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Q86VX9 (MON1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vacuolar fusion protein MON1 homolog A
Gene names
Name:MON1A
Synonyms:SAND1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes By similarity.

Sequence similarities

Belongs to the MON1/SAND family.

Sequence caution

The sequence AAH47022.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86VX9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86VX9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     43-204: Missing.
Isoform 3 (identifier: Q86VX9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     43-204: Missing.
     460-460: S → R
     461-555: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q86VX9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-204: MATDMQRKRS...DKNAIRSIHA → MHPGGGPSRA...TPGMAQGMEP
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Vacuolar fusion protein MON1 homolog A
PRO_0000285761

Amino acid modifications

Modified residue311Phosphoserine Ref.5
Modified residue561Phosphoserine By similarity
Modified residue911Phosphoserine By similarity

Natural variations

Alternative sequence1 – 204204MATDM…RSIHA → MHPGGGPSRAERLELGLGRE RPAKAIFLHRRPGEGGGRER CLRCGHVCVRRGPGPREAVP SGRPRPDTLTPPWVRQRAVT GTFCASWTPLRNRRAQRMAT DMQRKRSSECLDGTLTPSDG QSMERAESPTPGMAQGMEP in isoform 4.
VSP_047652
Alternative sequence43 – 204162Missing in isoform 2 and isoform 3.
VSP_024910
Alternative sequence4601S → R in isoform 3.
VSP_024911
Alternative sequence461 – 55595Missing in isoform 3.
VSP_024912

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2007. Version 2.
Checksum: 3428BEBFD9EA1626

FASTA55562,131
        10         20         30         40         50         60 
MATDMQRKRS SECLDGTLTP SDGQSMERAE SPTPGMAQGM EPGAGQEGAM FVHARSYEDL 

        70         80         90        100        110        120 
TESEDGAASG DSHKEGTRGP PPLPTDMRQI SQDFSELSTQ LTGVARDLQE EMLPGSSEDW 

       130        140        150        160        170        180 
LEPPGAVGRP ATEPPREGTT EGDEEDATEA WRLHQKHVFV LSEAGKPVYS RYGSEEALSS 

       190        200        210        220        230        240 
TMGVMVALVS FLEADKNAIR SIHADGYKVV FVRRSPLVLV AVARTRQSAQ ELAQELLYIY 

       250        260        270        280        290        300 
YQILSLLTGA QLSHIFQQKQ NYDLRRLLSG SERITDNLLQ LMARDPSFLM GAARCLPLAA 

       310        320        330        340        350        360 
AVRDTVSASL QQARARSLVF SILLARNQLV ALVRRKDQFL HPIDLHLLFN LISSSSSFRE 

       370        380        390        400        410        420 
GEAWTPVCLP KFNAAGFFHA HISYLEPDTD LCLLLVSTDR EDFFAVSDCR RRFQERLRKR 

       430        440        450        460        470        480 
GAHLALREAL RTPYYSVAQV GIPDLRHFLY KSKSSGLFTS PEIEAPYTSE EEQERLLGLY 

       490        500        510        520        530        540 
QYLHSRAHNA SRPLKTIYYT GPNENLLAWV TGAFELYMCY SPLGTKASAV SAIHKLMRWI 

       550 
RKEEDRLFIL TPLTY 

« Hide

Isoform 2 [UniParc].

Checksum: 08CD3CF132D5B963
Show »

FASTA39344,692
Isoform 3 [UniParc].

Checksum: 2B1C495E32796DC9
Show »

FASTA29833,713
Isoform 4 [UniParc].

Checksum: 1402A856E41AC982
Show »

FASTA49055,456

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Synovial cell.
[2]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain, Lung and Uterus.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK092018 mRNA. Translation: BAC03790.1.
AK315630 mRNA. Translation: BAG37998.1.
AC105935 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65037.1.
BC006299 mRNA. Translation: AAH06299.1.
BC009459 mRNA. Translation: AAH09459.1.
BC047022 mRNA. Translation: AAH47022.1. Different initiation.
CCDSCCDS46830.1. [Q86VX9-4]
RefSeqNP_001135973.1. NM_001142501.1. [Q86VX9-4]
NP_115731.2. NM_032355.3.
XP_006713408.1. XM_006713345.1. [Q86VX9-1]
UniGeneHs.655014.

3D structure databases

ProteinModelPortalQ86VX9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124041. 7 interactions.
IntActQ86VX9. 7 interactions.
MINTMINT-2877066.
STRING9606.ENSP00000296473.

Polymorphism databases

DMDM146324996.

Proteomic databases

MaxQBQ86VX9.
PaxDbQ86VX9.
PRIDEQ86VX9.

Protocols and materials databases

DNASU84315.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000455683; ENSP00000404793; ENSG00000164077. [Q86VX9-4]
GeneID84315.
KEGGhsa:84315.
UCSCuc003cxz.3. human. [Q86VX9-1]
uc003cya.3. human.

Organism-specific databases

CTD84315.
GeneCardsGC03M049946.
H-InvDBHIX0003326.
HGNCHGNC:28207. MON1A.
HPAHPA053752.
HPA058032.
MIM611464. gene.
neXtProtNX_Q86VX9.
PharmGKBPA142671340.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG256927.
HOGENOMHOG000031337.
HOVERGENHBG064381.
InParanoidQ86VX9.
OrthoDBEOG79GT63.
PhylomeDBQ86VX9.
TreeFamTF314665.

Gene expression databases

ArrayExpressQ86VX9.
BgeeQ86VX9.
CleanExHS_MON1A.
GenevestigatorQ86VX9.

Family and domain databases

InterProIPR004353. Vacuolar_fusion_protein_MON1.
[Graphical view]
PANTHERPTHR13027. PTHR13027. 1 hit.
PfamPF03164. Mon1. 1 hit.
[Graphical view]
PRINTSPR01546. YEAST73DUF.
ProtoNetSearch...

Other

GenomeRNAi84315.
NextBio74024.
PROQ86VX9.
SOURCESearch...

Entry information

Entry nameMON1A_HUMAN
AccessionPrimary (citable) accession number: Q86VX9
Secondary accession number(s): B2RDQ1 expand/collapse secondary AC list , G5E9N1, Q8NAV7, Q9BRF3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: July 9, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM