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Protein

P2Y purinoceptor 8

Gene

P2RY8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable receptor for purines coupled to G-proteins.

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 8
Short name:
P2Y8
Gene namesi
Name:P2RY8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000182162.10.
HGNCiHGNC:15524. P2RY8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19ExtracellularSequence analysisAdd BLAST19
Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini41 – 57CytoplasmicSequence analysisAdd BLAST17
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 88ExtracellularSequence analysis10
Transmembranei89 – 109Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini110 – 138CytoplasmicSequence analysisAdd BLAST29
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 187ExtracellularSequence analysisAdd BLAST28
Transmembranei188 – 208Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini209 – 237CytoplasmicSequence analysisAdd BLAST29
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 275ExtracellularSequence analysisAdd BLAST17
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 359CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi286530.
OpenTargetsiENSG00000182162.
PharmGKBiPA32873.

Polymorphism and mutation databases

BioMutaiP2RY8.
DMDMi74762454.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700311 – 359P2Y purinoceptor 8Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi11N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ86VZ1.
MaxQBiQ86VZ1.
PaxDbiQ86VZ1.
PeptideAtlasiQ86VZ1.
PRIDEiQ86VZ1.

PTM databases

iPTMnetiQ86VZ1.
PhosphoSitePlusiQ86VZ1.

Expressioni

Tissue specificityi

Barely detectable in normal blood leukocytes. Weaker expression was seen in heart, kidney and lung. Not detected in brain.2 Publications

Inductioni

Down-regulated during granulocytic regulation.

Gene expression databases

BgeeiENSG00000182162.
CleanExiHS_P2RY8.
ExpressionAtlasiQ86VZ1. baseline and differential.
GenevisibleiQ86VZ1. HS.

Organism-specific databases

HPAiHPA003631.

Interactioni

Protein-protein interaction databases

BioGridi130402. 29 interactors.
STRINGi9606.ENSP00000370697.

Structurei

3D structure databases

ProteinModelPortaliQ86VZ1.
SMRiQ86VZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi133 – 138Poly-Arg6

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEV4. Eukaryota.
ENOG4110S8Y. LUCA.
GeneTreeiENSGT00760000119001.
HOGENOMiHOG000231258.
HOVERGENiHBG105325.
InParanoidiQ86VZ1.
KOiK08386.
OMAiFQIYYHC.
OrthoDBiEOG091G0EL0.
PhylomeDBiQ86VZ1.
TreeFamiTF330775.

Family and domain databases

CDDicd15368. 7tmA_P2Y8. 1 hit.
InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027669. P2Y8_rcpt.
PANTHERiPTHR24232:SF66. PTHR24232:SF66. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q86VZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVPNSTGPD NATLQMLRNP AIAVALPVVY SLVAAVSIPG NLFSLWVLCR
60 70 80 90 100
RMGPRSPSVI FMINLSVTDL MLASVLPFQI YYHCNRHHWV FGVLLCNVVT
110 120 130 140 150
VAFYANMYSS ILTMTCISVE RFLGVLYPLS SKRWRRRRYA VAACAGTWLL
160 170 180 190 200
LLTALSPLAR TDLTYPVHAL GIITCFDVLK WTMLPSVAMW AVFLFTIFIL
210 220 230 240 250
LFLIPFVITV ACYTATILKL LRTEEAHGRE QRRRAVGLAA VVLLAFVTCF
260 270 280 290 300
APNNFVLLAH IVSRLFYGKS YYHVYKLTLC LSCLNNCLDP FVYYFASREF
310 320 330 340 350
QLRLREYLGC RRVPRDTLDT RRESLFSART TSVRSEAGAH PEGMEGATRP

GLQRQESVF
Length:359
Mass (Da):40,635
Last modified:June 1, 2003 - v1
Checksum:i565C43660B3C0CF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL683870 Genomic DNA. No translation available.
BC043610 mRNA. Translation: AAH43610.1.
CCDSiCCDS14115.1.
RefSeqiNP_835230.1. NM_178129.4.
XP_005274486.1. XM_005274429.3.
XP_005274835.1. XM_005274778.3.
XP_011543933.1. XM_011545631.2.
XP_011543934.1. XM_011545632.2.
XP_011544480.1. XM_011546178.2.
XP_011544481.1. XM_011546179.2.
UniGeneiHs.111377.

Genome annotation databases

EnsembliENST00000381297; ENSP00000370697; ENSG00000182162.
GeneIDi286530.
KEGGihsa:286530.
UCSCiuc004cpz.3. human.

Similar proteinsi

Entry informationi

Entry nameiP2RY8_HUMAN
AccessioniPrimary (citable) accession number: Q86VZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2003
Last modified: September 27, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families