Q86WG5 (MTMRD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myotubularin-related protein 13

Alternative name(s):
SET-binding factor 2

Gene names

Name:	SBF2
Synonyms:	CMT4B2, KIAA1766, MTMR13

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1849 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Guanine nucleotide exchange factor (GEF) which may activate RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Ref.10
Subunit structure	Interacts with MTMR2. Ref.8
Subcellular location	Cytoplasm. Membrane; Peripheral membrane protein. Note: Associated with membranes. Ref.8
Tissue specificity	Widely expressed. Expressed in spinal cord. Ref.1
Involvement in disease	Charcot-Marie-Tooth disease 4B2 (CMT4B2) [MIM:604563]: A recessive demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.1 Ref.5 Ref.6 Ref.7
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. Contains 1 dDENN domain. Contains 1 DENN domain. Contains 1 GRAM domain. Contains 1 myotubularin phosphatase domain. Contains 1 PH domain. Contains 1 uDENN domain.
Caution	In contrast to other members of the family, it lacks a canonical protein-tyrosine phosphatase domain and lacks the conserved Cys residue in position 1410 which is replaced by a Leu residue. It therefore probably does not have phosphatase activity.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Charcot-Marie-Tooth disease Neuropathy
Molecular function	Guanine-nucleotide releasing factor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	myelination Non-traceable author statement Ref.8. Source: UniProtKB protein tetramerization Inferred from electronic annotation. Source: Compara
Cellular_component	membrane Inferred from direct assay Ref.8. Source: UniProtKB vacuolar membrane Inferred from electronic annotation. Source: Compara
Molecular_function	Rab guanyl-nucleotide exchange factor activity Inferred from direct assay Ref.10. Source: UniProtKB phosphatase activity Inferred from electronic annotation. Source: InterPro phosphatase regulator activity Inferred from electronic annotation. Source: Compara phosphatidylinositol binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86WG5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 3 (identifier: Q86WG5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1152-1152: S → R
     1153-1849: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1849	1849	Myotubularin-related protein 13		PRO_0000094945
Regions
	Domain	18 – 86	69	UDENN
	Domain	116 – 298	183	DENN
	Domain	351 – 420	70	dDENN
	Domain	871 – 957	87	GRAM
	Domain	1108 – 1584	477	Myotubularin phosphatase
	Domain	1743 – 1847	105	PH
	Region	1630 – 1683	54	Interaction with MTMR2
Amino acid modifications
	Modified residue	1127	1	Phosphoserine Ref.11
Natural variations
	Alternative sequence	1152	1	S → R in isoform 3.		VSP_017157
	Alternative sequence	1153 – 1849	697	Missing in isoform 3.		VSP_017158
	Natural variant	303	1	P → L. Corresponds to variant rs16907355 [ dbSNP | Ensembl ].		VAR_051766
	Natural variant	679	1	E → K. Corresponds to variant rs7102464 [ dbSNP | Ensembl ].		VAR_051767
	Natural variant	1216	1	Q → E. Ref.2 Corresponds to variant rs12574508 [ dbSNP | Ensembl ].		VAR_051768
Experimental info
	Sequence conflict	1586	1	E → G in CAH18167. Ref.4
	Sequence conflict	1665	1	E → V in CAH18167. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 9EDBA3E3AC05DD3E	FASTA	1,849	208,464
	10 20 30 40 50 60 MARLADYFIV VGYDHEKPGS GEGLGKIIQR FPQKDWDDTP FPQGIELFCQ PGGWQLSRER 70 80 90 100 110 120 KQPTFFVVVL TDIDSDRHYC SCLTFYEAEI NLQGTKKEEI EGEAKVSGLI QPAEVFAPKS 130 140 150 160 170 180 LVLVSRLYYP EIFRACLGLI YTVYVDSLNV SLESLIANLC ACLVPAAGGS QKLFSLGAGD 190 200 210 220 230 240 RQLIQTPLHD SLPITGTSVA LLFQQLGIQN VLSLFCAVLT ENKVLFHSAS FQRLSDACRA 250 260 270 280 290 300 LESLMFPLKY SYPYIPILPA QLLEVLSSPT PFIIGVHSVF KTDVHELLDV IIADLDGGTI 310 320 330 340 350 360 KIPECIHLSS LPEPLLHQTQ SALSLILHPD LEVADHAFPP PRTALSHSKM LDKEVRAVFL 370 380 390 400 410 420 RLFAQLFQGY RSCLQLIRIH AEPVIHFHKT AFLGQRGLVE NDFLTKVLSG MAFAGFVSER 430 440 450 460 470 480 GPPYRSCDLF DELVAFEVER IKVEENNPVK MIKHVRELAE QLFKNENPNP HMAFQKVPRP 490 500 510 520 530 540 TEGSHLRVHI LPFPEINEAR VQELIQENVA KNQNAPPATR IEKKCVVPAG PPVVSIMDKV 550 560 570 580 590 600 TTVFNSAQRL EVVRNCISFI FENKILETEK TLPAALRALK GKAARQCLTD ELGLHVQQNR 610 620 630 640 650 660 AILDHQQFDY IIRMMNCTLQ DCSSLEEYNI AAALLPLTSA FYRKLAPGVS QFAYTCVQDH 670 680 690 700 710 720 PIWTNQQFWE TTFYNAVQEQ VRSLYLSAKE DNHAPHLKQK DKLPDDHYQE KTAMDLAAEQ 730 740 750 760 770 780 LRLWPTLSKS TQQELVQHEE STVFSQAIHF ANLMVNLLVP LDTSKNKLLR TSAPGDWESG 790 800 810 820 830 840 SNSIVTNSIA GSVAESYDTE SGFEDSENTD IANSVVRFIT RFIDKVCTES GVTQDHIKSL 850 860 870 880 890 900 HCMIPGIVAM HIETLEAVHR ESRRLPPIQK PKILRPALLP GEEIVCEGLR VLLDPDGREE 910 920 930 940 950 960 ATGGLLGGPQ LLPAEGALFL TTYRILFRGT PHDQLVGEQT VVRSFPIASI TKEKKITMQN 970 980 990 1000 1010 1020 QLQQNMQEGL QITSASFQLI KVAFDEEVSP EVVEIFKKQL MKFRYPQSIF STFAFAAGQT 1030 1040 1050 1060 1070 1080 TPQIILPKQK EKNTSFRTFS KTIVKGAKRA GKMTIGRQYL LKKKTGTIVE ERVNRPGWNE 1090 1100 1110 1120 1130 1140 DDDVSVSDES ELPTSTTLKA SEKSTMEQLV EKACFRDYQR LGLGTISGSS SRSRPEYFRI 1150 1160 1170 1180 1190 1200 TASNRMYSLC RSYPGLLVVP QAVQDSSLPR VARCYRHNRL PVVCWKNSRS GTLLLRSGGF 1210 1220 1230 1240 1250 1260 HGKGVVGLFK SQNSPQAAPT SSLESSSSIE QEKYLQALLN AVSVHQKLRG NSTLTVRPAF 1270 1280 1290 1300 1310 1320 ALSPGVWASL RSSTRLISSP TSFIDVGARL AGKDHSASFS NSSYLQNQLL KRQAALYIFG 1330 1340 1350 1360 1370 1380 EKSQLRNFKV EFALNCEFVP VEFHEIRQVK ASFKKLMRAC IPSTIPTDSE VTFLKALGDS 1390 1400 1410 1420 1430 1440 EWFPQLHRIM QLAVVVSEVL ENGSSVLVCL EEGWDITAQV TSLVQLLSDP FYRTLEGFQM 1450 1460 1470 1480 1490 1500 LVEKEWLSFG HKFSQRSSLT LNCQGSGFAP VFLQFLDCVH QVHNQYPTEF EFNLYYLKFL 1510 1520 1530 1540 1550 1560 AFHYVSNRFK TFLLDSDYER LEHGTLFDDK GEKHAKKGVC IWECIDRMHK RSPIFFNYLY 1570 1580 1590 1600 1610 1620 SPLEIEALKP NVNVSSLKKW DYYIEETLST GPSYDWMMLT PKHFPSEDSD LAGEAGPRSQ 1630 1640 1650 1660 1670 1680 RRTVWPCYDD VSCTQPDALT SLFSEIEKLE HKLNQAPEKW QQLWERVTVD LKEEPRTDRS 1690 1700 1710 1720 1730 1740 QRHLSRSPGI VSTNLPSYQK RSLLHLPDSS MGEEQNSSIS PSNGVERRAA TLYSQYTSKN 1750 1760 1770 1780 1790 1800 DENRSFEGTL YKRGALLKGW KPRWFVLDVT KHQLRYYDSG EDTSCKGHID LAEVEMVIPA 1810 1820 1830 1840 GPSMGAPKHT SDKAFFDLKT SKRVYNFCAQ DGQSAQQWMD KIQSCISDA
	Isoform 3 [UniParc]. Checksum: AE52CCAFC9E5C70F	FASTA	1,152	129,344
	10 20 30 40 50 60 MARLADYFIV VGYDHEKPGS GEGLGKIIQR FPQKDWDDTP FPQGIELFCQ PGGWQLSRER 70 80 90 100 110 120 KQPTFFVVVL TDIDSDRHYC SCLTFYEAEI NLQGTKKEEI EGEAKVSGLI QPAEVFAPKS 130 140 150 160 170 180 LVLVSRLYYP EIFRACLGLI YTVYVDSLNV SLESLIANLC ACLVPAAGGS QKLFSLGAGD 190 200 210 220 230 240 RQLIQTPLHD SLPITGTSVA LLFQQLGIQN VLSLFCAVLT ENKVLFHSAS FQRLSDACRA 250 260 270 280 290 300 LESLMFPLKY SYPYIPILPA QLLEVLSSPT PFIIGVHSVF KTDVHELLDV IIADLDGGTI 310 320 330 340 350 360 KIPECIHLSS LPEPLLHQTQ SALSLILHPD LEVADHAFPP PRTALSHSKM LDKEVRAVFL 370 380 390 400 410 420 RLFAQLFQGY RSCLQLIRIH AEPVIHFHKT AFLGQRGLVE NDFLTKVLSG MAFAGFVSER 430 440 450 460 470 480 GPPYRSCDLF DELVAFEVER IKVEENNPVK MIKHVRELAE QLFKNENPNP HMAFQKVPRP 490 500 510 520 530 540 TEGSHLRVHI LPFPEINEAR VQELIQENVA KNQNAPPATR IEKKCVVPAG PPVVSIMDKV 550 560 570 580 590 600 TTVFNSAQRL EVVRNCISFI FENKILETEK TLPAALRALK GKAARQCLTD ELGLHVQQNR 610 620 630 640 650 660 AILDHQQFDY IIRMMNCTLQ DCSSLEEYNI AAALLPLTSA FYRKLAPGVS QFAYTCVQDH 670 680 690 700 710 720 PIWTNQQFWE TTFYNAVQEQ VRSLYLSAKE DNHAPHLKQK DKLPDDHYQE KTAMDLAAEQ 730 740 750 760 770 780 LRLWPTLSKS TQQELVQHEE STVFSQAIHF ANLMVNLLVP LDTSKNKLLR TSAPGDWESG 790 800 810 820 830 840 SNSIVTNSIA GSVAESYDTE SGFEDSENTD IANSVVRFIT RFIDKVCTES GVTQDHIKSL 850 860 870 880 890 900 HCMIPGIVAM HIETLEAVHR ESRRLPPIQK PKILRPALLP GEEIVCEGLR VLLDPDGREE 910 920 930 940 950 960 ATGGLLGGPQ LLPAEGALFL TTYRILFRGT PHDQLVGEQT VVRSFPIASI TKEKKITMQN 970 980 990 1000 1010 1020 QLQQNMQEGL QITSASFQLI KVAFDEEVSP EVVEIFKKQL MKFRYPQSIF STFAFAAGQT 1030 1040 1050 1060 1070 1080 TPQIILPKQK EKNTSFRTFS KTIVKGAKRA GKMTIGRQYL LKKKTGTIVE ERVNRPGWNE 1090 1100 1110 1120 1130 1140 DDDVSVSDES ELPTSTTLKA SEKSTMEQLV EKACFRDYQR LGLGTISGSS SRSRPEYFRI 1150 TASNRMYSLC RR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mutation of the SBF2 gene, encoding a novel member of the myotubularin family, in Charcot-Marie-Tooth neuropathy type 4B2/11p15." Senderek J., Bergmann C., Weber S., Ketelsen U.-P., Schorle H., Rudnik-Schoeneborn S., Buettner R., Buchheim E., Zerres K. Hum. Mol. Genet. 12:349-356(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INVOLVEMENT IN CMT4B2, TISSUE SPECIFICITY. Tissue: Sciatic nerve.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLU-1216. Tissue: Brain, Cervix, Duodenum and Placenta.
[3]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 30-1152 (ISOFORM 3).
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1187-1849 (ISOFORM 1). Tissue: Fetal brain and Liver.
[5]	"Mutations in MTMR13, a new pseudophosphatase homologue of MTMR2 and Sbf1, in two families with an autosomal recessive demyelinating form of Charcot-Marie-Tooth disease associated with early-onset glaucoma." Azzedine H., Bolino A., Taieb T., Birouk N., Di Duca M., Bouhouche A., Benamou S., Mrabet A., Hammadouche T., Chkili T., Gouider R., Ravazzolo R., Brice A., Laporte J., LeGuern E. Am. J. Hum. Genet. 72:1141-1153(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN CMT4B2.
[6]	"SET binding factor 2 (SBF2) mutation causes CMT4B with juvenile onset glaucoma." Hirano R., Takashima H., Umehara F., Arimura H., Michizono K., Okamoto Y., Nakagawa M., Boerkoel C.F., Lupski J.R., Osame M., Arimura K. Neurology 63:577-580(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN CMT4B2.
[7]	"A new SBF2 mutation in a family with recessive demyelinating Charcot-Marie-Tooth (CMT4B2)." Conforti F.L., Muglia M., Mazzei R., Patitucci A., Valentino P., Magariello A., Sprovieri T., Bono F., Bergmann C., Gabriele A.L., Peluso G., Nistico R., Senderek J., Quattrone A. Neurology 63:1327-1328(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN CMT4B2.
[8]	"The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth disease." Robinson F.L., Dixon J.E. J. Biol. Chem. 280:31699-31707(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MTMR2, SUBCELLULAR LOCATION.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors." Yoshimura S., Gerondopoulos A., Linford A., Rigden D.J., Barr F.A. J. Cell Biol. 191:367-381(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION AS GUANYL-NUCLEOTIDE EXCHANGE FACTOR.
[11]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1127, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Web resources

Inherited peripheral neuropathies mutation db

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY234241 mRNA. Translation: AAO62733.1. BC011143 mRNA. Translation: AAH11143.1. BC043389 mRNA. Translation: AAH43389.1. BC053867 mRNA. Translation: AAH53867.1. BC063656 mRNA. Translation: AAH63656.1. BC101466 mRNA. Translation: AAI01467.1. AB051553 mRNA. Translation: BAB21857.1. BX538184 mRNA. Translation: CAD98056.1. CR749312 mRNA. Translation: CAH18167.1.
IPI	IPI00654703. IPI00719299.
RefSeq	NP_112224.1. NM_030962.3.
UniGene	Hs.577252.
3D structure databases
ProteinModelPortal	Q86WG5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86WG5. 1 interaction.
PTM databases
PhosphoSite	Q86WG5.
Polymorphism databases
DMDM	74750502.
Proteomic databases
PaxDb	Q86WG5.
PRIDE	Q86WG5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000256190; ENSP00000256190; ENSG00000133812.
GeneID	81846.
KEGG	hsa:81846.
UCSC	uc001mib.2. human. uc001mif.3. human.
Organism-specific databases
CTD	81846.
GeneCards	GC11M009800.
HGNC	HGNC:2135. SBF2.
HPA	HPA050933.
MIM	604563. phenotype. 607697. gene.
neXtProt	NX_Q86WG5.
Orphanet	99956. Charcot-Marie-Tooth disease type 4B2.
PharmGKB	PA26649.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG315534.
HOVERGEN	HBG052527.
InParanoid	Q86WG5.
OMA	IGVHSVF.
OrthoDB	EOG48D0TF.
PhylomeDB	Q86WG5.
Gene expression databases
ArrayExpress	Q86WG5.
Bgee	Q86WG5.
Genevestigator	Q86WG5.
GermOnline	ENSG00000133812. Homo sapiens.
Family and domain databases
Gene3D	2.30.29.30. 2 hits.
InterPro	IPR005112. dDENN_dom. IPR001194. DENN_dom. IPR004182. GRAM. IPR010569. Myotub-related. IPR017906. Myotubularin_phosphatase_dom. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR022096. SBF2. IPR005113. uDENN_dom. [Graphical view]
Pfam	PF03455. dDENN. 1 hit. PF02141. DENN. 1 hit. PF02893. GRAM. 1 hit. PF06602. Myotub-related. 1 hit. PF00169. PH. 1 hit. PF12335. SBF2. 1 hit. PF03456. uDENN. 1 hit. [Graphical view]
SMART	SM00801. dDENN. 1 hit. SM00799. DENN. 1 hit. SM00568. GRAM. 1 hit. SM00233. PH. 1 hit. SM00800. uDENN. 1 hit. [Graphical view]
PROSITE	PS50947. DDENN. 1 hit. PS50211. DENN. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS51339. PPASE_MYOTUBULARIN. 1 hit. PS50946. UDENN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SBF2. human.
GenomeRNAi	81846.
NextBio	72146.
SOURCE	Search...

Entry information

Entry name

MTMRD_HUMAN

Accession

Primary (citable) accession number: Q86WG5
Secondary accession number(s): Q3MJF0 , Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.