Q86WB0 (NIPA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear-interacting partner of ALK

Alternative name(s):
Nuclear-interacting partner of anaplastic lymphoma kinase
Short name=hNIPA
Zinc finger C3HC-type protein 1

Gene names

Name:	ZC3HC1
Synonyms:	NIPA
ORF Names:	HSPC216

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	502 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. Ref.6
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Interacts with the NPM-ALK fusion protein in a tyrosine phosphorylation-dependent manner. Interacts with SKP1. Component of a SCF(NIPA) E3 complex with SKP1, RBX1 and CUL1 when not phosphorylated on Ser-354. Interacts with CCNB1. Ref.1 Ref.6
Subcellular location	Nucleus Ref.1.
Tissue specificity	Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes. Ref.1
Developmental stage	Weakly expressed in G0/G1 phases, abundant during S and G2/M phases, and strongly decreases thereafter. Ref.6
Domain	The F-box-like region is required for the interaction with SKP1. Ref.6
Post-translational modification	Phosphorylated. Phosphorylated on Ser residues at G2/M phase, but not during S and G0 phases. May also be weakly phosphorylated on Tyr residues. Ser-354 phosphorylation, a major site during the course of cell-cycle-dedendent phosphorylation, results in its dissociation from the SCF(NIPA) complex, thereby preventing CCNB1 degradation leading to mitotic entry. Ref.1 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.16
Sequence similarities	Contains 1 C3HC-type zinc finger.
Caution	Reported to contain a F-box domain (Ref.6). Such domain is however not predicted by any detection method.
Sequence caution	The sequence AAF36136.1 differs from that shown. Reason: Frameshift at positions 93, 187 and 220. The sequence AAH28917.1 differs from that shown. Reason: Erroneous initiation. The sequence AAS07546.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAS07547.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis Ubl conjugation pathway
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Zinc-finger
Ligand	Metal-binding Zinc
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nuclear membrane Inferred from direct assay. Source: HPA
Molecular function	protein kinase binding Inferred from physical interaction. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86WB0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86WB0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: MAAPCEGQAF...IAPEEGGVDA → MRGLPRKREAWTQPHPLEALYESLRVLE

Note: No experimental confirmation available.

