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Protein

Vacuolar fusion protein MON1 homolog A

Gene

MON1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity). Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (PubMed:23084991).By similarity1 Publication

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar fusion protein MON1 homolog A
Gene namesi
Name:MON1A
Synonyms:SAND1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000164077.13
HGNCiHGNC:28207 MON1A
MIMi611464 gene
neXtProtiNX_Q86VX9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi84315
OpenTargetsiENSG00000164077
PharmGKBiPA142671340

Polymorphism and mutation databases

BioMutaiMON1A
DMDMi146324996

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002857611 – 652Vacuolar fusion protein MON1 homolog AAdd BLAST652

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei128PhosphoserineCombined sources1
Modified residuei153PhosphoserineBy similarity1
Modified residuei158PhosphothreonineCombined sources1
Modified residuei188PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ86VX9
PaxDbiQ86VX9
PeptideAtlasiQ86VX9
PRIDEiQ86VX9

PTM databases

iPTMnetiQ86VX9
PhosphoSitePlusiQ86VX9

Expressioni

Gene expression databases

BgeeiENSG00000164077
CleanExiHS_MON1A
ExpressionAtlasiQ86VX9 baseline and differential
GenevisibleiQ86VX9 HS

Organism-specific databases

HPAiHPA053752
HPA058032

Interactioni

Subunit structurei

Interacts with CCZ1 (PubMed:23084991). Found in a complex with RMC1, CCZ1, MON1A and MON1B (PubMed:29038162).2 Publications

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: UniProtKB

Protein-protein interaction databases

BioGridi124041, 9 interactors
IntActiQ86VX9, 8 interactors
MINTiQ86VX9
STRINGi9606.ENSP00000296473

Structurei

3D structure databases

ProteinModelPortaliQ86VX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MON1/SAND family.Curated

Phylogenomic databases

eggNOGiKOG0997 Eukaryota
ENOG410XR29 LUCA
GeneTreeiENSGT00390000006665
HOGENOMiHOG000031337
HOVERGENiHBG064381
InParanoidiQ86VX9
KOiK20195
OMAiTQLNHIF
OrthoDBiEOG091G066A
PhylomeDBiQ86VX9
TreeFamiTF314665

Family and domain databases

InterProiView protein in InterPro
IPR004353 Mon1
PANTHERiPTHR13027 PTHR13027, 1 hit
PfamiView protein in Pfam
PF03164 Mon1, 1 hit
PRINTSiPR01546 YEAST73DUF

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86VX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHPGGGPSRA ERLELGLGRE RPAKAIFLHR RPGEGGGRER CLRCGHVCVR
60 70 80 90 100
RGPGPREAVP SGRPRPDTLT PPWVRQRAVT GTFCASWTPL RNRRAQRMAT
110 120 130 140 150
DMQRKRSSEC LDGTLTPSDG QSMERAESPT PGMAQGMEPG AGQEGAMFVH
160 170 180 190 200
ARSYEDLTES EDGAASGDSH KEGTRGPPPL PTDMRQISQD FSELSTQLTG
210 220 230 240 250
VARDLQEEML PGSSEDWLEP PGAVGRPATE PPREGTTEGD EEDATEAWRL
260 270 280 290 300
HQKHVFVLSE AGKPVYSRYG SEEALSSTMG VMVALVSFLE ADKNAIRSIH
310 320 330 340 350
ADGYKVVFVR RSPLVLVAVA RTRQSAQELA QELLYIYYQI LSLLTGAQLS
360 370 380 390 400
HIFQQKQNYD LRRLLSGSER ITDNLLQLMA RDPSFLMGAA RCLPLAAAVR
410 420 430 440 450
DTVSASLQQA RARSLVFSIL LARNQLVALV RRKDQFLHPI DLHLLFNLIS
460 470 480 490 500
SSSSFREGEA WTPVCLPKFN AAGFFHAHIS YLEPDTDLCL LLVSTDREDF
510 520 530 540 550
FAVSDCRRRF QERLRKRGAH LALREALRTP YYSVAQVGIP DLRHFLYKSK
560 570 580 590 600
SSGLFTSPEI EAPYTSEEEQ ERLLGLYQYL HSRAHNASRP LKTIYYTGPN
610 620 630 640 650
ENLLAWVTGA FELYMCYSPL GTKASAVSAI HKLMRWIRKE EDRLFILTPL

TY
Note: No experimental confirmation available. Gene prediction based on EST data.
Length:652
Mass (Da):72,895
Last modified:March 28, 2018 - v3
Checksum:i344D326577E66FE2
GO
Isoform 2 (identifier: Q86VX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.
     140-301: Missing.

Show »
Length:393
Mass (Da):44,692
Checksum:i08CD3CF132D5B963
GO
Isoform 3 (identifier: Q86VX9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.
     140-301: Missing.
     557-557: S → R
     558-652: Missing.

Show »
Length:298
Mass (Da):33,713
Checksum:i2B1C495E32796DC9
GO
Isoform 4 (identifier: Q86VX9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-301: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:490
Mass (Da):55,456
Checksum:i1402A856E41AC982
GO
Isoform 5 (identifier: Q86VX9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Show »
Length:555
Mass (Da):62,131
Checksum:i3428BEBFD9EA1626
GO

Sequence cautioni

The sequence AAH47022 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0594301 – 97Missing in isoform 5, isoform 2 and isoform 3. 2 PublicationsAdd BLAST97
Alternative sequenceiVSP_059431140 – 301Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST162
Alternative sequenceiVSP_059432557S → R in isoform 3. 1 Publication1
Alternative sequenceiVSP_059433558 – 652Missing in isoform 3. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092018 mRNA Translation: BAC03790.1
AK315630 mRNA Translation: BAG37998.1
AC105935 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65037.1
CH471055 Genomic DNA Translation: EAW65038.1
BC006299 mRNA Translation: AAH06299.1
BC009459 mRNA Translation: AAH09459.1
BC047022 mRNA Translation: AAH47022.1 Different initiation.
CCDSiCCDS2808.2 [Q86VX9-1]
CCDS46830.1 [Q86VX9-4]
RefSeqiNP_001135973.1, NM_001142501.1 [Q86VX9-4]
NP_115731.2, NM_032355.3 [Q86VX9-1]
XP_006713408.1, XM_006713345.3 [Q86VX9-5]
XP_011532462.1, XM_011534160.1 [Q86VX9-5]
UniGeneiHs.655014

Genome annotation databases

EnsembliENST00000296473; ENSP00000296473; ENSG00000164077 [Q86VX9-1]
ENST00000455683; ENSP00000404793; ENSG00000164077 [Q86VX9-4]
GeneIDi84315
KEGGihsa:84315
UCSCiuc003cxz.4 human
uc003cya.4 human [Q86VX9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMON1A_HUMAN
AccessioniPrimary (citable) accession number: Q86VX9
Secondary accession number(s): B2RDQ1
, G5E9N1, Q8NAV7, Q9BRF3, X6R3V9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 28, 2018
Last modified: May 23, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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