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Protein

Protein unc-93 homolog A

Gene

UNC93A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein unc-93 homolog A
Short name:
HmUnc-93A
Short name:
Unc-93A
Gene namesi
Name:UNC93A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:12570. UNC93A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54346.
OpenTargetsiENSG00000112494.
PharmGKBiPA37207.

Polymorphism and mutation databases

BioMutaiUNC93A.
DMDMi67462066.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900361 – 457Protein unc-93 homolog AAdd BLAST457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi190N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86WB7.
PeptideAtlasiQ86WB7.
PRIDEiQ86WB7.

Expressioni

Tissue specificityi

Expressed in testis, small intestine, spleen, prostate and ovary.1 Publication

Gene expression databases

BgeeiENSG00000112494.
CleanExiHS_UNC93A.
ExpressionAtlasiQ86WB7. baseline and differential.
GenevisibleiQ86WB7. HS.

Organism-specific databases

HPAiHPA035729.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000230256.

Structurei

3D structure databases

ProteinModelPortaliQ86WB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the unc-93 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3097. Eukaryota.
ENOG410XTFP. LUCA.
GeneTreeiENSGT00530000063359.
HOGENOMiHOG000007567.
HOVERGENiHBG080785.
InParanoidiQ86WB7.
OMAiITGNTHA.
OrthoDBiEOG091G07EN.
PhylomeDBiQ86WB7.
TreeFamiTF314905.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR010291. Ion_channel_UNC-93.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF05978. UNC-93. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86WB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRSLRNVLV VSFGFLLLFT AYGGLQSLQS SLYSEEGLGV TALSTLYGGM
60 70 80 90 100
LLSSMFLPPL LIERLGCKGT IILSMCGYVA FSVGNFFASW YTLIPTSILL
110 120 130 140 150
GLGAAPLWSA QCTYLTITGN THAEKAGKRG KDMVNQYFGI FFLIFQSSGV
160 170 180 190 200
WGNLISSLVF GQTPSQETLP EEQLTSCGAS DCLMATTTTN STQRPSQQLV
210 220 230 240 250
YTLLGIYTGS GVLAVLMIAA FLQPIRDVQR ESEGEKKSVP FWSTLLSTFK
260 270 280 290 300
LYRDKRLCLL ILLPLYSGLQ QGFLSSEYTR SYVTCTLGIQ FVGYVMICFS
310 320 330 340 350
ATDALCSVLY GKVSQYTGRA VLYVLGAVTH VSCMIALLLW RPRADHLAVF
360 370 380 390 400
FVFSGLWGVA DAVWQTQNNA LYGVLFEKSK EAAFANYRLW EALGFVIAFG
410 420 430 440 450
YSMFLCVHVK LYILLGVLSL TMVAYGLVEC VESKNPIRPH APGQVNQAED

EEIQTKM
Length:457
Mass (Da):50,270
Last modified:June 1, 2003 - v1
Checksum:iB73491988637AA26
GO
Isoform 2 (identifier: Q86WB7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     167-208: Missing.

Note: No experimental confirmation available.
Show »
Length:415
Mass (Da):45,721
Checksum:i318D73E77F926E26
GO

Sequence cautioni

The sequence CAI42706 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0524736R → K.Corresponds to variant rs36110805dbSNPEnsembl.1
Natural variantiVAR_052474128K → Q.Corresponds to variant rs35313366dbSNPEnsembl.1
Natural variantiVAR_022650292V → I.1 PublicationCorresponds to variant rs2072767dbSNPEnsembl.1
Natural variantiVAR_052475295V → M.Corresponds to variant rs4708771dbSNPEnsembl.1
Natural variantiVAR_061874308V → M.Corresponds to variant rs35854179dbSNPEnsembl.1
Natural variantiVAR_022651387Y → H.1 PublicationCorresponds to variant rs663227dbSNPEnsembl.1
Natural variantiVAR_059849403M → I.Corresponds to variant rs9459921dbSNPEnsembl.1
Natural variantiVAR_022652403M → T.1 PublicationCorresponds to variant rs663606dbSNPEnsembl.1
Natural variantiVAR_022653409V → I.1 PublicationCorresponds to variant rs7739897dbSNPEnsembl.1
Natural variantiVAR_022654445V → A.1 PublicationCorresponds to variant rs752323292dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042772167 – 208Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ508812 mRNA. Translation: CAD48541.1.
AJ422141 mRNA. Translation: CAD19521.1.
AK091987 mRNA. Translation: BAG52457.1.
AL021331 Genomic DNA. Translation: CAI42706.1. Sequence problems.
BC098248 mRNA. Translation: AAH98248.1.
BC099718 mRNA. Translation: AAH99718.1.
BC105635 mRNA. Translation: AAI05636.1.
CCDSiCCDS47515.1. [Q86WB7-2]
CCDS5300.1. [Q86WB7-1]
RefSeqiNP_001137419.1. NM_001143947.1. [Q86WB7-2]
NP_061847.2. NM_018974.3. [Q86WB7-1]
XP_011534207.1. XM_011535905.2. [Q86WB7-1]
XP_011534208.1. XM_011535906.2. [Q86WB7-1]
XP_011534209.1. XM_011535907.2. [Q86WB7-1]
XP_016866447.1. XM_017010958.1. [Q86WB7-1]
UniGeneiHs.567508.

