Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

COMM domain-containing protein 7

Gene

COMMD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966).1 Publication1 Publication

GO - Molecular functioni

  • NF-kappaB binding Source: UniProtKB

GO - Biological processi

  • negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
  • tumor necrosis factor-mediated signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 7
Gene namesi
Name:COMMD7
Synonyms:C20orf92
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16223. COMMD7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25799.

Polymorphism and mutation databases

BioMutaiCOMMD7.
DMDMi108935829.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200COMM domain-containing protein 7PRO_0000077399Add
BLAST

Proteomic databases

MaxQBiQ86VX2.
PaxDbiQ86VX2.
PRIDEiQ86VX2.

PTM databases

PhosphoSiteiQ86VX2.

Expressioni

Tissue specificityi

Widely expressed with highest expression in lung.1 Publication

Gene expression databases

BgeeiQ86VX2.
CleanExiHS_COMMD7.
ExpressionAtlasiQ86VX2. baseline and differential.
GenevisibleiQ86VX2. HS.

Interactioni

Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA. Interacts with CCDC22, CCDC93, SCNN1B, CUL7.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC22O608263EBI-1550280,EBI-3943153

Protein-protein interaction databases

BioGridi127250. 11 interactions.
IntActiQ86VX2. 6 interactions.
STRINGi9606.ENSP00000278980.

Structurei

3D structure databases

ProteinModelPortaliQ86VX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini133 – 20068COMMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 COMM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG47192.
GeneTreeiENSGT00390000012419.
HOGENOMiHOG000031075.
HOVERGENiHBG051072.
InParanoidiQ86VX2.
OMAiRASMECF.
OrthoDBiEOG754HS6.
PhylomeDBiQ86VX2.
TreeFamiTF329046.

Family and domain databases

InterProiIPR017920. COMM.
IPR009886. HCaRG.
[Graphical view]
PfamiPF07258. HCaRG. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86VX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRLHCTEDP VPEAVGGDMQ QLNQLGAQQF SALTEVLFHF LTEPKEVERF
60 70 80 90 100
LAQLSEFATT NQISLGSLRS IVKSLLLVPN GALKKSLTAK QVQADFITLG
110 120 130 140 150
LSEEKATYFS EKWKQNAPTL ARWAIGQTLM INQLIDMEWK FGVTSGSSEL
160 170 180 190 200
EKVGSIFLQL KLVVKKGNQT ENVYIELTLP QFYSFLHEME RVRTSMECFC
Length:200
Mass (Da):22,540
Last modified:June 13, 2006 - v2
Checksum:i41D483117729B495
GO
Isoform 2 (identifier: Q86VX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-29: Missing.

Show »
Length:199
Mass (Da):22,412
Checksum:iB72082F9930706C2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441P → Q in AAS22244 (PubMed:15799966).Curated
Sequence conflicti44 – 441P → Q in AAH47440 (PubMed:15489334).Curated
Sequence conflicti117 – 1171A → T in AAS22244 (PubMed:15799966).Curated
Sequence conflicti117 – 1171A → T in AAH47440 (PubMed:15489334).Curated
Sequence conflicti171 – 1711E → K in AAS22244 (PubMed:15799966).Curated
Sequence conflicti171 – 1711E → K in AAH47440 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei29 – 291Missing in isoform 2. 1 PublicationVSP_038372

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542162 mRNA. Translation: AAS22244.1.
AK027893 mRNA. Translation: BAB55436.1.
AK096307 mRNA. Translation: BAG53254.1.
AL035071 Genomic DNA. No translation available.
BX640505 Genomic DNA. No translation available.
FO393400 Genomic DNA. No translation available.
CH471077 Genomic DNA. Translation: EAW76360.1.
BC000628 mRNA. Translation: AAH00628.3.
BC047440 mRNA. Translation: AAH47440.1.
BI821799 mRNA. No translation available.
CCDSiCCDS42864.1. [Q86VX2-1]
CCDS46587.1. [Q86VX2-2]
RefSeqiNP_001092809.1. NM_001099339.1. [Q86VX2-2]
NP_444269.2. NM_053041.2. [Q86VX2-1]
UniGeneiHs.408427.

Genome annotation databases

EnsembliENST00000278980; ENSP00000278980; ENSG00000149600. [Q86VX2-1]
ENST00000446419; ENSP00000395339; ENSG00000149600. [Q86VX2-2]
GeneIDi149951.
KEGGihsa:149951.
UCSCiuc002wya.4. human. [Q86VX2-1]
uc010ged.3. human. [Q86VX2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542162 mRNA. Translation: AAS22244.1.
AK027893 mRNA. Translation: BAB55436.1.
AK096307 mRNA. Translation: BAG53254.1.
AL035071 Genomic DNA. No translation available.
BX640505 Genomic DNA. No translation available.
FO393400 Genomic DNA. No translation available.
CH471077 Genomic DNA. Translation: EAW76360.1.
BC000628 mRNA. Translation: AAH00628.3.
BC047440 mRNA. Translation: AAH47440.1.
BI821799 mRNA. No translation available.
CCDSiCCDS42864.1. [Q86VX2-1]
CCDS46587.1. [Q86VX2-2]
RefSeqiNP_001092809.1. NM_001099339.1. [Q86VX2-2]
NP_444269.2. NM_053041.2. [Q86VX2-1]
UniGeneiHs.408427.

3D structure databases

ProteinModelPortaliQ86VX2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127250. 11 interactions.
IntActiQ86VX2. 6 interactions.
STRINGi9606.ENSP00000278980.

PTM databases

PhosphoSiteiQ86VX2.

Polymorphism and mutation databases

BioMutaiCOMMD7.
DMDMi108935829.

Proteomic databases

MaxQBiQ86VX2.
PaxDbiQ86VX2.
PRIDEiQ86VX2.

Protocols and materials databases

DNASUi149951.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278980; ENSP00000278980; ENSG00000149600. [Q86VX2-1]
ENST00000446419; ENSP00000395339; ENSG00000149600. [Q86VX2-2]
GeneIDi149951.
KEGGihsa:149951.
UCSCiuc002wya.4. human. [Q86VX2-1]
uc010ged.3. human. [Q86VX2-2]

Organism-specific databases

CTDi149951.
GeneCardsiGC20M031290.
HGNCiHGNC:16223. COMMD7.
neXtProtiNX_Q86VX2.
PharmGKBiPA25799.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47192.
GeneTreeiENSGT00390000012419.
HOGENOMiHOG000031075.
HOVERGENiHBG051072.
InParanoidiQ86VX2.
OMAiRASMECF.
OrthoDBiEOG754HS6.
PhylomeDBiQ86VX2.
TreeFamiTF329046.

Miscellaneous databases

GenomeRNAii149951.
NextBioi86276.
PROiQ86VX2.

Gene expression databases

BgeeiQ86VX2.
CleanExiHS_COMMD7.
ExpressionAtlasiQ86VX2. baseline and differential.
GenevisibleiQ86VX2. HS.

Family and domain databases

InterProiIPR017920. COMM.
IPR009886. HCaRG.
[Graphical view]
PfamiPF07258. HCaRG. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-110 (ISOFORM 2).
    Tissue: Brain and Eye.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding."
    Mao X., Gluck N., Chen B., Starokadomskyy P., Li H., Maine G.N., Burstein E.
    J. Biol. Chem. 286:32355-32365(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CUL7, SUBCELLULAR LOCATION.
  8. "Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel."
    Liu Y.F., Swart M., Ke Y., Ly K., McDonald F.J.
    Am. J. Physiol. 305:F80-F89(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SCNN1B.
  9. Cited for: INTERACTION WITH CCDC22.
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  11. Cited for: INTERACTION WITH CCDC93.

Entry informationi

Entry nameiCOMD7_HUMAN
AccessioniPrimary (citable) accession number: Q86VX2
Secondary accession number(s): A2BHJ2
, B3KTZ2, Q5JYB0, Q96SI7, Q9BW53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 13, 2006
Last modified: June 24, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.