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Q86VX2

- COMD7_HUMAN

UniProt

Q86VX2 - COMD7_HUMAN

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Protein

COMM domain-containing protein 7

Gene

COMMD7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Associates with the NF-kappa-B complex and suppresses its transcriptional activity.1 Publication

GO - Molecular functioni

  1. NF-kappaB binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  2. negative regulation of transcription, DNA-templated Source: UniProtKB
  3. tumor necrosis factor-mediated signaling pathway Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 7
Gene namesi
Name:COMMD7
Synonyms:C20orf92
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:16223. COMMD7.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25799.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200COMM domain-containing protein 7PRO_0000077399Add
BLAST

Proteomic databases

MaxQBiQ86VX2.
PaxDbiQ86VX2.
PRIDEiQ86VX2.

PTM databases

PhosphoSiteiQ86VX2.

Expressioni

Tissue specificityi

Widely expressed with highest expression in lung.1 Publication

Gene expression databases

BgeeiQ86VX2.
CleanExiHS_COMMD7.
ExpressionAtlasiQ86VX2. baseline and differential.
GenevestigatoriQ86VX2.

Interactioni

Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain).1 Publication

Protein-protein interaction databases

BioGridi127250. 8 interactions.
IntActiQ86VX2. 5 interactions.
STRINGi9606.ENSP00000278980.

Structurei

3D structure databases

ProteinModelPortaliQ86VX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini133 – 20068COMMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 COMM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG47192.
GeneTreeiENSGT00390000012419.
HOGENOMiHOG000031075.
HOVERGENiHBG051072.
InParanoidiQ86VX2.
OMAiCTQDPVP.
OrthoDBiEOG754HS6.
PhylomeDBiQ86VX2.
TreeFamiTF329046.

Family and domain databases

InterProiIPR017920. COMM.
IPR009886. HCaRG.
[Graphical view]
PfamiPF07258. HCaRG. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86VX2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRLHCTEDP VPEAVGGDMQ QLNQLGAQQF SALTEVLFHF LTEPKEVERF
60 70 80 90 100
LAQLSEFATT NQISLGSLRS IVKSLLLVPN GALKKSLTAK QVQADFITLG
110 120 130 140 150
LSEEKATYFS EKWKQNAPTL ARWAIGQTLM INQLIDMEWK FGVTSGSSEL
160 170 180 190 200
EKVGSIFLQL KLVVKKGNQT ENVYIELTLP QFYSFLHEME RVRTSMECFC
Length:200
Mass (Da):22,540
Last modified:June 13, 2006 - v2
Checksum:i41D483117729B495
GO
Isoform 2 (identifier: Q86VX2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-29: Missing.

Show »
Length:199
Mass (Da):22,412
Checksum:iB72082F9930706C2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441P → Q in AAS22244. (PubMed:15799966)Curated
Sequence conflicti44 – 441P → Q in AAH47440. (PubMed:15489334)Curated
Sequence conflicti117 – 1171A → T in AAS22244. (PubMed:15799966)Curated
Sequence conflicti117 – 1171A → T in AAH47440. (PubMed:15489334)Curated
Sequence conflicti171 – 1711E → K in AAS22244. (PubMed:15799966)Curated
Sequence conflicti171 – 1711E → K in AAH47440. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei29 – 291Missing in isoform 2. 1 PublicationVSP_038372

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY542162 mRNA. Translation: AAS22244.1.
AK027893 mRNA. Translation: BAB55436.1.
AK096307 mRNA. Translation: BAG53254.1.
AL035071 Genomic DNA. No translation available.
BX640505 Genomic DNA. No translation available.
FO393400 Genomic DNA. No translation available.
CH471077 Genomic DNA. Translation: EAW76360.1.
BC000628 mRNA. Translation: AAH00628.3.
BC047440 mRNA. Translation: AAH47440.1.
BI821799 mRNA. No translation available.
CCDSiCCDS42864.1. [Q86VX2-1]
CCDS46587.1. [Q86VX2-2]
RefSeqiNP_001092809.1. NM_001099339.1. [Q86VX2-2]
NP_444269.2. NM_053041.2. [Q86VX2-1]
UniGeneiHs.408427.

Genome annotation databases

EnsembliENST00000278980; ENSP00000278980; ENSG00000149600. [Q86VX2-1]
ENST00000446419; ENSP00000395339; ENSG00000149600. [Q86VX2-2]
GeneIDi149951.
KEGGihsa:149951.
UCSCiuc002wya.4. human. [Q86VX2-1]
uc010ged.3. human. [Q86VX2-2]

Polymorphism databases

DMDMi108935829.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY542162 mRNA. Translation: AAS22244.1 .
AK027893 mRNA. Translation: BAB55436.1 .
AK096307 mRNA. Translation: BAG53254.1 .
AL035071 Genomic DNA. No translation available.
BX640505 Genomic DNA. No translation available.
FO393400 Genomic DNA. No translation available.
CH471077 Genomic DNA. Translation: EAW76360.1 .
BC000628 mRNA. Translation: AAH00628.3 .
BC047440 mRNA. Translation: AAH47440.1 .
BI821799 mRNA. No translation available.
CCDSi CCDS42864.1. [Q86VX2-1 ]
CCDS46587.1. [Q86VX2-2 ]
RefSeqi NP_001092809.1. NM_001099339.1. [Q86VX2-2 ]
NP_444269.2. NM_053041.2. [Q86VX2-1 ]
UniGenei Hs.408427.

3D structure databases

ProteinModelPortali Q86VX2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127250. 8 interactions.
IntActi Q86VX2. 5 interactions.
STRINGi 9606.ENSP00000278980.

PTM databases

PhosphoSitei Q86VX2.

Polymorphism databases

DMDMi 108935829.

Proteomic databases

MaxQBi Q86VX2.
PaxDbi Q86VX2.
PRIDEi Q86VX2.

Protocols and materials databases

DNASUi 149951.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000278980 ; ENSP00000278980 ; ENSG00000149600 . [Q86VX2-1 ]
ENST00000446419 ; ENSP00000395339 ; ENSG00000149600 . [Q86VX2-2 ]
GeneIDi 149951.
KEGGi hsa:149951.
UCSCi uc002wya.4. human. [Q86VX2-1 ]
uc010ged.3. human. [Q86VX2-2 ]

Organism-specific databases

CTDi 149951.
GeneCardsi GC20M031290.
HGNCi HGNC:16223. COMMD7.
neXtProti NX_Q86VX2.
PharmGKBi PA25799.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47192.
GeneTreei ENSGT00390000012419.
HOGENOMi HOG000031075.
HOVERGENi HBG051072.
InParanoidi Q86VX2.
OMAi CTQDPVP.
OrthoDBi EOG754HS6.
PhylomeDBi Q86VX2.
TreeFami TF329046.

Miscellaneous databases

GenomeRNAii 149951.
NextBioi 86276.
PROi Q86VX2.

Gene expression databases

Bgeei Q86VX2.
CleanExi HS_COMMD7.
ExpressionAtlasi Q86VX2. baseline and differential.
Genevestigatori Q86VX2.

Family and domain databases

InterProi IPR017920. COMM.
IPR009886. HCaRG.
[Graphical view ]
Pfami PF07258. HCaRG. 1 hit.
[Graphical view ]
PROSITEi PS51269. COMM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-110 (ISOFORM 2).
    Tissue: Brain and Eye.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOMD7_HUMAN
AccessioniPrimary (citable) accession number: Q86VX2
Secondary accession number(s): A2BHJ2
, B3KTZ2, Q5JYB0, Q96SI7, Q9BW53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 13, 2006
Last modified: October 29, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3