Q86VZ4 (LRP11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Low-density lipoprotein receptor-related protein 11
Short name=LRP-11

Gene names

Name:

LRP11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the LDLR family. Contains 1 LDL-receptor class A domain. Contains 1 MANSC domain. Contains 1 PKD domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86VZ4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86VZ4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     205-237: EKDAPPLSKAGQDVVLHLPTDGVVLDGRESTDD → GKRATEGPALARALETRSALAKLEAKHTRAKLF
     238-500: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 37	37	Potential
	Chain	38 – 500	463	Low-density lipoprotein receptor-related protein 11		PRO_0000017337
Regions
	Topological domain	38 – 450	413	Extracellular Potential
	Transmembrane	451 – 473	23	Helical; Potential
	Topological domain	474 – 500	27	Cytoplasmic Potential
	Domain	99 – 184	86	MANSC
	Domain	210 – 305	96	PKD
	Domain	309 – 345	37	LDL-receptor class A
Amino acid modifications
	Glycosylation	164	1	N-linked (GlcNAc...) Potential
	Glycosylation	291	1	N-linked (GlcNAc...) Potential
	Glycosylation	401	1	N-linked (GlcNAc...) Potential
	Disulfide bond	310 ↔ 322		By similarity
	Disulfide bond	317 ↔ 335		By similarity
	Disulfide bond	329 ↔ 344		By similarity
Natural variations
	Alternative sequence	205 – 237	33	EKDAP…ESTDD → GKRATEGPALARALETRSAL AKLEAKHTRAKLF in isoform 2.		VSP_017535
	Alternative sequence	238 – 500	263	Missing in isoform 2.		VSP_017536
	Natural variant	92	1	P → R. Ref.3 Corresponds to variant rs9322225 [ dbSNP | Ensembl ].		VAR_025537
	Natural variant	281	1	T → M. Corresponds to variant rs9478945 [ dbSNP | Ensembl ].		VAR_056002
	Natural variant	351	1	R → H. Ref.3 Corresponds to variant rs17854254 [ dbSNP | Ensembl ].		VAR_025538
	Natural variant	442	1	G → R. Corresponds to variant rs9478144 [ dbSNP | Ensembl ].		VAR_056003

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 7, 2006. Version 2. Checksum: A90C62D2154C9C31	FASTA	500	53,311
	10 20 30 40 50 60 MASVAQESAG SQRRLPPRHG ALRGLLLLCL WLPSGRAALP PAAPLSELHA QLSGVEQLLE 70 80 90 100 110 120 EFRRQLQQER PQEELELELR AGGGPQEDCP GPGSGGYSAM PDAIIRTKDS LAAGASFLRA 130 140 150 160 170 180 PAAVRGWRQC VAACCSEPRC SVAVVELPRR PAPPAAVLGC YLFNCTARGR NVCKFALHSG 190 200 210 220 230 240 YSSYSLSRAP DGAALATARA SPRQEKDAPP LSKAGQDVVL HLPTDGVVLD GRESTDDHAI 250 260 270 280 290 300 VQYEWALLQG DPSVDMKVPQ SGTLKLSHLQ EGTYTFQLTV TDTAGQRSSD NVSVTVLRAA 310 320 330 340 350 360 YSTGGCLHTC SRYHFFCDDG CCIDITLACD GVQQCPDGSD EDFCQNLGLD RKMVTHTAAS 370 380 390 400 410 420 PALPRTTGPS EDAGGDSLVE KSQKATAPNK PPALSNTEKR NHSAFWGPES QIIPVMPDSS 430 440 450 460 470 480 SSGKNRKEES YIFESKGDGG GGEHPAPETG AVLPLALGLA ITALLLLMVA CRLRLVKQKL 490 500 KKARPITSEE SDYLINGMYL
	Isoform 2 [UniParc]. Checksum: A2D4FB54E841960C	FASTA	237	25,170
	10 20 30 40 50 60 MASVAQESAG SQRRLPPRHG ALRGLLLLCL WLPSGRAALP PAAPLSELHA QLSGVEQLLE 70 80 90 100 110 120 EFRRQLQQER PQEELELELR AGGGPQEDCP GPGSGGYSAM PDAIIRTKDS LAAGASFLRA 130 140 150 160 170 180 PAAVRGWRQC VAACCSEPRC SVAVVELPRR PAPPAAVLGC YLFNCTARGR NVCKFALHSG 190 200 210 220 230 YSSYSLSRAP DGAALATARA SPRQGKRATE GPALARALET RSALAKLEAK HTRAKLF

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS ARG-92 AND HIS-351. Tissue: Brain and Skin.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK027641 mRNA. Translation: BAB55257.1. AL355312 Genomic DNA. Translation: CAH72865.1. BC025239 mRNA. Translation: AAH25239.1. BC043141 mRNA. Translation: AAH43141.1.
IPI	IPI00045841. IPI00739809.
RefSeq	NP_116221.3. NM_032832.5.
UniGene	Hs.408355.
3D structure databases
ProteinModelPortal	Q86VZ4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86VZ4. 1 interaction.
PTM databases
PhosphoSite	Q86VZ4.
Polymorphism databases
DMDM	92058704.
Proteomic databases
PaxDb	Q86VZ4.
PRIDE	Q86VZ4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000239367; ENSP00000239367; ENSG00000120256.
GeneID	84918.
KEGG	hsa:84918.
UCSC	uc003qng.2. human.
Organism-specific databases
CTD	84918.
GeneCards	GC06M150139.
HGNC	HGNC:16936. LRP11.
neXtProt	NX_Q86VZ4.
PharmGKB	PA134880462.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG26598.
HOGENOM	HOG000113387.
HOVERGEN	HBG052354.
InParanoid	Q86VZ4.
OMA	IRTKDSL.
OrthoDB	EOG4SN1NS.
PhylomeDB	Q86VZ4.
Gene expression databases
ArrayExpress	Q86VZ4.
Bgee	Q86VZ4.
CleanEx	HS_LRP11.
Genevestigator	Q86VZ4.
GermOnline	ENSG00000120256. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.670. 1 hit. 4.10.400.10. 1 hit.
InterPro	IPR023415. LDLR_class-A_CS. IPR002172. LDrepeatLR_classA_rpt. IPR013980. MANSC. IPR011106. MANSC_N. IPR022409. PKD/Chitinase_dom. IPR000601. PKD_dom. [Graphical view]
Pfam	PF00057. Ldl_recept_a. 1 hit. PF07502. MANEC. 1 hit. [Graphical view]
SMART	SM00192. LDLa. 1 hit. SM00765. MANEC. 1 hit. SM00089. PKD. 1 hit. [Graphical view]
SUPFAM	SSF57424. LDL_rcpt_classA_cys-rich. 1 hit. SSF49299. PKD. 1 hit.
PROSITE	PS01209. LDLRA_1. 1 hit. PS50068. LDLRA_2. 1 hit. PS50986. MANSC. 1 hit. PS50093. PKD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	LRP11. human.
GenomeRNAi	84918.
NextBio	75320.

Entry information

Entry name

LRP11_HUMAN

Accession

Primary (citable) accession number: Q86VZ4
Secondary accession number(s): Q5VYC0, Q96SN6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	March 7, 2006
Last modified:	May 1, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.