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Protein

Solute carrier family 22 member 16

Gene

SLC22A16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent.2 Publications

GO - Molecular functioni

  • amine transmembrane transporter activity Source: MGI
  • carnitine transmembrane transporter activity Source: UniProtKB
  • organic cation transmembrane transporter activity Source: MGI

GO - Biological processi

  • acid secretion Source: UniProtKB
  • amine transport Source: GOC
  • carnitine transmembrane transport Source: GOC
  • carnitine transport Source: UniProtKB
  • cell differentiation Source: UniProtKB-KW
  • multicellular organism development Source: UniProtKB-KW
  • organic cation transport Source: UniProtKB
  • single fertilization Source: UniProtKB
  • spermatogenesis Source: UniProtKB-KW
  • sperm motility Source: UniProtKB
  • transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Ion transport, Spermatogenesis, Transport

Enzyme and pathway databases

ReactomeiR-HSA-549127. Organic cation transport.

Protein family/group databases

TCDBi2.A.1.19.12. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 16
Alternative name(s):
Carnitine transporter 2
Short name:
CT2
Fly-like putative transporter 2
Short name:
FLIPT2
Short name:
Flipt 2
Organic cation transporter OKB1
Organic cation/carnitine transporter 6
Gene namesi
Name:SLC22A16
Synonyms:OCT6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20302. SLC22A16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4321HelicalSequence analysisAdd
BLAST
Transmembranei152 – 17221HelicalSequence analysisAdd
BLAST
Transmembranei183 – 20321HelicalSequence analysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence analysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence analysisAdd
BLAST
Transmembranei268 – 28821HelicalSequence analysisAdd
BLAST
Transmembranei359 – 37921HelicalSequence analysisAdd
BLAST
Transmembranei389 – 40921HelicalSequence analysisAdd
BLAST
Transmembranei416 – 43621HelicalSequence analysisAdd
BLAST
Transmembranei441 – 46121HelicalSequence analysisAdd
BLAST
Transmembranei476 – 49621HelicalSequence analysisAdd
BLAST
Transmembranei501 – 52121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134911502.

Chemistry

ChEMBLiCHEMBL2073722.
DrugBankiDB00997. Doxorubicin.
DB00583. L-Carnitine.

Polymorphism and mutation databases

BioMutaiSLC22A16.
DMDMi74750474.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 577577Solute carrier family 22 member 16PRO_0000318991Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence analysis
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence analysis
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence analysis
Glycosylationi345 – 3451N-linked (GlcNAc...)Sequence analysis
Glycosylationi352 – 3521N-linked (GlcNAc...)Sequence analysis
Glycosylationi546 – 5461N-linked (GlcNAc...)Sequence analysis
Glycosylationi558 – 5581N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86VW1.
PRIDEiQ86VW1.

PTM databases

PhosphoSiteiQ86VW1.

Expressioni

Tissue specificityi

Widely expressed at low levels in adult tissues and fetal brain, lung, liver and kidney. Expressed in testis and epididymis (at protein level). Expressed at lower levels in bone marrow and fetal liver. Expressed in hematopoietic cells, including CD34+ leukocytes and leukemia cells. Abundantly expressed in ovarian cancer clear-cell adenocarcinoma. Expressed in endometrium (at protein level); highly expressed during the normal secretory phase, but expression is significantly reduced in the proliferative phase.6 Publications

Gene expression databases

BgeeiQ86VW1.
CleanExiHS_SLC22A16.
ExpressionAtlasiQ86VW1. baseline and differential.
GenevisibleiQ86VW1. HS.

Organism-specific databases

HPAiHPA036902.
HPA036903.

Interactioni

Protein-protein interaction databases

BioGridi124519. 29 interactions.
STRINGi9606.ENSP00000357915.

Chemistry

BindingDBiQ86VW1.

Structurei

3D structure databases

ProteinModelPortaliQ86VW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRIC. Eukaryota.
ENOG410YUFN. LUCA.
GeneTreeiENSGT00760000118852.
HOVERGENiHBG108436.
InParanoidiQ86VW1.
KOiK08212.
OMAiSKKEFPC.
OrthoDBiEOG7C8GH9.
PhylomeDBiQ86VW1.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86VW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSRHFEGIY DHVGHFGRFQ RVLYFICAFQ NISCGIHYLA SVFMGVTPHH
60 70 80 90 100
VCRPPGNVSQ VVFHNHSNWS LEDTGALLSS GQKDYVTVQL QNGEIWELSR
110 120 130 140 150
CSRNKRENTS SLGYEYTGSK KEFPCVDGYI YDQNTWKSTA VTQWNLVCDR
160 170 180 190 200
KWLAMLIQPL FMFGVLLGSV TFGYFSDRLG RRVVLWATSS SMFLFGIAAA
210 220 230 240 250
FAVDYYTFMA ARFFLAMVAS GYLVVGFVYV MEFIGMKSRT WASVHLHSFF
260 270 280 290 300
AVGTLLVALT GYLVRTWWLY QMILSTVTVP FILCCWVLPE TPFWLLSEGR
310 320 330 340 350
YEEAQKIVDI MAKWNRASSC KLSELLSLDL QGPVSNSPTE VQKHNLSYLF
360 370 380 390 400
YNWSITKRTL TVWLIWFTGS LGFYSFSLNS VNLGGNEYLN LFLLGVVEIP
410 420 430 440 450
AYTFVCIAMD KVGRRTVLAY SLFCSALACG VVMVIPQKHY ILGVVTAMVG
460 470 480 490 500
KFAIGAAFGL IYLYTAELYP TIVRSLAVGS GSMVCRLASI LAPFSVDLSS
510 520 530 540 550
IWIFIPQLFV GTMALLSGVL TLKLPETLGK RLATTWEEAA KLESENESKS
560 570
SKLLLTTNNS GLEKTEAITP RDSGLGE
Length:577
Mass (Da):64,614
Last modified:June 1, 2003 - v1
Checksum:iEA4ABBED0AE99632
GO
Isoform 2 (identifier: Q86VW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MGSRHFEGIYDHVGHFG → MRTLHAVSHPYSNSM
     58-89: Missing.

Show »
Length:543
Mass (Da):60,870
Checksum:i0751FA836E63CCB3
GO
Isoform 3 (identifier: Q86VW1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     509-577: FVGTMALLSG...ITPRDSGLGE → LGQHLQE

Show »
Length:515
Mass (Da):58,061
Checksum:i8AA05929FA585BF9
GO

Sequence cautioni

The sequence BAB71419.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti257 – 2571V → G in AAN52928 (PubMed:12372408).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti49 – 491H → R.
Corresponds to variant rs714368 [ dbSNP | Ensembl ].
VAR_038930
Natural varianti252 – 2521V → A.
Corresponds to variant rs723685 [ dbSNP | Ensembl ].
VAR_038931
Natural varianti409 – 4091M → T.4 Publications
Corresponds to variant rs12210538 [ dbSNP | Ensembl ].
VAR_038932
Natural varianti431 – 4311V → I.
Corresponds to variant rs35948062 [ dbSNP | Ensembl ].
VAR_038933

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1717MGSRH…VGHFG → MRTLHAVSHPYSNSM in isoform 2. 1 PublicationVSP_031336Add
BLAST
Alternative sequencei58 – 8932Missing in isoform 2. 1 PublicationVSP_031337Add
BLAST
Alternative sequencei509 – 57769FVGTM…SGLGE → LGQHLQE in isoform 3. 1 PublicationVSP_031338Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145502 mRNA. Translation: AAN52928.1.
AB055798 mRNA. Translation: BAC23062.1.
AF268892 mRNA. Translation: AAK58593.1.
AC002464 Genomic DNA. Translation: AAB67044.1.
AL050350, AC002464 Genomic DNA. Translation: CAI42512.1.
AL050350, AC002464 Genomic DNA. Translation: CAI42514.1.
CH471051 Genomic DNA. Translation: EAW48313.1.
BC047565 mRNA. Translation: AAH47565.1.
AK057306 mRNA. Translation: BAB71419.1. Different initiation.
CCDSiCCDS5084.1. [Q86VW1-1]
RefSeqiNP_149116.2. NM_033125.3. [Q86VW1-1]
XP_011534507.1. XM_011536205.1. [Q86VW1-3]
UniGeneiHs.520319.

Genome annotation databases

EnsembliENST00000330550; ENSP00000328583; ENSG00000004809. [Q86VW1-2]
ENST00000368919; ENSP00000357915; ENSG00000004809. [Q86VW1-1]
GeneIDi85413.
KEGGihsa:85413.
UCSCiuc003puf.5. human. [Q86VW1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145502 mRNA. Translation: AAN52928.1.
AB055798 mRNA. Translation: BAC23062.1.
AF268892 mRNA. Translation: AAK58593.1.
AC002464 Genomic DNA. Translation: AAB67044.1.
AL050350, AC002464 Genomic DNA. Translation: CAI42512.1.
AL050350, AC002464 Genomic DNA. Translation: CAI42514.1.
CH471051 Genomic DNA. Translation: EAW48313.1.
BC047565 mRNA. Translation: AAH47565.1.
AK057306 mRNA. Translation: BAB71419.1. Different initiation.
CCDSiCCDS5084.1. [Q86VW1-1]
RefSeqiNP_149116.2. NM_033125.3. [Q86VW1-1]
XP_011534507.1. XM_011536205.1. [Q86VW1-3]
UniGeneiHs.520319.

3D structure databases

ProteinModelPortaliQ86VW1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124519. 29 interactions.
STRINGi9606.ENSP00000357915.

Chemistry

BindingDBiQ86VW1.
ChEMBLiCHEMBL2073722.
DrugBankiDB00997. Doxorubicin.
DB00583. L-Carnitine.

Protein family/group databases

TCDBi2.A.1.19.12. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteiQ86VW1.

Polymorphism and mutation databases

BioMutaiSLC22A16.
DMDMi74750474.

Proteomic databases

PaxDbiQ86VW1.
PRIDEiQ86VW1.

Protocols and materials databases

DNASUi85413.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330550; ENSP00000328583; ENSG00000004809. [Q86VW1-2]
ENST00000368919; ENSP00000357915; ENSG00000004809. [Q86VW1-1]
GeneIDi85413.
KEGGihsa:85413.
UCSCiuc003puf.5. human. [Q86VW1-1]

Organism-specific databases

CTDi85413.
GeneCardsiSLC22A16.
HGNCiHGNC:20302. SLC22A16.
HPAiHPA036902.
HPA036903.
MIMi608276. gene.
neXtProtiNX_Q86VW1.
PharmGKBiPA134911502.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRIC. Eukaryota.
ENOG410YUFN. LUCA.
GeneTreeiENSGT00760000118852.
HOVERGENiHBG108436.
InParanoidiQ86VW1.
KOiK08212.
OMAiSKKEFPC.
OrthoDBiEOG7C8GH9.
PhylomeDBiQ86VW1.
TreeFamiTF315847.

Enzyme and pathway databases

ReactomeiR-HSA-549127. Organic cation transport.

Miscellaneous databases

ChiTaRSiSLC22A16. human.
GenomeRNAii85413.
NextBioi75982.
PROiQ86VW1.
SOURCEiSearch...

Gene expression databases

BgeeiQ86VW1.
CleanExiHS_SLC22A16.
ExpressionAtlasiQ86VW1. baseline and differential.
GenevisibleiQ86VW1. HS.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters."
    Eraly S.A., Nigam S.K.
    Biochem. Biophys. Res. Commun. 297:1159-1166(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT THR-409.
    Tissue: Kidney.
  2. "Identification of OCT6 as a novel organic cation transporter preferentially expressed in hematopoietic cells and leukemias."
    Gong S., Lu X., Xu Y., Swiderski C.F., Jordan C.T., Moscow J.A.
    Exp. Hematol. 30:1162-1169(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT THR-409.
  3. "Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition."
    Enomoto A., Wempe M.F., Tsuchida H., Shin H.J., Cha S.H., Anzai N., Goto A., Sakamoto A., Niwa T., Kanai Y., Anders M.W., Endou H.
    J. Biol. Chem. 277:36262-36271(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANT THR-409.
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 84-577 (ISOFORM 3), VARIANT THR-409.
    Tissue: Testis.
  9. "Expression of organic cation transporter SLC22A16 in human endometria."
    Sato N., Ito K., Onogawa T., Akahira J., Unno M., Abe T., Niikura H., Yaegashi N.
    Int. J. Gynecol. Pathol. 26:53-60(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  10. "Expression of organic cation transporter SLC22A16 in human epithelial ovarian cancer: a possible role of the adriamycin importer."
    Ota K., Ito K., Akahira J., Sato N., Onogawa T., Moriya T., Unno M., Abe T., Niikura H., Takano T., Yaegashi N.
    Int. J. Gynecol. Pathol. 26:334-340(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiS22AG_HUMAN
AccessioniPrimary (citable) accession number: Q86VW1
Secondary accession number(s): O14567
, Q5JXM1, Q8IUG8, Q8IZD5, Q96M90, Q96RU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.