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Protein

WD repeat-containing protein 5B

Gene

WDR5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

SignaLinkiQ86VZ2.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 5B
Gene namesi
Name:WDR5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:17826. WDR5B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38248.

Polymorphism and mutation databases

BioMutaiWDR5B.
DMDMi74762455.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330WD repeat-containing protein 5BPRO_0000278461Add
BLAST

Proteomic databases

PaxDbiQ86VZ2.
PRIDEiQ86VZ2.

PTM databases

iPTMnetiQ86VZ2.
PhosphoSiteiQ86VZ2.

Expressioni

Gene expression databases

BgeeiQ86VZ2.
CleanExiHS_WDR5B.
GenevisibleiQ86VZ2. HS.

Organism-specific databases

HPAiHPA042994.

Interactioni

Subunit structurei

Probable part of a cullin-RING E3 protein ligase complex containing CUL4B-DDB1 and a substrate-recruiting component (DCAF). Interacts with CUL4B and DDB1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi120039. 20 interactions.
IntActiQ86VZ2. 8 interactions.
STRINGi9606.ENSP00000330381.

Structurei

3D structure databases

ProteinModelPortaliQ86VZ2.
SMRiQ86VZ2. Positions 29-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati39 – 7840WD 1Add
BLAST
Repeati81 – 12242WD 2Add
BLAST
Repeati124 – 16441WD 3Add
BLAST
Repeati165 – 20440WD 4Add
BLAST
Repeati208 – 24942WD 5Add
BLAST
Repeati252 – 29241WD 6Add
BLAST
Repeati295 – 33036WD 7Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi188 – 1925DDB1-binding motif

Sequence similaritiesi

Belongs to the WD repeat WDR5/wds family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
GeneTreeiENSGT00810000125363.
HOGENOMiHOG000091642.
HOVERGENiHBG055117.
InParanoidiQ86VZ2.
KOiK14963.
OMAiGVCRIWD.
OrthoDBiEOG7MH0ZD.
PhylomeDBiQ86VZ2.
TreeFamiTF314125.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86VZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKESRDAK AQLALSSSAN QSKEVPENPN YALKCTLVGH TEAVSSVKFS
60 70 80 90 100
PNGEWLASSS ADRLIIIWGA YDGKYEKTLY GHNLEISDVA WSSDSSRLVS
110 120 130 140 150
ASDDKTLKLW DVRSGKCLKT LKGHSNYVFC CNFNPPSNLI ISGSFDETVK
160 170 180 190 200
IWEVKTGKCL KTLSAHSDPV SAVHFNCSGS LIVSGSYDGL CRIWDAASGQ
210 220 230 240 250
CLKTLVDDDN PPVSFVKFSP NGKYILTATL DNTLKLWDYS RGRCLKTYTG
260 270 280 290 300
HKNEKYCIFA NFSVTGGKWI VSGSEDNLVY IWNLQTKEIV QKLQGHTDVV
310 320 330
ISAACHPTEN LIASAALEND KTIKLWMSNH
Length:330
Mass (Da):36,338
Last modified:June 1, 2003 - v1
Checksum:iC2C47476F24716D5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti251 – 2511H → Q in BAA92110 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002149 mRNA. Translation: BAA92110.1.
AK315186 mRNA. Translation: BAG37626.1.
CR457279 mRNA. Translation: CAG33560.1.
CH471052 Genomic DNA. Translation: EAW79485.1.
BC043494 mRNA. Translation: AAH43494.1.
CCDSiCCDS3012.1.
RefSeqiNP_061942.2. NM_019069.3.
UniGeneiHs.567513.
Hs.594258.

Genome annotation databases

EnsembliENST00000330689; ENSP00000330381; ENSG00000196981.
GeneIDi54554.
KEGGihsa:54554.
UCSCiuc003efa.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002149 mRNA. Translation: BAA92110.1.
AK315186 mRNA. Translation: BAG37626.1.
CR457279 mRNA. Translation: CAG33560.1.
CH471052 Genomic DNA. Translation: EAW79485.1.
BC043494 mRNA. Translation: AAH43494.1.
CCDSiCCDS3012.1.
RefSeqiNP_061942.2. NM_019069.3.
UniGeneiHs.567513.
Hs.594258.

3D structure databases

ProteinModelPortaliQ86VZ2.
SMRiQ86VZ2. Positions 29-329.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120039. 20 interactions.
IntActiQ86VZ2. 8 interactions.
STRINGi9606.ENSP00000330381.

PTM databases

iPTMnetiQ86VZ2.
PhosphoSiteiQ86VZ2.

Polymorphism and mutation databases

BioMutaiWDR5B.
DMDMi74762455.

Proteomic databases

PaxDbiQ86VZ2.
PRIDEiQ86VZ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330689; ENSP00000330381; ENSG00000196981.
GeneIDi54554.
KEGGihsa:54554.
UCSCiuc003efa.2. human.

Organism-specific databases

CTDi54554.
GeneCardsiWDR5B.
HGNCiHGNC:17826. WDR5B.
HPAiHPA042994.
neXtProtiNX_Q86VZ2.
PharmGKBiPA38248.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
GeneTreeiENSGT00810000125363.
HOGENOMiHOG000091642.
HOVERGENiHBG055117.
InParanoidiQ86VZ2.
KOiK14963.
OMAiGVCRIWD.
OrthoDBiEOG7MH0ZD.
PhylomeDBiQ86VZ2.
TreeFamiTF314125.

Enzyme and pathway databases

SignaLinkiQ86VZ2.

Miscellaneous databases

GenomeRNAii54554.
NextBioi57028.
PROiQ86VZ2.

Gene expression databases

BgeeiQ86VZ2.
CleanExiHS_WDR5B.
GenevisibleiQ86VZ2. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Subthalamic nucleus.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.

Entry informationi

Entry nameiWDR5B_HUMAN
AccessioniPrimary (citable) accession number: Q86VZ2
Secondary accession number(s): B2RCM9, Q9NUL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.