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Protein

NACHT, LRR and PYD domains-containing protein 14

Gene

NLRP14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in inflammation and spermatogenesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi183 – 1908ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • multicellular organism development Source: UniProtKB-KW
  • spermatogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NACHT, LRR and PYD domains-containing protein 14
Alternative name(s):
Nucleotide-binding oligomerization domain protein 5
Gene namesi
Name:NLRP14
Synonyms:NALP14, NOD5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:22939. NLRP14.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162397917.

Polymorphism and mutation databases

BioMutaiNLRP14.
DMDMi38372322.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10931093NACHT, LRR and PYD domains-containing protein 14PRO_0000080901Add
BLAST

Proteomic databases

PaxDbiQ86W24.
PRIDEiQ86W24.

PTM databases

iPTMnetiQ86W24.
PhosphoSiteiQ86W24.

Expressioni

Tissue specificityi

Testis-specific.1 Publication

Developmental stagei

In the testis, expressed mainly in A dark spermatogonia, mid and late spermatocytes and spermatids but not in mitotically active A pale and B spermatogonia.1 Publication

Gene expression databases

BgeeiQ86W24.
CleanExiHS_NLRP14.
GenevisibleiQ86W24. HS.

Organism-specific databases

HPAiHPA039477.

Interactioni

Protein-protein interaction databases

BioGridi130710. 1 interaction.
STRINGi9606.ENSP00000299481.

Structurei

Secondary structure

1
1093
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 124Combined sources
Helixi14 – 196Combined sources
Helixi24 – 3815Combined sources
Turni39 – 413Combined sources
Helixi45 – 528Combined sources
Helixi55 – 6511Combined sources
Helixi69 – 8113Combined sources
Helixi85 – 10016Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4N1JX-ray2.60A/B/C/D1-100[»]
4N1KX-ray3.00A/B/C/D1-100[»]
4N1LX-ray1.99A1-100[»]
ProteinModelPortaliQ86W24.
SMRiQ86W24. Positions 7-100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9797PyrinPROSITE-ProRule annotationAdd
BLAST
Domaini177 – 499323NACHTPROSITE-ProRule annotationAdd
BLAST
Repeati730 – 75021LRR 1Add
BLAST
Repeati759 – 78022LRR 2Add
BLAST
Repeati787 – 80721LRR 3Add
BLAST
Repeati816 – 83621LRR 4Add
BLAST
Repeati844 – 86421LRR 5Add
BLAST
Repeati873 – 89422LRR 6Add
BLAST
Repeati901 – 92121LRR 7Add
BLAST
Repeati930 – 95122LRR 8Add
BLAST
Repeati958 – 97821LRR 9Add
BLAST
Repeati987 – 100822LRR 10Add
BLAST
Repeati1015 – 103521LRR 11Add
BLAST

