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Protein

Protein phosphatase 1 regulatory subunit 27

Gene

PPP1R27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.1 Publication

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB
  • protein phosphatase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  • negative regulation of phosphatase activity Source: UniProtKB

Keywordsi

Molecular functionProtein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 27
Alternative name(s):
Dysferlin-interacting protein 1
Toonin
Gene namesi
Name:PPP1R27
Synonyms:DYSFIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000182676.4.
HGNCiHGNC:16813. PPP1R27.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182676.
PharmGKBiPA27555.

Polymorphism and mutation databases

BioMutaiPPP1R27.
DMDMi74750495.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002644691 – 154Protein phosphatase 1 regulatory subunit 27Add BLAST154

Proteomic databases

PaxDbiQ86WC6.
PeptideAtlasiQ86WC6.
PRIDEiQ86WC6.

PTM databases

iPTMnetiQ86WC6.
PhosphoSitePlusiQ86WC6.

Expressioni

Gene expression databases

BgeeiENSG00000182676.
CleanExiHS_DYSFIP1.
ExpressionAtlasiQ86WC6. baseline and differential.
GenevisibleiQ86WC6. HS.

Organism-specific databases

HPAiHPA048632.

Interactioni

Subunit structurei

Interacts with DYSF and PPP1CA.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621366EBI-5235602,EBI-357253

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi125525. 1 interactor.
IntActiQ86WC6. 8 interactors.
STRINGi9606.ENSP00000331065.

Structurei

3D structure databases

ProteinModelPortaliQ86WC6.
SMRiQ86WC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati63 – 92ANK 1Add BLAST30
Repeati96 – 125ANK 2Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 19Poly-Arg6

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0505. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00760000119141.
HOGENOMiHOG000231238.
HOVERGENiHBG080189.
InParanoidiQ86WC6.
KOiK17566.
OMAiHFPNDVV.
OrthoDBiEOG091G0U5T.
PhylomeDBiQ86WC6.
TreeFamiTF333311.

Family and domain databases

CDDicd00204. ANK. 1 hit.
Gene3Di1.25.40.20. 1 hit.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR036770. Ankyrin_rpt-contain_sf.
SMARTiView protein in SMART
SM00248. ANK. 2 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.

Sequencei

Sequence statusi: Complete.

Q86WC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSRTARYAR YSPRQRRRRM LADRSVRFPN DVLFLDHIRQ GDLEQVGRFI
60 70 80 90 100
RTRKVSLATI HPSGLAALHE AVLSGNLECV KLLVKYGADI HQRDEAGWTP
110 120 130 140 150
LHIACSDGYP DIARYLISLG ADRDATNDDG DLPSDLIDPD YKELVELFKG

TTMD
Length:154
Mass (Da):17,438
Last modified:June 1, 2003 - v1
Checksum:iD7D1644A5C906B76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF434846 mRNA. Translation: AAO67357.1.
BC093707 mRNA. Translation: AAH93707.1.
BC112094 mRNA. Translation: AAI12095.1.
CCDSiCCDS32767.1.
RefSeqiNP_001007534.1. NM_001007533.3.
UniGeneiHs.454720.

Genome annotation databases

EnsembliENST00000330261; ENSP00000331065; ENSG00000182676.
GeneIDi116729.
KEGGihsa:116729.
UCSCiuc002kbj.2. human.

Similar proteinsi

Entry informationi

Entry nameiPPR27_HUMAN
AccessioniPrimary (citable) accession number: Q86WC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM