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Protein

Protein phosphatase 1 regulatory subunit 27

Gene

PPP1R27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.1 Publication

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB
  • protein phosphatase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  • negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 27
Alternative name(s):
Dysferlin-interacting protein 1
Toonin
Gene namesi
Name:PPP1R27
Synonyms:DYSFIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:16813. PPP1R27.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27555.

Polymorphism and mutation databases

BioMutaiPPP1R27.
DMDMi74750495.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154Protein phosphatase 1 regulatory subunit 27PRO_0000264469Add
BLAST

Proteomic databases

PaxDbiQ86WC6.
PeptideAtlasiQ86WC6.
PRIDEiQ86WC6.

PTM databases

iPTMnetiQ86WC6.
PhosphoSiteiQ86WC6.

Expressioni

Gene expression databases

BgeeiQ86WC6.
CleanExiHS_DYSFIP1.
ExpressionAtlasiQ86WC6. baseline and differential.
GenevisibleiQ86WC6. HS.

Organism-specific databases

HPAiHPA048632.

Interactioni

Subunit structurei

Interacts with DYSF and PPP1CA.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621362EBI-5235602,EBI-357253

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi125525. 1 interaction.
IntActiQ86WC6. 1 interaction.
STRINGi9606.ENSP00000331065.

Structurei

3D structure databases

ProteinModelPortaliQ86WC6.
SMRiQ86WC6. Positions 33-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati63 – 9230ANK 1Add
BLAST
Repeati96 – 12530ANK 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 196Poly-Arg

Sequence similaritiesi

Contains 2 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0505. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00800000124147.
HOGENOMiHOG000231238.
HOVERGENiHBG080189.
InParanoidiQ86WC6.
KOiK17566.
OMAiHFPNDVV.
OrthoDBiEOG7SXW56.
PhylomeDBiQ86WC6.
TreeFamiTF333311.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86WC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSRTARYAR YSPRQRRRRM LADRSVRFPN DVLFLDHIRQ GDLEQVGRFI
60 70 80 90 100
RTRKVSLATI HPSGLAALHE AVLSGNLECV KLLVKYGADI HQRDEAGWTP
110 120 130 140 150
LHIACSDGYP DIARYLISLG ADRDATNDDG DLPSDLIDPD YKELVELFKG

TTMD
Length:154
Mass (Da):17,438
Last modified:June 1, 2003 - v1
Checksum:iD7D1644A5C906B76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF434846 mRNA. Translation: AAO67357.1.
BC093707 mRNA. Translation: AAH93707.1.
BC112094 mRNA. Translation: AAI12095.1.
CCDSiCCDS32767.1.
RefSeqiNP_001007534.1. NM_001007533.3.
UniGeneiHs.454720.

Genome annotation databases

EnsembliENST00000330261; ENSP00000331065; ENSG00000182676.
GeneIDi116729.
KEGGihsa:116729.
UCSCiuc002kbj.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF434846 mRNA. Translation: AAO67357.1.
BC093707 mRNA. Translation: AAH93707.1.
BC112094 mRNA. Translation: AAI12095.1.
CCDSiCCDS32767.1.
RefSeqiNP_001007534.1. NM_001007533.3.
UniGeneiHs.454720.

3D structure databases

ProteinModelPortaliQ86WC6.
SMRiQ86WC6. Positions 33-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125525. 1 interaction.
IntActiQ86WC6. 1 interaction.
STRINGi9606.ENSP00000331065.

PTM databases

iPTMnetiQ86WC6.
PhosphoSiteiQ86WC6.

Polymorphism and mutation databases

BioMutaiPPP1R27.
DMDMi74750495.

Proteomic databases

PaxDbiQ86WC6.
PeptideAtlasiQ86WC6.
PRIDEiQ86WC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330261; ENSP00000331065; ENSG00000182676.
GeneIDi116729.
KEGGihsa:116729.
UCSCiuc002kbj.2. human.

Organism-specific databases

CTDi116729.
GeneCardsiPPP1R27.
HGNCiHGNC:16813. PPP1R27.
HPAiHPA048632.
neXtProtiNX_Q86WC6.
PharmGKBiPA27555.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0505. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00800000124147.
HOGENOMiHOG000231238.
HOVERGENiHBG080189.
InParanoidiQ86WC6.
KOiK17566.
OMAiHFPNDVV.
OrthoDBiEOG7SXW56.
PhylomeDBiQ86WC6.
TreeFamiTF333311.

Miscellaneous databases

GenomeRNAii116729.
PROiQ86WC6.

Gene expression databases

BgeeiQ86WC6.
CleanExiHS_DYSFIP1.
ExpressionAtlasiQ86WC6. baseline and differential.
GenevisibleiQ86WC6. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel gene interacting with dysferlin in skeletal muscle."
    Vafiadaki E., Laval S.H., Brown J.D., Anderson L.V.B., Bashir R., Bushby K.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH DYSF.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Docking motif-guided mapping of the interactome of protein phosphatase-1."
    Hendrickx A., Beullens M., Ceulemans H., Den Abt T., Van Eynde A., Nicolaescu E., Lesage B., Bollen M.
    Chem. Biol. 16:365-371(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PPP1CA.

Entry informationi

Entry nameiPPR27_HUMAN
AccessioniPrimary (citable) accession number: Q86WC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2003
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.