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Protein

Vacuolar fusion protein MON1 homolog A

Gene

MON1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity). Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (PubMed:23084991).By similarity1 Publication

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar fusion protein MON1 homolog A
Gene namesi
Name:MON1A
Synonyms:SAND1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000164077.13.
HGNCiHGNC:28207. MON1A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi84315.
OpenTargetsiENSG00000164077.
PharmGKBiPA142671340.

Polymorphism and mutation databases

BioMutaiMON1A.
DMDMi146324996.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002857611 – 555Vacuolar fusion protein MON1 homolog AAdd BLAST555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineCombined sources1
Modified residuei56PhosphoserineBy similarity1
Modified residuei61PhosphothreonineCombined sources1
Modified residuei91PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86VX9.
MaxQBiQ86VX9.
PaxDbiQ86VX9.
PeptideAtlasiQ86VX9.
PRIDEiQ86VX9.

PTM databases

iPTMnetiQ86VX9.
PhosphoSitePlusiQ86VX9.

Expressioni

Gene expression databases

BgeeiENSG00000164077.
CleanExiHS_MON1A.
ExpressionAtlasiQ86VX9. baseline and differential.
GenevisibleiQ86VX9. HS.

Organism-specific databases

HPAiHPA053752.
HPA058032.

Interactioni

Subunit structurei

Interacts with CCZ1 (PubMed:23084991).1 Publication

Protein-protein interaction databases

BioGridi124041. 9 interactors.
IntActiQ86VX9. 8 interactors.
MINTiMINT-2877066.
STRINGi9606.ENSP00000296473.

Structurei

3D structure databases

ProteinModelPortaliQ86VX9.
SMRiQ86VX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MON1/SAND family.Curated

Phylogenomic databases

eggNOGiKOG0997. Eukaryota.
ENOG410XR29. LUCA.
GeneTreeiENSGT00390000006665.
HOGENOMiHOG000031337.
HOVERGENiHBG064381.
InParanoidiQ86VX9.
KOiK20195.
PhylomeDBiQ86VX9.
TreeFamiTF314665.

Family and domain databases

InterProiView protein in InterPro
IPR004353. Mon1.
PANTHERiPTHR13027. PTHR13027. 1 hit.
PfamiView protein in Pfam
PF03164. Mon1. 1 hit.
PRINTSiPR01546. YEAST73DUF.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86VX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATDMQRKRS SECLDGTLTP SDGQSMERAE SPTPGMAQGM EPGAGQEGAM
60 70 80 90 100
FVHARSYEDL TESEDGAASG DSHKEGTRGP PPLPTDMRQI SQDFSELSTQ
110 120 130 140 150
LTGVARDLQE EMLPGSSEDW LEPPGAVGRP ATEPPREGTT EGDEEDATEA
160 170 180 190 200
WRLHQKHVFV LSEAGKPVYS RYGSEEALSS TMGVMVALVS FLEADKNAIR
210 220 230 240 250
SIHADGYKVV FVRRSPLVLV AVARTRQSAQ ELAQELLYIY YQILSLLTGA
260 270 280 290 300
QLSHIFQQKQ NYDLRRLLSG SERITDNLLQ LMARDPSFLM GAARCLPLAA
310 320 330 340 350
AVRDTVSASL QQARARSLVF SILLARNQLV ALVRRKDQFL HPIDLHLLFN
360 370 380 390 400
LISSSSSFRE GEAWTPVCLP KFNAAGFFHA HISYLEPDTD LCLLLVSTDR
410 420 430 440 450
EDFFAVSDCR RRFQERLRKR GAHLALREAL RTPYYSVAQV GIPDLRHFLY
460 470 480 490 500
KSKSSGLFTS PEIEAPYTSE EEQERLLGLY QYLHSRAHNA SRPLKTIYYT
510 520 530 540 550
GPNENLLAWV TGAFELYMCY SPLGTKASAV SAIHKLMRWI RKEEDRLFIL

TPLTY
Length:555
Mass (Da):62,131
Last modified:May 1, 2007 - v2
Checksum:i3428BEBFD9EA1626
GO
Isoform 2 (identifier: Q86VX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-204: Missing.

Show »
Length:393
Mass (Da):44,692
Checksum:i08CD3CF132D5B963
GO
Isoform 3 (identifier: Q86VX9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-204: Missing.
     460-460: S → R
     461-555: Missing.

Note: No experimental confirmation available.
Show »
Length:298
Mass (Da):33,713
Checksum:i2B1C495E32796DC9
GO
Isoform 4 (identifier: Q86VX9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-204: MATDMQRKRS...DKNAIRSIHA → MHPGGGPSRA...TPGMAQGMEP

Note: No experimental confirmation available.
Show »
Length:490
Mass (Da):55,456
Checksum:i1402A856E41AC982
GO

Sequence cautioni

The sequence AAH47022 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0476521 – 204MATDM…RSIHA → MHPGGGPSRAERLELGLGRE RPAKAIFLHRRPGEGGGRER CLRCGHVCVRRGPGPREAVP SGRPRPDTLTPPWVRQRAVT GTFCASWTPLRNRRAQRMAT DMQRKRSSECLDGTLTPSDG QSMERAESPTPGMAQGMEP in isoform 4. CuratedAdd BLAST204
Alternative sequenceiVSP_02491043 – 204Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST162
Alternative sequenceiVSP_024911460S → R in isoform 3. 1 Publication1
Alternative sequenceiVSP_024912461 – 555Missing in isoform 3. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092018 mRNA. Translation: BAC03790.1.
AK315630 mRNA. Translation: BAG37998.1.
AC105935 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65037.1.
BC006299 mRNA. Translation: AAH06299.1.
BC009459 mRNA. Translation: AAH09459.1.
BC047022 mRNA. Translation: AAH47022.1. Different initiation.
CCDSiCCDS46830.1. [Q86VX9-4]
RefSeqiNP_001135973.1. NM_001142501.1. [Q86VX9-4]
NP_115731.2. NM_032355.3.
XP_006713408.1. XM_006713345.3. [Q86VX9-1]
XP_011532462.1. XM_011534160.1. [Q86VX9-1]
UniGeneiHs.655014.

Genome annotation databases

EnsembliENST00000455683; ENSP00000404793; ENSG00000164077. [Q86VX9-4]
GeneIDi84315.
KEGGihsa:84315.
UCSCiuc003cya.4. human. [Q86VX9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMON1A_HUMAN
AccessioniPrimary (citable) accession number: Q86VX9
Secondary accession number(s): B2RDQ1
, G5E9N1, Q8NAV7, Q9BRF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: September 27, 2017
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families