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Protein

Low-density lipoprotein receptor-related protein 11

Gene

LRP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • phosphoprotein binding Source: AgBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 11
Short name:
LRP-11
Gene namesi
Name:LRP11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:16936. LRP11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini38 – 450413ExtracellularSequence analysisAdd
BLAST
Transmembranei451 – 47323HelicalSequence analysisAdd
BLAST
Topological domaini474 – 50027CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134880462.

Polymorphism and mutation databases

BioMutaiLRP11.
DMDMi92058704.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737Sequence analysisAdd
BLAST
Chaini38 – 500463Low-density lipoprotein receptor-related protein 11PRO_0000017337Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence analysis
Glycosylationi291 – 2911N-linked (GlcNAc...)Sequence analysis
Disulfide bondi310 ↔ 322PROSITE-ProRule annotation
Disulfide bondi317 ↔ 335PROSITE-ProRule annotation
Disulfide bondi329 ↔ 344PROSITE-ProRule annotation
Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence analysis
Modified residuei491 – 4911PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ86VZ4.
MaxQBiQ86VZ4.
PaxDbiQ86VZ4.
PeptideAtlasiQ86VZ4.
PRIDEiQ86VZ4.
TopDownProteomicsiQ86VZ4-1. [Q86VZ4-1]

PTM databases

iPTMnetiQ86VZ4.
PhosphoSiteiQ86VZ4.

Expressioni

Gene expression databases

BgeeiENSG00000120256.
CleanExiHS_LRP11.
ExpressionAtlasiQ86VZ4. baseline and differential.
GenevisibleiQ86VZ4. HS.

Organism-specific databases

HPAiHPA064002.

Interactioni

GO - Molecular functioni

  • phosphoprotein binding Source: AgBase

Protein-protein interaction databases

BioGridi124354. 17 interactions.
IntActiQ86VZ4. 1 interaction.
STRINGi9606.ENSP00000239367.

Structurei

3D structure databases

ProteinModelPortaliQ86VZ4.
SMRiQ86VZ4. Positions 98-184, 212-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini99 – 18486MANSCPROSITE-ProRule annotationAdd
BLAST
Domaini210 – 30596PKDPROSITE-ProRule annotationAdd
BLAST
Domaini309 – 34537LDL-receptor class APROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the LDLR family.Curated
Contains 1 LDL-receptor class A domain.PROSITE-ProRule annotation
Contains 1 MANSC domain.PROSITE-ProRule annotation
Contains 1 PKD domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIM4. Eukaryota.
ENOG410XSFD. LUCA.
GeneTreeiENSGT00840000129825.
HOGENOMiHOG000113387.
HOVERGENiHBG052354.
InParanoidiQ86VZ4.
OMAiCLWLPSG.
OrthoDBiEOG091G0ET0.
PhylomeDBiQ86VZ4.
TreeFamiTF325867.

Family and domain databases

Gene3Di2.60.40.670. 1 hit.
4.10.400.10. 1 hit.
InterProiIPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR013980. MANSC_dom.
IPR011106. MANSC_N.
IPR022409. PKD/Chitinase_dom.
IPR000601. PKD_dom.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF07502. MANEC. 1 hit.
[Graphical view]
SMARTiSM00192. LDLa. 1 hit.
SM00765. MANEC. 1 hit.
SM00089. PKD. 1 hit.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS50986. MANSC. 1 hit.
PS50093. PKD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86VZ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASVAQESAG SQRRLPPRHG ALRGLLLLCL WLPSGRAALP PAAPLSELHA
60 70 80 90 100
QLSGVEQLLE EFRRQLQQER PQEELELELR AGGGPQEDCP GPGSGGYSAM
110 120 130 140 150
PDAIIRTKDS LAAGASFLRA PAAVRGWRQC VAACCSEPRC SVAVVELPRR
160 170 180 190 200
PAPPAAVLGC YLFNCTARGR NVCKFALHSG YSSYSLSRAP DGAALATARA
210 220 230 240 250
SPRQEKDAPP LSKAGQDVVL HLPTDGVVLD GRESTDDHAI VQYEWALLQG
260 270 280 290 300
DPSVDMKVPQ SGTLKLSHLQ EGTYTFQLTV TDTAGQRSSD NVSVTVLRAA
310 320 330 340 350
YSTGGCLHTC SRYHFFCDDG CCIDITLACD GVQQCPDGSD EDFCQNLGLD
360 370 380 390 400
RKMVTHTAAS PALPRTTGPS EDAGGDSLVE KSQKATAPNK PPALSNTEKR
410 420 430 440 450
NHSAFWGPES QIIPVMPDSS SSGKNRKEES YIFESKGDGG GGEHPAPETG
460 470 480 490 500
AVLPLALGLA ITALLLLMVA CRLRLVKQKL KKARPITSEE SDYLINGMYL
Length:500
Mass (Da):53,311
Last modified:March 7, 2006 - v2
Checksum:iA90C62D2154C9C31
GO
Isoform 2 (identifier: Q86VZ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-237: EKDAPPLSKAGQDVVLHLPTDGVVLDGRESTDD → GKRATEGPALARALETRSALAKLEAKHTRAKLF
     238-500: Missing.

Note: No experimental confirmation available.
Show »
Length:237
Mass (Da):25,170
Checksum:iA2D4FB54E841960C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921P → R.1 Publication
Corresponds to variant rs9322225 [ dbSNP | Ensembl ].
VAR_025537
Natural varianti281 – 2811T → M.
Corresponds to variant rs9478945 [ dbSNP | Ensembl ].
VAR_056002
Natural varianti351 – 3511R → H.1 Publication
Corresponds to variant rs17854254 [ dbSNP | Ensembl ].
VAR_025538
Natural varianti442 – 4421G → R.
Corresponds to variant rs9478144 [ dbSNP | Ensembl ].
VAR_056003

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei205 – 23733EKDAP…ESTDD → GKRATEGPALARALETRSAL AKLEAKHTRAKLF in isoform 2. 1 PublicationVSP_017535Add
BLAST
Alternative sequencei238 – 500263Missing in isoform 2. 1 PublicationVSP_017536Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027641 mRNA. Translation: BAB55257.1.
AL355312 Genomic DNA. Translation: CAH72865.1.
BC025239 mRNA. Translation: AAH25239.1.
BC043141 mRNA. Translation: AAH43141.1.
CCDSiCCDS5220.1. [Q86VZ4-1]
RefSeqiNP_116221.3. NM_032832.5. [Q86VZ4-1]
UniGeneiHs.408355.

Genome annotation databases

EnsembliENST00000239367; ENSP00000239367; ENSG00000120256. [Q86VZ4-1]
GeneIDi84918.
KEGGihsa:84918.
UCSCiuc003qng.3. human. [Q86VZ4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027641 mRNA. Translation: BAB55257.1.
AL355312 Genomic DNA. Translation: CAH72865.1.
BC025239 mRNA. Translation: AAH25239.1.
BC043141 mRNA. Translation: AAH43141.1.
CCDSiCCDS5220.1. [Q86VZ4-1]
RefSeqiNP_116221.3. NM_032832.5. [Q86VZ4-1]
UniGeneiHs.408355.

3D structure databases

ProteinModelPortaliQ86VZ4.
SMRiQ86VZ4. Positions 98-184, 212-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124354. 17 interactions.
IntActiQ86VZ4. 1 interaction.
STRINGi9606.ENSP00000239367.

PTM databases

iPTMnetiQ86VZ4.
PhosphoSiteiQ86VZ4.

Polymorphism and mutation databases

BioMutaiLRP11.
DMDMi92058704.

Proteomic databases

EPDiQ86VZ4.
MaxQBiQ86VZ4.
PaxDbiQ86VZ4.
PeptideAtlasiQ86VZ4.
PRIDEiQ86VZ4.
TopDownProteomicsiQ86VZ4-1. [Q86VZ4-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239367; ENSP00000239367; ENSG00000120256. [Q86VZ4-1]
GeneIDi84918.
KEGGihsa:84918.
UCSCiuc003qng.3. human. [Q86VZ4-1]

Organism-specific databases

CTDi84918.
GeneCardsiLRP11.
HGNCiHGNC:16936. LRP11.
HPAiHPA064002.
neXtProtiNX_Q86VZ4.
PharmGKBiPA134880462.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIM4. Eukaryota.
ENOG410XSFD. LUCA.
GeneTreeiENSGT00840000129825.
HOGENOMiHOG000113387.
HOVERGENiHBG052354.
InParanoidiQ86VZ4.
OMAiCLWLPSG.
OrthoDBiEOG091G0ET0.
PhylomeDBiQ86VZ4.
TreeFamiTF325867.

Miscellaneous databases

ChiTaRSiLRP11. human.
GenomeRNAii84918.
PROiQ86VZ4.

Gene expression databases

BgeeiENSG00000120256.
CleanExiHS_LRP11.
ExpressionAtlasiQ86VZ4. baseline and differential.
GenevisibleiQ86VZ4. HS.

Family and domain databases

Gene3Di2.60.40.670. 1 hit.
4.10.400.10. 1 hit.
InterProiIPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR013980. MANSC_dom.
IPR011106. MANSC_N.
IPR022409. PKD/Chitinase_dom.
IPR000601. PKD_dom.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF07502. MANEC. 1 hit.
[Graphical view]
SMARTiSM00192. LDLa. 1 hit.
SM00765. MANEC. 1 hit.
SM00089. PKD. 1 hit.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS50986. MANSC. 1 hit.
PS50093. PKD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRP11_HUMAN
AccessioniPrimary (citable) accession number: Q86VZ4
Secondary accession number(s): Q5VYC0, Q96SN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.