Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NACHT, LRR and PYD domains-containing protein 14

Gene

NLRP14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in inflammation and spermatogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi183 – 190ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • multicellular organism development Source: UniProtKB-KW
  • spermatogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NACHT, LRR and PYD domains-containing protein 14
Alternative name(s):
Nucleotide-binding oligomerization domain protein 5
Gene namesi
Name:NLRP14
Synonyms:NALP14, NOD5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:22939. NLRP14.

Pathology & Biotechi

Organism-specific databases

DisGeNETi338323.
OpenTargetsiENSG00000158077.
PharmGKBiPA162397917.

Polymorphism and mutation databases

BioMutaiNLRP14.
DMDMi38372322.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809011 – 1093NACHT, LRR and PYD domains-containing protein 14Add BLAST1093

Proteomic databases

PaxDbiQ86W24.
PeptideAtlasiQ86W24.
PRIDEiQ86W24.

PTM databases

iPTMnetiQ86W24.
PhosphoSitePlusiQ86W24.

Expressioni

Tissue specificityi

Testis-specific.1 Publication

Developmental stagei

In the testis, expressed mainly in A dark spermatogonia, mid and late spermatocytes and spermatids but not in mitotically active A pale and B spermatogonia.1 Publication

Gene expression databases

BgeeiENSG00000158077.
CleanExiHS_NLRP14.
GenevisibleiQ86W24. HS.

Organism-specific databases

HPAiHPA039477.

Interactioni

Protein-protein interaction databases

BioGridi130710. 1 interactor.
STRINGi9606.ENSP00000299481.

Structurei

Secondary structure

11093
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 12Combined sources4
Helixi14 – 19Combined sources6
Helixi24 – 38Combined sources15
Turni39 – 41Combined sources3
Helixi45 – 52Combined sources8
Helixi55 – 65Combined sources11
Helixi69 – 81Combined sources13
Helixi85 – 100Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4N1JX-ray2.60A/B/C/D1-100[»]
4N1KX-ray3.00A/B/C/D1-100[»]
4N1LX-ray1.99A1-100[»]
ProteinModelPortaliQ86W24.
SMRiQ86W24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 97PyrinPROSITE-ProRule annotationAdd BLAST97
Domaini177 – 499NACHTPROSITE-ProRule annotationAdd BLAST323
Repeati730 – 750LRR 1Add BLAST21
Repeati759 – 780LRR 2Add BLAST22
Repeati787 – 807LRR 3Add BLAST21
Repeati816 – 836LRR 4Add BLAST21
Repeati844 – 864LRR 5Add BLAST21
Repeati873 – 894LRR 6Add BLAST22
Repeati901 – 921LRR 7Add BLAST21
Repeati930 – 951LRR 8Add BLAST22
Repeati958 – 978LRR 9Add BLAST21
Repeati987 – 1008LRR 10Add BLAST22
Repeati1015 – 1035LRR 11Add BLAST21

