UniProtKB - Q86W26 (NAL10_HUMAN)
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Protein
NACHT, LRR and PYD domains-containing protein 10
Gene
NLRP10
Organism
Homo sapiens (Human)
Status
Functioni
Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed:15096476). Displays anti-inflammatory activity (PubMed:20393137). Required for immunity against C.albicans infection (By similarity). Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection (PubMed:22672233). Contributes to T-cell-mediated inflammatory responses in the skin (By similarity). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed:28766990). Exhibits both ATPase and GTPase activities (PubMed:23861819).By similarity4 Publications
Kineticsi
- KM=169.3 µM for ATP1 Publication
- KM=295.6 µM for GTP1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 173 – 180 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- GTPase activity Source: UniProtKB
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- defense response to fungus Source: UniProtKB
- defense response to Gram-negative bacterium Source: UniProtKB
- inflammatory response Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- positive regulation of defense response to bacterium Source: UniProtKB
- positive regulation of inflammatory response Source: UniProtKB
- positive regulation of interleukin-1 alpha secretion Source: UniProtKB
- positive regulation of interleukin-6 secretion Source: UniProtKB
- positive regulation of interleukin-8 secretion Source: UniProtKB
- positive regulation of T-helper 17 type immune response Source: UniProtKB
- positive regulation of T-helper 1 type immune response Source: UniProtKB
Keywordsi
Biological process | Adaptive immunity, Immunity, Inflammatory response, Innate immunity |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: NACHT, LRR and PYD domains-containing protein 10Alternative name(s): Nucleotide-binding oligomerization domain protein 8 |
Gene namesi | Name:NLRP10 Synonyms:NALP10, NOD8, PYNOD |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000182261.3. |
HGNCi | HGNC:21464. NLRP10. |
MIMi | 609662. gene. |
neXtProti | NX_Q86W26. |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 179 | K → A: Reduced release of IL8 following invasive bacterial infection. 1 Publication | 1 | |
Mutagenesisi | 252 | D → A: Reduced release of IL8 following invasive bacterial infection. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 338322. |
OpenTargetsi | ENSG00000182261. |
PharmGKBi | PA162397832. |
Polymorphism and mutation databases
BioMutai | NLRP10. |
DMDMi | 46396380. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080896 | 1 – 655 | NACHT, LRR and PYD domains-containing protein 10Add BLAST | 655 |
Proteomic databases
PaxDbi | Q86W26. |
PeptideAtlasi | Q86W26. |
PRIDEi | Q86W26. |
PTM databases
iPTMneti | Q86W26. |
PhosphoSitePlusi | Q86W26. |
Expressioni
Tissue specificityi
Highly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level) (PubMed:22672233). Widely expressed with highest levels in heart, brain and skeletal muscle (PubMed:15096476). Also expressed in liver, colon, dermis and epidermis (PubMed:15096476). Little expression detected in myeloid cells or peripheral blood mononuclear cells (PubMed:15096476).2 Publications
Inductioni
By infection with the periodontal pathogens T.forsythia and F.nucleatum (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000182261. |
CleanExi | HS_NLRP10. |
ExpressionAtlasi | Q86W26. baseline and differential. |
Genevisiblei | Q86W26. HS. |
Organism-specific databases
HPAi | HPA039498. HPA040101. |
Interactioni
Subunit structurei
Oligomerizes (PubMed:15096476). Interacts with PYCARD (PubMed:15096476). Also interacts with CASP1 and IL1B (PubMed:15096476). Interacts with NOD1 and components of the NOD1 signaling pathway including RIPK2, NR2C2/TAK1 and IKBKG/NEMO (PubMed:22672233).2 Publications
Protein-protein interaction databases
BioGridi | 130709. 7 interactors. |
STRINGi | 9606.ENSP00000327763. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 9 – 19 | Combined sources | 11 | |
Helixi | 22 – 36 | Combined sources | 15 | |
Helixi | 46 – 48 | Combined sources | 3 | |
Turni | 49 – 51 | Combined sources | 3 | |
Helixi | 54 – 64 | Combined sources | 11 | |
Helixi | 67 – 79 | Combined sources | 13 | |
Turni | 80 – 82 | Combined sources | 3 | |
Helixi | 84 – 93 | Combined sources | 10 | |
Helixi | 96 – 98 | Combined sources | 3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2M5V | NMR | - | A | 1-100 | [»] | |
ProteinModelPortali | Q86W26. | |||||
SMRi | Q86W26. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 96 | PyrinPROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 167 – 484 | NACHTPROSITE-ProRule annotationAdd BLAST | 318 |
Domaini
The pyrin and ATP-binding domains are required to elicit cytokine release following bacterial infection.
