Reviewed, UniProtKB/Swiss-Prot Q86W74 (ANR46_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat domain-containing protein 46
Alternative name(s):
    Ankyrin repeat small protein
      Short name=ANK-S

Gene names

Name:

ANKRD46

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Contains 4 ANK repeats.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	ANK repeat Repeat Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86W74-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86W74-2)

The sequence of this isoform differs from the canonical sequence as follows:
     213-232: RRTLRLGSFARQDRSRIQAI → VSGVLPFVENQPELVH

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 232	232	Ankyrin repeat domain-containing protein 46		PRO_0000244577
Regions
	Transmembrane	190 – 210	21	Potential
	Repeat	11 – 40	30	ANK 1
	Repeat	44 – 73	30	ANK 2
	Repeat	77 – 103	27	ANK 3
	Repeat	107 – 138	32	ANK 4
Natural variations
	Alternative sequence	213 – 232	20	RRTLR…RIQAI → VSGVLPFVENQPELVH in isoform 2.		VSP_019606

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 63A3088747ED7E9A	FASTA	232	25,967
	10 20 30 40 50 60 MSYVFVNDSS QTNVPLLQAC IDGDFNYSKR LLESGFDPNI RDSRGRTGLH LAAARGNVDI 70 80 90 100 110 120 CQLLHKFGAD LLATDYQGNT ALHLCGHVDT IQFLVSNGLK IDICNHQGAT PLVLAKRRGV 130 140 150 160 170 180 NKDVIRLLES LEEQEVKGFN RGTHSKLETM QTAESESAME SHSLLNPNLQ QGEGVLSSFR 190 200 210 220 230 TTWQEFVEDL GFWRVLLLIF VIALLSLGIA YYRRTLRLGS FARQDRSRIQ AI
	Isoform 2. Checksum: F49A43CE49A28A0C	FASTA	228	25,330
	10 20 30 40 50 60 MSYVFVNDSS QTNVPLLQAC IDGDFNYSKR LLESGFDPNI RDSRGRTGLH LAAARGNVDI 70 80 90 100 110 120 CQLLHKFGAD LLATDYQGNT ALHLCGHVDT IQFLVSNGLK IDICNHQGAT PLVLAKRRGV 130 140 150 160 170 180 NKDVIRLLES LEEQEVKGFN RGTHSKLETM QTAESESAME SHSLLNPNLQ QGEGVLSSFR 190 200 210 220 TTWQEFVEDL GFWRVLLLIF VIALLSLGIA YYVSGVLPFV ENQPELVH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel ankyrin-repeat containing gene expressed in SAMP8 hippocampus." Yamamura N., Koike N., Nomura Y., Sakaki Y., Tashiro T., Furihata C. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lymph node.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Placenta and Skin.
[4]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB077205 mRNA. Translation: BAD23947.1. AL832842 mRNA. Translation: CAI46169.1. BC050396 mRNA. Translation: AAH50396.1. BC060843 mRNA. Translation: AAH60843.1.
IPI	IPI00329014. IPI00418525.
RefSeq	NP_940683.1.
UniGene	Hs.530199
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q86W74.
Genome annotation databases
Ensembl	ENST00000358990; ENSP00000351881; ENSG00000186106; Homo sapiens. [Genome view]
GeneID	157567.
KEGG	hsa:157567.
UCSC	uc003yjm.2. human. uc003yjn.1. human.
Organism-specific databases
CTD	157567.
GeneCards	GC08M101602.
HGNC	HGNC:27229. ANKRD46.
PharmGKB	PA142672613.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG279380.
HOVERGEN	Q86W74.
InParanoid	Q86W74.
OMA	PLATDYQ.
OrthoDB	EOG96HJVW.
Gene expression databases
ArrayExpress	Q86W74.
Bgee	Q86W74.
CleanEx	HS_ANKRD46.
Genevestigator	Q86W74.
GermOnline	ENSG00000186106. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 4 hits. [Graphical view]
SMART	SM00248. ANK. 3 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	87483.

Entry information

Entry name

ANR46_HUMAN

Accession

Primary (citable) accession number: Q86W74
Secondary accession number(s): Q6P9B7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 1, 2003
Last modified:	December 15, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.