UniProtKB - Q86W33 (TPRA1_HUMAN)
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Protein
Transmembrane protein adipocyte-associated 1
Gene
TPRA1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- G-protein coupled receptor activity Source: ProtInc
GO - Biological processi
- aging Source: ProtInc
- embryonic cleavage Source: Ensembl
- lipid metabolic process Source: ProtInc
- negative regulation of mitotic cell cycle phase transition Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein adipocyte-associated 1Alternative name(s): Integral membrane protein GPR175 Transmembrane protein 227 |
Gene namesi | Name:TPRA1 Synonyms:GPR175, TMEM227 ORF Names:PP6566 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000163870.14. |
HGNCi | HGNC:30413. TPRA1. |
MIMi | 608336. gene. |
neXtProti | NX_Q86W33. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 48 – 68 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 76 – 96 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 123 – 143 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 151 – 171 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Transmembranei | 192 – 212 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 234 – 254 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Transmembranei | 265 – 285 | Helical; Name=7Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000163870. |
PharmGKBi | PA165698543. |
Polymorphism and mutation databases
DMDMi | 74727643. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076099 | 1 – 373 | Transmembrane protein adipocyte-associated 1Add BLAST | 373 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 11 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 23 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 361 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | Q86W33. |
PaxDbi | Q86W33. |
PeptideAtlasi | Q86W33. |
PRIDEi | Q86W33. |
PTM databases
iPTMneti | Q86W33. |
PhosphoSitePlusi | Q86W33. |
Expressioni
Tissue specificityi
Ubiquitous, with higher levels in heart, placenta and kidney.1 Publication
Gene expression databases
Bgeei | ENSG00000163870. |
CleanExi | HS_GPR175. |
ExpressionAtlasi | Q86W33. baseline and differential. |
Genevisiblei | Q86W33. HS. |
Organism-specific databases
HPAi | HPA019784. |
Interactioni
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
NLGN3 | Q9NZ94-2 | 3 | EBI-16424742,EBI-16423037 |
Protein-protein interaction databases
BioGridi | 126289. 31 interactors. |
IntActi | Q86W33. 1 interactor. |
Family & Domainsi
Sequence similaritiesi
Belongs to the UPF0359 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4536. Eukaryota. ENOG410XRXY. LUCA. |
GeneTreei | ENSGT00390000016807. |
HOGENOMi | HOG000112778. |
HOVERGENi | HBG081569. |
InParanoidi | Q86W33. |
OMAi | CAGIIEG. |
OrthoDBi | EOG091G074F. |
PhylomeDBi | Q86W33. |
TreeFami | TF314072. |
Family and domain databases
InterProi | View protein in InterPro IPR018781. TPRA40. |
PANTHERi | PTHR15876. PTHR15876. 1 hit. |
Pfami | View protein in Pfam PF10160. Tmemb_40. 1 hit. |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q86W33-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MDTLEEVTWA NGSTALPPPL APNISVPHRC LLLLYEDIGT SRVRYWDLLL
60 70 80 90 100
LIPNVLFLIF LLWKLPSARA KIRITSSPIF ITFYILVFVV ALVGIARAVV
110 120 130 140 150
SMTVSTSNAA TVADKILWEI TRFFLLAIEL SVIILGLAFG HLESKSSIKR
160 170 180 190 200
VLAITTVLSL AYSVTQGTLE ILYPDAHLSA EDFNIYGHGG RQFWLVSSCF
210 220 230 240 250
FFLVYSLVVI LPKTPLKERI SLPSRRSFYV YAGILALLNL LQGLGSVLLC
260 270 280 290 300
FDIIEGLCCV DATTFLYFSF FAPLIYVAFL RGFFGSEPKI LFSYKCQVDE
310 320 330 340 350
TEEPDVHLPQ PYAVARREGL EAAGAAGASA ASYSSTQFDS AGGVAYLDDI
360 370
ASMPCHTGSI NSTDSERWKA INA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 141 – 142 | HL → TW in BAA89782 (Ref. 1) Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016934 | 204 – 293 | VYSLV…KILFS → LCRCHNLPVLQLLRSAHLRG FPPGLLRLGAQDPLLLQMPS GRDRGARCTPTPALRCGPAG GPGGCRGCWGLSCQLLEHAV RLCRRGGLPG in isoform 3. 1 PublicationAdd BLAST | 90 | |
Alternative sequenceiVSP_016932 | 204 – 239 | VYSLV…LALLN → LGGASTCMRASWHCSTYCRG WGVCCCASTSSRGSAV in isoform 2. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_016933 | 240 – 373 | Missing in isoform 2. 1 PublicationAdd BLAST | 134 | |
Alternative sequenceiVSP_016935 | 294 – 373 | Missing in isoform 3. 1 PublicationAdd BLAST | 80 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB037108 mRNA. Translation: BAA89782.1. AF289568 mRNA. Translation: AAL55752.1. AC023593 Genomic DNA. No translation available. AC084035 Genomic DNA. No translation available. CH471052 Genomic DNA. Translation: EAW79343.1. CH471052 Genomic DNA. Translation: EAW79344.1. BC017058 mRNA. Translation: AAH17058.1. BC050711 mRNA. Translation: AAH50711.1. |
CCDSi | CCDS3042.1. [Q86W33-1] CCDS46899.1. [Q86W33-3] |
RefSeqi | NP_001129525.1. NM_001136053.2. [Q86W33-1] NP_001136118.1. NM_001142646.2. [Q86W33-3] XP_006713558.1. XM_006713495.3. [Q86W33-1] XP_006713559.1. XM_006713496.2. [Q86W33-1] XP_006713560.1. XM_006713497.3. [Q86W33-1] XP_011510724.1. XM_011512422.1. [Q86W33-1] XP_016861196.1. XM_017005707.1. [Q86W33-1] XP_016861197.1. XM_017005708.1. [Q86W33-1] |
UniGenei | Hs.617549. Hs.6418. |
Genome annotation databases
Ensembli | ENST00000296210; ENSP00000296210; ENSG00000163870. [Q86W33-3] ENST00000355552; ENSP00000347748; ENSG00000163870. [Q86W33-1] ENST00000393400; ENSP00000377056; ENSG00000163870. [Q86W33-2] ENST00000450633; ENSP00000413428; ENSG00000163870. [Q86W33-1] ENST00000489960; ENSP00000418298; ENSG00000163870. [Q86W33-1] |
GeneIDi | 131601. |
KEGGi | hsa:131601. |
UCSCi | uc003ejn.4. human. [Q86W33-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | TPRA1_HUMAN | |
Accessioni | Q86W33Primary (citable) accession number: Q86W33 Secondary accession number(s): A8MVB8 Q9P2R4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2006 |
Last sequence update: | June 1, 2003 | |
Last modified: | February 28, 2018 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |