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Q86VZ1

- P2RY8_HUMAN

UniProt

Q86VZ1 - P2RY8_HUMAN

Protein

P2Y purinoceptor 8

Gene

P2RY8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Probable receptor for purines coupled to G-proteins.

    GO - Molecular functioni

    1. G-protein coupled purinergic nucleotide receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    P2Y purinoceptor 8
    Short name:
    P2Y8
    Gene namesi
    Name:P2RY8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:15524. P2RY8.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32873.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359P2Y purinoceptor 8PRO_0000070031Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)1 Publication
    Glycosylationi11 – 111N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ86VZ1.
    PaxDbiQ86VZ1.
    PRIDEiQ86VZ1.

    PTM databases

    PhosphoSiteiQ86VZ1.

    Expressioni

    Tissue specificityi

    Barely detectable in normal blood leukocytes. Weaker expression was seen in heart, kidney and lung. Not detected in brain.2 Publications

    Inductioni

    Down-regulated during granulocytic regulation.

    Gene expression databases

    BgeeiQ86VZ1.
    CleanExiHS_P2RY8.
    GenevestigatoriQ86VZ1.

    Organism-specific databases

    HPAiHPA003631.

    Interactioni

    Protein-protein interaction databases

    BioGridi130402. 1 interaction.
    STRINGi9606.ENSP00000370697.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86VZ1.
    SMRiQ86VZ1. Positions 17-301.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini41 – 5717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini79 – 8810ExtracellularSequence Analysis
    Topological domaini110 – 13829CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 18728ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini209 – 23729CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27517ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini297 – 35963CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei276 – 29621Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi133 – 1386Poly-Arg

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG145033.
    HOGENOMiHOG000231258.
    HOVERGENiHBG105325.
    InParanoidiQ86VZ1.
    KOiK08386.
    OMAiFYANMYS.
    OrthoDBiEOG7SR4MX.
    PhylomeDBiQ86VZ1.
    TreeFamiTF330775.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR027669. P2Y8_rcpt.
    [Graphical view]
    PANTHERiPTHR24232:SF25. PTHR24232:SF25. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q86VZ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQVPNSTGPD NATLQMLRNP AIAVALPVVY SLVAAVSIPG NLFSLWVLCR    50
    RMGPRSPSVI FMINLSVTDL MLASVLPFQI YYHCNRHHWV FGVLLCNVVT 100
    VAFYANMYSS ILTMTCISVE RFLGVLYPLS SKRWRRRRYA VAACAGTWLL 150
    LLTALSPLAR TDLTYPVHAL GIITCFDVLK WTMLPSVAMW AVFLFTIFIL 200
    LFLIPFVITV ACYTATILKL LRTEEAHGRE QRRRAVGLAA VVLLAFVTCF 250
    APNNFVLLAH IVSRLFYGKS YYHVYKLTLC LSCLNNCLDP FVYYFASREF 300
    QLRLREYLGC RRVPRDTLDT RRESLFSART TSVRSEAGAH PEGMEGATRP 350
    GLQRQESVF 359
    Length:359
    Mass (Da):40,635
    Last modified:June 1, 2003 - v1
    Checksum:i565C43660B3C0CF7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL683870 Genomic DNA. Translation: CAI39849.1.
    BC043610 mRNA. Translation: AAH43610.1.
    CCDSiCCDS14115.1.
    RefSeqiNP_835230.1. NM_178129.4.
    XP_005274486.1. XM_005274429.1.
    XP_005274487.1. XM_005274430.1.
    XP_005274835.1. XM_005274778.1.
    XP_005274836.1. XM_005274779.1.
    XP_006724506.1. XM_006724443.1.
    XP_006724927.1. XM_006724864.1.
    UniGeneiHs.111377.

    Genome annotation databases

    EnsembliENST00000381297; ENSP00000370697; ENSG00000182162.
    GeneIDi286530.
    KEGGihsa:286530.
    UCSCiuc004cpz.2. human.

    Polymorphism databases

    DMDMi74762454.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL683870 Genomic DNA. Translation: CAI39849.1 .
    BC043610 mRNA. Translation: AAH43610.1 .
    CCDSi CCDS14115.1.
    RefSeqi NP_835230.1. NM_178129.4.
    XP_005274486.1. XM_005274429.1.
    XP_005274487.1. XM_005274430.1.
    XP_005274835.1. XM_005274778.1.
    XP_005274836.1. XM_005274779.1.
    XP_006724506.1. XM_006724443.1.
    XP_006724927.1. XM_006724864.1.
    UniGenei Hs.111377.

    3D structure databases

    ProteinModelPortali Q86VZ1.
    SMRi Q86VZ1. Positions 17-301.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130402. 1 interaction.
    STRINGi 9606.ENSP00000370697.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q86VZ1.

    Polymorphism databases

    DMDMi 74762454.

    Proteomic databases

    MaxQBi Q86VZ1.
    PaxDbi Q86VZ1.
    PRIDEi Q86VZ1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381297 ; ENSP00000370697 ; ENSG00000182162 .
    GeneIDi 286530.
    KEGGi hsa:286530.
    UCSCi uc004cpz.2. human.

    Organism-specific databases

    CTDi 286530.
    GeneCardsi GC0XM001625.
    HGNCi HGNC:15524. P2RY8.
    HPAi HPA003631.
    MIMi 300525. gene.
    neXtProti NX_Q86VZ1.
    PharmGKBi PA32873.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG145033.
    HOGENOMi HOG000231258.
    HOVERGENi HBG105325.
    InParanoidi Q86VZ1.
    KOi K08386.
    OMAi FYANMYS.
    OrthoDBi EOG7SR4MX.
    PhylomeDBi Q86VZ1.
    TreeFami TF330775.

    Miscellaneous databases

    GeneWikii P2RY8.
    GenomeRNAii 286530.
    NextBioi 96262.
    PROi Q86VZ1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q86VZ1.
    CleanExi HS_P2RY8.
    Genevestigatori Q86VZ1.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR027669. P2Y8_rcpt.
    [Graphical view ]
    PANTHERi PTHR24232:SF25. PTHR24232:SF25. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lymph.
    3. "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells."
      Adrian K., Bernhard M.K., Breitinger H.-G., Ogilvie A.
      Biochim. Biophys. Acta 1492:127-138(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    4. "Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males."
      Cantagrel V., Lossi A.-M., Boulanger S., Depetris D., Mattei M.-G., Gecz J., Schwartz C.E., Van Maldergem L., Villard L.
      J. Med. Genet. 41:736-742(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-5 AND ASN-11.
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiP2RY8_HUMAN
    AccessioniPrimary (citable) accession number: Q86VZ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3