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Q86VX2

- COMD7_HUMAN

UniProt

Q86VX2 - COMD7_HUMAN

Protein

COMM domain-containing protein 7

Gene

COMMD7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Associates with the NF-kappa-B complex and suppresses its transcriptional activity.1 Publication

    GO - Molecular functioni

    1. NF-kappaB binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
    2. negative regulation of transcription, DNA-templated Source: UniProtKB
    3. tumor necrosis factor-mediated signaling pathway Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    COMM domain-containing protein 7
    Gene namesi
    Name:COMMD7
    Synonyms:C20orf92
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:16223. COMMD7.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25799.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 200200COMM domain-containing protein 7PRO_0000077399Add
    BLAST

    Proteomic databases

    MaxQBiQ86VX2.
    PaxDbiQ86VX2.
    PRIDEiQ86VX2.

    PTM databases

    PhosphoSiteiQ86VX2.

    Expressioni

    Tissue specificityi

    Widely expressed with highest expression in lung.1 Publication

    Gene expression databases

    BgeeiQ86VX2.
    CleanExiHS_COMMD7.
    GenevestigatoriQ86VX2.

    Interactioni

    Subunit structurei

    Interacts (via COMM domain) with COMMD1 (via COMM domain).1 Publication

    Protein-protein interaction databases

    BioGridi127250. 6 interactions.
    IntActiQ86VX2. 5 interactions.
    STRINGi9606.ENSP00000278980.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86VX2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini133 – 20068COMMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 COMM domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG47192.
    HOGENOMiHOG000031075.
    HOVERGENiHBG051072.
    InParanoidiQ86VX2.
    OMAiCTQDPVP.
    OrthoDBiEOG754HS6.
    PhylomeDBiQ86VX2.
    TreeFamiTF329046.

    Family and domain databases

    InterProiIPR017920. COMM.
    IPR009886. HCaRG.
    [Graphical view]
    PfamiPF07258. HCaRG. 1 hit.
    [Graphical view]
    PROSITEiPS51269. COMM. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86VX2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGRLHCTEDP VPEAVGGDMQ QLNQLGAQQF SALTEVLFHF LTEPKEVERF    50
    LAQLSEFATT NQISLGSLRS IVKSLLLVPN GALKKSLTAK QVQADFITLG 100
    LSEEKATYFS EKWKQNAPTL ARWAIGQTLM INQLIDMEWK FGVTSGSSEL 150
    EKVGSIFLQL KLVVKKGNQT ENVYIELTLP QFYSFLHEME RVRTSMECFC 200
    Length:200
    Mass (Da):22,540
    Last modified:June 13, 2006 - v2
    Checksum:i41D483117729B495
    GO
    Isoform 2 (identifier: Q86VX2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         29-29: Missing.

    Show »
    Length:199
    Mass (Da):22,412
    Checksum:iB72082F9930706C2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti44 – 441P → Q in AAS22244. (PubMed:15799966)Curated
    Sequence conflicti44 – 441P → Q in AAH47440. (PubMed:15489334)Curated
    Sequence conflicti117 – 1171A → T in AAS22244. (PubMed:15799966)Curated
    Sequence conflicti117 – 1171A → T in AAH47440. (PubMed:15489334)Curated
    Sequence conflicti171 – 1711E → K in AAS22244. (PubMed:15799966)Curated
    Sequence conflicti171 – 1711E → K in AAH47440. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei29 – 291Missing in isoform 2. 1 PublicationVSP_038372

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY542162 mRNA. Translation: AAS22244.1.
    AK027893 mRNA. Translation: BAB55436.1.
    AK096307 mRNA. Translation: BAG53254.1.
    AL035071 Genomic DNA. No translation available.
    BX640505 Genomic DNA. No translation available.
    FO393400 Genomic DNA. No translation available.
    CH471077 Genomic DNA. Translation: EAW76360.1.
    BC000628 mRNA. Translation: AAH00628.3.
    BC047440 mRNA. Translation: AAH47440.1.
    BI821799 mRNA. No translation available.
    CCDSiCCDS42864.1. [Q86VX2-1]
    CCDS46587.1. [Q86VX2-2]
    RefSeqiNP_001092809.1. NM_001099339.1. [Q86VX2-2]
    NP_444269.2. NM_053041.2. [Q86VX2-1]
    UniGeneiHs.408427.

    Genome annotation databases

    EnsembliENST00000278980; ENSP00000278980; ENSG00000149600. [Q86VX2-1]
    ENST00000446419; ENSP00000395339; ENSG00000149600. [Q86VX2-2]
    GeneIDi149951.
    KEGGihsa:149951.
    UCSCiuc002wya.4. human. [Q86VX2-1]
    uc010ged.3. human. [Q86VX2-2]

    Polymorphism databases

    DMDMi108935829.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY542162 mRNA. Translation: AAS22244.1 .
    AK027893 mRNA. Translation: BAB55436.1 .
    AK096307 mRNA. Translation: BAG53254.1 .
    AL035071 Genomic DNA. No translation available.
    BX640505 Genomic DNA. No translation available.
    FO393400 Genomic DNA. No translation available.
    CH471077 Genomic DNA. Translation: EAW76360.1 .
    BC000628 mRNA. Translation: AAH00628.3 .
    BC047440 mRNA. Translation: AAH47440.1 .
    BI821799 mRNA. No translation available.
    CCDSi CCDS42864.1. [Q86VX2-1 ]
    CCDS46587.1. [Q86VX2-2 ]
    RefSeqi NP_001092809.1. NM_001099339.1. [Q86VX2-2 ]
    NP_444269.2. NM_053041.2. [Q86VX2-1 ]
    UniGenei Hs.408427.

    3D structure databases

    ProteinModelPortali Q86VX2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127250. 6 interactions.
    IntActi Q86VX2. 5 interactions.
    STRINGi 9606.ENSP00000278980.

    PTM databases

    PhosphoSitei Q86VX2.

    Polymorphism databases

    DMDMi 108935829.

    Proteomic databases

    MaxQBi Q86VX2.
    PaxDbi Q86VX2.
    PRIDEi Q86VX2.

    Protocols and materials databases

    DNASUi 149951.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000278980 ; ENSP00000278980 ; ENSG00000149600 . [Q86VX2-1 ]
    ENST00000446419 ; ENSP00000395339 ; ENSG00000149600 . [Q86VX2-2 ]
    GeneIDi 149951.
    KEGGi hsa:149951.
    UCSCi uc002wya.4. human. [Q86VX2-1 ]
    uc010ged.3. human. [Q86VX2-2 ]

    Organism-specific databases

    CTDi 149951.
    GeneCardsi GC20M031290.
    HGNCi HGNC:16223. COMMD7.
    neXtProti NX_Q86VX2.
    PharmGKBi PA25799.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47192.
    HOGENOMi HOG000031075.
    HOVERGENi HBG051072.
    InParanoidi Q86VX2.
    OMAi CTQDPVP.
    OrthoDBi EOG754HS6.
    PhylomeDBi Q86VX2.
    TreeFami TF329046.

    Miscellaneous databases

    GenomeRNAii 149951.
    NextBioi 86276.
    PROi Q86VX2.

    Gene expression databases

    Bgeei Q86VX2.
    CleanExi HS_COMMD7.
    Genevestigatori Q86VX2.

    Family and domain databases

    InterProi IPR017920. COMM.
    IPR009886. HCaRG.
    [Graphical view ]
    Pfami PF07258. HCaRG. 1 hit.
    [Graphical view ]
    PROSITEi PS51269. COMM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-110 (ISOFORM 2).
      Tissue: Brain and Eye.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCOMD7_HUMAN
    AccessioniPrimary (citable) accession number: Q86VX2
    Secondary accession number(s): A2BHJ2
    , B3KTZ2, Q5JYB0, Q96SI7, Q9BW53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3