ras-assoc.
IPR011524. SARAH_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamPF00788. RA. 1 hit.
[Graphical view]
SMARTSM00314. RA. 1 hit.
[Graphical view]
SUPFAMSSF54236. SSF54236. 1 hit.
PROSITEPS50200. RA. 1 hit.
PS50951. SARAH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRASSF3. human.
GenomeRNAi283349.
NextBio93829.
PROQ86WH2.
SOURCESearch...

Entry information

Entry nameRASF3_HUMAN
AccessionPrimary (citable) accession number: Q86WH2
Secondary accession number(s): Q86WH1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM