Q86WD7 (SPA9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serpin A9

Alternative name(s):
Centerin
Germinal center B-cell-expressed transcript 1 protein

Gene names

Name:	SERPINA9
Synonyms:	GCET1, SERPINA11
ORF Names:	UNQ692/PRO1337

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro). Ref.7
Subcellular location	Isoform 1: Secreted Ref.8 Ref.9. Isoform 2: Cytoplasm Probable Ref.8 Ref.9. Isoform 3: Cytoplasm Probable Ref.8 Ref.9. Isoform 4: Cytoplasm Probable Ref.8 Ref.9. Isoform 5: Cytoplasm Probable Ref.8 Ref.9. Isoform 6: Cytoplasm Probable Ref.8 Ref.9. Isoform 7: Membrane; Single-pass type II membrane protein Potential Ref.8 Ref.9.
Tissue specificity	Highly expressed in normal germinal center (GC) B-cells and GC B-cell-derived malignancies. Ref.1 Ref.7 Ref.8 Ref.9
Sequence similarities	Belongs to the serpin family.
Sequence caution	The sequence AAO32345.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Molecular function	Protease inhibitor Serine protease inhibitor
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of proteolysis Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	serine-type endopeptidase inhibitor activity Inferred from direct assay Ref.6. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86WD7-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86WD7-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQGQGRRRGTCKDIFCSKM
     73-172: Missing.

Isoform 3 (identifier: Q86WD7-3)

Also known as: SERPINA11a;

The sequence of this isoform differs from the canonical sequence as follows:
     1-417: MASYLYGVLF...LGKVENPTKS → MRSAGGRGEI...KFLGQCQEAV

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

Isoform 4 (identifier: Q86WD7-4)

Also known as: SERPINA11b;

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: MASYLYGVLF...NTDFAFRLYR → MRSAGGRGEI...RTGQEKRNLQ
     351-352: AT → VS
     353-417: Missing.

Isoform 5 (identifier: Q86WD7-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.

Isoform 6 (identifier: Q86WD7-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.

Isoform 7 (identifier: Q86WD7-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQGQGRRRGTCKDIFCSKM

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 417	394	Serpin A9		PRO_0000041971
Amino acid modifications
	Glycosylation	101	1	N-linked (GlcNAc...) Potential
	Glycosylation	390	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 417	417	MASYL…NPTKS → MRSAGGRGEIKVRRELQPSK QVSGLTNHARTGQEKRNLQR HILFQNGILPLWSTLCCWPL CSNLLCVPGQCPQCIPPPFL HKEHPCLTGVFPQHRLCLPP IPQAGFGDPESEHLLLPCEC LHFPGHALPWGPLSHQDPDS PGPGLQPHTHTRVCHPPGLP APGSLTDCSQQRPDLEDGKC PLRQEGAAAAGKFLGQCQEA V in isoform 3.		VSP_041492
	Alternative sequence	1 – 131	131	Missing in isoform 5.		VSP_041488
	Alternative sequence	1 – 80	80	Missing in isoform 6.		VSP_041489
	Alternative sequence	1 – 57	57	MASYL…FRLYR → MRSAGGRGEIKVRRELQPSK QVSGLTNHARTGQEKRNLQ in isoform 4.		VSP_041490
	Alternative sequence	1	1	M → MQGQGRRRGTCKDIFCSKM in isoform 2 and isoform 7.		VSP_041491
	Alternative sequence	73 – 172	100	Missing in isoform 2.		VSP_041493
	Alternative sequence	351 – 352	2	AT → VS in isoform 4.		VSP_041494
	Alternative sequence	353 – 417	65	Missing in isoform 4.		VSP_041495
	Natural variant	24	1	A → V. Corresponds to variant rs4905204 [ dbSNP | Ensembl ].		VAR_047344
	Natural variant	218	1	P → L. Ref.3 Corresponds to variant rs17090921 [ dbSNP | Ensembl ].		VAR_047345
	Natural variant	236	1	H → Q. Ref.3 Corresponds to variant rs28583900 [ dbSNP | Ensembl ].		VAR_047346
	Natural variant	292	1	R → I. Ref.3 Corresponds to variant rs28618118 [ dbSNP | Ensembl ].		VAR_047347
	Natural variant	330	1	V → A. Ref.1 Ref.3 Corresponds to variant rs11628722 [ dbSNP | Ensembl ].		VAR_047348
Experimental info
	Sequence conflict	23	1	P → L in AAO65242. Ref.1
	Sequence conflict	23	1	P → L in AAO65243. Ref.1
	Sequence conflict	23	1	P → L in AAQ89063. Ref.3
	Sequence conflict	93	1	Q → E in BAG62686. Ref.4
	Sequence conflict	174	1	R → G in AAO65245. Ref.1
	Sequence conflict	207	1	F → S in BAG62686. Ref.4
	Sequence conflict	224	1	N → D in AAO65242. Ref.1
	Sequence conflict	228	1	L → P in AAO65244. Ref.1
	Sequence conflict	371	1	T → A in AAO65242. Ref.1
	Sequence conflict	411	1	V → A in AAO65243. Ref.1
	Sequence conflict	411	1	V → A in BAG62686. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (A) [UniParc]. Last modified November 25, 2008. Version 3. Checksum: C7693D34FD2E12AB	FASTA	417	46,557
	10 20 30 40 50 60 MASYLYGVLF AVGLCAPIYC VSPANAPSAY PRPSSTKSTP ASQVYSLNTD FAFRLYRRLV 70 80 90 100 110 120 LETPSQNIFF SPVSVSTSLA MLSLGAHSVT KTQILQGLGF NLTHTPESAI HQGFQHLVHS 130 140 150 160 170 180 LTVPSKDLTL KMGSALFVKK ELQLQANFLG NVKRLYEAEV FSTDFSNPSI AQARINSHVK 190 200 210 220 230 240 KKTQGKVVDI IQGLDLLTAM VLVNHIFFKA KWEKPFHPEY TRKNFPFLVG EQVTVHVPMM 250 260 270 280 290 300 HQKEQFAFGV DTELNCFVLQ MDYKGDAVAF FVLPSKGKMR QLEQALSART LRKWSHSLQK 310 320 330 340 350 360 RWIEVFIPRF SISASYNLET ILPKMGIQNV FDKNADFSGI AKRDSLQVSK ATHKAVLDVS 370 380 390 400 410 EEGTEATAAT TTKFIVRSKD GPSYFTVSFN RTFLMMITNK ATDGILFLGK VENPTKS
	Isoform 2 (B) [UniParc]. Checksum: 5141D59448BC3077	FASTA	335	37,776
	10 20 30 40 50 60 MQGQGRRRGT CKDIFCSKMA SYLYGVLFAV GLCAPIYCVS PANAPSAYPR PSSTKSTPAS 70 80 90 100 110 120 QVYSLNTDFA FRLYRRLVLE TPSQNIFFSP ARINSHVKKK TQGKVVDIIQ GLDLLTAMVL 130 140 150 160 170 180 VNHIFFKAKW EKPFHPEYTR KNFPFLVGEQ VTVHVPMMHQ KEQFAFGVDT ELNCFVLQMD 190 200 210 220 230 240 YKGDAVAFFV LPSKGKMRQL EQALSARTLR KWSHSLQKRW IEVFIPRFSI SASYNLETIL 250 260 270 280 290 300 PKMGIQNVFD KNADFSGIAK RDSLQVSKAT HKAVLDVSEE GTEATAATTT KFIVRSKDGP 310 320 330 SYFTVSFNRT FLMMITNKAT DGILFLGKVE NPTKS
	Isoform 3 (SERPINA11a) [UniParc]. Checksum: F805EC2CB516559E	FASTA	201	21,908
	10 20 30 40 50 60 MRSAGGRGEI KVRRELQPSK QVSGLTNHAR TGQEKRNLQR HILFQNGILP LWSTLCCWPL 70 80 90 100 110 120 CSNLLCVPGQ CPQCIPPPFL HKEHPCLTGV FPQHRLCLPP IPQAGFGDPE SEHLLLPCEC 130 140 150 160 170 180 LHFPGHALPW GPLSHQDPDS PGPGLQPHTH TRVCHPPGLP APGSLTDCSQ QRPDLEDGKC 190 200 PLRQEGAAAA GKFLGQCQEA V
	Isoform 4 (SERPINA11b) [UniParc]. Checksum: 619119ADE7028784	FASTA	334	37,665
	10 20 30 40 50 60 MRSAGGRGEI KVRRELQPSK QVSGLTNHAR TGQEKRNLQR LVLETPSQNI FFSPVSVSTS 70 80 90 100 110 120 LAMLSLGAHS VTKTQILQGL GFNLTHTPES AIHQGFQHLV HSLTVPSKDL TLKMGSALFV 130 140 150 160 170 180 KKELQLQANF LGNVKRLYEA EVFSTDFSNP SIAQARINSH VKKKTQGKVV DIIQGLDLLT 190 200 210 220 230 240 AMVLVNHIFF KAKWEKPFHP EYTRKNFPFL VGEQVTVHVP MMHQKEQFAF GVDTELNCFV 250 260 270 280 290 300 LQMDYKGDAV AFFVLPSKGK MRQLEQALSA RTLRKWSHSL QKRWIEVFIP RFSISASYNL 310 320 330 ETILPKMGIQ NVFDKNADFS GIAKRDSLQV SKVS
	Isoform 5 [UniParc]. Checksum: 529682149DC6DD49	FASTA	286	32,400
	10 20 30 40 50 60 MGSALFVKKE LQLQANFLGN VKRLYEAEVF STDFSNPSIA QARINSHVKK KTQGKVVDII 70 80 90 100 110 120 QGLDLLTAMV LVNHIFFKAK WEKPFHPEYT RKNFPFLVGE QVTVHVPMMH QKEQFAFGVD 130 140 150 160 170 180 TELNCFVLQM DYKGDAVAFF VLPSKGKMRQ LEQALSARTL RKWSHSLQKR WIEVFIPRFS 190 200 210 220 230 240 ISASYNLETI LPKMGIQNVF DKNADFSGIA KRDSLQVSKA THKAVLDVSE EGTEATAATT 250 260 270 280 TKFIVRSKDG PSYFTVSFNR TFLMMITNKA TDGILFLGKV ENPTKS
	Isoform 6 [UniParc]. Checksum: C948BF44A88BC48F	FASTA	337	37,915
	10 20 30 40 50 60 MLSLGAHSVT KTQILQGLGF NLTHTPESAI HQGFQHLVHS LTVPSKDLTL KMGSALFVKK 70 80 90 100 110 120 ELQLQANFLG NVKRLYEAEV FSTDFSNPSI AQARINSHVK KKTQGKVVDI IQGLDLLTAM 130 140 150 160 170 180 VLVNHIFFKA KWEKPFHPEY TRKNFPFLVG EQVTVHVPMM HQKEQFAFGV DTELNCFVLQ 190 200 210 220 230 240 MDYKGDAVAF FVLPSKGKMR QLEQALSART LRKWSHSLQK RWIEVFIPRF SISASYNLET 250 260 270 280 290 300 ILPKMGIQNV FDKNADFSGI AKRDSLQVSK ATHKAVLDVS EEGTEATAAT TTKFIVRSKD 310 320 330 GPSYFTVSFN RTFLMMITNK ATDGILFLGK VENPTKS
	Isoform 7 [UniParc]. Checksum: 66C6CB6397A442D6	FASTA	435	48,610
	10 20 30 40 50 60 MQGQGRRRGT CKDIFCSKMA SYLYGVLFAV GLCAPIYCVS PANAPSAYPR PSSTKSTPAS 70 80 90 100 110 120 QVYSLNTDFA FRLYRRLVLE TPSQNIFFSP VSVSTSLAML SLGAHSVTKT QILQGLGFNL 130 140 150 160 170 180 THTPESAIHQ GFQHLVHSLT VPSKDLTLKM GSALFVKKEL QLQANFLGNV KRLYEAEVFS 190 200 210 220 230 240 TDFSNPSIAQ ARINSHVKKK TQGKVVDIIQ GLDLLTAMVL VNHIFFKAKW EKPFHPEYTR 250 260 270 280 290 300 KNFPFLVGEQ VTVHVPMMHQ KEQFAFGVDT ELNCFVLQMD YKGDAVAFFV LPSKGKMRQL 310 320 330 340 350 360 EQALSARTLR KWSHSLQKRW IEVFIPRFSI SASYNLETIL PKMGIQNVFD KNADFSGIAK 370 380 390 400 410 420 RDSLQVSKAT HKAVLDVSEE GTEATAATTT KFIVRSKDGP SYFTVSFNRT FLMMITNKAT 430 DGILFLGKVE NPTKS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two newly characterized germinal center B-cell-associated genes, GCET1 and GCET2, have differential expression in normal and neoplastic B cells." Pan Z., Shen Y., Du C., Zhou G., Rosenwald A., Staudt L.M., Greiner T.C., McKeithan T.W., Chan W.C. Am. J. Pathol. 163:135-144(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 5; 6 AND 7), VARIANT ALA-330, TISSUE SPECIFICITY.
[2]	Ju S.G., Zhang X.G. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4). Tissue: Blood.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS LEU-218; GLN-236; ILE-292 AND ALA-330.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7). Tissue: Spleen.
[5]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7). Tissue: Lymph.
[7]	"Molecular characterization of centerin, a germinal centre cell serpin." Paterson M.A., Horvath A.J., Pike R.N., Coughlin P.B. Biochem. J. 405:489-494(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, MASS SPECTROMETRY, TISSUE SPECIFICITY.
[8]	"Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas." Paterson M.A., Hosking P.S., Coughlin P.B. Am. J. Clin. Pathol. 130:117-126(2008) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[9]	"Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas." Montes-Moreno S., Roncador G., Maestre L., Martinez N., Sanchez-Verde L., Camacho F.I., Cannata J., Martinez-Torrecuadrada J.L., Shen Y., Chan W.C., Piris M.A. Blood 111:351-358(2008) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY220118 mRNA. Translation: AAO65242.1. AY220119 mRNA. Translation: AAO65243.1. AY220120 mRNA. Translation: AAO65244.1. AY220121 mRNA. Translation: AAO65245.1. AY185496 mRNA. Translation: AAO32345.1. Sequence problems. AY185497 mRNA. Translation: AAO32346.1. AY358700 mRNA. Translation: AAQ89063.1. AK301082 mRNA. Translation: BAG62686.1. AL132708 Genomic DNA. No translation available. BC111498 mRNA. Translation: AAI11499.1.
IPI	IPI00395944. IPI00651635. IPI00651735. IPI00941036. IPI00942892. IPI00944611. IPI01014997.
RefSeq	NP_001035983.1. NM_001042518.1. NP_783866.2. NM_175739.3.
UniGene	Hs.317970.
3D structure databases
ProteinModelPortal	Q86WD7.
ModBase	Search...
Protein family/group databases
MEROPS	I04.082.
PTM databases
PhosphoSite	Q86WD7.
Polymorphism databases
DMDM	215274213.
Proteomic databases
PaxDb	Q86WD7.
PRIDE	Q86WD7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298845; ENSP00000298845; ENSG00000170054. ENST00000337425; ENSP00000337133; ENSG00000170054. ENST00000380365; ENSP00000369723; ENSG00000170054. ENST00000424550; ENSP00000409012; ENSG00000170054. ENST00000448305; ENSP00000414092; ENSG00000170054. ENST00000538527; ENSP00000441511; ENSG00000170054. ENST00000546329; ENSP00000445476; ENSG00000170054.
GeneID	327657.
KEGG	hsa:327657.
UCSC	uc001yde.3. human. uc001ydf.3. human. uc001ydg.3. human. uc001ydi.1. human.
Organism-specific databases
CTD	327657.
GeneCards	GC14M094929.
H-InvDB	HIX0037697.
HGNC	HGNC:15995. SERPINA9.
neXtProt	NX_Q86WD7.
PharmGKB	PA38077.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4826.
HOVERGEN	HBG005957.
InParanoid	Q86WD7.
OMA	GFQHLVH.
Gene expression databases
Bgee	Q86WD7.
CleanEx	HS_SERPINA11. HS_SERPINA9.
Genevestigator	Q86WD7.
GermOnline	ENSG00000170054. Homo sapiens.
Family and domain databases
InterPro	IPR000295. Prot_inh_Lserp2. IPR023795. Protease_inhib_I4_serpin_CS. IPR023796. Serpin_dom. IPR000215. Serpin_fam. [Graphical view]
PANTHER	PTHR11461. PTHR11461. 1 hit.
Pfam	PF00079. Serpin. 1 hit. [Graphical view]
PRINTS	PR00780. LEUSERPINII.
SMART	SM00093. SERPIN. 1 hit. [Graphical view]
SUPFAM	SSF56574. Prot_inh_serpin. 1 hit.
PROSITE	PS00284. SERPIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	327657.
NextBio	96722.

Entry information

Entry name

SPA9_HUMAN

Accession

Primary (citable) accession number: Q86WD7
Secondary accession number(s): B4DVH4 , B9ZVX3, Q2T9J2, Q6UWP9, Q86WD4, Q86WD5, Q86WD6, Q86YP6, Q86YP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 86 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.