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Protein

Liprin-beta-1

Gene

PPFIBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.1 Publication

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

GO - Biological processi

  • cell adhesion Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Liprin-beta-1
Alternative name(s):
Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1
Short name:
PTPRF-interacting protein-binding protein 1
hSGT2
Gene namesi
Name:PPFIBP1
Synonyms:KIAA1230
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:9249. PPFIBP1.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • focal adhesion Source: UniProtKB
  • plasma membrane Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi8496.
OpenTargetsiENSG00000110841.
PharmGKBiPA33570.

Polymorphism and mutation databases

BioMutaiPPFIBP1.
DMDMi90185247.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910341 – 1011Liprin-beta-1Add BLAST1011

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphoserineCombined sources1
Modified residuei39PhosphothreonineCombined sources1
Modified residuei40PhosphoserineCombined sources1
Modified residuei322N6-acetyllysineCombined sources1
Modified residuei434PhosphoserineBy similarity1
Modified residuei466PhosphoserineCombined sources1
Modified residuei540PhosphoserineCombined sources1
Modified residuei579PhosphoserineCombined sources1
Modified residuei601PhosphoserineCombined sources1
Modified residuei636PhosphoserineBy similarity1
Modified residuei794PhosphoserineCombined sources1
Modified residuei999PhosphoserineCombined sources1
Modified residuei1001PhosphoserineCombined sources1
Modified residuei1003PhosphoserineCombined sources1
Modified residuei1005PhosphothreonineCombined sources1
Isoform 2 (identifier: Q86W92-2)
Modified residuei523PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ86W92.
MaxQBiQ86W92.
PaxDbiQ86W92.
PeptideAtlasiQ86W92.
PRIDEiQ86W92.

PTM databases

iPTMnetiQ86W92.
PhosphoSitePlusiQ86W92.

Expressioni

Tissue specificityi

Widely expressed. Absent in liver.1 Publication

Gene expression databases

BgeeiENSG00000110841.
CleanExiHS_PPFIBP1.
ExpressionAtlasiQ86W92. baseline and differential.
GenevisibleiQ86W92. HS.

Organism-specific databases

HPAiHPA001924.

Interactioni

Subunit structurei

Forms homodimers and heterodimers. Interacts with S100A4 in a calcium-dependent mode.1 Publication

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi114068. 35 interactors.
DIPiDIP-42195N.
IntActiQ86W92. 16 interactors.
MINTiMINT-1683640.
STRINGi9606.ENSP00000314724.

Structurei

3D structure databases

ProteinModelPortaliQ86W92.
SMRiQ86W92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini647 – 711SAM 1PROSITE-ProRule annotationAdd BLAST65
Domaini719 – 782SAM 2PROSITE-ProRule annotationAdd BLAST64
Domaini804 – 876SAM 3PROSITE-ProRule annotationAdd BLAST73

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili156 – 405Sequence analysisAdd BLAST250

Domaini

The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha and interaction with S100A4.

Sequence similaritiesi

Belongs to the liprin family. Liprin-beta subfamily.Curated
Contains 3 SAM (sterile alpha motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1899. Eukaryota.
ENOG410XSFF. LUCA.
GeneTreeiENSGT00760000119138.
HOGENOMiHOG000082535.
HOVERGENiHBG052331.
InParanoidiQ86W92.
OMAiVPEEFHT.
OrthoDBiEOG091G01OJ.
PhylomeDBiQ86W92.
TreeFamiTF314207.