Isoform 3 (identifier: Q86WB0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     341-411: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 502	501	Nuclear-interacting partner of ALK		PRO_0000096849
Regions
	Zinc finger	102 – 156	55	C3HC-type
	Region	170 – 210	41	F-box-like
	Motif	396 – 402	7	Nuclear localization signal Ref.1
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.14
	Modified residue	24	1	Phosphoserine Ref.7 Ref.8 Ref.10 Ref.13
	Modified residue	28	1	Phosphothreonine Ref.7 Ref.8 Ref.13
	Modified residue	58	1	Phosphoserine Ref.14 Ref.16
	Modified residue	62	1	Phosphoserine Ref.14 Ref.16
	Modified residue	84	1	Phosphothreonine Ref.10
	Modified residue	321	1	Phosphoserine Ref.7 Ref.8 Ref.11 Ref.12 Ref.13 Ref.14 Ref.16
	Modified residue	333	1	Phosphothreonine Ref.13
	Modified residue	335	1	Phosphoserine Ref.13 Ref.14 Ref.16
	Modified residue	338	1	Phosphoserine Ref.13 Ref.14 Ref.15 Ref.16
	Modified residue	344	1	Phosphoserine Ref.13 Ref.14 Ref.16
	Modified residue	354	1	Phosphoserine Ref.1 Ref.7 Ref.13 Ref.16
	Modified residue	357	1	Phosphoserine Ref.13
	Modified residue	359	1	Phosphoserine Ref.16
	Modified residue	370	1	Phosphoserine Ref.9 Ref.13 Ref.16
	Modified residue	384	1	Phosphothreonine Ref.13
	Modified residue	387	1	Phosphothreonine Ref.13 Ref.14 Ref.16
	Modified residue	394	1	Phosphoserine Ref.13
	Modified residue	395	1	Phosphoserine Ref.11 Ref.12 Ref.13 Ref.14 Ref.16
Natural variations
	Alternative sequence	1 – 49	49	MAAPC…GGVDA → MRGLPRKREAWTQPHPLEAL YESLRVLE in isoform 2.		VSP_015217
	Alternative sequence	341 – 411	71	Missing in isoform 3.		VSP_015218
	Natural variant	271	1	T → A. Ref.5 Corresponds to variant rs1464890 [ dbSNP | Ensembl ].		VAR_023312
	Natural variant	363	1	R → H. Ref.5 Corresponds to variant rs11556924 [ dbSNP | Ensembl ].		VAR_023313
Experimental info
	Mutagenesis	105	1	Y → F: Does not strongly affect phosphorylation status; when associated with F-137. Ref.1
	Mutagenesis	137	1	Y → F: Does not strongly affect phosphorylation status; when associated with F-105. Ref.1
	Mutagenesis	170 – 171	2	LP → FM: Abolishes interaction with SKP1.
	Mutagenesis	354	1	S → A: Strongly reduces phosphorylation and induces the formation of a constitutive SCF(NIPA) E3 complex that degrades CCNB1 at G2/M phase and delays mitotic entry. Ref.1 Ref.6
	Mutagenesis	398 – 401	4	RKAK → AAAA: Induces a complete cytoplasmic redistribution. Ref.1
	Mutagenesis	399	1	K → P: Induces a partial cytoplasmic redistribution. Ref.1
	Sequence conflict	179	1	V → I in BAB14024. Ref.3
	Sequence conflict	278	1	K → R in AAF36136. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: D5DEDF9E30070586	FASTA	502	55,262
	10 20 30 40 50 60 MAAPCEGQAF AVGVEKNWGA VVRSPEGTPQ KIRQLIDEGI APEEGGVDAK DTSATSQSVN 70 80 90 100 110 120 GSPQAEQPSL ESTSKEAFFS RVETFSSLKW AGKPFELSPL VCAKYGWVTV ECDMLKCSSC 130 140 150 160 170 180 QAFLCASLQP AFDFDRYKQR CAELKKALCT AHEKFCFWPD SPSPDRFGML PLDEPAILVS 190 200 210 220 230 240 EFLDRFQSLC HLDLQLPSLR PEDLKTMCLT EDKISLLLHL LEDELDHRTD ERKTTIKLGS 250 260 270 280 290 300 DIQVHVTACI LSVCGWACSS SLESMQLSLI TCSQCMRKVG LWGFQQIESS MTDLDASFGL 310 320 330 340 350 360 TSSPIPGLEG RPERLPLVPE SPRRMMTRSQ DATFSPGSEQ AEKSPGPIVS RTRSWDSSSP 370 380 390 400 410 420 VDRPEPEAAS PTTRTRPVTR SMGTGDTPGL EVPSSPLRKA KRARLCSSSS SDTSSRSFFD 430 440 450 460 470 480 PTSQHRDWCP WVNITLGKES RENGGTEPDA SAPAEPGWKA VLTILLAHKQ SSQPAETDSM 490 500 SLSEKSRKVF RIFRQWESLC SC
	Isoform 2 [UniParc]. Checksum: B0EF4F07386A8554	FASTA	481	53,559
	10 20 30 40 50 60 MRGLPRKREA WTQPHPLEAL YESLRVLEKD TSATSQSVNG SPQAEQPSLE STSKEAFFSR 70 80 90 100 110 120 VETFSSLKWA GKPFELSPLV CAKYGWVTVE CDMLKCSSCQ AFLCASLQPA FDFDRYKQRC 130 140 150 160 170 180 AELKKALCTA HEKFCFWPDS PSPDRFGMLP LDEPAILVSE FLDRFQSLCH LDLQLPSLRP 190 200 210 220 230 240 EDLKTMCLTE DKISLLLHLL EDELDHRTDE RKTTIKLGSD IQVHVTACIL SVCGWACSSS 250 260 270 280 290 300 LESMQLSLIT CSQCMRKVGL WGFQQIESSM TDLDASFGLT SSPIPGLEGR PERLPLVPES 310 320 330 340 350 360 PRRMMTRSQD ATFSPGSEQA EKSPGPIVSR TRSWDSSSPV DRPEPEAASP TTRTRPVTRS 370 380 390 400 410 420 MGTGDTPGLE VPSSPLRKAK RARLCSSSSS DTSSRSFFDP TSQHRDWCPW VNITLGKESR 430 440 450 460 470 480 ENGGTEPDAS APAEPGWKAV LTILLAHKQS SQPAETDSMS LSEKSRKVFR IFRQWESLCS C
	Isoform 3 [UniParc]. Checksum: EC1DCB8077C127C7	FASTA	431	47,771
	10 20 30 40 50 60 MAAPCEGQAF AVGVEKNWGA VVRSPEGTPQ KIRQLIDEGI APEEGGVDAK DTSATSQSVN 70 80 90 100 110 120 GSPQAEQPSL ESTSKEAFFS RVETFSSLKW AGKPFELSPL VCAKYGWVTV ECDMLKCSSC 130 140 150 160 170 180 QAFLCASLQP AFDFDRYKQR CAELKKALCT AHEKFCFWPD SPSPDRFGML PLDEPAILVS 190 200 210 220 230 240 EFLDRFQSLC HLDLQLPSLR PEDLKTMCLT EDKISLLLHL LEDELDHRTD ERKTTIKLGS 250 260 270 280 290 300 DIQVHVTACI LSVCGWACSS SLESMQLSLI TCSQCMRKVG LWGFQQIESS MTDLDASFGL 310 320 330 340 350 360 TSSPIPGLEG RPERLPLVPE SPRRMMTRSQ DATFSPGSEQ DTSSRSFFDP TSQHRDWCPW 370 380 390 400 410 420 VNITLGKESR ENGGTEPDAS APAEPGWKAV LTILLAHKQS SQPAETDSMS LSEKSRKVFR 430 IFRQWESLCS C

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA)." Ouyang T., Bai R.-Y., Bassermann F., von Klitzing C., Klumpen S., Miething C., Morris S.W., Peschel C., Duyster J. J. Biol. Chem. 278:30028-30036(2003) [PubMed: 12748172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, NUCLEAR LOCALIZATION SIGNAL, INTERACTION WITH NPM-ALK FUSION PROTEIN, PHOSPHORYLATION AT SER-354, MUTAGENESIS OF TYR-105; TYR-137; SER-354; LYS-399 AND 398-ARG--LYS-401.
[2]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed: 11042152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Umbilical cord blood.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Mammary gland.
[4]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-271 AND HIS-363. Tissue: Kidney and Mammary gland.
[6]	"NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry." Bassermann F., von Klitzing C., Munch S., Bai R.-Y., Kawaguchi H., Morris S.W., Peschel C., Duyster J. Cell 122:45-57(2005) [PubMed: 16009132] [Abstract] Cited for: FUNCTION, PHOSPHORYLATION, DEVELOPMENTAL STAGE, DOMAIN, INTERACTION WITH SKP1 AND CCNB1, IDENTIFICATION IN SCF(NIPA) COMPLEX WITH SKP1; CUL1 AND RBX1, MUTAGENESIS OF 170-LEU-PRO-171 AND SER-354.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24; THR-28; SER-321 AND SER-354, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24; THR-28 AND SER-321, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-370, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24 AND THR-84, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321 AND SER-395, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321 AND SER-395, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24; THR-28; SER-321; THR-333; SER-335; SER-338; SER-344; SER-354; SER-357; SER-370; THR-384; THR-387; SER-394 AND SER-395, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58; SER-62; SER-321; SER-335; SER-338; SER-344; THR-387 AND SER-395, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[15]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338, MASS SPECTROMETRY.
[16]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58; SER-62; SER-321; SER-335; SER-338; SER-344; SER-354; SER-359; SER-370; THR-387 AND SER-395, MASS SPECTROMETRY. Tissue: Leukemic T-cell.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ537494 mRNA. Translation: CAD61161.1. AF151050 mRNA. Translation: AAF36136.1. Frameshift. AK001317 mRNA. Translation: BAA91619.1. AK022373 mRNA. Translation: BAB14024.1. AC073320 Genomic DNA. Translation: AAS07546.1. Sequence problems. AC073320 Genomic DNA. Translation: AAS07547.1. Sequence problems. AC087071 Genomic DNA. No translation available. BC011551 mRNA. Translation: AAH11551.1. BC028917 mRNA. Translation: AAH28917.1. Different initiation.
IPI	IPI00301421. IPI00339382. IPI00479595.
RefSeq	NP_057562.3. NM_016478.3.
UniGene	Hs.194157.
3D structure databases
ProteinModelPortal	Q86WB0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q86WB0.
PTM databases
PhosphoSite	Q86WB0.
Polymorphism databases
DMDM	73921220.
Proteomic databases
PRIDE	Q86WB0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000358303; ENSP00000351052; ENSG00000091732.
GeneID	51530.
KEGG	hsa:51530.
UCSC	uc003vph.1. human. uc003vpi.1. human. uc010lma.1. human.
Organism-specific databases
CTD	51530.
GeneCards	GC07M129658.
H-InvDB	HIX0007070.
HGNC	HGNC:29913. ZC3HC1.
HPA	HPA019089. HPA024023.
neXtProt	NX_Q86WB0.
PharmGKB	PA134931869.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000006086.
HOVERGEN	HBG082030.
InParanoid	Q86WB0.
OMA	RFPLVPE.
OrthoDB	EOG4B2SXH.
Gene expression databases
ArrayExpress	Q86WB0.
Bgee	Q86WB0.
CleanEx	HS_ZC3HC1.
Genevestigator	Q86WB0.
GermOnline	ENSG00000091732. Homo sapiens.
Family and domain databases
InterPro	IPR013909. NIPA/Rsm1. IPR012935. Znf_C3HC-like. [Graphical view]
Pfam	PF08600. Rsm1. 1 hit. PF07967. zf-C3HC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	55270.

Entry information

Entry name

NIPA_HUMAN

Accession

Primary (citable) accession number: Q86WB0
Secondary accession number(s): A6NH66 , Q75MF3, Q75MF4, Q8N330, Q96F75, Q9HA34, Q9NVX4, Q9P0R0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.