The NACHT domain is required for inhibition of CASP1 autoprocessing.
Sequence similaritiesi
Belongs to the NLRP family.Curated
Phylogenomic databases
eggNOGi | ENOG410IGPF. Eukaryota. ENOG410Y19A. LUCA. |
GeneTreei | ENSGT00900000140813. |
HOGENOMi | HOG000113728. |
HOVERGENi | HBG052572. |
InParanoidi | Q86W26. |
KOi | K22266. |
OMAi | DIFMAYV. |
OrthoDBi | EOG091G01CG. |
PhylomeDBi | Q86W26. |
Family and domain databases
InterProi | View protein in InterPro IPR004020. DAPIN. IPR011029. DEATH-like_dom_sf. IPR007111. NACHT_NTPase. IPR027417. P-loop_NTPase. |
Pfami | View protein in Pfam PF02758. PYRIN. 1 hit. |
SMARTi | View protein in SMART SM01289. PYRIN. 1 hit. |
SUPFAMi | SSF47986. SSF47986. 1 hit. SSF52540. SSF52540. 1 hit. |
PROSITEi | View protein in PROSITE PS50824. DAPIN. 1 hit. PS50837. NACHT. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q86W26-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAMAKARKPR EALLWALSDL EENDFKKLKF YLRDMTLSEG QPPLARGELE
60 70 80 90 100
GLIPVDLAEL LISKYGEKEA VKVVLKGLKV MNLLELVDQL SHICLHDYRE
110 120 130 140 150
VYREHVRCLE EWQEAGVNGR YNQVLLVAKP SSESPESLAC PFPEQELESV
160 170 180 190 200
TVEALFDSGE KPSLAPSLVV LQGSAGTGKT TLARKMVLDW ATGTLYPGRF
210 220 230 240 250
DYVFYVSCKE VVLLLESKLE QLLFWCCGDN QAPVTEILRQ PERLLFILDG
260 270 280 290 300
FDELQRPFEE KLKKRGLSPK ESLLHLLIRR HTLPTCSLLI TTRPLALRNL
310 320 330 340 350
EPLLKQARHV HILGFSEEER ARYFSSYFTD EKQADRAFDI VQKNDILYKA
360 370 380 390 400
CQVPGICWVV CSWLQGQMER GKVVLETPRN STDIFMAYVS TFLPPDDDGG
410 420 430 440 450
CSELSRHRVL RSLCSLAAEG IQHQRFLFEE AELRKHNLDG PRLAAFLSSN
460 470 480 490 500
DYQLGLAIKK FYSFRHISFQ DFFHAMSYLV KEDQSRLGKE SRREVQRLLE
510 520 530 540 550
VKEQEGNDEM TLTMQFLLDI SKKDSFSNLE LKFCFRISPC LAQDLKHFKE
560 570 580 590 600
QMESMKHNRT WDLEFSLYEA KIKNLVKGIQ MNNVSFKIKH SNEKKSQSQN
610 620 630 640 650
LFSVKSSLSH GPKEEQKCPS VHGQKEGKDN IAGTQKEAST GKGRGTEETP
KNTYI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY154465 mRNA. Translation: AAO18161.1. AY489192 mRNA. Translation: AAS67384.1. BK001110 mRNA. Translation: DAA01243.1. BC104957 mRNA. Translation: AAI04958.1. |
CCDSi | CCDS7784.1. |
RefSeqi | NP_789791.1. NM_176821.3. XP_011518345.1. XM_011520043.2. |
UniGenei | Hs.449636. |
Genome annotation databases
Ensembli | ENST00000328600; ENSP00000327763; ENSG00000182261. ENST00000612291; ENSP00000478480; ENSG00000276780. ENST00000625327; ENSP00000486762; ENSG00000281166. |
GeneIDi | 338322. |
KEGGi | hsa:338322. |
UCSCi | uc001mfv.2. human. |
Similar proteinsi
Entry informationi
Entry namei | NAL10_HUMAN | |
Accessioni | Q86W26Primary (citable) accession number: Q86W26 Secondary accession number(s): Q2M3C4, Q6JGT0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | June 1, 2003 | |
Last modified: | January 31, 2018 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Caution
Despite its official name, does not contain LRR repeats.Curated
Was originally thought to play a role in adaptive immunity through control of dendritic cell-mediated antigen transport to lymph nodes from peripheral sites. However, this was later shown to be dependent on DOCK8.By similarity