Q86VX9 (MON1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vacuolar fusion protein MON1 homolog A

Gene names

Name:	MON1A
Synonyms:	SAND1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	555 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes By similarity.
Sequence similarities	Belongs to the MON1/SAND family.
Sequence caution	The sequence AAH47022.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular iron ion homeostasis Inferred from electronic annotation. Source: Compara protein secretion Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86VX9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86VX9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     43-204: Missing.

Isoform 3 (identifier: Q86VX9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     43-204: Missing.
     460-460: S → R
     461-555: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 555	555	Vacuolar fusion protein MON1 homolog A		PRO_0000285761
Amino acid modifications
	Modified residue	31	1	Phosphoserine Ref.4
	Modified residue	56	1	Phosphoserine By similarity
	Modified residue	57	1	Phosphotyrosine By similarity
	Modified residue	69	1	Phosphoserine By similarity
	Modified residue	72	1	Phosphoserine By similarity
	Modified residue	91	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	43 – 204	162	Missing in isoform 2 and isoform 3.		VSP_024910
	Alternative sequence	460	1	S → R in isoform 3.		VSP_024911
	Alternative sequence	461 – 555	95	Missing in isoform 3.		VSP_024912

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2007. Version 2. Checksum: 3428BEBFD9EA1626	FASTA	555	62,131
	10 20 30 40 50 60 MATDMQRKRS SECLDGTLTP SDGQSMERAE SPTPGMAQGM EPGAGQEGAM FVHARSYEDL 70 80 90 100 110 120 TESEDGAASG DSHKEGTRGP PPLPTDMRQI SQDFSELSTQ LTGVARDLQE EMLPGSSEDW 130 140 150 160 170 180 LEPPGAVGRP ATEPPREGTT EGDEEDATEA WRLHQKHVFV LSEAGKPVYS RYGSEEALSS 190 200 210 220 230 240 TMGVMVALVS FLEADKNAIR SIHADGYKVV FVRRSPLVLV AVARTRQSAQ ELAQELLYIY 250 260 270 280 290 300 YQILSLLTGA QLSHIFQQKQ NYDLRRLLSG SERITDNLLQ LMARDPSFLM GAARCLPLAA 310 320 330 340 350 360 AVRDTVSASL QQARARSLVF SILLARNQLV ALVRRKDQFL HPIDLHLLFN LISSSSSFRE 370 380 390 400 410 420 GEAWTPVCLP KFNAAGFFHA HISYLEPDTD LCLLLVSTDR EDFFAVSDCR RRFQERLRKR 430 440 450 460 470 480 GAHLALREAL RTPYYSVAQV GIPDLRHFLY KSKSSGLFTS PEIEAPYTSE EEQERLLGLY 490 500 510 520 530 540 QYLHSRAHNA SRPLKTIYYT GPNENLLAWV TGAFELYMCY SPLGTKASAV SAIHKLMRWI 550 RKEEDRLFIL TPLTY
	Isoform 2 [UniParc]. Checksum: 08CD3CF132D5B963	FASTA	393	44,692
	10 20 30 40 50 60 MATDMQRKRS SECLDGTLTP SDGQSMERAE SPTPGMAQGM EPDGYKVVFV RRSPLVLVAV 70 80 90 100 110 120 ARTRQSAQEL AQELLYIYYQ ILSLLTGAQL SHIFQQKQNY DLRRLLSGSE RITDNLLQLM 130 140 150 160 170 180 ARDPSFLMGA ARCLPLAAAV RDTVSASLQQ ARARSLVFSI LLARNQLVAL VRRKDQFLHP 190 200 210 220 230 240 IDLHLLFNLI SSSSSFREGE AWTPVCLPKF NAAGFFHAHI SYLEPDTDLC LLLVSTDRED 250 260 270 280 290 300 FFAVSDCRRR FQERLRKRGA HLALREALRT PYYSVAQVGI PDLRHFLYKS KSSGLFTSPE 310 320 330 340 350 360 IEAPYTSEEE QERLLGLYQY LHSRAHNASR PLKTIYYTGP NENLLAWVTG AFELYMCYSP 370 380 390 LGTKASAVSA IHKLMRWIRK EEDRLFILTP LTY
	Isoform 3 [UniParc]. Checksum: 2B1C495E32796DC9	FASTA	298	33,713
	10 20 30 40 50 60 MATDMQRKRS SECLDGTLTP SDGQSMERAE SPTPGMAQGM EPDGYKVVFV RRSPLVLVAV 70 80 90 100 110 120 ARTRQSAQEL AQELLYIYYQ ILSLLTGAQL SHIFQQKQNY DLRRLLSGSE RITDNLLQLM 130 140 150 160 170 180 ARDPSFLMGA ARCLPLAAAV RDTVSASLQQ ARARSLVFSI LLARNQLVAL VRRKDQFLHP 190 200 210 220 230 240 IDLHLLFNLI SSSSSFREGE AWTPVCLPKF NAAGFFHAHI SYLEPDTDLC LLLVSTDRED 250 260 270 280 290 FFAVSDCRRR FQERLRKRGA HLALREALRT PYYSVAQVGI PDLRHFLYKS KSSGLFTR

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Synovial cell.
[2]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain, Lung and Uterus.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK092018 mRNA. Translation: BAC03790.1. AK315630 mRNA. Translation: BAG37998.1. AC105935 Genomic DNA. No translation available. BC006299 mRNA. Translation: AAH06299.1. BC009459 mRNA. Translation: AAH09459.1. BC047022 mRNA. Translation: AAH47022.1. Different initiation.
IPI	IPI00168139. IPI00798049. IPI00926005.
RefSeq	NP_001135973.1. NM_001142501.1. NP_115731.2. NM_032355.3.
UniGene	Hs.655014.
3D structure databases
ProteinModelPortal	Q86VX9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86VX9. 4 interactions.
MINT	MINT-2877066.
STRING	9606.ENSP00000296473.
Polymorphism databases
DMDM	146324996.
Proteomic databases
PaxDb	Q86VX9.
PRIDE	Q86VX9.
Protocols and materials databases
DNASU	84315.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000296473; ENSP00000296473; ENSG00000164077. ENST00000417270; ENSP00000399613; ENSG00000164077.
GeneID	84315.
KEGG	hsa:84315.
UCSC	uc003cxz.3. human. uc003cya.3. human. uc003cyb.2. human.
Organism-specific databases
CTD	84315.
GeneCards	GC03M049946.
H-InvDB	HIX0003326.
HGNC	HGNC:28207. MON1A.
MIM	611464. gene.
neXtProt	NX_Q86VX9.
PharmGKB	PA142671340.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG256927.
HOGENOM	HOG000031337.
HOVERGEN	HBG064381.
InParanoid	Q86VX9.
OrthoDB	EOG4CZBFS.
PhylomeDB	Q86VX9.
Gene expression databases
ArrayExpress	Q86VX9.
Bgee	Q86VX9.
CleanEx	HS_MON1A.
Genevestigator	Q86VX9.
Family and domain databases
InterPro	IPR004353. Vacuolar_fusion_protein_MON1. [Graphical view]
PANTHER	PTHR13027. PTHR13027. 1 hit.
Pfam	PF03164. Mon1. 1 hit. [Graphical view]
PRINTS	PR01546. YEAST73DUF.
ProtoNet	Search...
Other
GenomeRNAi	84315.
NextBio	74024.
SOURCE	Search...

Entry information

Entry name

MON1A_HUMAN

Accession

Primary (citable) accession number: Q86VX9
Secondary accession number(s): B2RDQ1, Q8NAV7, Q9BRF3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	May 1, 2007
Last modified:	April 3, 2013
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.