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Q86VX9

- MON1A_HUMAN

UniProt

Q86VX9 - MON1A_HUMAN

Protein

Vacuolar fusion protein MON1 homolog A

Gene

MON1A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (01 May 2007)
      Previous versions | rss
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    Functioni

    Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vacuolar fusion protein MON1 homolog A
    Gene namesi
    Name:MON1A
    Synonyms:SAND1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:28207. MON1A.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671340.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Vacuolar fusion protein MON1 homolog APRO_0000285761Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei31 – 311Phosphoserine1 Publication
    Modified residuei56 – 561PhosphoserineBy similarity
    Modified residuei91 – 911PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ86VX9.
    PaxDbiQ86VX9.
    PRIDEiQ86VX9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ86VX9.
    BgeeiQ86VX9.
    CleanExiHS_MON1A.
    GenevestigatoriQ86VX9.

    Organism-specific databases

    HPAiHPA053752.
    HPA058032.

    Interactioni

    Protein-protein interaction databases

    BioGridi124041. 7 interactions.
    IntActiQ86VX9. 7 interactions.
    MINTiMINT-2877066.
    STRINGi9606.ENSP00000296473.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86VX9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MON1/SAND family.Curated

    Phylogenomic databases

    eggNOGiNOG256927.
    HOGENOMiHOG000031337.
    HOVERGENiHBG064381.
    InParanoidiQ86VX9.
    OrthoDBiEOG79GT63.
    PhylomeDBiQ86VX9.
    TreeFamiTF314665.

    Family and domain databases

    InterProiIPR004353. Vacuolar_fusion_protein_MON1.
    [Graphical view]
    PANTHERiPTHR13027. PTHR13027. 1 hit.
    PfamiPF03164. Mon1. 1 hit.
    [Graphical view]
    PRINTSiPR01546. YEAST73DUF.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86VX9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATDMQRKRS SECLDGTLTP SDGQSMERAE SPTPGMAQGM EPGAGQEGAM    50
    FVHARSYEDL TESEDGAASG DSHKEGTRGP PPLPTDMRQI SQDFSELSTQ 100
    LTGVARDLQE EMLPGSSEDW LEPPGAVGRP ATEPPREGTT EGDEEDATEA 150
    WRLHQKHVFV LSEAGKPVYS RYGSEEALSS TMGVMVALVS FLEADKNAIR 200
    SIHADGYKVV FVRRSPLVLV AVARTRQSAQ ELAQELLYIY YQILSLLTGA 250
    QLSHIFQQKQ NYDLRRLLSG SERITDNLLQ LMARDPSFLM GAARCLPLAA 300
    AVRDTVSASL QQARARSLVF SILLARNQLV ALVRRKDQFL HPIDLHLLFN 350
    LISSSSSFRE GEAWTPVCLP KFNAAGFFHA HISYLEPDTD LCLLLVSTDR 400
    EDFFAVSDCR RRFQERLRKR GAHLALREAL RTPYYSVAQV GIPDLRHFLY 450
    KSKSSGLFTS PEIEAPYTSE EEQERLLGLY QYLHSRAHNA SRPLKTIYYT 500
    GPNENLLAWV TGAFELYMCY SPLGTKASAV SAIHKLMRWI RKEEDRLFIL 550
    TPLTY 555
    Length:555
    Mass (Da):62,131
    Last modified:May 1, 2007 - v2
    Checksum:i3428BEBFD9EA1626
    GO
    Isoform 2 (identifier: Q86VX9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         43-204: Missing.

    Show »
    Length:393
    Mass (Da):44,692
    Checksum:i08CD3CF132D5B963
    GO
    Isoform 3 (identifier: Q86VX9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         43-204: Missing.
         460-460: S → R
         461-555: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:298
    Mass (Da):33,713
    Checksum:i2B1C495E32796DC9
    GO
    Isoform 4 (identifier: Q86VX9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-204: MATDMQRKRS...DKNAIRSIHA → MHPGGGPSRA...TPGMAQGMEP

    Note: No experimental confirmation available.

    Show »
    Length:490
    Mass (Da):55,456
    Checksum:i1402A856E41AC982
    GO

    Sequence cautioni

    The sequence AAH47022.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 204204MATDM…RSIHA → MHPGGGPSRAERLELGLGRE RPAKAIFLHRRPGEGGGRER CLRCGHVCVRRGPGPREAVP SGRPRPDTLTPPWVRQRAVT GTFCASWTPLRNRRAQRMAT DMQRKRSSECLDGTLTPSDG QSMERAESPTPGMAQGMEP in isoform 4. CuratedVSP_047652Add
    BLAST
    Alternative sequencei43 – 204162Missing in isoform 2 and isoform 3. 2 PublicationsVSP_024910Add
    BLAST
    Alternative sequencei460 – 4601S → R in isoform 3. 1 PublicationVSP_024911
    Alternative sequencei461 – 55595Missing in isoform 3. 1 PublicationVSP_024912Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK092018 mRNA. Translation: BAC03790.1.
    AK315630 mRNA. Translation: BAG37998.1.
    AC105935 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW65037.1.
    BC006299 mRNA. Translation: AAH06299.1.
    BC009459 mRNA. Translation: AAH09459.1.
    BC047022 mRNA. Translation: AAH47022.1. Different initiation.
    CCDSiCCDS46830.1. [Q86VX9-4]
    RefSeqiNP_001135973.1. NM_001142501.1. [Q86VX9-4]
    NP_115731.2. NM_032355.3.
    XP_006713408.1. XM_006713345.1. [Q86VX9-1]
    UniGeneiHs.655014.

    Genome annotation databases

    EnsembliENST00000455683; ENSP00000404793; ENSG00000164077. [Q86VX9-4]
    GeneIDi84315.
    KEGGihsa:84315.
    UCSCiuc003cxz.3. human. [Q86VX9-1]
    uc003cya.3. human.

    Polymorphism databases

    DMDMi146324996.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK092018 mRNA. Translation: BAC03790.1 .
    AK315630 mRNA. Translation: BAG37998.1 .
    AC105935 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW65037.1 .
    BC006299 mRNA. Translation: AAH06299.1 .
    BC009459 mRNA. Translation: AAH09459.1 .
    BC047022 mRNA. Translation: AAH47022.1 . Different initiation.
    CCDSi CCDS46830.1. [Q86VX9-4 ]
    RefSeqi NP_001135973.1. NM_001142501.1. [Q86VX9-4 ]
    NP_115731.2. NM_032355.3.
    XP_006713408.1. XM_006713345.1. [Q86VX9-1 ]
    UniGenei Hs.655014.

    3D structure databases

    ProteinModelPortali Q86VX9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124041. 7 interactions.
    IntActi Q86VX9. 7 interactions.
    MINTi MINT-2877066.
    STRINGi 9606.ENSP00000296473.

    Polymorphism databases

    DMDMi 146324996.

    Proteomic databases

    MaxQBi Q86VX9.
    PaxDbi Q86VX9.
    PRIDEi Q86VX9.

    Protocols and materials databases

    DNASUi 84315.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000455683 ; ENSP00000404793 ; ENSG00000164077 . [Q86VX9-4 ]
    GeneIDi 84315.
    KEGGi hsa:84315.
    UCSCi uc003cxz.3. human. [Q86VX9-1 ]
    uc003cya.3. human.

    Organism-specific databases

    CTDi 84315.
    GeneCardsi GC03M049946.
    H-InvDB HIX0003326.
    HGNCi HGNC:28207. MON1A.
    HPAi HPA053752.
    HPA058032.
    MIMi 611464. gene.
    neXtProti NX_Q86VX9.
    PharmGKBi PA142671340.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG256927.
    HOGENOMi HOG000031337.
    HOVERGENi HBG064381.
    InParanoidi Q86VX9.
    OrthoDBi EOG79GT63.
    PhylomeDBi Q86VX9.
    TreeFami TF314665.

    Miscellaneous databases

    GenomeRNAii 84315.
    NextBioi 74024.
    PROi Q86VX9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86VX9.
    Bgeei Q86VX9.
    CleanExi HS_MON1A.
    Genevestigatori Q86VX9.

    Family and domain databases

    InterProi IPR004353. Vacuolar_fusion_protein_MON1.
    [Graphical view ]
    PANTHERi PTHR13027. PTHR13027. 1 hit.
    Pfami PF03164. Mon1. 1 hit.
    [Graphical view ]
    PRINTSi PR01546. YEAST73DUF.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Synovial cell.
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain, Lung and Uterus.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiMON1A_HUMAN
    AccessioniPrimary (citable) accession number: Q86VX9
    Secondary accession number(s): B2RDQ1
    , G5E9N1, Q8NAV7, Q9BRF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3