Family and domain databases

Gene3Di1.10.150.50. 3 hits.
InterProiIPR029515. Liprin.
IPR030437. PPFIBP1.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PANTHERiPTHR12587. PTHR12587. 1 hit.
PTHR12587:SF16. PTHR12587:SF16. 1 hit.
PfamiPF00536. SAM_1. 2 hits.
PF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 3 hits.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 3 hits.
PROSITEiPS50105. SAM_DOMAIN. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86W92-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMSDASDMLA AALEQMDGII AGSKALEYSN GIFDCQSPTS PFMGSLRALH
60 70 80 90 100
LVEDLRGLLE MMETDEKEGL RCQIPDSTAE TLVEWLQSQM TNGHLPGNGD
110 120 130 140 150
VYQERLARLE NDKESLVLQV SVLTDQVEAQ GEKIRDLEFC LEEHREKVNA
160 170 180 190 200
TEEMLQQELL SRTSLETQKL DLMAEISNLK LKLTAVEKDR LDYEDKFRDT
210 220 230 240 250
EGLIQEINDL RLKVSEMDSE RLQYEKKLKS TKSLMAKLSS MKIKVGQMQY
260 270 280 290 300
EKQRMEQKWE SLKDELASLK EQLEEKESEV KRLQEKLVCK MKGEGVEIVD
310 320 330 340 350
RDIEVQKMKK AVESLMAANE EKDRKIEDLR QCLNRYKKMQ DTVVLAQGKD
360 370 380 390 400
GEYEELLNSS SISSLLDAQG FSDLEKSPSP TPVMGSPSCD PFNTSVPEEF
410 420 430 440 450
HTTILQVSIP SLLPATVSME TSEKSKLTPK PETSFEENDG NIILGATVDT
460 470 480 490 500
QLCDKLLTSS LQKSSSLGNL KKETSDGEKE TIQKTSEDRA PAESRPFGTL
510 520 530 540 550
PPRPPGQDTS MDDNPFGTRK VRSSFGRGFF KIKSNKRTAS APNLAETEKE
560 570 580 590 600
TAEHLDLAGA SSRPKDSQRN SPFQIPPPSP DSKKKSRGIM KLFGKLRRSQ
610 620 630 640 650
STTFNPDDMS EPEFKRGGTR ATAGPRLGWS RDLGQSNSDL DMPFAKWTKE
660 670 680 690 700
QVCNWLMEQG LGSYLNSGKH WIASGQTLLQ ASQQDLEKEL GIKHSLHRKK
710 720 730 740 750
LQLALQALGS EEETNHGKLD FNWVTRWLDD IGLPQYKTQF DEGRVDGRML
760 770 780 790 800
HYMTVDDLLS LKVVSVLHHL SIKRAIQVLR INNFEPNCLR RRPSDENTIA
810 820 830 840 850
PSEVQKWTNH RVMEWLRSVD LAEYAPNLRG SGVHGGLMVL EPRFNVETMA
860 870 880 890 900
QLLNIPPNKT LLRRHLATHF NLLIGAEAQH QKRDAMELPD YVLLTATAKV
910 920 930 940 950
KPKKLAFSNF GNLRKKKQED GEEYVCPMEL GQASGSASKK GFKPGLDMRL
960 970 980 990 1000
YEEDDLDRLE QMEDSEGTVR QIGAFSEGIN NLTHMLKEDD MFKDFAARSP
1010
SASITDEDSN V
Note: No experimental confirmation available.
Length:1,011
Mass (Da):114,024
Last modified:March 7, 2006 - v2
Checksum:i20E30DD99ACD5A92
GO
Isoform 2 (identifier: Q86W92-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-263: Missing.
     302-302: D → DENFKKKLKEKN
     349-349: K → KKGK
     544-544: L → LDRKRSASAPTL

Note: No experimental confirmation available.Combined sources
Show »
Length:1,005
Mass (Da):113,181
Checksum:iE399A3BB86F46BAE
GO
Isoform 3 (identifier: Q86W92-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.

Note: No experimental confirmation available.
Show »
Length:858
Mass (Da):96,965
Checksum:iD5BE6B7D1D47C76A
GO
Isoform 4 (identifier: Q86W92-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-263: Missing.

Note: No experimental confirmation available.
Show »
Length:980
Mass (Da):110,297
Checksum:iA521EFCC0589E24B
GO
Isoform 5 (identifier: Q86W92-5) [UniParc]FASTAAdd to basket
Also known as: L2

The sequence of this isoform differs from the canonical sequence as follows:
     158-170: ELLSRTSLETQKL → VCAEARTKMGFPC
     171-1011: Missing.

Note: Due to intron retention.
Show »
Length:170
Mass (Da):18,972
Checksum:iC281D0F4E7896A7B
GO

Sequence cautioni

The sequence AAH46159 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA86544 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti308M → K in AAH46159 (PubMed:15489334).Curated1
Sequence conflicti453C → R in AAC26103 (PubMed:9624153).Curated1
Sequence conflicti553E → A in AAC26103 (PubMed:9624153).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017758148V → L.5 PublicationsCorresponds to variant rs2194816dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0093941 – 153Missing in isoform 3. 1 PublicationAdd BLAST153
Alternative sequenceiVSP_009395158 – 170ELLSR…ETQKL → VCAEARTKMGFPC in isoform 5. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_009396171 – 1011Missing in isoform 5. 2 PublicationsAdd BLAST841
Alternative sequenceiVSP_009397233 – 263Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST31
Alternative sequenceiVSP_009398302D → DENFKKKLKEKN in isoform 2. 1 Publication1
Alternative sequenceiVSP_009399349K → KKGK in isoform 2. 1 Publication1
Alternative sequenceiVSP_009400544L → LDRKRSASAPTL in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034802 mRNA. Translation: AAC26103.1.
AB033056 mRNA. Translation: BAA86544.2. Different initiation.
AJ276680 mRNA. Translation: CAB77544.1.
AB049149 mRNA. Translation: BAB39690.1.
BC046159 mRNA. Translation: AAH46159.1. Different initiation.
BC050281 mRNA. Translation: AAH50281.1.
CCDSiCCDS55812.1. [Q86W92-1]
CCDS55813.1. [Q86W92-4]
CCDS55814.1. [Q86W92-3]
CCDS8713.1. [Q86W92-2]
RefSeqiNP_001185844.1. NM_001198915.1. [Q86W92-3]
NP_001185845.1. NM_001198916.1.
NP_003613.3. NM_003622.3.
NP_803193.2. NM_177444.2.
UniGeneiHs.172445.

