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Q86WD7

- SPA9_HUMAN

UniProt

Q86WD7 - SPA9_HUMAN

Protein

Serpin A9

Gene

SERPINA9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 3 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro).1 Publication

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: UniProtKB

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: RefGenome
    2. regulation of proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI04.082.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serpin A9
    Alternative name(s):
    Centerin
    Germinal center B-cell-expressed transcript 1 protein
    Gene namesi
    Name:SERPINA9
    Synonyms:GCET1, SERPINA11
    ORF Names:UNQ692/PRO1337
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:15995. SERPINA9.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular space Source: InterPro
    3. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38077.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 417394Serpin A9PRO_0000041971Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ86WD7.
    PaxDbiQ86WD7.
    PRIDEiQ86WD7.

    PTM databases

    PhosphoSiteiQ86WD7.

    Expressioni

    Tissue specificityi

    Highly expressed in normal germinal center (GC) B-cells and GC B-cell-derived malignancies.4 Publications

    Gene expression databases

    BgeeiQ86WD7.
    CleanExiHS_SERPINA11.
    HS_SERPINA9.
    GenevestigatoriQ86WD7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86WD7.
    SMRiQ86WD7. Positions 43-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    HOVERGENiHBG005957.
    InParanoidiQ86WD7.
    OMAiFLMMITN.
    OrthoDBiEOG7QC7W9.
    PhylomeDBiQ86WD7.
    TreeFamiTF343201.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86WD7-1) [UniParc]FASTAAdd to Basket

    Also known as: A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASYLYGVLF AVGLCAPIYC VSPANAPSAY PRPSSTKSTP ASQVYSLNTD    50
    FAFRLYRRLV LETPSQNIFF SPVSVSTSLA MLSLGAHSVT KTQILQGLGF 100
    NLTHTPESAI HQGFQHLVHS LTVPSKDLTL KMGSALFVKK ELQLQANFLG 150
    NVKRLYEAEV FSTDFSNPSI AQARINSHVK KKTQGKVVDI IQGLDLLTAM 200
    VLVNHIFFKA KWEKPFHPEY TRKNFPFLVG EQVTVHVPMM HQKEQFAFGV 250
    DTELNCFVLQ MDYKGDAVAF FVLPSKGKMR QLEQALSART LRKWSHSLQK 300
    RWIEVFIPRF SISASYNLET ILPKMGIQNV FDKNADFSGI AKRDSLQVSK 350
    ATHKAVLDVS EEGTEATAAT TTKFIVRSKD GPSYFTVSFN RTFLMMITNK 400
    ATDGILFLGK VENPTKS 417
    Length:417
    Mass (Da):46,557
    Last modified:November 25, 2008 - v3
    Checksum:iC7693D34FD2E12AB
    GO
    Isoform 2 (identifier: Q86WD7-2) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MQGQGRRRGTCKDIFCSKM
         73-172: Missing.

    Show »
    Length:335
    Mass (Da):37,776
    Checksum:i5141D59448BC3077
    GO
    Isoform 3 (identifier: Q86WD7-3) [UniParc]FASTAAdd to Basket

    Also known as: SERPINA11a

    The sequence of this isoform differs from the canonical sequence as follows:
         1-417: MASYLYGVLF...LGKVENPTKS → MRSAGGRGEI...KFLGQCQEAV

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

    Show »
    Length:201
    Mass (Da):21,908
    Checksum:iF805EC2CB516559E
    GO
    Isoform 4 (identifier: Q86WD7-4) [UniParc]FASTAAdd to Basket

    Also known as: SERPINA11b

    The sequence of this isoform differs from the canonical sequence as follows:
         1-57: MASYLYGVLF...NTDFAFRLYR → MRSAGGRGEI...RTGQEKRNLQ
         351-352: AT → VS
         353-417: Missing.

    Show »
    Length:334
    Mass (Da):37,665
    Checksum:i619119ADE7028784
    GO
    Isoform 5 (identifier: Q86WD7-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-131: Missing.

    Show »
    Length:286
    Mass (Da):32,400
    Checksum:i529682149DC6DD49
    GO
    Isoform 6 (identifier: Q86WD7-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-80: Missing.

    Show »
    Length:337
    Mass (Da):37,915
    Checksum:iC948BF44A88BC48F
    GO
    Isoform 7 (identifier: Q86WD7-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MQGQGRRRGTCKDIFCSKM

