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Q86WD7 (SPA9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serpin A9
Alternative name(s):
Centerin
Germinal center B-cell-expressed transcript 1 protein
Gene names
Name:SERPINA9
Synonyms:GCET1, SERPINA11
ORF Names:UNQ692/PRO1337
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro). Ref.7

Subcellular location

Isoform 1: Secreted Ref.8 Ref.9.

Isoform 2: Cytoplasm Probable Ref.8 Ref.9.

Isoform 3: Cytoplasm Probable Ref.8 Ref.9.

Isoform 4: Cytoplasm Probable Ref.8 Ref.9.

Isoform 5: Cytoplasm Probable Ref.8 Ref.9.

Isoform 6: Cytoplasm Probable Ref.8 Ref.9.

Isoform 7: Membrane; Single-pass type II membrane protein Potential Ref.8 Ref.9.

Tissue specificity

Highly expressed in normal germinal center (GC) B-cells and GC B-cell-derived malignancies. Ref.1 Ref.7 Ref.8 Ref.9

Sequence similarities

Belongs to the serpin family.

Sequence caution

The sequence AAO32345.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86WD7-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86WD7-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQGQGRRRGTCKDIFCSKM
     73-172: Missing.
Isoform 3 (identifier: Q86WD7-3)

Also known as: SERPINA11a;

The sequence of this isoform differs from the canonical sequence as follows:
     1-417: MASYLYGVLF...LGKVENPTKS → MRSAGGRGEI...KFLGQCQEAV
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Isoform 4 (identifier: Q86WD7-4)

Also known as: SERPINA11b;

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: MASYLYGVLF...NTDFAFRLYR → MRSAGGRGEI...RTGQEKRNLQ
     351-352: AT → VS
     353-417: Missing.
Isoform 5 (identifier: Q86WD7-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.
Isoform 6 (identifier: Q86WD7-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.
Isoform 7 (identifier: Q86WD7-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQGQGRRRGTCKDIFCSKM

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 417394Serpin A9
PRO_0000041971

Amino acid modifications

Glycosylation1011N-linked (GlcNAc...) Potential
Glycosylation3901N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 417417MASYL…NPTKS → MRSAGGRGEIKVRRELQPSK QVSGLTNHARTGQEKRNLQR HILFQNGILPLWSTLCCWPL CSNLLCVPGQCPQCIPPPFL HKEHPCLTGVFPQHRLCLPP IPQAGFGDPESEHLLLPCEC LHFPGHALPWGPLSHQDPDS PGPGLQPHTHTRVCHPPGLP APGSLTDCSQQRPDLEDGKC PLRQEGAAAAGKFLGQCQEA V in isoform 3.
VSP_041492
Alternative sequence1 – 131131Missing in isoform 5.
VSP_041488
Alternative sequence1 – 8080Missing in isoform 6.
VSP_041489
Alternative sequence1 – 5757MASYL…FRLYR → MRSAGGRGEIKVRRELQPSK QVSGLTNHARTGQEKRNLQ in isoform 4.
VSP_041490
Alternative sequence11M → MQGQGRRRGTCKDIFCSKM in isoform 2 and isoform 7.
VSP_041491
Alternative sequence73 – 172100Missing in isoform 2.
VSP_041493
Alternative sequence351 – 3522AT → VS in isoform 4.
VSP_041494
Alternative sequence353 – 41765Missing in isoform 4.
VSP_041495
Natural variant241A → V.
Corresponds to variant rs4905204 [ dbSNP | Ensembl ].
VAR_047344
Natural variant2181P → L. Ref.3
Corresponds to variant rs17090921 [ dbSNP | Ensembl ].
VAR_047345
Natural variant2361H → Q. Ref.3
Corresponds to variant rs28583900 [ dbSNP | Ensembl ].
VAR_047346
Natural variant2921R → I. Ref.3
Corresponds to variant rs28618118 [ dbSNP | Ensembl ].
VAR_047347
Natural variant3301V → A. Ref.1 Ref.3
Corresponds to variant rs11628722 [ dbSNP | Ensembl ].
VAR_047348

Experimental info

Sequence conflict231P → L in AAO65242. Ref.1
Sequence conflict231P → L in AAO65243. Ref.1
Sequence conflict231P → L in AAQ89063. Ref.3
Sequence conflict931Q → E in BAG62686. Ref.4
Sequence conflict1741R → G in AAO65245. Ref.1
Sequence conflict2071F → S in BAG62686. Ref.4
Sequence conflict2241N → D in AAO65242. Ref.1
Sequence conflict2281L → P in AAO65244. Ref.1
Sequence conflict3711T → A in AAO65242. Ref.1
Sequence conflict4111V → A in AAO65243. Ref.1
Sequence conflict4111V → A in BAG62686. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (A) [UniParc].

Last modified November 25, 2008. Version 3.
Checksum: C7693D34FD2E12AB

FASTA41746,557
        10         20         30         40         50         60 
MASYLYGVLF AVGLCAPIYC VSPANAPSAY PRPSSTKSTP ASQVYSLNTD FAFRLYRRLV 

        70         80         90        100        110        120 
LETPSQNIFF SPVSVSTSLA MLSLGAHSVT KTQILQGLGF NLTHTPESAI HQGFQHLVHS 

       130        140        150        160        170        180 
LTVPSKDLTL KMGSALFVKK ELQLQANFLG NVKRLYEAEV FSTDFSNPSI AQARINSHVK 

       190        200        210        220        230        240 
KKTQGKVVDI IQGLDLLTAM VLVNHIFFKA KWEKPFHPEY TRKNFPFLVG EQVTVHVPMM 

       250        260        270        280        290        300 
HQKEQFAFGV DTELNCFVLQ MDYKGDAVAF FVLPSKGKMR QLEQALSART LRKWSHSLQK 

       310        320        330        340        350        360 
RWIEVFIPRF SISASYNLET ILPKMGIQNV FDKNADFSGI AKRDSLQVSK ATHKAVLDVS 

       370        380        390        400        410 
EEGTEATAAT TTKFIVRSKD GPSYFTVSFN RTFLMMITNK ATDGILFLGK VENPTKS 

« Hide

Isoform 2 (B) [UniParc].

Checksum: 5141D59448BC3077
Show »

FASTA33537,776
Isoform 3 (SERPINA11a) [UniParc].

Checksum: F805EC2CB516559E
Show »

FASTA20121,908
Isoform 4 (SERPINA11b) [UniParc].

Checksum: 619119ADE7028784
Show »

FASTA33437,665
Isoform 5 [UniParc].

Checksum: 529682149DC6DD49
Show »

FASTA28632,400
Isoform 6 [UniParc].

Checksum: C948BF44A88BC48F
Show »

FASTA33737,915
Isoform 7 [UniParc].

Checksum: 66C6CB6397A442D6
Show »

FASTA43548,610

References

« Hide 'large scale' references
[1]"Two newly characterized germinal center B-cell-associated genes, GCET1 and GCET2, have differential expression in normal and neoplastic B cells."
Pan Z., Shen Y., Du C., Zhou G., Rosenwald A., Staudt L.M., Greiner T.C., McKeithan T.W., Chan W.C.
Am. J. Pathol. 163:135-144(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 5; 6 AND 7), VARIANT ALA-330, TISSUE SPECIFICITY.
[2]Ju S.G., Zhang X.G.
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
Tissue: Blood.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS LEU-218; GLN-236; ILE-292 AND ALA-330.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
Tissue: Spleen.
[5]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
Tissue: Lymph.
[7]"Molecular characterization of centerin, a germinal centre cell serpin."
Paterson M.A., Horvath A.J., Pike R.N., Coughlin P.B.
Biochem. J. 405:489-494(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY.
[8]"Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas."
Paterson M.A., Hosking P.S., Coughlin P.B.
Am. J. Clin. Pathol. 130:117-126(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[9]"Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas."
Montes-Moreno S., Roncador G., Maestre L., Martinez N., Sanchez-Verde L., Camacho F.I., Cannata J., Martinez-Torrecuadrada J.L., Shen Y., Chan W.C., Piris M.A.
Blood 111:351-358(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY220118 mRNA. Translation: AAO65242.1.
AY220119 mRNA. Translation: AAO65243.1.
AY220120 mRNA. Translation: AAO65244.1.
AY220121 mRNA. Translation: AAO65245.1.
AY185496 mRNA. Translation: AAO32345.1. Sequence problems.
AY185497 mRNA. Translation: AAO32346.1.
AY358700 mRNA. Translation: AAQ89063.1.
AK301082 mRNA. Translation: BAG62686.1.
AL132708 Genomic DNA. No translation available.
BC111498 mRNA. Translation: AAI11499.1.
RefSeqNP_001035983.1. NM_001042518.1.
NP_001271204.1. NM_001284275.1.
NP_001271205.1. NM_001284276.1.
NP_783866.2. NM_175739.3.
UniGeneHs.317970.

3D structure databases

ProteinModelPortalQ86WD7.
SMRQ86WD7. Positions 43-416.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI04.082.

PTM databases

PhosphoSiteQ86WD7.

Polymorphism databases

DMDM215274213.

Proteomic databases

PaxDbQ86WD7.
PRIDEQ86WD7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000298845; ENSP00000298845; ENSG00000170054. [Q86WD7-2]
ENST00000337425; ENSP00000337133; ENSG00000170054. [Q86WD7-7]
ENST00000380365; ENSP00000369723; ENSG00000170054. [Q86WD7-1]
ENST00000424550; ENSP00000409012; ENSG00000170054. [Q86WD7-5]
ENST00000448305; ENSP00000414092; ENSG00000170054. [Q86WD7-6]
ENST00000538527; ENSP00000441511; ENSG00000170054. [Q86WD7-3]
ENST00000546329; ENSP00000445476; ENSG00000170054. [Q86WD7-4]
GeneID327657.
KEGGhsa:327657.
UCSCuc001yde.3. human. [Q86WD7-2]
uc001ydf.3. human. [Q86WD7-7]
uc001ydg.3. human. [Q86WD7-1]
uc001ydi.1. human. [Q86WD7-4]

Organism-specific databases

CTD327657.
GeneCardsGC14M094929.
H-InvDBHIX0037697.
HGNCHGNC:15995. SERPINA9.
neXtProtNX_Q86WD7.
PharmGKBPA38077.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4826.
HOVERGENHBG005957.
InParanoidQ86WD7.
OMAFQHLVHS.
OrthoDBEOG7QC7W9.
PhylomeDBQ86WD7.
TreeFamTF343201.

Gene expression databases

BgeeQ86WD7.
CleanExHS_SERPINA11.
HS_SERPINA9.
GenevestigatorQ86WD7.

Family and domain databases

InterProIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
PROSITEPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSERPINA9.
GenomeRNAi327657.
NextBio96722.
PROQ86WD7.

Entry information

Entry nameSPA9_HUMAN
AccessionPrimary (citable) accession number: Q86WD7
Secondary accession number(s): B4DVH4 expand/collapse secondary AC list , B9ZVX3, Q2T9J2, Q6UWP9, Q86WD4, Q86WD5, Q86WD6, Q86YP6, Q86YP7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: November 25, 2008
Last modified: April 16, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM