Q86VX2 (COMD7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
COMM domain-containing protein 7

Gene names

Name:	COMMD7
Synonyms:	C20orf92

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Associates with the NF-kappa-B complex and suppresses its transcriptional activity. Ref.1
Subunit structure	Interacts (via COMM domain) with COMMD1 (via COMM domain). Ref.1
Tissue specificity	Widely expressed with highest expression in lung. Ref.1
Sequence similarities	Contains 1 COMM domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of NF-kappaB transcription factor activity Inferred from direct assay Ref.1. Source: UniProtKB negative regulation of transcription, DNA-dependent Inferred from direct assay Ref.1. Source: UniProtKB tumor necrosis factor-mediated signaling pathway Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	NF-kappaB binding Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86VX2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86VX2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     29-29: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 200	200	COMM domain-containing protein 7		PRO_0000077399
Regions
	Domain	133 – 200	68	COMM
Natural variations
	Alternative sequence	29	1	Missing in isoform 2.		VSP_038372
Experimental info
	Sequence conflict	44	1	P → Q in AAS22244. Ref.1
	Sequence conflict	44	1	P → Q in AAH47440. Ref.5
	Sequence conflict	117	1	A → T in AAS22244. Ref.1
	Sequence conflict	117	1	A → T in AAH47440. Ref.5
	Sequence conflict	171	1	E → K in AAS22244. Ref.1
	Sequence conflict	171	1	E → K in AAH47440. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 13, 2006. Version 2. Checksum: 41D483117729B495	FASTA	200	22,540
	10 20 30 40 50 60 MGRLHCTEDP VPEAVGGDMQ QLNQLGAQQF SALTEVLFHF LTEPKEVERF LAQLSEFATT 70 80 90 100 110 120 NQISLGSLRS IVKSLLLVPN GALKKSLTAK QVQADFITLG LSEEKATYFS EKWKQNAPTL 130 140 150 160 170 180 ARWAIGQTLM INQLIDMEWK FGVTSGSSEL EKVGSIFLQL KLVVKKGNQT ENVYIELTLP 190 200 QFYSFLHEME RVRTSMECFC
	Isoform 2 [UniParc]. Checksum: B72082F9930706C2	FASTA	199	22,412
	10 20 30 40 50 60 MGRLHCTEDP VPEAVGGDMQ QLNQLGAQFS ALTEVLFHFL TEPKEVERFL AQLSEFATTN 70 80 90 100 110 120 QISLGSLRSI VKSLLLVPNG ALKKSLTAKQ VQADFITLGL SEEKATYFSE KWKQNAPTLA 130 140 150 160 170 180 RWAIGQTLMI NQLIDMEWKF GVTSGSSELE KVGSIFLQLK LVVKKGNQTE NVYIELTLPQ 190 FYSFLHEMER VRTSMECFC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"COMMD proteins, a novel family of structural and functional homologs of MURR1." Burstein E., Hoberg J.E., Wilkinson A.S., Rumble J.M., Csomos R.A., Komarck C.M., Maine G.N., Wilkinson J.C., Mayo M.W., Duckett C.S. J. Biol. Chem. 280:22222-22232(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-110 (ISOFORM 2). Tissue: Brain and Eye.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY542162 mRNA. Translation: AAS22244.1. AK027893 mRNA. Translation: BAB55436.1. AK096307 mRNA. Translation: BAG53254.1. AL035071, BX640505, CR383702 Genomic DNA. Translation: CAI19095.2. BX640505, AL035071, CR383702 Genomic DNA. Translation: CAM28357.1. CR383702, AL035071, BX640505 Genomic DNA. Translation: CAI95302.2. CH471077 Genomic DNA. Translation: EAW76360.1. BC000628 mRNA. Translation: AAH00628.3. BC047440 mRNA. Translation: AAH47440.1. BI821799 mRNA. No translation available.
IPI	IPI00743772. IPI00853293.
RefSeq	NP_001092809.1. NM_001099339.1. NP_444269.2. NM_053041.2.
UniGene	Hs.408427.
3D structure databases
ProteinModelPortal	Q86VX2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86VX2. 5 interactions.
STRING	9606.ENSP00000278980.
PTM databases
PhosphoSite	Q86VX2.
Polymorphism databases
DMDM	108935829.
Proteomic databases
PaxDb	Q86VX2.
PRIDE	Q86VX2.
Protocols and materials databases
DNASU	149951.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000278980; ENSP00000278980; ENSG00000149600. ENST00000446419; ENSP00000395339; ENSG00000149600.
GeneID	149951.
KEGG	hsa:149951.
UCSC	uc002wya.4. human. uc010ged.3. human.
Organism-specific databases
CTD	149951.
GeneCards	GC20M031290.
HGNC	HGNC:16223. COMMD7.
neXtProt	NX_Q86VX2.
PharmGKB	PA25799.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47192.
HOGENOM	HOG000031075.
HOVERGEN	HBG051072.
InParanoid	Q86VX2.
OMA	RASMECF.
OrthoDB	EOG4WM4VV.
Gene expression databases
Bgee	Q86VX2.
CleanEx	HS_COMMD7.
Genevestigator	Q86VX2.
GermOnline	ENSG00000149600. Homo sapiens.
Family and domain databases
InterPro	IPR017920. COMM. IPR009886. HCaRG. [Graphical view]
Pfam	PF07258. HCaRG. 1 hit. [Graphical view]
PROSITE	PS51269. COMM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	149951.
NextBio	86276.

Entry information

Entry name

COMD7_HUMAN

Accession

Primary (citable) accession number: Q86VX2
Secondary accession number(s): A2BHJ2 , B3KTZ2, Q5JYB0, Q96SI7, Q9BW53

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	June 13, 2006
Last modified:	April 3, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.