Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Spermatogenesis-associated protein 24

Gene

SPATA24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 24
Alternative name(s):
Testis protein T6441 homolog
Gene namesi
Name:SPATA24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:27322. SPATA24.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi202051.
OpenTargetsiENSG00000170469.
PharmGKBiPA165660551.

Polymorphism and mutation databases

BioMutaiSPATA24.
DMDMi182701380.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003289791 – 205Spermatogenesis-associated protein 24Add BLAST205

Proteomic databases

PaxDbiQ86W54.
PeptideAtlasiQ86W54.
PRIDEiQ86W54.

PTM databases

iPTMnetiQ86W54.
PhosphoSitePlusiQ86W54.

Expressioni

Gene expression databases

BgeeiENSG00000170469.
ExpressionAtlasiQ86W54. baseline and differential.
GenevisibleiQ86W54. HS.

Organism-specific databases

HPAiHPA044000.

Interactioni

Subunit structurei

Homodimer. Interacts with CBX3, CBX5, GMNN, GTF2B, TBPL1 and the polycomb proteins PHCF2, RNF2 and SCMH1 but not with CBX1 or PCGF2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CALCOCO2Q131373EBI-3916986,EBI-739580
CEP72Q9P2093EBI-3916986,EBI-739498
KRT31Q153233EBI-3916986,EBI-948001
KRTAP4-2Q9BYR53EBI-3916986,EBI-10172511
LZTS2Q9BRK43EBI-3916986,EBI-741037
MID2Q9UJV3-23EBI-3916986,EBI-10172526

Protein-protein interaction databases

BioGridi128415. 34 interactors.
IntActiQ86W54. 26 interactors.
MINTiMINT-8417719.
STRINGi9606.ENSP00000414920.

Structurei

3D structure databases

ProteinModelPortaliQ86W54.
SMRiQ86W54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 185Required for interaction with CBX5 and TBPL1By similarityAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili17 – 166Sequence analysisAdd BLAST150

Sequence similaritiesi

Belongs to the SPATA24 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IXKM. Eukaryota.
ENOG4112259. LUCA.
GeneTreeiENSGT00390000007817.
HOGENOMiHOG000154494.
HOVERGENiHBG108541.
InParanoidiQ86W54.
OMAiCSHIKEL.
PhylomeDBiQ86W54.
TreeFamiTF338733.

Family and domain databases

InterProiIPR029176. SPATA24.
[Graphical view]
PfamiPF15175. SPATA24. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86W54-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATPLGWSKA GSGSVCLALD QLRDVIESQE ELIHQLRNVM VLQDENFVSK
60 70 80 90 100
EEFQAVEKKL VEEKAAHAKT KVLLAKEEEK LQFALGEVEV LSKQLEKEKL
110 120 130 140 150
AFEKALSSVK SKVLQESSKK DQLITKCNEI ESHIIKQEDI LNGKENEIKE
160 170 180 190 200
LQQVISQQKQ IFRNHMSDFR IQKQQESYMA QVLDQKHKKA SGTRQARSHQ

HPREK
Length:205
Mass (Da):23,587
Last modified:April 8, 2008 - v2
Checksum:i039AD7AAB94C69E3
GO
Isoform 2 (identifier: Q86W54-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-205: EIESHIIKQE...ARSHQHPREK → GRREARALHH...GLKGPGRPRK

Show »
Length:188
Mass (Da):20,847
Checksum:iA889BABAC81B7669
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032867129 – 205EIESH…HPREK → GRREARALHHGYINGLFPNH PVPVSKAGFHSNTCPQLRIQ AGPGGPHLRKGLKGPGRPRK in isoform 2. 1 PublicationAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC040037 mRNA. No translation available.
BC050563 mRNA. Translation: AAH50563.1.
AC135457 Genomic DNA. No translation available.
CCDSiCCDS47274.1. [Q86W54-1]
RefSeqiNP_919272.1. NM_194296.1. [Q86W54-1]
UniGeneiHs.373612.

Genome annotation databases

EnsembliENST00000450845; ENSP00000414920; ENSG00000170469. [Q86W54-1]
ENST00000451821; ENSP00000400524; ENSG00000170469. [Q86W54-2]
GeneIDi202051.
KEGGihsa:202051.
UCSCiuc003lel.5. human. [Q86W54-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC040037 mRNA. No translation available.
BC050563 mRNA. Translation: AAH50563.1.
AC135457 Genomic DNA. No translation available.
CCDSiCCDS47274.1. [Q86W54-1]
RefSeqiNP_919272.1. NM_194296.1. [Q86W54-1]
UniGeneiHs.373612.

3D structure databases

ProteinModelPortaliQ86W54.
SMRiQ86W54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128415. 34 interactors.
IntActiQ86W54. 26 interactors.
MINTiMINT-8417719.
STRINGi9606.ENSP00000414920.

PTM databases

iPTMnetiQ86W54.
PhosphoSitePlusiQ86W54.

Polymorphism and mutation databases

BioMutaiSPATA24.
DMDMi182701380.

Proteomic databases

PaxDbiQ86W54.
PeptideAtlasiQ86W54.
PRIDEiQ86W54.

Protocols and materials databases

DNASUi202051.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000450845; ENSP00000414920; ENSG00000170469. [Q86W54-1]
ENST00000451821; ENSP00000400524; ENSG00000170469. [Q86W54-2]
GeneIDi202051.
KEGGihsa:202051.
UCSCiuc003lel.5. human. [Q86W54-1]

Organism-specific databases

CTDi202051.
DisGeNETi202051.
GeneCardsiSPATA24.
HGNCiHGNC:27322. SPATA24.
HPAiHPA044000.
neXtProtiNX_Q86W54.
OpenTargetsiENSG00000170469.
PharmGKBiPA165660551.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXKM. Eukaryota.
ENOG4112259. LUCA.
GeneTreeiENSGT00390000007817.
HOGENOMiHOG000154494.
HOVERGENiHBG108541.
InParanoidiQ86W54.
OMAiCSHIKEL.
PhylomeDBiQ86W54.
TreeFamiTF338733.

Miscellaneous databases

GenomeRNAii202051.
PROiQ86W54.

Gene expression databases

BgeeiENSG00000170469.
ExpressionAtlasiQ86W54. baseline and differential.
GenevisibleiQ86W54. HS.

Family and domain databases

InterProiIPR029176. SPATA24.
[Graphical view]
PfamiPF15175. SPATA24. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPA24_HUMAN
AccessioniPrimary (citable) accession number: Q86W54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 30, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.