Sequence similaritiesi

Belongs to the NLRP family.Curated
Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 NACHT domain.PROSITE-ProRule annotation
Contains 1 pyrin domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00860000133669.
HOGENOMiHOG000294064.
HOVERGENiHBG063656.
InParanoidiQ86W24.
OMAiWLWECNL.
OrthoDBiEOG091G01CG.
PhylomeDBiQ86W24.
TreeFamiTF340267.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.300. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 4 hits.
PF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50824. DAPIN. 1 hit.
PS50837. NACHT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86W24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSSSSSFF PDFGLLLYLE ELNKEELNTF KLFLKETMEP EHGLTPWNEV
60 70 80 90 100
KKARREDLAN LMKKYYPGEK AWSVSLKIFG KMNLKDLCER AKEEINWSAQ
110 120 130 140 150
TIGPDDAKAG ETQEDQEAVL GDGTEYRNRI KEKFCITWDK KSLAGKPEDF
160 170 180 190 200
HHGIAEKDRK LLEHLFDVDV KTGAQPQIVV LQGAAGVGKT TLVRKAMLDW
210 220 230 240 250
AEGSLYQQRF KYVFYLNGRE INQLKERSFA QLISKDWPST EGPIEEIMYQ
260 270 280 290 300
PSSLLFIIDS FDELNFAFEE PEFALCEDWT QEHPVSFLMS SLLRKVMLPE
310 320 330 340 350
ASLLVTTRLT TSKRLKQLLK NHHYVELLGM SEDAREEYIY QFFEDKRWAM
360 370 380 390 400
KVFSSLKSNE MLFSMCQVPL VCWAACTCLK QQMEKGGDVT LTCQTTTALF
410 420 430 440 450
TCYISSLFTP VDGGSPSLPN QAQLRRLCQV AAKGIWTMTY VFYRENLRRL
460 470 480 490 500
GLTQSDVSSF MDSNIIQKDA EYENCYVFTH LHVQEFFAAM FYMLKGSWEA
510 520 530 540 550
GNPSCQPFED LKSLLQSTSY KDPHLTQMKC FLFGLLNEDR VKQLERTFNC
560 570 580 590 600
KMSLKIKSKL LQCMEVLGNS DYSPSQLGFL ELFHCLYETQ DKAFISQAMR
610 620 630 640 650
CFPKVAINIC EKIHLLVSSF CLKHCRCLRT IRLSVTVVFE KKILKTSLPT
660 670 680 690 700
NTWDGDRITH CWQDLCSVLH TNEHLRELDL YHSNLDKSAM NILHHELRHP
710 720 730 740 750
NCKLQKLLLK FITFPDGCQD ISTSLIHNKN LMHLDLKGSD IGDNGVKSLC
760 770 780 790 800
EALKHPECKL QTLRLESCNL TVFCCLNISN ALIRSQSLIF LNLSTNNLLD
810 820 830 840 850
DGVQLLCEAL RHPKCYLERL SLESCGLTEA GCEYLSLALI SNKRLTHLCL
860 870 880 890 900
ADNVLGDGGV KLMSDALQHA QCTLKSLVLR RCHFTSLSSE YLSTSLLHNK
910 920 930 940 950
SLTHLDLGSN WLQDNGVKLL CDVFRHPSCN LQDLELMGCV LTNACCLDLA
960 970 980 990 1000
SVILNNPNLR SLDLGNNDLQ DDGVKILCDA LRYPNCNIQR LGLEYCGLTS
1010 1020 1030 1040 1050
LCCQDLSSAL ICNKRLIKMN LTQNTLGYEG IVKLYKVLKS PKCKLQVLGL
1060 1070 1080 1090
CKEAFDEEAQ KLLEAVGVSN PHLIIKPDCN YHNEEDVSWW WCF
Length:1,093
Mass (Da):124,733
Last modified:June 1, 2003 - v1
Checksum:i124EEACE22A11D6F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05362221E → K.Corresponds to variant rs11041150dbSNPEnsembl.1
Natural variantiVAR_03193248N → T.1 PublicationCorresponds to variant rs12801277dbSNPEnsembl.1
Natural variantiVAR_03193355R → Q.1 Publication1
Natural variantiVAR_03193486D → V.2 PublicationsCorresponds to variant rs199735773dbSNPEnsembl.1
Natural variantiVAR_03193592K → R.1 PublicationCorresponds to variant rs16921697dbSNPEnsembl.1
Natural variantiVAR_03193698S → L.1 PublicationCorresponds to variant rs117823353dbSNPEnsembl.1
Natural variantiVAR_031937375A → T.1 PublicationCorresponds to variant rs368562565dbSNPEnsembl.1
Natural variantiVAR_031938397T → I.1 PublicationCorresponds to variant rs76670455dbSNPEnsembl.1
Natural variantiVAR_031939441V → M.1 PublicationCorresponds to variant rs147389856dbSNPEnsembl.1
Natural variantiVAR_053623511L → F.Corresponds to variant rs11041151dbSNPEnsembl.1
Natural variantiVAR_031940522D → G.1 Publication1
Natural variantiVAR_036387779S → C in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_024180808E → K.1 PublicationCorresponds to variant rs10839708dbSNPEnsembl.1
Natural variantiVAR_031941951S → T.1 PublicationCorresponds to variant rs117124176dbSNPEnsembl.1
Natural variantiVAR_031942954L → S.1 PublicationCorresponds to variant rs117583918dbSNPEnsembl.1
Natural variantiVAR_0319431010L → F.1 PublicationCorresponds to variant rs17280682dbSNPEnsembl.1
Natural variantiVAR_0319441019M → I.1 PublicationCorresponds to variant rs115776642dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY154469 mRNA. Translation: AAO18165.1.
BK001107 mRNA. Translation: DAA01240.1.
CCDSiCCDS7776.1.
RefSeqiNP_789792.1. NM_176822.3.
UniGeneiHs.449637.

Genome annotation databases

EnsembliENST00000299481; ENSP00000299481; ENSG00000158077.
GeneIDi338323.
KEGGihsa:338323.
UCSCiuc001mfb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY154469 mRNA. Translation: AAO18165.1.
BK001107 mRNA. Translation: DAA01240.1.
CCDSiCCDS7776.1.
RefSeqiNP_789792.1. NM_176822.3.
UniGeneiHs.449637.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4N1JX-ray2.60A/B/C/D1-100[»]
4N1KX-ray3.00A/B/C/D1-100[»]
4N1LX-ray1.99A1-100[»]
ProteinModelPortaliQ86W24.
SMRiQ86W24.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130710. 1 interactor.
STRINGi9606.ENSP00000299481.

PTM databases

iPTMnetiQ86W24.
PhosphoSitePlusiQ86W24.

Polymorphism and mutation databases

BioMutaiNLRP14.
DMDMi38372322.

Proteomic databases

PaxDbiQ86W24.
PeptideAtlasiQ86W24.
PRIDEiQ86W24.

Protocols and materials databases

DNASUi338323.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299481; ENSP00000299481; ENSG00000158077.
GeneIDi338323.
KEGGihsa:338323.
UCSCiuc001mfb.2. human.

Organism-specific databases

CTDi338323.
DisGeNETi338323.
GeneCardsiNLRP14.
HGNCiHGNC:22939. NLRP14.
HPAiHPA039477.
MIMi609665. gene.
neXtProtiNX_Q86W24.
OpenTargetsiENSG00000158077.
PharmGKBiPA162397917.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00860000133669.
HOGENOMiHOG000294064.
HOVERGENiHBG063656.
InParanoidiQ86W24.
OMAiWLWECNL.
OrthoDBiEOG091G01CG.
PhylomeDBiQ86W24.
TreeFamiTF340267.

Miscellaneous databases

ChiTaRSiNLRP14. human.
GeneWikiiNLRP14.
GenomeRNAii338323.
PROiQ86W24.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158077.
CleanExiHS_NLRP14.
GenevisibleiQ86W24. HS.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.300. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 4 hits.
PF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50824. DAPIN. 1 hit.
PS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAL14_HUMAN
AccessioniPrimary (citable) accession number: Q86W24
Secondary accession number(s): Q7RTR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.