    Show »
    Length:435
    Mass (Da):48,610
    Checksum:i66C6CB6397A442D6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 231P → L in AAO65242. (PubMed:12819018)Curated
    Sequence conflicti23 – 231P → L in AAO65243. (PubMed:12819018)Curated
    Sequence conflicti23 – 231P → L in AAQ89063. (PubMed:12975309)Curated
    Sequence conflicti93 – 931Q → E in BAG62686. (PubMed:14702039)Curated
    Sequence conflicti174 – 1741R → G in AAO65245. (PubMed:12819018)Curated
    Sequence conflicti207 – 2071F → S in BAG62686. (PubMed:14702039)Curated
    Sequence conflicti224 – 2241N → D in AAO65242. (PubMed:12819018)Curated
    Sequence conflicti228 – 2281L → P in AAO65244. (PubMed:12819018)Curated
    Sequence conflicti371 – 3711T → A in AAO65242. (PubMed:12819018)Curated
    Sequence conflicti411 – 4111V → A in AAO65243. (PubMed:12819018)Curated
    Sequence conflicti411 – 4111V → A in BAG62686. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti24 – 241A → V.
    Corresponds to variant rs4905204 [ dbSNP | Ensembl ].
    VAR_047344
    Natural varianti218 – 2181P → L.1 Publication
    Corresponds to variant rs17090921 [ dbSNP | Ensembl ].
    VAR_047345
    Natural varianti236 – 2361H → Q.1 Publication
    Corresponds to variant rs28583900 [ dbSNP | Ensembl ].
    VAR_047346
    Natural varianti292 – 2921R → I.1 Publication
    Corresponds to variant rs28618118 [ dbSNP | Ensembl ].
    VAR_047347
    Natural varianti330 – 3301V → A.2 Publications
    Corresponds to variant rs11628722 [ dbSNP | Ensembl ].
    VAR_047348

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 417417MASYL…NPTKS → MRSAGGRGEIKVRRELQPSK QVSGLTNHARTGQEKRNLQR HILFQNGILPLWSTLCCWPL CSNLLCVPGQCPQCIPPPFL HKEHPCLTGVFPQHRLCLPP IPQAGFGDPESEHLLLPCEC LHFPGHALPWGPLSHQDPDS PGPGLQPHTHTRVCHPPGLP APGSLTDCSQQRPDLEDGKC PLRQEGAAAAGKFLGQCQEA V in isoform 3. 1 PublicationVSP_041492Add
    BLAST
    Alternative sequencei1 – 131131Missing in isoform 5. 1 PublicationVSP_041488Add
    BLAST
    Alternative sequencei1 – 8080Missing in isoform 6. 1 PublicationVSP_041489Add
    BLAST
    Alternative sequencei1 – 5757MASYL…FRLYR → MRSAGGRGEIKVRRELQPSK QVSGLTNHARTGQEKRNLQ in isoform 4. 1 PublicationVSP_041490Add
    BLAST
    Alternative sequencei1 – 11M → MQGQGRRRGTCKDIFCSKM in isoform 2 and isoform 7. 3 PublicationsVSP_041491
    Alternative sequencei73 – 172100Missing in isoform 2. 1 PublicationVSP_041493Add
    BLAST
    Alternative sequencei351 – 3522AT → VS in isoform 4. 1 PublicationVSP_041494
    Alternative sequencei353 – 41765Missing in isoform 4. 1 PublicationVSP_041495Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY220118 mRNA. Translation: AAO65242.1.
    AY220119 mRNA. Translation: AAO65243.1.
    AY220120 mRNA. Translation: AAO65244.1.
    AY220121 mRNA. Translation: AAO65245.1.
    AY185496 mRNA. Translation: AAO32345.1. Sequence problems.
    AY185497 mRNA. Translation: AAO32346.1.
    AY358700 mRNA. Translation: AAQ89063.1.
    AK301082 mRNA. Translation: BAG62686.1.
    AL132708 Genomic DNA. No translation available.
    BC111498 mRNA. Translation: AAI11499.1.
    CCDSiCCDS41982.1. [Q86WD7-7]
    CCDS41983.1. [Q86WD7-2]
    CCDS61542.1. [Q86WD7-5]
    RefSeqiNP_001035983.1. NM_001042518.1. [Q86WD7-2]
    NP_001271204.1. NM_001284275.1.
    NP_001271205.1. NM_001284276.1. [Q86WD7-5]
    NP_783866.2. NM_175739.3. [Q86WD7-7]
    UniGeneiHs.317970.

    Genome annotation databases

    EnsembliENST00000298845; ENSP00000298845; ENSG00000170054. [Q86WD7-2]
    ENST00000337425; ENSP00000337133; ENSG00000170054. [Q86WD7-7]
    ENST00000380365; ENSP00000369723; ENSG00000170054. [Q86WD7-1]
    ENST00000424550; ENSP00000409012; ENSG00000170054. [Q86WD7-5]
    ENST00000448305; ENSP00000414092; ENSG00000170054. [Q86WD7-6]
    ENST00000538527; ENSP00000441511; ENSG00000170054. [Q86WD7-3]
    ENST00000546329; ENSP00000445476; ENSG00000170054. [Q86WD7-4]
    GeneIDi327657.
    KEGGihsa:327657.
    UCSCiuc001yde.3. human. [Q86WD7-2]
    uc001ydf.3. human. [Q86WD7-7]
    uc001ydg.3. human. [Q86WD7-1]
    uc001ydi.1. human. [Q86WD7-4]

    Polymorphism databases

    DMDMi215274213.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY220118 mRNA. Translation: AAO65242.1 .
    AY220119 mRNA. Translation: AAO65243.1 .
    AY220120 mRNA. Translation: AAO65244.1 .
    AY220121 mRNA. Translation: AAO65245.1 .
    AY185496 mRNA. Translation: AAO32345.1 . Sequence problems.
    AY185497 mRNA. Translation: AAO32346.1 .
    AY358700 mRNA. Translation: AAQ89063.1 .
    AK301082 mRNA. Translation: BAG62686.1 .
    AL132708 Genomic DNA. No translation available.
    BC111498 mRNA. Translation: AAI11499.1 .
    CCDSi CCDS41982.1. [Q86WD7-7 ]
    CCDS41983.1. [Q86WD7-2 ]
    CCDS61542.1. [Q86WD7-5 ]
    RefSeqi NP_001035983.1. NM_001042518.1. [Q86WD7-2 ]
    NP_001271204.1. NM_001284275.1.
    NP_001271205.1. NM_001284276.1. [Q86WD7-5 ]
    NP_783866.2. NM_175739.3. [Q86WD7-7 ]
    UniGenei Hs.317970.

    3D structure databases

    ProteinModelPortali Q86WD7.
    SMRi Q86WD7. Positions 43-416.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I04.082.

    PTM databases

    PhosphoSitei Q86WD7.

    Polymorphism databases

    DMDMi 215274213.

    Proteomic databases

    MaxQBi Q86WD7.
    PaxDbi Q86WD7.
    PRIDEi Q86WD7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000298845 ; ENSP00000298845 ; ENSG00000170054 . [Q86WD7-2 ]
    ENST00000337425 ; ENSP00000337133 ; ENSG00000170054 . [Q86WD7-7 ]
    ENST00000380365 ; ENSP00000369723 ; ENSG00000170054 . [Q86WD7-1 ]
    ENST00000424550 ; ENSP00000409012 ; ENSG00000170054 . [Q86WD7-5 ]
    ENST00000448305 ; ENSP00000414092 ; ENSG00000170054 . [Q86WD7-6 ]
    ENST00000538527 ; ENSP00000441511 ; ENSG00000170054 . [Q86WD7-3 ]
    ENST00000546329 ; ENSP00000445476 ; ENSG00000170054 . [Q86WD7-4 ]
    GeneIDi 327657.
    KEGGi hsa:327657.
    UCSCi uc001yde.3. human. [Q86WD7-2 ]
    uc001ydf.3. human. [Q86WD7-7 ]
    uc001ydg.3. human. [Q86WD7-1 ]
    uc001ydi.1. human. [Q86WD7-4 ]

    Organism-specific databases

    CTDi 327657.
    GeneCardsi GC14M094929.
    H-InvDB HIX0037697.
    HGNCi HGNC:15995. SERPINA9.
    MIMi 615677. gene.
    neXtProti NX_Q86WD7.
    PharmGKBi PA38077.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4826.
    HOVERGENi HBG005957.
    InParanoidi Q86WD7.
    OMAi FLMMITN.
    OrthoDBi EOG7QC7W9.
    PhylomeDBi Q86WD7.
    TreeFami TF343201.

    Miscellaneous databases

    GeneWikii SERPINA9.
    GenomeRNAii 327657.
    NextBioi 96722.
    PROi Q86WD7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q86WD7.
    CleanExi HS_SERPINA11.
    HS_SERPINA9.
    Genevestigatori Q86WD7.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two newly characterized germinal center B-cell-associated genes, GCET1 and GCET2, have differential expression in normal and neoplastic B cells."
      Pan Z., Shen Y., Du C., Zhou G., Rosenwald A., Staudt L.M., Greiner T.C., McKeithan T.W., Chan W.C.
      Am. J. Pathol. 163:135-144(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 5; 6 AND 7), VARIANT ALA-330, TISSUE SPECIFICITY.
    2. Ju S.G., Zhang X.G.
      Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
      Tissue: Blood.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS LEU-218; GLN-236; ILE-292 AND ALA-330.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
      Tissue: Spleen.
    5. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
      Tissue: Lymph.
    7. "Molecular characterization of centerin, a germinal centre cell serpin."
      Paterson M.A., Horvath A.J., Pike R.N., Coughlin P.B.
      Biochem. J. 405:489-494(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY.
    8. "Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas."
      Paterson M.A., Hosking P.S., Coughlin P.B.
      Am. J. Clin. Pathol. 130:117-126(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    9. "Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas."
      Montes-Moreno S., Roncador G., Maestre L., Martinez N., Sanchez-Verde L., Camacho F.I., Cannata J., Martinez-Torrecuadrada J.L., Shen Y., Chan W.C., Piris M.A.
      Blood 111:351-358(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiSPA9_HUMAN
    AccessioniPrimary (citable) accession number: Q86WD7
    Secondary accession number(s): B4DVH4
    , B9ZVX3, Q2T9J2, Q6UWP9, Q86WD4, Q86WD5, Q86WD6, Q86YP6, Q86YP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 99 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3