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Protein

Ankyrin repeat domain-containing protein 46

Gene

ANKRD46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 46
Alternative name(s):
Ankyrin repeat small protein
Short name:
ANK-S
Gene namesi
Name:ANKRD46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000186106.11.
HGNCiHGNC:27229. ANKRD46.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi157567.
OpenTargetsiENSG00000186106.
PharmGKBiPA142672613.

Polymorphism and mutation databases

BioMutaiANKRD46.
DMDMi74750488.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002445771 – 232Ankyrin repeat domain-containing protein 46Add BLAST232

Proteomic databases

EPDiQ86W74.
MaxQBiQ86W74.
PaxDbiQ86W74.
PeptideAtlasiQ86W74.
PRIDEiQ86W74.

PTM databases

iPTMnetiQ86W74.
PhosphoSitePlusiQ86W74.

Expressioni

Gene expression databases

BgeeiENSG00000186106.
CleanExiHS_ANKRD46.
ExpressionAtlasiQ86W74. baseline and differential.
GenevisibleiQ86W74. HS.

Organism-specific databases

HPAiHPA013758.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MFFQ9GZY8-54EBI-12109402,EBI-11956541

Protein-protein interaction databases

BioGridi127604. 28 interactors.
IntActiQ86W74. 14 interactors.
STRINGi9606.ENSP00000335287.

Structurei

3D structure databases

ProteinModelPortaliQ86W74.
SMRiQ86W74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 40ANK 1Add BLAST30
Repeati44 – 73ANK 2Add BLAST30
Repeati77 – 103ANK 3Add BLAST27
Repeati107 – 138ANK 4Add BLAST32

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0508. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00790000123078.
HOGENOMiHOG000033966.
HOVERGENiHBG080854.
InParanoidiQ86W74.
OMAiATEYQGN.
OrthoDBiEOG091G0IKL.
PhylomeDBiQ86W74.
TreeFamiTF330790.

Family and domain databases

CDDicd00204. ANK. 1 hit.
Gene3Di1.25.40.20. 1 hit.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR036770. Ankyrin_rpt-contain_sf.
PfamiView protein in Pfam
PF12796. Ank_2. 1 hit.
SMARTiView protein in SMART
SM00248. ANK. 3 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86W74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYVFVNDSS QTNVPLLQAC IDGDFNYSKR LLESGFDPNI RDSRGRTGLH
60 70 80 90 100
LAAARGNVDI CQLLHKFGAD LLATDYQGNT ALHLCGHVDT IQFLVSNGLK
110 120 130 140 150
IDICNHQGAT PLVLAKRRGV NKDVIRLLES LEEQEVKGFN RGTHSKLETM
160 170 180 190 200
QTAESESAME SHSLLNPNLQ QGEGVLSSFR TTWQEFVEDL GFWRVLLLIF
210 220 230
VIALLSLGIA YYRRTLRLGS FARQDRSRIQ AI
Length:232
Mass (Da):25,967
Last modified:June 1, 2003 - v1
Checksum:i63A3088747ED7E9A
GO
Isoform 2 (identifier: Q86W74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-232: RRTLRLGSFARQDRSRIQAI → VSGVLPFVENQPELVH

Show »
Length:228
Mass (Da):25,330
Checksum:iF49A43CE49A28A0C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019606213 – 232RRTLR…RIQAI → VSGVLPFVENQPELVH in isoform 2. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077205 mRNA. Translation: BAD23947.1.
AL832842 mRNA. Translation: CAI46169.1.
BC050396 mRNA. Translation: AAH50396.1.
BC060843 mRNA. Translation: AAH60843.1.
CCDSiCCDS59109.1. [Q86W74-1]
CCDS6287.1. [Q86W74-2]
RefSeqiNP_001257306.1. NM_001270377.1. [Q86W74-2]
NP_001257307.1. NM_001270378.1. [Q86W74-2]
NP_001257308.1. NM_001270379.1. [Q86W74-1]
NP_940683.1. NM_198401.3. [Q86W74-2]
XP_006716572.1. XM_006716509.1. [Q86W74-2]
XP_016868595.1. XM_017013106.1. [Q86W74-2]
UniGeneiHs.530199.

Genome annotation databases

EnsembliENST00000335659; ENSP00000335287; ENSG00000186106. [Q86W74-2]
ENST00000519597; ENSP00000430056; ENSG00000186106. [Q86W74-2]
ENST00000520311; ENSP00000428388; ENSG00000186106. [Q86W74-2]
ENST00000520552; ENSP00000429015; ENSG00000186106. [Q86W74-1]
GeneIDi157567.
KEGGihsa:157567.
UCSCiuc003yjm.5. human. [Q86W74-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiANR46_HUMAN
AccessioniPrimary (citable) accession number: Q86W74
Secondary accession number(s): Q6P9B7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM