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Q86VX9

- MON1A_HUMAN

UniProt

Q86VX9 - MON1A_HUMAN

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Protein
Vacuolar fusion protein MON1 homolog A
Gene
MON1A, SAND1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar fusion protein MON1 homolog A
Gene namesi
Name:MON1A
Synonyms:SAND1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:28207. MON1A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671340.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Vacuolar fusion protein MON1 homolog A
PRO_0000285761Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei31 – 311Phosphoserine1 Publication
Modified residuei56 – 561Phosphoserine By similarity
Modified residuei91 – 911Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ86VX9.
PaxDbiQ86VX9.
PRIDEiQ86VX9.

Expressioni

Gene expression databases

ArrayExpressiQ86VX9.
BgeeiQ86VX9.
CleanExiHS_MON1A.
GenevestigatoriQ86VX9.

Organism-specific databases

HPAiHPA053752.
HPA058032.

Interactioni

Protein-protein interaction databases

BioGridi124041. 7 interactions.
IntActiQ86VX9. 7 interactions.
MINTiMINT-2877066.
STRINGi9606.ENSP00000296473.

Structurei

3D structure databases

ProteinModelPortaliQ86VX9.

Family & Domainsi

Sequence similaritiesi

Belongs to the MON1/SAND family.

Phylogenomic databases

eggNOGiNOG256927.
HOGENOMiHOG000031337.
HOVERGENiHBG064381.
InParanoidiQ86VX9.
OrthoDBiEOG79GT63.
PhylomeDBiQ86VX9.
TreeFamiTF314665.

Family and domain databases

InterProiIPR004353. Vacuolar_fusion_protein_MON1.
[Graphical view]
PANTHERiPTHR13027. PTHR13027. 1 hit.
PfamiPF03164. Mon1. 1 hit.
[Graphical view]
PRINTSiPR01546. YEAST73DUF.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86VX9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MATDMQRKRS SECLDGTLTP SDGQSMERAE SPTPGMAQGM EPGAGQEGAM    50
FVHARSYEDL TESEDGAASG DSHKEGTRGP PPLPTDMRQI SQDFSELSTQ 100
LTGVARDLQE EMLPGSSEDW LEPPGAVGRP ATEPPREGTT EGDEEDATEA 150
WRLHQKHVFV LSEAGKPVYS RYGSEEALSS TMGVMVALVS FLEADKNAIR 200
SIHADGYKVV FVRRSPLVLV AVARTRQSAQ ELAQELLYIY YQILSLLTGA 250
QLSHIFQQKQ NYDLRRLLSG SERITDNLLQ LMARDPSFLM GAARCLPLAA 300
AVRDTVSASL QQARARSLVF SILLARNQLV ALVRRKDQFL HPIDLHLLFN 350
LISSSSSFRE GEAWTPVCLP KFNAAGFFHA HISYLEPDTD LCLLLVSTDR 400
EDFFAVSDCR RRFQERLRKR GAHLALREAL RTPYYSVAQV GIPDLRHFLY 450
KSKSSGLFTS PEIEAPYTSE EEQERLLGLY QYLHSRAHNA SRPLKTIYYT 500
GPNENLLAWV TGAFELYMCY SPLGTKASAV SAIHKLMRWI RKEEDRLFIL 550
TPLTY 555
Length:555
Mass (Da):62,131
Last modified:May 1, 2007 - v2
Checksum:i3428BEBFD9EA1626
GO
Isoform 2 (identifier: Q86VX9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-204: Missing.

Show »
Length:393
Mass (Da):44,692
Checksum:i08CD3CF132D5B963
GO
Isoform 3 (identifier: Q86VX9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-204: Missing.
     460-460: S → R
     461-555: Missing.

Note: No experimental confirmation available.

Show »
Length:298
Mass (Da):33,713
Checksum:i2B1C495E32796DC9
GO
Isoform 4 (identifier: Q86VX9-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-204: MATDMQRKRS...DKNAIRSIHA → MHPGGGPSRA...TPGMAQGMEP

Note: No experimental confirmation available.

Show »
Length:490
Mass (Da):55,456
Checksum:i1402A856E41AC982
GO

Sequence cautioni

The sequence AAH47022.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 204204MATDM…RSIHA → MHPGGGPSRAERLELGLGRE RPAKAIFLHRRPGEGGGRER CLRCGHVCVRRGPGPREAVP SGRPRPDTLTPPWVRQRAVT GTFCASWTPLRNRRAQRMAT DMQRKRSSECLDGTLTPSDG QSMERAESPTPGMAQGMEP in isoform 4.
VSP_047652Add
BLAST
Alternative sequencei43 – 204162Missing in isoform 2 and isoform 3.
VSP_024910Add
BLAST
Alternative sequencei460 – 4601S → R in isoform 3.
VSP_024911
Alternative sequencei461 – 55595Missing in isoform 3.
VSP_024912Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK092018 mRNA. Translation: BAC03790.1.
AK315630 mRNA. Translation: BAG37998.1.
AC105935 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65037.1.
BC006299 mRNA. Translation: AAH06299.1.
BC009459 mRNA. Translation: AAH09459.1.
BC047022 mRNA. Translation: AAH47022.1. Different initiation.
CCDSiCCDS46830.1. [Q86VX9-4]
RefSeqiNP_001135973.1. NM_001142501.1. [Q86VX9-4]
NP_115731.2. NM_032355.3.
XP_006713408.1. XM_006713345.1. [Q86VX9-1]
UniGeneiHs.655014.

Genome annotation databases

EnsembliENST00000455683; ENSP00000404793; ENSG00000164077. [Q86VX9-4]
GeneIDi84315.
KEGGihsa:84315.
UCSCiuc003cxz.3. human. [Q86VX9-1]
uc003cya.3. human.

Polymorphism databases

DMDMi146324996.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK092018 mRNA. Translation: BAC03790.1 .
AK315630 mRNA. Translation: BAG37998.1 .
AC105935 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65037.1 .
BC006299 mRNA. Translation: AAH06299.1 .
BC009459 mRNA. Translation: AAH09459.1 .
BC047022 mRNA. Translation: AAH47022.1 . Different initiation.
CCDSi CCDS46830.1. [Q86VX9-4 ]
RefSeqi NP_001135973.1. NM_001142501.1. [Q86VX9-4 ]
NP_115731.2. NM_032355.3.
XP_006713408.1. XM_006713345.1. [Q86VX9-1 ]
UniGenei Hs.655014.

3D structure databases

ProteinModelPortali Q86VX9.
ModBasei Search...

Protein-protein interaction databases

BioGridi 124041. 7 interactions.
IntActi Q86VX9. 7 interactions.
MINTi MINT-2877066.
STRINGi 9606.ENSP00000296473.

Polymorphism databases

DMDMi 146324996.

Proteomic databases

MaxQBi Q86VX9.
PaxDbi Q86VX9.
PRIDEi Q86VX9.

Protocols and materials databases

DNASUi 84315.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000455683 ; ENSP00000404793 ; ENSG00000164077 . [Q86VX9-4 ]
GeneIDi 84315.
KEGGi hsa:84315.
UCSCi uc003cxz.3. human. [Q86VX9-1 ]
uc003cya.3. human.

Organism-specific databases

CTDi 84315.
GeneCardsi GC03M049946.
H-InvDB HIX0003326.
HGNCi HGNC:28207. MON1A.
HPAi HPA053752.
HPA058032.
MIMi 611464. gene.
neXtProti NX_Q86VX9.
PharmGKBi PA142671340.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG256927.
HOGENOMi HOG000031337.
HOVERGENi HBG064381.
InParanoidi Q86VX9.
OrthoDBi EOG79GT63.
PhylomeDBi Q86VX9.
TreeFami TF314665.

Miscellaneous databases

GenomeRNAii 84315.
NextBioi 74024.
PROi Q86VX9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q86VX9.
Bgeei Q86VX9.
CleanExi HS_MON1A.
Genevestigatori Q86VX9.

Family and domain databases

InterProi IPR004353. Vacuolar_fusion_protein_MON1.
[Graphical view ]
PANTHERi PTHR13027. PTHR13027. 1 hit.
Pfami PF03164. Mon1. 1 hit.
[Graphical view ]
PRINTSi PR01546. YEAST73DUF.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Synovial cell.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain, Lung and Uterus.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiMON1A_HUMAN
AccessioniPrimary (citable) accession number: Q86VX9
Secondary accession number(s): B2RDQ1
, G5E9N1, Q8NAV7, Q9BRF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: July 9, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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