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Protein

Sodium-independent sulfate anion transporter

Gene

SLC26A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC).1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Anion exchange, Ion transport, Transport

Protein family/group databases

TCDBi2.A.53.1.10. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-independent sulfate anion transporter
Alternative name(s):
Solute carrier family 26 member 11
Gene namesi
Name:SLC26A11Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:14471. SLC26A11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151ExtracellularSequence analysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence analysisAdd
BLAST
Topological domaini73 – 731CytoplasmicSequence analysis
Transmembranei74 – 9421HelicalSequence analysisAdd
BLAST
Topological domaini95 – 1006ExtracellularSequence analysis
Transmembranei101 – 11717HelicalSequence analysisAdd
BLAST
Topological domaini118 – 1192CytoplasmicSequence analysis
Transmembranei120 – 14021HelicalSequence analysisAdd
BLAST
Topological domaini141 – 1477ExtracellularSequence analysis
Transmembranei148 – 16821HelicalSequence analysisAdd
BLAST
Topological domaini169 – 19729CytoplasmicSequence analysisAdd
BLAST
Transmembranei198 – 21821HelicalSequence analysisAdd
BLAST
Topological domaini219 – 25032ExtracellularSequence analysisAdd
BLAST
Transmembranei251 – 27121HelicalSequence analysisAdd
BLAST
Topological domaini272 – 30736CytoplasmicSequence analysisAdd
BLAST
Transmembranei308 – 32821HelicalSequence analysisAdd
BLAST
Topological domaini329 – 34113ExtracellularSequence analysisAdd
BLAST
Transmembranei342 – 36221HelicalSequence analysisAdd
BLAST
Topological domaini363 – 37412CytoplasmicSequence analysisAdd
BLAST
Transmembranei375 – 39521HelicalSequence analysisAdd
BLAST
Topological domaini396 – 3983ExtracellularSequence analysis
Transmembranei399 – 41921HelicalSequence analysisAdd
BLAST
Topological domaini420 – 44122CytoplasmicSequence analysisAdd
BLAST
Transmembranei442 – 46221HelicalSequence analysisAdd
BLAST
Topological domaini463 – 606144ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • intracellular membrane-bounded organelle Source: HPA
  • lysosomal membrane Source: UniProtKB
  • nucleoplasm Source: HPA
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37888.

Polymorphism and mutation databases

BioMutaiSLC26A11.
DMDMi182705284.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 606606Sodium-independent sulfate anion transporterPRO_0000320686Add
BLAST

Proteomic databases

EPDiQ86WA9.
MaxQBiQ86WA9.
PaxDbiQ86WA9.
PeptideAtlasiQ86WA9.
PRIDEiQ86WA9.

PTM databases

iPTMnetiQ86WA9.
PhosphoSiteiQ86WA9.
SwissPalmiQ86WA9.

Expressioni

Tissue specificityi

Detected in all tissues tested with highest expression observed in brain, kidney, HEVEC and placenta and lowest in pancreas, skeletal muscle, liver, lung and heart.2 Publications

Gene expression databases

BgeeiENSG00000181045.
CleanExiHS_SLC26A11.
ExpressionAtlasiQ86WA9. baseline and differential.
GenevisibleiQ86WA9. HS.

Organism-specific databases

HPAiHPA029893.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355384.

Structurei

3D structure databases

ProteinModelPortaliQ86WA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini470 – 584115STASPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOVERGENiHBG054728.
InParanoidiQ86WA9.
KOiK14708.
OMAiKMDFVAG.
OrthoDBiEOG091G05ML.
PhylomeDBiQ86WA9.
TreeFamiTF323537.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 1 hit.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86WA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSSVTALGQ ARSSGPGMAP SACCCSPAAL QRRLPILAWL PSYSLQWLKM
60 70 80 90 100
DFVAGLSVGL TAIPQALAYA EVAGLPPQYG LYSAFMGCFV YFFLGTSRDV
110 120 130 140 150
TLGPTAIMSL LVSFYTFHEP AYAVLLAFLS GCIQLAMGVL RLGFLLDFIS
160 170 180 190 200
YPVIKGFTSA AAVTIGFGQI KNLLGLQNIP RPFFLQVYHT FLRIAETRVG
210 220 230 240 250
DAVLGLVCML LLLVLKLMRD HVPPVHPEMP PGVRLSRGLV WAATTARNAL
260 270 280 290 300
VVSFAALVAY SFEVTGYQPF ILTGETAEGL PPVRIPPFSV TTANGTISFT
310 320 330 340 350
EMVQDMGAGL AVVPLMGLLE SIAVAKAFAS QNNYRIDANQ ELLAIGLTNM
360 370 380 390 400
LGSLVSSYPV TGSFGRTAVN AQSGVCTPAG GLVTGVLVLL SLDYLTSLFY
410 420 430 440 450
YIPKSALAAV IIMAVAPLFD TKIFRTLWRV KRLDLLPLCV TFLLCFWEVQ
460 470 480 490 500
YGILAGALVS LLMLLHSAAR PETKVSEGPV LVLQPASGLS FPAMEALREE
510 520 530 540 550
ILSRALEVSP PRCLVLECTH VCSIDYTVVL GLGELLQDFQ KQGVALAFVG
560 570 580 590 600
LQVPVLRVLL SADLKGFQYF STLEEAEKHL RQEPGTQPYN IREDSILDQK

VALLKA
Length:606
Mass (Da):65,299
Last modified:February 26, 2008 - v2
Checksum:iA0D974B49F16450D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141S → Y in CAD66450 (PubMed:12626430).Curated
Sequence conflicti319 – 3191L → M in CAD66450 (PubMed:12626430).Curated
Sequence conflicti324 – 3241V → M in AAM92902 (PubMed:11087667).Curated
Sequence conflicti328 – 3281F → S in AAO26673 (Ref. 2) Curated
Sequence conflicti332 – 3321N → D in CAD66450 (PubMed:12626430).Curated
Sequence conflicti415 – 4151V → A in AAO26673 (Ref. 2) Curated
Sequence conflicti569 – 5691Y → H in AAO26673 (Ref. 2) Curated
Sequence conflicti579 – 5791H → R in BAC11496 (PubMed:16303743).Curated
Sequence conflicti583 – 5831E → K in AAH35900 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti122 – 1221Y → C.1 Publication
Corresponds to variant rs765188926 [ dbSNP | Ensembl ].
VAR_068239

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ544073 mRNA. Translation: CAD66450.1.
AF345195 mRNA. Translation: AAO26673.1.
AK315132 mRNA. Translation: BAG37584.1.
AK075248 mRNA. Translation: BAC11496.1.
BC035900 mRNA. Translation: AAH35900.2.
BC047451 mRNA. Translation: AAH47451.1.
AF331524 mRNA. Translation: AAM92902.1.
CCDSiCCDS11771.2.
RefSeqiNP_001159819.1. NM_001166347.1.
NP_001159820.1. NM_001166348.1.
NP_001159821.1. NM_001166349.1.
NP_775897.3. NM_173626.3.
UniGeneiHs.4866.

Genome annotation databases

EnsembliENST00000361193; ENSP00000355384; ENSG00000181045.
ENST00000411502; ENSP00000403998; ENSG00000181045.
ENST00000546047; ENSP00000440724; ENSG00000181045.
ENST00000572725; ENSP00000459470; ENSG00000181045.
GeneIDi284129.
KEGGihsa:284129.
UCSCiuc002jyb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ544073 mRNA. Translation: CAD66450.1.
AF345195 mRNA. Translation: AAO26673.1.
AK315132 mRNA. Translation: BAG37584.1.
AK075248 mRNA. Translation: BAC11496.1.
BC035900 mRNA. Translation: AAH35900.2.
BC047451 mRNA. Translation: AAH47451.1.
AF331524 mRNA. Translation: AAM92902.1.
CCDSiCCDS11771.2.
RefSeqiNP_001159819.1. NM_001166347.1.
NP_001159820.1. NM_001166348.1.
NP_001159821.1. NM_001166349.1.
NP_775897.3. NM_173626.3.
UniGeneiHs.4866.

3D structure databases

ProteinModelPortaliQ86WA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355384.

Protein family/group databases

TCDBi2.A.53.1.10. the sulfate permease (sulp) family.

PTM databases

iPTMnetiQ86WA9.
PhosphoSiteiQ86WA9.
SwissPalmiQ86WA9.

Polymorphism and mutation databases

BioMutaiSLC26A11.
DMDMi182705284.

Proteomic databases

EPDiQ86WA9.
MaxQBiQ86WA9.
PaxDbiQ86WA9.
PeptideAtlasiQ86WA9.
PRIDEiQ86WA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361193; ENSP00000355384; ENSG00000181045.
ENST00000411502; ENSP00000403998; ENSG00000181045.
ENST00000546047; ENSP00000440724; ENSG00000181045.
ENST00000572725; ENSP00000459470; ENSG00000181045.
GeneIDi284129.
KEGGihsa:284129.
UCSCiuc002jyb.3. human.

Organism-specific databases

CTDi284129.
GeneCardsiSLC26A11.
HGNCiHGNC:14471. SLC26A11.
HPAiHPA029893.
MIMi610117. gene.
neXtProtiNX_Q86WA9.
PharmGKBiPA37888.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOVERGENiHBG054728.
InParanoidiQ86WA9.
KOiK14708.
OMAiKMDFVAG.
OrthoDBiEOG091G05ML.
PhylomeDBiQ86WA9.
TreeFamiTF323537.

Miscellaneous databases

ChiTaRSiSLC26A11. human.
GenomeRNAii284129.
PROiQ86WA9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181045.
CleanExiHS_SLC26A11.
ExpressionAtlasiQ86WA9. baseline and differential.
GenevisibleiQ86WA9. HS.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 1 hit.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS2611_HUMAN
AccessioniPrimary (citable) accession number: Q86WA9
Secondary accession number(s): B2RCI7
, Q86VX1, Q86YX7, Q8IV11, Q8N2I1, Q8NG03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 7, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.