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Protein

WD repeat-containing protein 5B

Gene

WDR5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:G66-33723-MONOMER.
SignaLinkiQ86VZ2.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 5B
Gene namesi
Name:WDR5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:17826. WDR5B.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196981.
PharmGKBiPA38248.

Polymorphism and mutation databases

BioMutaiWDR5B.
DMDMi74762455.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002784611 – 330WD repeat-containing protein 5BAdd BLAST330

Proteomic databases

EPDiQ86VZ2.
MaxQBiQ86VZ2.
PaxDbiQ86VZ2.
PeptideAtlasiQ86VZ2.
PRIDEiQ86VZ2.

PTM databases

iPTMnetiQ86VZ2.
PhosphoSitePlusiQ86VZ2.

Expressioni

Gene expression databases

BgeeiENSG00000196981.
CleanExiHS_WDR5B.
GenevisibleiQ86VZ2. HS.

Organism-specific databases

HPAiHPA042994.

Interactioni

Subunit structurei

Probable part of a cullin-RING E3 protein ligase complex containing CUL4B-DDB1 and a substrate-recruiting component (DCAF). Interacts with CUL4B and DDB1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi120039. 20 interactors.
IntActiQ86VZ2. 8 interactors.
STRINGi9606.ENSP00000330381.

Structurei

3D structure databases

ProteinModelPortaliQ86VZ2.
SMRiQ86VZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati39 – 78WD 1Add BLAST40
Repeati81 – 122WD 2Add BLAST42
Repeati124 – 164WD 3Add BLAST41
Repeati165 – 204WD 4Add BLAST40
Repeati208 – 249WD 5Add BLAST42
Repeati252 – 292WD 6Add BLAST41
Repeati295 – 330WD 7Add BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi188 – 192DDB1-binding motif5

Sequence similaritiesi

Belongs to the WD repeat WDR5/wds family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
GeneTreeiENSGT00810000125363.
HOGENOMiHOG000091642.
HOVERGENiHBG055117.
InParanoidiQ86VZ2.
KOiK14963.
OMAiIKLWMSN.
OrthoDBiEOG091G0CM2.
PhylomeDBiQ86VZ2.
TreeFamiTF314125.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86VZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKESRDAK AQLALSSSAN QSKEVPENPN YALKCTLVGH TEAVSSVKFS
60 70 80 90 100
PNGEWLASSS ADRLIIIWGA YDGKYEKTLY GHNLEISDVA WSSDSSRLVS
110 120 130 140 150
ASDDKTLKLW DVRSGKCLKT LKGHSNYVFC CNFNPPSNLI ISGSFDETVK
160 170 180 190 200
IWEVKTGKCL KTLSAHSDPV SAVHFNCSGS LIVSGSYDGL CRIWDAASGQ
210 220 230 240 250
CLKTLVDDDN PPVSFVKFSP NGKYILTATL DNTLKLWDYS RGRCLKTYTG
260 270 280 290 300
HKNEKYCIFA NFSVTGGKWI VSGSEDNLVY IWNLQTKEIV QKLQGHTDVV
310 320 330
ISAACHPTEN LIASAALEND KTIKLWMSNH
Length:330
Mass (Da):36,338
Last modified:June 1, 2003 - v1
Checksum:iC2C47476F24716D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti251H → Q in BAA92110 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002149 mRNA. Translation: BAA92110.1.
AK315186 mRNA. Translation: BAG37626.1.
CR457279 mRNA. Translation: CAG33560.1.
CH471052 Genomic DNA. Translation: EAW79485.1.
BC043494 mRNA. Translation: AAH43494.1.
CCDSiCCDS3012.1.
RefSeqiNP_061942.2. NM_019069.3.
UniGeneiHs.567513.
Hs.594258.

Genome annotation databases

EnsembliENST00000330689; ENSP00000330381; ENSG00000196981.
GeneIDi54554.
KEGGihsa:54554.
UCSCiuc003efa.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002149 mRNA. Translation: BAA92110.1.
AK315186 mRNA. Translation: BAG37626.1.
CR457279 mRNA. Translation: CAG33560.1.
CH471052 Genomic DNA. Translation: EAW79485.1.
BC043494 mRNA. Translation: AAH43494.1.
CCDSiCCDS3012.1.
RefSeqiNP_061942.2. NM_019069.3.
UniGeneiHs.567513.
Hs.594258.

3D structure databases

ProteinModelPortaliQ86VZ2.
SMRiQ86VZ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120039. 20 interactors.
IntActiQ86VZ2. 8 interactors.
STRINGi9606.ENSP00000330381.

PTM databases

iPTMnetiQ86VZ2.
PhosphoSitePlusiQ86VZ2.

Polymorphism and mutation databases

BioMutaiWDR5B.
DMDMi74762455.

Proteomic databases

EPDiQ86VZ2.
MaxQBiQ86VZ2.
PaxDbiQ86VZ2.
PeptideAtlasiQ86VZ2.
PRIDEiQ86VZ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330689; ENSP00000330381; ENSG00000196981.
GeneIDi54554.
KEGGihsa:54554.
UCSCiuc003efa.2. human.

Organism-specific databases

CTDi54554.
GeneCardsiWDR5B.
HGNCiHGNC:17826. WDR5B.
HPAiHPA042994.
neXtProtiNX_Q86VZ2.
OpenTargetsiENSG00000196981.
PharmGKBiPA38248.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
GeneTreeiENSGT00810000125363.
HOGENOMiHOG000091642.
HOVERGENiHBG055117.
InParanoidiQ86VZ2.
KOiK14963.
OMAiIKLWMSN.
OrthoDBiEOG091G0CM2.
PhylomeDBiQ86VZ2.
TreeFamiTF314125.

Enzyme and pathway databases

BioCyciZFISH:G66-33723-MONOMER.
SignaLinkiQ86VZ2.

Miscellaneous databases

GenomeRNAii54554.
PROiQ86VZ2.

Gene expression databases

BgeeiENSG00000196981.
CleanExiHS_WDR5B.
GenevisibleiQ86VZ2. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR5B_HUMAN
AccessioniPrimary (citable) accession number: Q86VZ2
Secondary accession number(s): B2RCM9, Q9NUL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.