Genome annotation databases

EnsembliENST00000228425; ENSP00000228425; ENSG00000110841. [Q86W92-2]
ENST00000318304; ENSP00000314724; ENSG00000110841. [Q86W92-1]
ENST00000535047; ENSP00000444046; ENSG00000110841. [Q86W92-5]
ENST00000537927; ENSP00000445425; ENSG00000110841. [Q86W92-3]
ENST00000542629; ENSP00000443442; ENSG00000110841. [Q86W92-4]
GeneIDi8496.
KEGGihsa:8496.
UCSCiuc001rhz.3. human. [Q86W92-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034802 mRNA. Translation: AAC26103.1.
AB033056 mRNA. Translation: BAA86544.2. Different initiation.
AJ276680 mRNA. Translation: CAB77544.1.
AB049149 mRNA. Translation: BAB39690.1.
BC046159 mRNA. Translation: AAH46159.1. Different initiation.
BC050281 mRNA. Translation: AAH50281.1.
CCDSiCCDS55812.1. [Q86W92-1]
CCDS55813.1. [Q86W92-4]
CCDS55814.1. [Q86W92-3]
CCDS8713.1. [Q86W92-2]
RefSeqiNP_001185844.1. NM_001198915.1. [Q86W92-3]
NP_001185845.1. NM_001198916.1.
NP_003613.3. NM_003622.3.
NP_803193.2. NM_177444.2.
UniGeneiHs.172445.

3D structure databases

ProteinModelPortaliQ86W92.
SMRiQ86W92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114068. 35 interactors.
DIPiDIP-42195N.
IntActiQ86W92. 16 interactors.
MINTiMINT-1683640.
STRINGi9606.ENSP00000314724.

PTM databases

iPTMnetiQ86W92.
PhosphoSitePlusiQ86W92.

Polymorphism and mutation databases

BioMutaiPPFIBP1.
DMDMi90185247.

Proteomic databases

EPDiQ86W92.
MaxQBiQ86W92.
PaxDbiQ86W92.
PeptideAtlasiQ86W92.
PRIDEiQ86W92.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228425; ENSP00000228425; ENSG00000110841. [Q86W92-2]
ENST00000318304; ENSP00000314724; ENSG00000110841. [Q86W92-1]
ENST00000535047; ENSP00000444046; ENSG00000110841. [Q86W92-5]
ENST00000537927; ENSP00000445425; ENSG00000110841. [Q86W92-3]
ENST00000542629; ENSP00000443442; ENSG00000110841. [Q86W92-4]
GeneIDi8496.
KEGGihsa:8496.
UCSCiuc001rhz.3. human. [Q86W92-1]

Organism-specific databases

CTDi8496.
DisGeNETi8496.
GeneCardsiPPFIBP1.
HGNCiHGNC:9249. PPFIBP1.
HPAiHPA001924.
MIMi603141. gene.
neXtProtiNX_Q86W92.
OpenTargetsiENSG00000110841.
PharmGKBiPA33570.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1899. Eukaryota.
ENOG410XSFF. LUCA.
GeneTreeiENSGT00760000119138.
HOGENOMiHOG000082535.
HOVERGENiHBG052331.
InParanoidiQ86W92.
OMAiVPEEFHT.
OrthoDBiEOG091G01OJ.
PhylomeDBiQ86W92.
TreeFamiTF314207.

Miscellaneous databases

ChiTaRSiPPFIBP1. human.
GeneWikiiPPFIBP1.
GenomeRNAii8496.
PROiQ86W92.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110841.
CleanExiHS_PPFIBP1.
ExpressionAtlasiQ86W92. baseline and differential.
GenevisibleiQ86W92. HS.

Family and domain databases

Gene3Di1.10.150.50. 3 hits.
InterProiIPR029515. Liprin.
IPR030437. PPFIBP1.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PANTHERiPTHR12587. PTHR12587. 1 hit.
PTHR12587:SF16. PTHR12587:SF16. 1 hit.
PfamiPF00536. SAM_1. 2 hits.
PF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 3 hits.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 3 hits.
PROSITEiPS50105. SAM_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIPB1_HUMAN
AccessioniPrimary (citable) accession number: Q86W92
Secondary accession number(s): O75336
, Q86X70, Q9NY03, Q9ULJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: March 7, 2006
Last modified: November 30, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.