Genome annotation databases

EnsembliENST00000230256; ENSP00000230256; ENSG00000112494. [Q86WB7-1]
ENST00000366829; ENSP00000355794; ENSG00000112494. [Q86WB7-2]
GeneIDi54346.
KEGGihsa:54346.
UCSCiuc003qvq.4. human. [Q86WB7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ508812 mRNA. Translation: CAD48541.1.
AJ422141 mRNA. Translation: CAD19521.1.
AK091987 mRNA. Translation: BAG52457.1.
AL021331 Genomic DNA. Translation: CAI42706.1. Sequence problems.
BC098248 mRNA. Translation: AAH98248.1.
BC099718 mRNA. Translation: AAH99718.1.
BC105635 mRNA. Translation: AAI05636.1.
CCDSiCCDS47515.1. [Q86WB7-2]
CCDS5300.1. [Q86WB7-1]
RefSeqiNP_001137419.1. NM_001143947.1. [Q86WB7-2]
NP_061847.2. NM_018974.3. [Q86WB7-1]
XP_011534207.1. XM_011535905.2. [Q86WB7-1]
XP_011534208.1. XM_011535906.2. [Q86WB7-1]
XP_011534209.1. XM_011535907.2. [Q86WB7-1]
XP_016866447.1. XM_017010958.1. [Q86WB7-1]
UniGeneiHs.567508.

3D structure databases

ProteinModelPortaliQ86WB7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000230256.

Polymorphism and mutation databases

BioMutaiUNC93A.
DMDMi67462066.

Proteomic databases

PaxDbiQ86WB7.
PeptideAtlasiQ86WB7.
PRIDEiQ86WB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230256; ENSP00000230256; ENSG00000112494. [Q86WB7-1]
ENST00000366829; ENSP00000355794; ENSG00000112494. [Q86WB7-2]
GeneIDi54346.
KEGGihsa:54346.
UCSCiuc003qvq.4. human. [Q86WB7-1]

Organism-specific databases

CTDi54346.
DisGeNETi54346.
GeneCardsiUNC93A.
HGNCiHGNC:12570. UNC93A.
HPAiHPA035729.
MIMi607995. gene.
neXtProtiNX_Q86WB7.
OpenTargetsiENSG00000112494.
PharmGKBiPA37207.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3097. Eukaryota.
ENOG410XTFP. LUCA.
GeneTreeiENSGT00530000063359.
HOGENOMiHOG000007567.
HOVERGENiHBG080785.
InParanoidiQ86WB7.
OMAiITGNTHA.
OrthoDBiEOG091G07EN.
PhylomeDBiQ86WB7.
TreeFamiTF314905.

Miscellaneous databases

GenomeRNAii54346.
PROiQ86WB7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112494.
CleanExiHS_UNC93A.
ExpressionAtlasiQ86WB7. baseline and differential.
GenevisibleiQ86WB7. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR010291. Ion_channel_UNC-93.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF05978. UNC-93. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiUN93A_HUMAN
AccessioniPrimary (citable) accession number: Q86WB7
Secondary accession number(s): B3KRP5, Q4QQJ4, Q5JZD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Although UNC93A gene is located in a region of the genome frequently associated with ovarian cancer, no evidence have been found for a tumor suppressor function.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.