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Q86VZ1 (P2RY8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
P2Y purinoceptor 8

Short name=P2Y8
Gene names
Name:P2RY8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable receptor for purines coupled to G-proteins.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Barely detectable in normal blood leukocytes. Weaker expression was seen in heart, kidney and lung. Not detected in brain. Ref.3 Ref.4

Induction

Down-regulated during granulocytic regulation.

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359P2Y purinoceptor 8
PRO_0000070031

Regions

Topological domain1 – 1919Extracellular Potential
Transmembrane20 – 4021Helical; Name=1; Potential
Topological domain41 – 5717Cytoplasmic Potential
Transmembrane58 – 7821Helical; Name=2; Potential
Topological domain79 – 8810Extracellular Potential
Transmembrane89 – 10921Helical; Name=3; Potential
Topological domain110 – 13829Cytoplasmic Potential
Transmembrane139 – 15921Helical; Name=4; Potential
Topological domain160 – 18728Extracellular Potential
Transmembrane188 – 20821Helical; Name=5; Potential
Topological domain209 – 23729Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 27517Extracellular Potential
Transmembrane276 – 29621Helical; Name=7; Potential
Topological domain297 – 35963Cytoplasmic Potential
Compositional bias133 – 1386Poly-Arg

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Ref.5
Glycosylation111N-linked (GlcNAc...) Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q86VZ1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 565C43660B3C0CF7

FASTA35940,635
        10         20         30         40         50         60 
MQVPNSTGPD NATLQMLRNP AIAVALPVVY SLVAAVSIPG NLFSLWVLCR RMGPRSPSVI 

        70         80         90        100        110        120 
FMINLSVTDL MLASVLPFQI YYHCNRHHWV FGVLLCNVVT VAFYANMYSS ILTMTCISVE 

       130        140        150        160        170        180 
RFLGVLYPLS SKRWRRRRYA VAACAGTWLL LLTALSPLAR TDLTYPVHAL GIITCFDVLK 

       190        200        210        220        230        240 
WTMLPSVAMW AVFLFTIFIL LFLIPFVITV ACYTATILKL LRTEEAHGRE QRRRAVGLAA 

       250        260        270        280        290        300 
VVLLAFVTCF APNNFVLLAH IVSRLFYGKS YYHVYKLTLC LSCLNNCLDP FVYYFASREF 

       310        320        330        340        350 
QLRLREYLGC RRVPRDTLDT RRESLFSART TSVRSEAGAH PEGMEGATRP GLQRQESVF 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lymph.
[3]"Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells."
Adrian K., Bernhard M.K., Breitinger H.-G., Ogilvie A.
Biochim. Biophys. Acta 1492:127-138(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[4]"Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males."
Cantagrel V., Lossi A.-M., Boulanger S., Depetris D., Mattei M.-G., Gecz J., Schwartz C.E., Van Maldergem L., Villard L.
J. Med. Genet. 41:736-742(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[5]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-5 AND ASN-11.
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL683870 Genomic DNA. Translation: CAI39849.1.
BC043610 mRNA. Translation: AAH43610.1.
CCDSCCDS14115.1.
RefSeqNP_835230.1. NM_178129.4.
XP_005274486.1. XM_005274429.1.
XP_005274487.1. XM_005274430.1.
XP_005274835.1. XM_005274778.1.
XP_005274836.1. XM_005274779.1.
XP_006724506.1. XM_006724443.1.
XP_006724927.1. XM_006724864.1.
UniGeneHs.111377.

3D structure databases

ProteinModelPortalQ86VZ1.
SMRQ86VZ1. Positions 17-301.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid130402. 1 interaction.
STRING9606.ENSP00000370697.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ86VZ1.

Polymorphism databases

DMDM74762454.

Proteomic databases

MaxQBQ86VZ1.
PaxDbQ86VZ1.
PRIDEQ86VZ1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381297; ENSP00000370697; ENSG00000182162.
GeneID286530.
KEGGhsa:286530.
UCSCuc004cpz.2. human.

Organism-specific databases

CTD286530.
GeneCardsGC0XM001625.
HGNCHGNC:15524. P2RY8.
HPAHPA003631.
MIM300525. gene.
neXtProtNX_Q86VZ1.
PharmGKBPA32873.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG145033.
HOGENOMHOG000231258.
HOVERGENHBG105325.
InParanoidQ86VZ1.
KOK08386.
OMAFYANMYS.
OrthoDBEOG7SR4MX.
PhylomeDBQ86VZ1.
TreeFamTF330775.

Gene expression databases

BgeeQ86VZ1.
CleanExHS_P2RY8.
GenevestigatorQ86VZ1.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027669. P2Y8_rcpt.
[Graphical view]
PANTHERPTHR24232:SF25. PTHR24232:SF25. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiP2RY8.
GenomeRNAi286530.
NextBio96262.
PROQ86VZ1.
SOURCESearch...

Entry information

Entry nameP2RY8_HUMAN
AccessionPrimary (citable) accession number: Q86VZ1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries