Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein unc-93 homolog A

Gene

UNC93A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein unc-93 homolog A
Short name:
HmUnc-93A
Short name:
Unc-93A
Gene namesi
Name:UNC93A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:12570. UNC93A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Transmembranei42 – 6221HelicalSequence analysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence analysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence analysisAdd
BLAST
Transmembranei140 – 16021HelicalSequence analysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence analysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence analysisAdd
BLAST
Transmembranei291 – 31121HelicalSequence analysisAdd
BLAST
Transmembranei320 – 34021HelicalSequence analysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence analysisAdd
BLAST
Transmembranei395 – 41521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37207.

Polymorphism and mutation databases

BioMutaiUNC93A.
DMDMi67462066.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Protein unc-93 homolog APRO_0000190036Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86WB7.
PRIDEiQ86WB7.

Expressioni

Tissue specificityi

Expressed in testis, small intestine, spleen, prostate and ovary.1 Publication

Gene expression databases

BgeeiQ86WB7.
CleanExiHS_UNC93A.
ExpressionAtlasiQ86WB7. baseline and differential.
GenevisibleiQ86WB7. HS.

Organism-specific databases

HPAiHPA035729.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000230256.

Structurei

3D structure databases

ProteinModelPortaliQ86WB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the unc-93 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3097. Eukaryota.
ENOG410XTFP. LUCA.
GeneTreeiENSGT00530000063359.
HOGENOMiHOG000007567.
HOVERGENiHBG080785.
InParanoidiQ86WB7.
OMAiCTYLTIT.
PhylomeDBiQ86WB7.
TreeFamiTF314905.

Family and domain databases

InterProiIPR010291. Ion_channel_UNC-93.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF05978. UNC-93. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86WB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRSLRNVLV VSFGFLLLFT AYGGLQSLQS SLYSEEGLGV TALSTLYGGM
60 70 80 90 100
LLSSMFLPPL LIERLGCKGT IILSMCGYVA FSVGNFFASW YTLIPTSILL
110 120 130 140 150
GLGAAPLWSA QCTYLTITGN THAEKAGKRG KDMVNQYFGI FFLIFQSSGV
160 170 180 190 200
WGNLISSLVF GQTPSQETLP EEQLTSCGAS DCLMATTTTN STQRPSQQLV
210 220 230 240 250
YTLLGIYTGS GVLAVLMIAA FLQPIRDVQR ESEGEKKSVP FWSTLLSTFK
260 270 280 290 300
LYRDKRLCLL ILLPLYSGLQ QGFLSSEYTR SYVTCTLGIQ FVGYVMICFS
310 320 330 340 350
ATDALCSVLY GKVSQYTGRA VLYVLGAVTH VSCMIALLLW RPRADHLAVF
360 370 380 390 400
FVFSGLWGVA DAVWQTQNNA LYGVLFEKSK EAAFANYRLW EALGFVIAFG
410 420 430 440 450
YSMFLCVHVK LYILLGVLSL TMVAYGLVEC VESKNPIRPH APGQVNQAED

EEIQTKM
Length:457
Mass (Da):50,270
Last modified:June 1, 2003 - v1
Checksum:iB73491988637AA26
GO
Isoform 2 (identifier: Q86WB7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     167-208: Missing.

Note: No experimental confirmation available.
Show »
Length:415
Mass (Da):45,721
Checksum:i318D73E77F926E26
GO

Sequence cautioni

The sequence CAI42706.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61R → K.
Corresponds to variant rs36110805 [ dbSNP | Ensembl ].
VAR_052473
Natural varianti128 – 1281K → Q.
Corresponds to variant rs35313366 [ dbSNP | Ensembl ].
VAR_052474
Natural varianti292 – 2921V → I.1 Publication
Corresponds to variant rs2072767 [ dbSNP | Ensembl ].
VAR_022650
Natural varianti295 – 2951V → M.
Corresponds to variant rs4708771 [ dbSNP | Ensembl ].
VAR_052475
Natural varianti308 – 3081V → M.
Corresponds to variant rs35854179 [ dbSNP | Ensembl ].
VAR_061874
Natural varianti387 – 3871Y → H.1 Publication
Corresponds to variant rs663227 [ dbSNP | Ensembl ].
VAR_022651
Natural varianti403 – 4031M → I.
Corresponds to variant rs9459921 [ dbSNP | Ensembl ].
VAR_059849
Natural varianti403 – 4031M → T.1 Publication
Corresponds to variant rs663606 [ dbSNP | Ensembl ].
VAR_022652
Natural varianti409 – 4091V → I.1 Publication
Corresponds to variant rs7739897 [ dbSNP | Ensembl ].
VAR_022653
Natural varianti445 – 4451V → A.1 Publication
VAR_022654

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei167 – 20842Missing in isoform 2. 1 PublicationVSP_042772Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ508812 mRNA. Translation: CAD48541.1.
AJ422141 mRNA. Translation: CAD19521.1.
AK091987 mRNA. Translation: BAG52457.1.
AL021331 Genomic DNA. Translation: CAI42706.1. Sequence problems.
BC098248 mRNA. Translation: AAH98248.1.
BC099718 mRNA. Translation: AAH99718.1.
BC105635 mRNA. Translation: AAI05636.1.
CCDSiCCDS47515.1. [Q86WB7-2]
CCDS5300.1. [Q86WB7-1]
RefSeqiNP_001137419.1. NM_001143947.1. [Q86WB7-2]
NP_061847.2. NM_018974.3. [Q86WB7-1]
XP_011534207.1. XM_011535905.1. [Q86WB7-1]
XP_011534208.1. XM_011535906.1. [Q86WB7-1]
XP_011534209.1. XM_011535907.1. [Q86WB7-1]
UniGeneiHs.567508.

Genome annotation databases

EnsembliENST00000230256; ENSP00000230256; ENSG00000112494. [Q86WB7-1]
ENST00000366829; ENSP00000355794; ENSG00000112494. [Q86WB7-2]
GeneIDi54346.
KEGGihsa:54346.
UCSCiuc003qvq.4. human. [Q86WB7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ508812 mRNA. Translation: CAD48541.1.
AJ422141 mRNA. Translation: CAD19521.1.
AK091987 mRNA. Translation: BAG52457.1.
AL021331 Genomic DNA. Translation: CAI42706.1. Sequence problems.
BC098248 mRNA. Translation: AAH98248.1.
BC099718 mRNA. Translation: AAH99718.1.
BC105635 mRNA. Translation: AAI05636.1.
CCDSiCCDS47515.1. [Q86WB7-2]
CCDS5300.1. [Q86WB7-1]
RefSeqiNP_001137419.1. NM_001143947.1. [Q86WB7-2]
NP_061847.2. NM_018974.3. [Q86WB7-1]
XP_011534207.1. XM_011535905.1. [Q86WB7-1]
XP_011534208.1. XM_011535906.1. [Q86WB7-1]
XP_011534209.1. XM_011535907.1. [Q86WB7-1]
UniGeneiHs.567508.

3D structure databases

ProteinModelPortaliQ86WB7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000230256.

Polymorphism and mutation databases

BioMutaiUNC93A.
DMDMi67462066.

Proteomic databases

PaxDbiQ86WB7.
PRIDEiQ86WB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230256; ENSP00000230256; ENSG00000112494. [Q86WB7-1]
ENST00000366829; ENSP00000355794; ENSG00000112494. [Q86WB7-2]
GeneIDi54346.
KEGGihsa:54346.
UCSCiuc003qvq.4. human. [Q86WB7-1]

Organism-specific databases

CTDi54346.
GeneCardsiUNC93A.
HGNCiHGNC:12570. UNC93A.
HPAiHPA035729.
MIMi607995. gene.
neXtProtiNX_Q86WB7.
PharmGKBiPA37207.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3097. Eukaryota.
ENOG410XTFP. LUCA.
GeneTreeiENSGT00530000063359.
HOGENOMiHOG000007567.
HOVERGENiHBG080785.
InParanoidiQ86WB7.
OMAiCTYLTIT.
PhylomeDBiQ86WB7.
TreeFamiTF314905.

Miscellaneous databases

GenomeRNAii54346.
NextBioi56591.
PROiQ86WB7.
SOURCEiSearch...

Gene expression databases

BgeeiQ86WB7.
CleanExiHS_UNC93A.
ExpressionAtlasiQ86WB7. baseline and differential.
GenevisibleiQ86WB7. HS.

Family and domain databases

InterProiIPR010291. Ion_channel_UNC-93.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF05978. UNC-93. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer."
    Liu Y., Dodds P., Emilion G., Mungall A.J., Dunham I., Beck S., Wells R.S., Charnock F.M.L., Ganesan T.S.
    BMC Genet. 3:20-20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS ILE-292; HIS-387; THR-403; ILE-409 AND ALA-445.
    Tissue: Ovary.
  2. "Cloning and characterization of mammalian homologs of unc-93 from Caenorhabditis elegans, a protein relevant for muscle contraction."
    Kollewe A.
    Thesis (2001), University of Hannover, Germany
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver and Spleen.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiUN93A_HUMAN
AccessioniPrimary (citable) accession number: Q86WB7
Secondary accession number(s): B3KRP5, Q4QQJ4, Q5JZD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2003
Last modified: March 16, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Although UNC93A gene is located in a region of the genome frequently associated with ovarian cancer, no evidence have been found for a tumor suppressor function.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.