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Protein

Testis-specific Y-encoded-like protein 5

Gene

TSPYL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7.2 Publications

GO - Biological processi

  • cellular response to gamma radiation Source: UniProtKB
  • nucleosome assembly Source: InterPro
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of protein kinase B signaling Source: UniProtKB
  • positive regulation of protein ubiquitination Source: UniProtKB
  • regulation of growth Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific Y-encoded-like protein 5
Short name:
TSPY-like protein 5
Gene namesi
Name:TSPYL5
Synonyms:KIAA1750
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:29367. TSPYL5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394738.

Polymorphism and mutation databases

BioMutaiTSPYL5.
DMDMi160198165.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Testis-specific Y-encoded-like protein 5PRO_0000307277Add
BLAST

Proteomic databases

EPDiQ86VY4.
MaxQBiQ86VY4.
PaxDbiQ86VY4.
PeptideAtlasiQ86VY4.
PRIDEiQ86VY4.

PTM databases

iPTMnetiQ86VY4.
PhosphoSiteiQ86VY4.

Expressioni

Gene expression databases

BgeeiENSG00000180543.
CleanExiHS_TSPYL5.
GenevisibleiQ86VY4. HS.

Organism-specific databases

HPAiHPA031347.

Interactioni

Subunit structurei

Interacts with USP7.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
USP7Q930094EBI-3436472,EBI-302474

Protein-protein interaction databases

BioGridi124538. 1 interaction.
IntActiQ86VY4. 1 interaction.
STRINGi9606.ENSP00000322802.

Structurei

3D structure databases

ProteinModelPortaliQ86VY4.
SMRiQ86VY4. Positions 201-383.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1508. Eukaryota.
ENOG410XQRX. LUCA.
GeneTreeiENSGT00530000062882.
HOGENOMiHOG000004793.
HOVERGENiHBG014779.
InParanoidiQ86VY4.
KOiK11288.
OMAiCRLPLDC.
OrthoDBiEOG091G00YT.
PhylomeDBiQ86VY4.
TreeFamiTF313386.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 1 hit.
PfamiPF00956. NAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86VY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRSRGRKS SRAKNRGKGR AKARVRPAPD DAPRDPDPSQ YQSLGEDTQA
60 70 80 90 100
AQVQAGAGWG GLEAAASAQL LRLGEEAACR LPLDCGLALR ARAAGDHGQA
110 120 130 140 150
AARPGPGKAA SLSERLAADT VFVGTAGTVG RPKNAPRVGN RRGPAGKKAP
160 170 180 190 200
ETCSTAGRGP QVIAGGRQKK GAAGENTSVS AGEEKKEERD AGSGPPATEG
210 220 230 240 250
SMDTLENVQL KLENMNAQAD RAYLRLSRKF GQLRLQHLER RNHLIQNIPG
260 270 280 290 300
FWGQAFQNHP QLASFLNSQE KEVLSYLNSL EVEELGLARL GYKIKFYFDR
310 320 330 340 350
NPYFQNKVLI KEYGCGPSGQ VVSRSTPIQW LPGHDLQSLS QGNPENNRSF
360 370 380 390 400
FGWFSNHSSI ESDKIVEIIN EELWPNPLQF YLLSEGARVE KGKEKEGRQG
410
PGKQPMETTQ PGVSQSN
Length:417
Mass (Da):45,143
Last modified:October 23, 2007 - v2
Checksum:i920E123167C08829
GO

Sequence cautioni

The sequence BAB21841 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti120 – 1201T → S.
Corresponds to variant rs2635164 [ dbSNP | Ensembl ].
VAR_035393
Natural varianti365 – 3651I → V.1 Publication
Corresponds to variant rs17854366 [ dbSNP | Ensembl ].
VAR_035394

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051537 mRNA. Translation: BAB21841.1. Different initiation.
AK091445 mRNA. Translation: BAG52362.1.
BC045630 mRNA. Translation: AAH45630.1.
CCDSiCCDS34927.1.
RefSeqiNP_277047.2. NM_033512.2.
UniGeneiHs.173094.

Genome annotation databases

EnsembliENST00000322128; ENSP00000322802; ENSG00000180543.
GeneIDi85453.
KEGGihsa:85453.
UCSCiuc003yhy.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051537 mRNA. Translation: BAB21841.1. Different initiation.
AK091445 mRNA. Translation: BAG52362.1.
BC045630 mRNA. Translation: AAH45630.1.
CCDSiCCDS34927.1.
RefSeqiNP_277047.2. NM_033512.2.
UniGeneiHs.173094.

3D structure databases

ProteinModelPortaliQ86VY4.
SMRiQ86VY4. Positions 201-383.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124538. 1 interaction.
IntActiQ86VY4. 1 interaction.
STRINGi9606.ENSP00000322802.

PTM databases

iPTMnetiQ86VY4.
PhosphoSiteiQ86VY4.

Polymorphism and mutation databases

BioMutaiTSPYL5.
DMDMi160198165.

Proteomic databases

EPDiQ86VY4.
MaxQBiQ86VY4.
PaxDbiQ86VY4.
PeptideAtlasiQ86VY4.
PRIDEiQ86VY4.

Protocols and materials databases

DNASUi85453.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322128; ENSP00000322802; ENSG00000180543.
GeneIDi85453.
KEGGihsa:85453.
UCSCiuc003yhy.4. human.

Organism-specific databases

CTDi85453.
GeneCardsiTSPYL5.
H-InvDBHIX0007667.
HGNCiHGNC:29367. TSPYL5.
HPAiHPA031347.
MIMi614721. gene.
neXtProtiNX_Q86VY4.
PharmGKBiPA128394738.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1508. Eukaryota.
ENOG410XQRX. LUCA.
GeneTreeiENSGT00530000062882.
HOGENOMiHOG000004793.
HOVERGENiHBG014779.
InParanoidiQ86VY4.
KOiK11288.
OMAiCRLPLDC.
OrthoDBiEOG091G00YT.
PhylomeDBiQ86VY4.
TreeFamiTF313386.

Miscellaneous databases

ChiTaRSiTSPYL5. human.
GenomeRNAii85453.
PROiQ86VY4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180543.
CleanExiHS_TSPYL5.
GenevisibleiQ86VY4. HS.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 1 hit.
PfamiPF00956. NAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSYL5_HUMAN
AccessioniPrimary (citable) accession number: Q86VY4
Secondary accession number(s): B3KRF0, Q9C0B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: September 7, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.