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Protein

Serpin A9

Gene

SERPINA9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro).1 Publication

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.082.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin A9
Alternative name(s):
Centerin
Germinal center B-cell-expressed transcript 1 protein
Gene namesi
Name:SERPINA9
Synonyms:GCET1, SERPINA11
ORF Names:UNQ692/PRO1337
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:15995. SERPINA9.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular space Source: GO_Central
  3. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38077.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 417394Serpin A9PRO_0000041971Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ86WD7.
PaxDbiQ86WD7.
PRIDEiQ86WD7.

PTM databases

PhosphoSiteiQ86WD7.

Expressioni

Tissue specificityi

Highly expressed in normal germinal center (GC) B-cells and GC B-cell-derived malignancies.4 Publications

Gene expression databases

BgeeiQ86WD7.
CleanExiHS_SERPINA11.
HS_SERPINA9.
GenevestigatoriQ86WD7.

Structurei

3D structure databases

ProteinModelPortaliQ86WD7.
SMRiQ86WD7. Positions 43-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOVERGENiHBG005957.
InParanoidiQ86WD7.
OMAiFLMMITN.
OrthoDBiEOG7QC7W9.
PhylomeDBiQ86WD7.
TreeFamiTF343201.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86WD7-1) [UniParc]FASTAAdd to basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASYLYGVLF AVGLCAPIYC VSPANAPSAY PRPSSTKSTP ASQVYSLNTD
60 70 80 90 100
FAFRLYRRLV LETPSQNIFF SPVSVSTSLA MLSLGAHSVT KTQILQGLGF
110 120 130 140 150
NLTHTPESAI HQGFQHLVHS LTVPSKDLTL KMGSALFVKK ELQLQANFLG
160 170 180 190 200
NVKRLYEAEV FSTDFSNPSI AQARINSHVK KKTQGKVVDI IQGLDLLTAM
210 220 230 240 250
VLVNHIFFKA KWEKPFHPEY TRKNFPFLVG EQVTVHVPMM HQKEQFAFGV
260 270 280 290 300
DTELNCFVLQ MDYKGDAVAF FVLPSKGKMR QLEQALSART LRKWSHSLQK
310 320 330 340 350
RWIEVFIPRF SISASYNLET ILPKMGIQNV FDKNADFSGI AKRDSLQVSK
360 370 380 390 400
ATHKAVLDVS EEGTEATAAT TTKFIVRSKD GPSYFTVSFN RTFLMMITNK
410
ATDGILFLGK VENPTKS
Length:417
Mass (Da):46,557
Last modified:November 24, 2008 - v3
Checksum:iC7693D34FD2E12AB
GO
Isoform 2 (identifier: Q86WD7-2) [UniParc]FASTAAdd to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQGQGRRRGTCKDIFCSKM
     73-172: Missing.

Show »
Length:335
Mass (Da):37,776
Checksum:i5141D59448BC3077
GO
Isoform 3 (identifier: Q86WD7-3) [UniParc]FASTAAdd to basket

Also known as: SERPINA11a

The sequence of this isoform differs from the canonical sequence as follows:
     1-417: MASYLYGVLF...LGKVENPTKS → MRSAGGRGEI...KFLGQCQEAV

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

Show »
Length:201
Mass (Da):21,908
Checksum:iF805EC2CB516559E
GO
Isoform 4 (identifier: Q86WD7-4) [UniParc]FASTAAdd to basket

Also known as: SERPINA11b

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: MASYLYGVLF...NTDFAFRLYR → MRSAGGRGEI...RTGQEKRNLQ
     351-352: AT → VS
     353-417: Missing.

Show »
Length:334
Mass (Da):37,665
Checksum:i619119ADE7028784
GO
Isoform 5 (identifier: Q86WD7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.

Show »
Length:286
Mass (Da):32,400
Checksum:i529682149DC6DD49
GO
Isoform 6 (identifier: Q86WD7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.

Show »
Length:337
Mass (Da):37,915
Checksum:iC948BF44A88BC48F
GO
Isoform 7 (identifier: Q86WD7-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQGQGRRRGTCKDIFCSKM

Show »
Length:435
Mass (Da):48,610
Checksum:i66C6CB6397A442D6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231P → L in AAO65242 (PubMed:12819018).Curated
Sequence conflicti23 – 231P → L in AAO65243 (PubMed:12819018).Curated
Sequence conflicti23 – 231P → L in AAQ89063 (PubMed:12975309).Curated
Sequence conflicti93 – 931Q → E in BAG62686 (PubMed:14702039).Curated
Sequence conflicti174 – 1741R → G in AAO65245 (PubMed:12819018).Curated
Sequence conflicti207 – 2071F → S in BAG62686 (PubMed:14702039).Curated
Sequence conflicti224 – 2241N → D in AAO65242 (PubMed:12819018).Curated
Sequence conflicti228 – 2281L → P in AAO65244 (PubMed:12819018).Curated
Sequence conflicti371 – 3711T → A in AAO65242 (PubMed:12819018).Curated
Sequence conflicti411 – 4111V → A in AAO65243 (PubMed:12819018).Curated
Sequence conflicti411 – 4111V → A in BAG62686 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241A → V.
Corresponds to variant rs4905204 [ dbSNP | Ensembl ].
VAR_047344
Natural varianti218 – 2181P → L.1 Publication
Corresponds to variant rs17090921 [ dbSNP | Ensembl ].
VAR_047345
Natural varianti236 – 2361H → Q.1 Publication
Corresponds to variant rs28583900 [ dbSNP | Ensembl ].
VAR_047346
Natural varianti292 – 2921R → I.1 Publication
Corresponds to variant rs28618118 [ dbSNP | Ensembl ].
VAR_047347
Natural varianti330 – 3301V → A.2 Publications
Corresponds to variant rs11628722 [ dbSNP | Ensembl ].
VAR_047348

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 417417MASYL…NPTKS → MRSAGGRGEIKVRRELQPSK QVSGLTNHARTGQEKRNLQR HILFQNGILPLWSTLCCWPL CSNLLCVPGQCPQCIPPPFL HKEHPCLTGVFPQHRLCLPP IPQAGFGDPESEHLLLPCEC LHFPGHALPWGPLSHQDPDS PGPGLQPHTHTRVCHPPGLP APGSLTDCSQQRPDLEDGKC PLRQEGAAAAGKFLGQCQEA V in isoform 3. 1 PublicationVSP_041492Add
BLAST
Alternative sequencei1 – 131131Missing in isoform 5. 1 PublicationVSP_041488Add
BLAST
Alternative sequencei1 – 8080Missing in isoform 6. 1 PublicationVSP_041489Add
BLAST
Alternative sequencei1 – 5757MASYL…FRLYR → MRSAGGRGEIKVRRELQPSK QVSGLTNHARTGQEKRNLQ in isoform 4. 1 PublicationVSP_041490Add
BLAST
Alternative sequencei1 – 11M → MQGQGRRRGTCKDIFCSKM in isoform 2 and isoform 7. 3 PublicationsVSP_041491
Alternative sequencei73 – 172100Missing in isoform 2. 1 PublicationVSP_041493Add
BLAST
Alternative sequencei351 – 3522AT → VS in isoform 4. 1 PublicationVSP_041494
Alternative sequencei353 – 41765Missing in isoform 4. 1 PublicationVSP_041495Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY220118 mRNA. Translation: AAO65242.1.
AY220119 mRNA. Translation: AAO65243.1.
AY220120 mRNA. Translation: AAO65244.1.
AY220121 mRNA. Translation: AAO65245.1.
AY185496 mRNA. Translation: AAO32345.1. Sequence problems.
AY185497 mRNA. Translation: AAO32346.1.
AY358700 mRNA. Translation: AAQ89063.1.
AK301082 mRNA. Translation: BAG62686.1.
AL132708 Genomic DNA. No translation available.
BC111498 mRNA. Translation: AAI11499.1.
CCDSiCCDS41982.1. [Q86WD7-7]
CCDS41983.1. [Q86WD7-2]
CCDS61542.1. [Q86WD7-5]
RefSeqiNP_001035983.1. NM_001042518.1. [Q86WD7-2]
NP_001271204.1. NM_001284275.1.
NP_001271205.1. NM_001284276.1. [Q86WD7-5]
NP_783866.2. NM_175739.3. [Q86WD7-7]
UniGeneiHs.317970.

Genome annotation databases

EnsembliENST00000298845; ENSP00000298845; ENSG00000170054. [Q86WD7-2]
ENST00000337425; ENSP00000337133; ENSG00000170054. [Q86WD7-7]
ENST00000380365; ENSP00000369723; ENSG00000170054. [Q86WD7-1]
ENST00000424550; ENSP00000409012; ENSG00000170054. [Q86WD7-5]
ENST00000448305; ENSP00000414092; ENSG00000170054. [Q86WD7-6]
ENST00000538527; ENSP00000441511; ENSG00000170054. [Q86WD7-3]
ENST00000546329; ENSP00000445476; ENSG00000170054. [Q86WD7-4]
GeneIDi327657.
KEGGihsa:327657.
UCSCiuc001yde.3. human. [Q86WD7-2]
uc001ydf.3. human. [Q86WD7-7]
uc001ydg.3. human. [Q86WD7-1]
uc001ydi.1. human. [Q86WD7-4]

Polymorphism databases

DMDMi215274213.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY220118 mRNA. Translation: AAO65242.1.
AY220119 mRNA. Translation: AAO65243.1.
AY220120 mRNA. Translation: AAO65244.1.
AY220121 mRNA. Translation: AAO65245.1.
AY185496 mRNA. Translation: AAO32345.1. Sequence problems.
AY185497 mRNA. Translation: AAO32346.1.
AY358700 mRNA. Translation: AAQ89063.1.
AK301082 mRNA. Translation: BAG62686.1.
AL132708 Genomic DNA. No translation available.
BC111498 mRNA. Translation: AAI11499.1.
CCDSiCCDS41982.1. [Q86WD7-7]
CCDS41983.1. [Q86WD7-2]
CCDS61542.1. [Q86WD7-5]
RefSeqiNP_001035983.1. NM_001042518.1. [Q86WD7-2]
NP_001271204.1. NM_001284275.1.
NP_001271205.1. NM_001284276.1. [Q86WD7-5]
NP_783866.2. NM_175739.3. [Q86WD7-7]
UniGeneiHs.317970.

3D structure databases

ProteinModelPortaliQ86WD7.
SMRiQ86WD7. Positions 43-416.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI04.082.

PTM databases

PhosphoSiteiQ86WD7.

Polymorphism databases

DMDMi215274213.

Proteomic databases

MaxQBiQ86WD7.
PaxDbiQ86WD7.
PRIDEiQ86WD7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298845; ENSP00000298845; ENSG00000170054. [Q86WD7-2]
ENST00000337425; ENSP00000337133; ENSG00000170054. [Q86WD7-7]
ENST00000380365; ENSP00000369723; ENSG00000170054. [Q86WD7-1]
ENST00000424550; ENSP00000409012; ENSG00000170054. [Q86WD7-5]
ENST00000448305; ENSP00000414092; ENSG00000170054. [Q86WD7-6]
ENST00000538527; ENSP00000441511; ENSG00000170054. [Q86WD7-3]
ENST00000546329; ENSP00000445476; ENSG00000170054. [Q86WD7-4]
GeneIDi327657.
KEGGihsa:327657.
UCSCiuc001yde.3. human. [Q86WD7-2]
uc001ydf.3. human. [Q86WD7-7]
uc001ydg.3. human. [Q86WD7-1]
uc001ydi.1. human. [Q86WD7-4]

Organism-specific databases

CTDi327657.
GeneCardsiGC14M094929.
H-InvDBHIX0037697.
HGNCiHGNC:15995. SERPINA9.
MIMi615677. gene.
neXtProtiNX_Q86WD7.
PharmGKBiPA38077.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOVERGENiHBG005957.
InParanoidiQ86WD7.
OMAiFLMMITN.
OrthoDBiEOG7QC7W9.
PhylomeDBiQ86WD7.
TreeFamiTF343201.

Miscellaneous databases

ChiTaRSiSERPINA9. human.
GeneWikiiSERPINA9.
GenomeRNAii327657.
NextBioi96722.
PROiQ86WD7.
SOURCEiSearch...

Gene expression databases

BgeeiQ86WD7.
CleanExiHS_SERPINA11.
HS_SERPINA9.
GenevestigatoriQ86WD7.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two newly characterized germinal center B-cell-associated genes, GCET1 and GCET2, have differential expression in normal and neoplastic B cells."
    Pan Z., Shen Y., Du C., Zhou G., Rosenwald A., Staudt L.M., Greiner T.C., McKeithan T.W., Chan W.C.
    Am. J. Pathol. 163:135-144(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 5; 6 AND 7), VARIANT ALA-330, TISSUE SPECIFICITY.
  2. Ju S.G., Zhang X.G.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
    Tissue: Blood.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS LEU-218; GLN-236; ILE-292 AND ALA-330.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
    Tissue: Spleen.
  5. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
    Tissue: Lymph.
  7. "Molecular characterization of centerin, a germinal centre cell serpin."
    Paterson M.A., Horvath A.J., Pike R.N., Coughlin P.B.
    Biochem. J. 405:489-494(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY.
  8. "Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas."
    Paterson M.A., Hosking P.S., Coughlin P.B.
    Am. J. Clin. Pathol. 130:117-126(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  9. "Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas."
    Montes-Moreno S., Roncador G., Maestre L., Martinez N., Sanchez-Verde L., Camacho F.I., Cannata J., Martinez-Torrecuadrada J.L., Shen Y., Chan W.C., Piris M.A.
    Blood 111:351-358(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSPA9_HUMAN
AccessioniPrimary (citable) accession number: Q86WD7
Secondary accession number(s): B4DVH4
, B9ZVX3, Q2T9J2, Q6UWP9, Q86WD4, Q86WD5, Q86WD6, Q86YP6, Q86YP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2005
Last sequence update: November 24, 2008
Last modified: March 3, 2015
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.