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Protein

NACHT, LRR and PYD domains-containing protein 13

Gene

NLRP13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in inflammation.Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi235 – 2428ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NACHT, LRR and PYD domains-containing protein 13
Alternative name(s):
Nucleotide-binding oligomerization domain protein 14
Gene namesi
Name:NLRP13
Synonyms:NALP13, NOD14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:22937. NLRP13.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162397891.

Polymorphism and mutation databases

BioMutaiNLRP13.
DMDMi145559500.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10431043NACHT, LRR and PYD domains-containing protein 13PRO_0000080900Add
BLAST

Proteomic databases

PaxDbiQ86W25.
PRIDEiQ86W25.

PTM databases

iPTMnetiQ86W25.
PhosphoSiteiQ86W25.

Expressioni

Gene expression databases

BgeeiQ86W25.
CleanExiHS_NLRP13.
ExpressionAtlasiQ86W25. baseline and differential.
GenevisibleiQ86W25. HS.

Organism-specific databases

HPAiHPA060459.

Interactioni

Protein-protein interaction databases

BioGridi125963. 2 interactions.
STRINGi9606.ENSP00000343891.

Structurei

3D structure databases

ProteinModelPortaliQ86W25.
SMRiQ86W25. Positions 16-104, 680-1043.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 107107PyrinPROSITE-ProRule annotationAdd
BLAST
Domaini229 – 558330NACHTPROSITE-ProRule annotationAdd
BLAST
Repeati725 – 74925LRR 1Add
BLAST
Repeati781 – 80424LRR 2Add
BLAST
Repeati837 – 86428LRR 3Add
BLAST
Repeati894 – 91724LRR 4Add
BLAST
Repeati923 – 94624LRR 5Add
BLAST
Repeati951 – 97828LRR 6Add
BLAST
Repeati1007 – 103024LRR 7Add
BLAST

Sequence similaritiesi

Belongs to the NLRP family.Curated
Contains 7 LRR (leucine-rich) repeats.Curated
Contains 1 NACHT domain.PROSITE-ProRule annotation
Contains 1 pyrin domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410JA4D. Eukaryota.
ENOG411152B. LUCA.
GeneTreeiENSGT00840000129675.
HOGENOMiHOG000294064.
InParanoidiQ86W25.
OMAiSKDEHEE.
OrthoDBiEOG7P5T07.
PhylomeDBiQ86W25.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.300. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 4 hits.
PF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50824. DAPIN. 1 hit.
PS50837. NACHT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86W25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFSVITCPN GGTNQGLLPY LMALDQYQLE EFKLCLEPQQ LMDFWSAPQG
60 70 80 90 100
HFPRIPWANL RAADPLNLSF LLDEHFPKGQ AWKVVLGIFQ TMNLTSLCEK
110 120 130 140 150
VRAEMKENVQ TQELQDPTQE DLEMLEAAAG NMQTQGCQDP NQEELDELEE
160 170 180 190 200
ETGNVQAQGC QDPNQEEPEM LEEADHRRKY RENMKAELLE TWDNISWPKD
210 220 230 240 250
HVYIRNTSKD EHEELQRLLD PNRTRAQAQT IVLVGRAGVG KTTLAMQAML
260 270 280 290 300
HWANGVLFQQ RFSYVFYLSC HKIRYMKETT FAELISLDWP DFDAPIEEFM
310 320 330 340 350
SQPEKLLFII DGFEEIIISE SRSESLDDGS PCTDWYQELP VTKILHSLLK
360 370 380 390 400
KELVPLATLL ITIKTWFVRD LKASLVNPCF VQITGFTGDD LRVYFMRHFD
410 420 430 440 450
DSSEVEKILQ QLRKNETLFH SCSAPMVCWT VCSCLKQPKV RYYDLQSITQ
460 470 480 490 500
TTTSLYAYFF SNLFSTAEVD LADDSWPGQW RALCSLAIEG LWSMNFTFNK
510 520 530 540 550
EDTEIEGLEV PFIDSLYEFN ILQKINDCGG CTTFTHLSFQ EFFAAMSFVL
560 570 580 590 600
EEPREFPPHS TKPQEMKMLL QHVLLDKEAY WTPVVLFFFG LLNKNIAREL
610 620 630 640 650
EDTLHCKISP RVMEELLKWG EELGKAESAS LQFHILRLFH CLHESQEEDF
660 670 680 690 700
TKKMLGRIFE VDLNILEDEE LQASSFCLKH CKRLNKLRLS VSSHILERDL
710 720 730 740 750
EILETSKFDS RMHAWNSICS TLVTNENLHE LDLSNSKLHA SSVKGLCLAL
760 770 780 790 800
KNPRCKVQKL TCKSVTPEWV LQDLIIALQG NSKLTHLNFS SNKLGMTVPL
810 820 830 840 850
ILKALRHSAC NLKYLCLEKC NLSAASCQDL ALFLTSIQHV TRLCLGFNRL
860 870 880 890 900
QDDGIKLLCA ALTHPKCALE RLELWFCQLA APACKHLSDA LLQNRSLTHL
910 920 930 940 950
NLSKNSLRDE GVKFLCEALG RPDGNLQSLN LSGCSFTREG CGELANALSH
960 970 980 990 1000
NHNVKILDLG ENDLQDDGVK LLCEALKPHR ALHTLGLAKC NLTTACCQHL
1010 1020 1030 1040
FSVLSSSKSL VNLNLLGNEL DTDGVKMLCK ALKKSTCRLQ KLG
Length:1,043
Mass (Da):118,884
Last modified:April 17, 2007 - v2
Checksum:iD2BAE6D83ACCA112
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1030 – 104314KALKK…LQKLG → FKKTCTM in DAA01241 (PubMed:12766759).CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti247 – 2471Q → R.1 Publication
Corresponds to variant rs303997 [ dbSNP | Ensembl ].
VAR_031707
Natural varianti781 – 7811N → S.
Corresponds to variant rs17711239 [ dbSNP | Ensembl ].
VAR_031708

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY154468 mRNA. Translation: AAO18164.1.
BK001108 mRNA. Translation: DAA01241.1.
CCDSiCCDS33119.1.
RefSeqiNP_789780.2. NM_176810.2.
UniGeneiHs.446924.

Genome annotation databases

EnsembliENST00000342929; ENSP00000343891; ENSG00000173572.
GeneIDi126204.
KEGGihsa:126204.
UCSCiuc010ygg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY154468 mRNA. Translation: AAO18164.1.
BK001108 mRNA. Translation: DAA01241.1.
CCDSiCCDS33119.1.
RefSeqiNP_789780.2. NM_176810.2.
UniGeneiHs.446924.

3D structure databases

ProteinModelPortaliQ86W25.
SMRiQ86W25. Positions 16-104, 680-1043.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125963. 2 interactions.
STRINGi9606.ENSP00000343891.

PTM databases

iPTMnetiQ86W25.
PhosphoSiteiQ86W25.

Polymorphism and mutation databases

BioMutaiNLRP13.
DMDMi145559500.

Proteomic databases

PaxDbiQ86W25.
PRIDEiQ86W25.

Protocols and materials databases

DNASUi126204.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342929; ENSP00000343891; ENSG00000173572.
GeneIDi126204.
KEGGihsa:126204.
UCSCiuc010ygg.3. human.

Organism-specific databases

CTDi126204.
GeneCardsiNLRP13.
H-InvDBHIX0040054.
HGNCiHGNC:22937. NLRP13.
HPAiHPA060459.
MIMi609660. gene.
neXtProtiNX_Q86W25.
PharmGKBiPA162397891.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JA4D. Eukaryota.
ENOG411152B. LUCA.
GeneTreeiENSGT00840000129675.
HOGENOMiHOG000294064.
InParanoidiQ86W25.
OMAiSKDEHEE.
OrthoDBiEOG7P5T07.
PhylomeDBiQ86W25.

Miscellaneous databases

GeneWikiiNLRP13.
GenomeRNAii126204.
PROiQ86W25.
SOURCEiSearch...

Gene expression databases

BgeeiQ86W25.
CleanExiHS_NLRP13.
ExpressionAtlasiQ86W25. baseline and differential.
GenevisibleiQ86W25. HS.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.300. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 4 hits.
PF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50824. DAPIN. 1 hit.
PS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "NALPs: a novel protein family involved in inflammation."
    Tschopp J., Martinon F., Burns K.
    Nat. Rev. Mol. Cell Biol. 4:95-104(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-247.
  2. "NODs: intracellular proteins involved in inflammation and apoptosis."
    Inohara N., Nunez G.
    Nat. Rev. Immunol. 3:371-382(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiNAL13_HUMAN
AccessioniPrimary (citable) accession number: Q86W25
Secondary accession number(s): Q7RTR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 17, 2007
Last modified: June 8, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.