Reviewed, UniProtKB/Swiss-Prot Q86VX2 (COMD7_HUMAN)

Names and origin

Protein names

Recommended name:
    COMM domain-containing protein 7

Gene names

Name:	COMMD7
Synonyms:	C20orf92

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Interacts with COMMD1 via its COMM domain. Also associates with the NF-kappa-B complex and suppresses its transcriptional activity. Ref.1
Tissue specificity	Widely expressed with highest expression in lung. Ref.1
Sequence similarities	Contains 1 COMM domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	negative regulation of NF-kappaB transcription factor activity Ref.1 Inferred from direct assay. Source: UniProtKB negative regulation of transcription Ref.1 Inferred from direct assay. Source: UniProtKB tumor necrosis factor-mediated signaling pathway Ref.1 Inferred from direct assay. Source: UniProtKB
Molecular function	NF-kappaB binding Ref.1 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
COMMD1	Q8N668	1	EBI-1550280,EBI-1550112

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86VX2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86VX2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     29-29: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 200	200	COMM domain-containing protein 7		PRO_0000077399
Regions
	Domain	133 – 200	68	COMM
Natural variations
	Alternative sequence	29	1	Missing in isoform 2.		VSP_038372
Experimental info
	Sequence conflict	44	1	P → Q in AAS22244. Ref.1
	Sequence conflict	44	1	P → Q in AAH47440. Ref.4
	Sequence conflict	117	1	A → T in AAS22244. Ref.1
	Sequence conflict	117	1	A → T in AAH47440. Ref.4
	Sequence conflict	171	1	E → K in AAS22244. Ref.1
	Sequence conflict	171	1	E → K in AAH47440. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 13, 2006. Version 2. Checksum: 41D483117729B495	FASTA	200	22,540
	10 20 30 40 50 60 MGRLHCTEDP VPEAVGGDMQ QLNQLGAQQF SALTEVLFHF LTEPKEVERF LAQLSEFATT 70 80 90 100 110 120 NQISLGSLRS IVKSLLLVPN GALKKSLTAK QVQADFITLG LSEEKATYFS EKWKQNAPTL 130 140 150 160 170 180 ARWAIGQTLM INQLIDMEWK FGVTSGSSEL EKVGSIFLQL KLVVKKGNQT ENVYIELTLP 190 200 QFYSFLHEME RVRTSMECFC
	Isoform 2. Checksum: B72082F9930706C2	FASTA	199	22,412
	10 20 30 40 50 60 MGRLHCTEDP VPEAVGGDMQ QLNQLGAQFS ALTEVLFHFL TEPKEVERFL AQLSEFATTN 70 80 90 100 110 120 QISLGSLRSI VKSLLLVPNG ALKKSLTAKQ VQADFITLGL SEEKATYFSE KWKQNAPTLA 130 140 150 160 170 180 RWAIGQTLMI NQLIDMEWKF GVTSGSSELE KVGSIFLQLK LVVKKGNQTE NVYIELTLPQ 190 FYSFLHEMER VRTSMECFC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"COMMD proteins, a novel family of structural and functional homologs of MURR1." Burstein E., Hoberg J.E., Wilkinson A.S., Rumble J.M., Csomos R.A., Komarck C.M., Maine G.N., Wilkinson J.C., Mayo M.W., Duckett C.S. J. Biol. Chem. 280:22222-22232(2005) [PubMed: 15799966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT, TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) AND NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-110 (ISOFORM 2). Tissue: Brain and Eye.
[6]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY542162 mRNA. Translation: AAS22244.1. AK027893 mRNA. Translation: BAB55436.1. AK096307 mRNA. Translation: BAG53254.1. AL035071, BX640505, CR383702 Genomic DNA. Translation: CAI19095.2. BX640505, AL035071, CR383702 Genomic DNA. Translation: CAM28357.1. CR383702, AL035071, BX640505 Genomic DNA. Translation: CAI95302.2. CH471077 Genomic DNA. Translation: EAW76360.1. BC000628 mRNA. Translation: AAH00628.3. BC047440 mRNA. Translation: AAH47440.1. BI821799 mRNA. No translation available.
IPI	IPI00743772.
RefSeq	NP_001092809.1. NP_444269.2.
UniGene	Hs.408427
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86VX2. 3 interactions.
STRING	Q86VX2.
Proteomic databases
PRIDE	Q86VX2.
Genome annotation databases
Ensembl	ENST00000278980; ENSP00000278980; ENSG00000149600; Homo sapiens. [Genome view]
GeneID	149951.
KEGG	hsa:149951.
UCSC	uc002wya.2. human.
Organism-specific databases
CTD	149951.
GeneCards	GC20M030754.
HGNC	HGNC:16223. COMMD7.
PharmGKB	PA25799.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q86VX2.
HOVERGEN	Q86VX2.
OMA	AVGQTLM
OrthoDB	EOG9FXTSR
Gene expression databases
ArrayExpress	Q86VX2.
Bgee	Q86VX2.
CleanEx	HS_COMMD7.
Genevestigator	Q86VX2.
GermOnline	ENSG00000149600. Homo sapiens.
Family and domain databases
InterPro	IPR017920. COMM. IPR009886. HCaRG. [Graphical view]
Pfam	PF07258. HCaRG. 1 hit. [Graphical view]
PROSITE	PS51269. COMM. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	86276.

Entry information

Entry name

COMD7_HUMAN

Accession

Primary (citable) accession number: Q86VX2
Secondary accession number(s): A2BHJ2 , B3KTZ2, Q5JYB0, Q96SI7, Q9BW53

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	June 13, 2006
Last modified:	November 24, 2009
This is version 46 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.