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Protein

Ankyrin repeat domain-containing protein 46

Gene

ANKRD46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 46
Alternative name(s):
Ankyrin repeat small protein
Short name:
ANK-S
Gene namesi
Name:ANKRD46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:27229. ANKRD46.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei190 – 21021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672613.

Polymorphism and mutation databases

BioMutaiANKRD46.
DMDMi74750488.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 232232Ankyrin repeat domain-containing protein 46PRO_0000244577Add
BLAST

Proteomic databases

EPDiQ86W74.
MaxQBiQ86W74.
PaxDbiQ86W74.
PeptideAtlasiQ86W74.
PRIDEiQ86W74.

PTM databases

iPTMnetiQ86W74.
PhosphoSiteiQ86W74.

Expressioni

Gene expression databases

BgeeiENSG00000186106.
CleanExiHS_ANKRD46.
ExpressionAtlasiQ86W74. baseline and differential.
GenevisibleiQ86W74. HS.

Organism-specific databases

HPAiHPA013758.

Interactioni

Protein-protein interaction databases

BioGridi127604. 22 interactions.
IntActiQ86W74. 1 interaction.
STRINGi9606.ENSP00000335287.

Structurei

3D structure databases

ProteinModelPortaliQ86W74.
SMRiQ86W74. Positions 6-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 4030ANK 1Add
BLAST
Repeati44 – 7330ANK 2Add
BLAST
Repeati77 – 10327ANK 3Add
BLAST
Repeati107 – 13832ANK 4Add
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0508. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00790000123078.
HOGENOMiHOG000033966.
HOVERGENiHBG080854.
InParanoidiQ86W74.
OMAiATEYQGN.
OrthoDBiEOG091G0IKL.
PhylomeDBiQ86W74.
TreeFamiTF330790.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86W74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYVFVNDSS QTNVPLLQAC IDGDFNYSKR LLESGFDPNI RDSRGRTGLH
60 70 80 90 100
LAAARGNVDI CQLLHKFGAD LLATDYQGNT ALHLCGHVDT IQFLVSNGLK
110 120 130 140 150
IDICNHQGAT PLVLAKRRGV NKDVIRLLES LEEQEVKGFN RGTHSKLETM
160 170 180 190 200
QTAESESAME SHSLLNPNLQ QGEGVLSSFR TTWQEFVEDL GFWRVLLLIF
210 220 230
VIALLSLGIA YYRRTLRLGS FARQDRSRIQ AI
Length:232
Mass (Da):25,967
Last modified:June 1, 2003 - v1
Checksum:i63A3088747ED7E9A
GO
Isoform 2 (identifier: Q86W74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-232: RRTLRLGSFARQDRSRIQAI → VSGVLPFVENQPELVH

Show »
Length:228
Mass (Da):25,330
Checksum:iF49A43CE49A28A0C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei213 – 23220RRTLR…RIQAI → VSGVLPFVENQPELVH in isoform 2. 2 PublicationsVSP_019606Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077205 mRNA. Translation: BAD23947.1.
AL832842 mRNA. Translation: CAI46169.1.
BC050396 mRNA. Translation: AAH50396.1.
BC060843 mRNA. Translation: AAH60843.1.
CCDSiCCDS59109.1. [Q86W74-1]
CCDS6287.1. [Q86W74-2]
RefSeqiNP_001257306.1. NM_001270377.1. [Q86W74-2]
NP_001257307.1. NM_001270378.1. [Q86W74-2]
NP_001257308.1. NM_001270379.1. [Q86W74-1]
NP_940683.1. NM_198401.3. [Q86W74-2]
XP_006716572.1. XM_006716509.1. [Q86W74-2]
UniGeneiHs.530199.

Genome annotation databases

EnsembliENST00000335659; ENSP00000335287; ENSG00000186106. [Q86W74-2]
ENST00000519597; ENSP00000430056; ENSG00000186106. [Q86W74-2]
ENST00000520311; ENSP00000428388; ENSG00000186106. [Q86W74-2]
ENST00000520552; ENSP00000429015; ENSG00000186106. [Q86W74-1]
GeneIDi157567.
KEGGihsa:157567.
UCSCiuc003yjm.5. human. [Q86W74-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077205 mRNA. Translation: BAD23947.1.
AL832842 mRNA. Translation: CAI46169.1.
BC050396 mRNA. Translation: AAH50396.1.
BC060843 mRNA. Translation: AAH60843.1.
CCDSiCCDS59109.1. [Q86W74-1]
CCDS6287.1. [Q86W74-2]
RefSeqiNP_001257306.1. NM_001270377.1. [Q86W74-2]
NP_001257307.1. NM_001270378.1. [Q86W74-2]
NP_001257308.1. NM_001270379.1. [Q86W74-1]
NP_940683.1. NM_198401.3. [Q86W74-2]
XP_006716572.1. XM_006716509.1. [Q86W74-2]
UniGeneiHs.530199.

3D structure databases

ProteinModelPortaliQ86W74.
SMRiQ86W74. Positions 6-203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127604. 22 interactions.
IntActiQ86W74. 1 interaction.
STRINGi9606.ENSP00000335287.

PTM databases

iPTMnetiQ86W74.
PhosphoSiteiQ86W74.

Polymorphism and mutation databases

BioMutaiANKRD46.
DMDMi74750488.

Proteomic databases

EPDiQ86W74.
MaxQBiQ86W74.
PaxDbiQ86W74.
PeptideAtlasiQ86W74.
PRIDEiQ86W74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335659; ENSP00000335287; ENSG00000186106. [Q86W74-2]
ENST00000519597; ENSP00000430056; ENSG00000186106. [Q86W74-2]
ENST00000520311; ENSP00000428388; ENSG00000186106. [Q86W74-2]
ENST00000520552; ENSP00000429015; ENSG00000186106. [Q86W74-1]
GeneIDi157567.
KEGGihsa:157567.
UCSCiuc003yjm.5. human. [Q86W74-1]

Organism-specific databases

CTDi157567.
GeneCardsiANKRD46.
H-InvDBHIX0007686.
HGNCiHGNC:27229. ANKRD46.
HPAiHPA013758.
neXtProtiNX_Q86W74.
PharmGKBiPA142672613.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0508. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00790000123078.
HOGENOMiHOG000033966.
HOVERGENiHBG080854.
InParanoidiQ86W74.
OMAiATEYQGN.
OrthoDBiEOG091G0IKL.
PhylomeDBiQ86W74.
TreeFamiTF330790.

Miscellaneous databases

ChiTaRSiANKRD46. human.
GenomeRNAii157567.
PROiQ86W74.

Gene expression databases

BgeeiENSG00000186106.
CleanExiHS_ANKRD46.
ExpressionAtlasiQ86W74. baseline and differential.
GenevisibleiQ86W74. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANR46_HUMAN
AccessioniPrimary (citable) accession number: Q86W74
Secondary accession number(s): Q6P9B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.