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Q86WH2

- RASF3_HUMAN

UniProt

Q86WH2 - RASF3_HUMAN

Protein

Ras association domain-containing protein 3

Gene

RASSF3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. protein binding Source: IntAct

    GO - Biological processi

    1. signal transduction Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras association domain-containing protein 3
    Gene namesi
    Name:RASSF3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:14271. RASSF3.

    Subcellular locationi

    Cytoplasm 1 Publication. Cytoplasmcytoskeleton 1 Publication
    Note: Localized to microtubules in vascular endothelial cells.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. microtubule Source: UniProtKB-KW
    3. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34247.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 238237Ras association domain-containing protein 3PRO_0000240396Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ86WH2.
    PaxDbiQ86WH2.
    PRIDEiQ86WH2.

    PTM databases

    PhosphoSiteiQ86WH2.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ86WH2.
    BgeeiQ86WH2.
    CleanExiHS_RASSF3.
    GenevestigatoriQ86WH2.

    Organism-specific databases

    HPAiCAB034035.
    HPA038469.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-2845202,EBI-2845202
    STK3Q131886EBI-2845202,EBI-992580
    STK4Q130436EBI-2845202,EBI-367376

    Protein-protein interaction databases

    BioGridi129534. 5 interactions.
    IntActiQ86WH2. 22 interactions.
    STRINGi9606.ENSP00000336616.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86WH2.
    SMRiQ86WH2. Positions 52-185, 189-233.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini79 – 186108Ras-associatingPROSITE-ProRule annotationAdd
    BLAST
    Domaini187 – 23448SARAHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Ras-associating domain.PROSITE-ProRule annotation
    Contains 1 SARAH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG257702.
    HOGENOMiHOG000013025.
    HOVERGENiHBG054362.
    InParanoidiQ86WH2.
    KOiK09852.
    OMAiNEIVACH.
    OrthoDBiEOG7TF796.
    PhylomeDBiQ86WH2.
    TreeFamiTF319243.

    Family and domain databases

    InterProiIPR000159. Ras-assoc.
    IPR011524. SARAH_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF00788. RA. 1 hit.
    [Graphical view]
    SMARTiSM00314. RA. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS50200. RA. 1 hit.
    PS50951. SARAH. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86WH2-1) [UniParc]FASTAAdd to Basket

    Also known as: A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSGYSSLEE DAEDFFFTAR TSFFRRAPQG KPRSGQQDVE KEKETHSYLS    50
    KEEIKEKVHK YNLAVTDKLK MTLNSNGIYT GFIKVQMELC KPPQTSPNSG 100
    KLSPSSNGCM NTLHISSTNT VGEVIEALLK KFLVTESPAK FALYKRCHRE 150
    DQVYACKLSD REHPLYLRLV AGPRTDTLSF VLREHEIGEW EAFSLPELQN 200
    FLRILDKEED EQLQNLKRRY TAYRQKLEEA LREVWKPD 238
    Length:238
    Mass (Da):27,562
    Last modified:June 1, 2003 - v1
    Checksum:i2C8AD10649259811
    GO
    Isoform 2 (identifier: Q86WH2-2) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         74-90: NSNGIYTGFIKVQMELC → STPASSQTGNIHSTCVW
         91-238: Missing.

    Show »
    Length:90
    Mass (Da):10,265
    Checksum:iEEFFEA9B843855E2
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti232 – 2321R → H.1 Publication
    Corresponds to variant rs74098110 [ dbSNP | Ensembl ].
    VAR_026724

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei74 – 9017NSNGI…QMELC → STPASSQTGNIHSTCVW in isoform 2. 1 PublicationVSP_019353Add
    BLAST
    Alternative sequencei91 – 238148Missing in isoform 2. 1 PublicationVSP_019354Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY217662 mRNA. Translation: AAO61687.1.
    AY217663 mRNA. Translation: AAO61688.1.
    BC100951 mRNA. Translation: AAI00952.1.
    BC100949 mRNA. Translation: AAI00950.1.
    CCDSiCCDS8969.1. [Q86WH2-1]
    RefSeqiNP_835463.1. NM_178169.3. [Q86WH2-1]
    UniGeneiHs.643605.

    Genome annotation databases

    EnsembliENST00000283172; ENSP00000283172; ENSG00000153179. [Q86WH2-2]
    ENST00000336061; ENSP00000336616; ENSG00000153179. [Q86WH2-1]
    ENST00000542104; ENSP00000443021; ENSG00000153179. [Q86WH2-1]
    GeneIDi283349.
    KEGGihsa:283349.
    UCSCiuc001ssd.3. human. [Q86WH2-1]

    Polymorphism databases

    DMDMi74714093.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY217662 mRNA. Translation: AAO61687.1 .
    AY217663 mRNA. Translation: AAO61688.1 .
    BC100951 mRNA. Translation: AAI00952.1 .
    BC100949 mRNA. Translation: AAI00950.1 .
    CCDSi CCDS8969.1. [Q86WH2-1 ]
    RefSeqi NP_835463.1. NM_178169.3. [Q86WH2-1 ]
    UniGenei Hs.643605.

    3D structure databases

    ProteinModelPortali Q86WH2.
    SMRi Q86WH2. Positions 52-185, 189-233.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129534. 5 interactions.
    IntActi Q86WH2. 22 interactions.
    STRINGi 9606.ENSP00000336616.

    PTM databases

    PhosphoSitei Q86WH2.

    Polymorphism databases

    DMDMi 74714093.

    Proteomic databases

    MaxQBi Q86WH2.
    PaxDbi Q86WH2.
    PRIDEi Q86WH2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000283172 ; ENSP00000283172 ; ENSG00000153179 . [Q86WH2-2 ]
    ENST00000336061 ; ENSP00000336616 ; ENSG00000153179 . [Q86WH2-1 ]
    ENST00000542104 ; ENSP00000443021 ; ENSG00000153179 . [Q86WH2-1 ]
    GeneIDi 283349.
    KEGGi hsa:283349.
    UCSCi uc001ssd.3. human. [Q86WH2-1 ]

    Organism-specific databases

    CTDi 283349.
    GeneCardsi GC12P065004.
    HGNCi HGNC:14271. RASSF3.
    HPAi CAB034035.
    HPA038469.
    MIMi 607019. gene.
    neXtProti NX_Q86WH2.
    PharmGKBi PA34247.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG257702.
    HOGENOMi HOG000013025.
    HOVERGENi HBG054362.
    InParanoidi Q86WH2.
    KOi K09852.
    OMAi NEIVACH.
    OrthoDBi EOG7TF796.
    PhylomeDBi Q86WH2.
    TreeFami TF319243.

    Miscellaneous databases

    ChiTaRSi RASSF3. human.
    GenomeRNAii 283349.
    NextBioi 93829.
    PROi Q86WH2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86WH2.
    Bgeei Q86WH2.
    CleanExi HS_RASSF3.
    Genevestigatori Q86WH2.

    Family and domain databases

    InterProi IPR000159. Ras-assoc.
    IPR011524. SARAH_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF00788. RA. 1 hit.
    [Graphical view ]
    SMARTi SM00314. RA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS50200. RA. 1 hit.
    PS50951. SARAH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "RASSF5 is transcriptionally inactivated by an epigenetic mechanism in ovarian cancers."
      Burbee D.G., White M.A., Miller D.S., Minna J.D., Muller C.Y.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1."
      Tommasi S., Dammann R., Jin S.-G., Zhang X.-F., Avruch J., Pfeifer G.P.
      Oncogene 21:2713-2720(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, VARIANT HIS-232.
    4. "Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes."
      Fujita H., Fukuhara S., Sakurai A., Yamagishi A., Kamioka Y., Nakaoka Y., Masuda M., Mochizuki N.
      J. Biol. Chem. 280:5022-5031(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRASF3_HUMAN
    AccessioniPrimary (citable) accession number: Q86WH2
    Secondary accession number(s): Q86WH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was termed (PubMed:15489334) RASSF5.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3