Sequence similaritiesi

Belongs to the NLRP family.Curated
Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 NACHT domain.PROSITE-ProRule annotation
Contains 1 pyrin domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00840000129675.
HOGENOMiHOG000294064.
HOVERGENiHBG063656.
InParanoidiQ86W24.
OMAiPNTFRSN.
OrthoDBiEOG7P5T07.
PhylomeDBiQ86W24.
TreeFamiTF340267.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.300. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 4 hits.
PF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50824. DAPIN. 1 hit.
PS50837. NACHT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86W24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSSSSSFF PDFGLLLYLE ELNKEELNTF KLFLKETMEP EHGLTPWNEV
60 70 80 90 100
KKARREDLAN LMKKYYPGEK AWSVSLKIFG KMNLKDLCER AKEEINWSAQ
110 120 130 140 150
TIGPDDAKAG ETQEDQEAVL GDGTEYRNRI KEKFCITWDK KSLAGKPEDF
160 170 180 190 200
HHGIAEKDRK LLEHLFDVDV KTGAQPQIVV LQGAAGVGKT TLVRKAMLDW
210 220 230 240 250
AEGSLYQQRF KYVFYLNGRE INQLKERSFA QLISKDWPST EGPIEEIMYQ
260 270 280 290 300
PSSLLFIIDS FDELNFAFEE PEFALCEDWT QEHPVSFLMS SLLRKVMLPE
310 320 330 340 350
ASLLVTTRLT TSKRLKQLLK NHHYVELLGM SEDAREEYIY QFFEDKRWAM
360 370 380 390 400
KVFSSLKSNE MLFSMCQVPL VCWAACTCLK QQMEKGGDVT LTCQTTTALF
410 420 430 440 450
TCYISSLFTP VDGGSPSLPN QAQLRRLCQV AAKGIWTMTY VFYRENLRRL
460 470 480 490 500
GLTQSDVSSF MDSNIIQKDA EYENCYVFTH LHVQEFFAAM FYMLKGSWEA
510 520 530 540 550
GNPSCQPFED LKSLLQSTSY KDPHLTQMKC FLFGLLNEDR VKQLERTFNC
560 570 580 590 600
KMSLKIKSKL LQCMEVLGNS DYSPSQLGFL ELFHCLYETQ DKAFISQAMR
610 620 630 640 650
CFPKVAINIC EKIHLLVSSF CLKHCRCLRT IRLSVTVVFE KKILKTSLPT
660 670 680 690 700
NTWDGDRITH CWQDLCSVLH TNEHLRELDL YHSNLDKSAM NILHHELRHP
710 720 730 740 750
NCKLQKLLLK FITFPDGCQD ISTSLIHNKN LMHLDLKGSD IGDNGVKSLC
760 770 780 790 800
EALKHPECKL QTLRLESCNL TVFCCLNISN ALIRSQSLIF LNLSTNNLLD
810 820 830 840 850
DGVQLLCEAL RHPKCYLERL SLESCGLTEA GCEYLSLALI SNKRLTHLCL
860 870 880 890 900
ADNVLGDGGV KLMSDALQHA QCTLKSLVLR RCHFTSLSSE YLSTSLLHNK
910 920 930 940 950
SLTHLDLGSN WLQDNGVKLL CDVFRHPSCN LQDLELMGCV LTNACCLDLA
960 970 980 990 1000
SVILNNPNLR SLDLGNNDLQ DDGVKILCDA LRYPNCNIQR LGLEYCGLTS
1010 1020 1030 1040 1050
LCCQDLSSAL ICNKRLIKMN LTQNTLGYEG IVKLYKVLKS PKCKLQVLGL
1060 1070 1080 1090
CKEAFDEEAQ KLLEAVGVSN PHLIIKPDCN YHNEEDVSWW WCF
Length:1,093
Mass (Da):124,733
Last modified:June 1, 2003 - v1
Checksum:i124EEACE22A11D6F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211E → K.
Corresponds to variant rs11041150 [ dbSNP | Ensembl ].
VAR_053622
Natural varianti48 – 481N → T.1 Publication
Corresponds to variant rs12801277 [ dbSNP | Ensembl ].
VAR_031932
Natural varianti55 – 551R → E Requires 2 nucleotide substitutions. 1 Publication
VAR_031933
Natural varianti86 – 861D → V Associated with spermatogenic failure. 1 Publication
Corresponds to variant rs199735773 [ dbSNP | Ensembl ].
VAR_031934
Natural varianti92 – 921K → R.1 Publication
Corresponds to variant rs16921697 [ dbSNP | Ensembl ].
VAR_031935
Natural varianti98 – 981S → L.1 Publication
Corresponds to variant rs117823353 [ dbSNP | Ensembl ].
VAR_031936
Natural varianti375 – 3751A → T Associated with spermatogenic failure. 1 Publication
VAR_031937
Natural varianti397 – 3971T → I.1 Publication
Corresponds to variant rs76670455 [ dbSNP | Ensembl ].
VAR_031938
Natural varianti441 – 4411V → M.1 Publication
Corresponds to variant rs147389856 [ dbSNP | Ensembl ].
VAR_031939
Natural varianti511 – 5111L → F.
Corresponds to variant rs11041151 [ dbSNP | Ensembl ].
VAR_053623
Natural varianti522 – 5221D → Q Associated with spermatogenic failure; requires 2 nucleotide substitutions. 1 Publication
VAR_031940
Natural varianti779 – 7791S → C in a breast cancer sample; somatic mutation. 1 Publication
VAR_036387
Natural varianti808 – 8081E → K.1 Publication
Corresponds to variant rs10839708 [ dbSNP | Ensembl ].
VAR_024180
Natural varianti951 – 9511S → T.1 Publication
Corresponds to variant rs117124176 [ dbSNP | Ensembl ].
VAR_031941
Natural varianti954 – 9541L → S.1 Publication
Corresponds to variant rs117583918 [ dbSNP | Ensembl ].
VAR_031942
Natural varianti1010 – 10101L → F.1 Publication
Corresponds to variant rs17280682 [ dbSNP | Ensembl ].
VAR_031943
Natural varianti1019 – 10191M → I Associated with spermatogenic failure. 1 Publication
Corresponds to variant rs115776642 [ dbSNP | Ensembl ].
VAR_031944

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY154469 mRNA. Translation: AAO18165.1.
BK001107 mRNA. Translation: DAA01240.1.
CCDSiCCDS7776.1.
RefSeqiNP_789792.1. NM_176822.3.
UniGeneiHs.449637.

Genome annotation databases

EnsembliENST00000299481; ENSP00000299481; ENSG00000158077.
GeneIDi338323.
KEGGihsa:338323.
UCSCiuc001mfb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY154469 mRNA. Translation: AAO18165.1.
BK001107 mRNA. Translation: DAA01240.1.
CCDSiCCDS7776.1.
RefSeqiNP_789792.1. NM_176822.3.
UniGeneiHs.449637.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4N1JX-ray2.60A/B/C/D1-100[»]
4N1KX-ray3.00A/B/C/D1-100[»]
4N1LX-ray1.99A1-100[»]
ProteinModelPortaliQ86W24.
SMRiQ86W24. Positions 7-100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130710. 1 interaction.
STRINGi9606.ENSP00000299481.

PTM databases

iPTMnetiQ86W24.
PhosphoSiteiQ86W24.

Polymorphism and mutation databases

BioMutaiNLRP14.
DMDMi38372322.

Proteomic databases

PaxDbiQ86W24.
PRIDEiQ86W24.

Protocols and materials databases

DNASUi338323.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299481; ENSP00000299481; ENSG00000158077.
GeneIDi338323.
KEGGihsa:338323.
UCSCiuc001mfb.2. human.

Organism-specific databases

CTDi338323.
GeneCardsiNLRP14.
HGNCiHGNC:22939. NLRP14.
HPAiHPA039477.
MIMi609665. gene.
neXtProtiNX_Q86W24.
PharmGKBiPA162397917.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00840000129675.
HOGENOMiHOG000294064.
HOVERGENiHBG063656.
InParanoidiQ86W24.
OMAiPNTFRSN.
OrthoDBiEOG7P5T07.
PhylomeDBiQ86W24.
TreeFamiTF340267.

Miscellaneous databases

ChiTaRSiNLRP14. human.
GeneWikiiNLRP14.
GenomeRNAii338323.
PROiQ86W24.
SOURCEiSearch...

Gene expression databases

BgeeiQ86W24.
CleanExiHS_NLRP14.
GenevisibleiQ86W24. HS.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.300. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 4 hits.
PF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50824. DAPIN. 1 hit.
PS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "NALPs: a novel protein family involved in inflammation."
    Tschopp J., Martinon F., Burns K.
    Nat. Rev. Mol. Cell Biol. 4:95-104(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "NODs: intracellular proteins involved in inflammation and apoptosis."
    Inohara N., Nunez G.
    Nat. Rev. Immunol. 3:371-382(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure."
    Westerveld G.H., Korver C.M., van Pelt A.M.M., Leschot N.J., van der Veen F., Repping S., Lombardi M.P.
    Hum. Reprod. 21:3178-3184(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANTS THR-48; GLU-55; VAL-86; ARG-92; LEU-98; THR-375; ILE-397; MET-441; GLN-522; LYS-808; THR-951; SER-954; PHE-1010 AND ILE-1019.
  4. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-779.

Entry informationi

Entry nameiNAL14_HUMAN
AccessioniPrimary (citable) accession number: Q86W24
Secondary accession number(s): Q7RTR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.