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Q86VW0

- SESD1_HUMAN

UniProt

Q86VW0 - SESD1_HUMAN

Protein

SEC14 domain and spectrin repeat-containing protein 1

Gene

SESTD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1.1 Publication

    GO - Molecular functioni

    1. phosphatidic acid binding Source: UniProtKB
    2. phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB
    3. phosphatidylinositol-3,5-bisphosphate binding Source: UniProtKB
    4. phosphatidylinositol-3-phosphate binding Source: UniProtKB
    5. phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB
    6. phosphatidylinositol-4-phosphate binding Source: UniProtKB
    7. phosphatidylinositol-5-phosphate binding Source: UniProtKB
    8. protein binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SEC14 domain and spectrin repeat-containing protein 1
    Alternative name(s):
    Huntingtin-interacting protein-like protein
    Protein Solo
    Gene namesi
    Name:SESTD1
    Synonyms:SOLO
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:18379. SESTD1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38534.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 696696SEC14 domain and spectrin repeat-containing protein 1PRO_0000309479Add
    BLAST

    Proteomic databases

    MaxQBiQ86VW0.
    PaxDbiQ86VW0.
    PRIDEiQ86VW0.

    PTM databases

    PhosphoSiteiQ86VW0.

    Expressioni

    Tissue specificityi

    Broad expression. High expression in thalamus and brain. Significantly expressed in vasculature.1 Publication

    Gene expression databases

    ArrayExpressiQ86VW0.
    BgeeiQ86VW0.
    CleanExiHS_SESTD1.
    GenevestigatoriQ86VW0.

    Interactioni

    Subunit structurei

    Interacts (via the spectrin 1 repeat) with TRPC4 and TRPC5 (via CIRB domain). Interacts with CTNNB1.1 Publication

    Protein-protein interaction databases

    BioGridi124826. 1 interaction.
    IntActiQ86VW0. 4 interactions.
    MINTiMINT-4875522.
    STRINGi9606.ENSP00000415332.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86VW0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 153153CRAL-TRIOPROSITE-ProRule annotationAdd
    BLAST
    Repeati275 – 378104Spectrin 1Add
    BLAST
    Repeati381 – 494114Spectrin 2Add
    BLAST
    Repeati500 – 602103Spectrin 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the SOLO family.Curated
    Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
    Contains 3 spectrin repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG149526.
    HOGENOMiHOG000072717.
    HOVERGENiHBG104429.
    InParanoidiQ86VW0.
    OMAiCPMEEEL.
    OrthoDBiEOG7D59MS.
    PhylomeDBiQ86VW0.
    TreeFamiTF332003.

    Family and domain databases

    InterProiIPR001251. CRAL-TRIO_dom.
    IPR018159. Spectrin/alpha-actinin.
    [Graphical view]
    PfamiPF13716. CRAL_TRIO_2. 1 hit.
    [Graphical view]
    SMARTiSM00150. SPEC. 2 hits.
    [Graphical view]
    PROSITEiPS50191. CRAL_TRIO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q86VW0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEASVILPIL KKKLAFLSGG KDRRSGLILT IPLCLEQTNM DELSVTLDYL    50
    LSIPSEKCKA RGFTVIVDGR KSQWNVVKTV VVMLQNVVPA EVSLVCVVKP 100
    DEFWDKKVTH FCFWKEKDRL GFEVILVSAN KLTRYIEPCQ LTEDFGGSLT 150
    YDHMDWLNKR LVFEKFTKES TSLLDELALI NNGSDKGNQQ EKERSVDLNF 200
    LPSVDPETVL QTGHELLSEL QQRRFNGSDG GVSWSPMDDE LLAQPQVMKL 250
    LDSLREQYTR YQEVCRQRSK RTQLEEIQQK VMQVVNWLEG PGSEQLRAQW 300
    GIGDSIRASQ ALQQKHEEIE SQHSEWFAVY VELNQQIAAL LNAGDEEDLV 350
    ELKSLQQQLS DVCYRQASQL EFRQNLLQAA LEFHGVAQDL SQQLDGLLGM 400
    LCVDVAPADG ASIQQTLKLL EEKLKSVDVG LQGLREKGQG LLDQISNQAS 450
    WAYGKDVTIE NKENVDHIQG VMEDMQLRKQ RCEDMVDVRR LKMLQMVQLF 500
    KCEEDAAQAV EWLSELLDAL LKTHIRLGDD AQETKVLLEK HRKFVDVAQS 550
    TYDYGRQLLQ ATVVLCQSLR CTSRSSGDTL PRLNRVWKQF TIASEERVHR 600
    LEMAIAFHSN AEKILQDCPE EPEAINDEEQ FDEIEAVGKS LLDRLTVPVV 650
    YPDGTEQYFG SPSDMASTAE NIRDRMKLVN LKRQQLRHPE MVTTES 696
    Length:696
    Mass (Da):79,348
    Last modified:November 13, 2007 - v2
    Checksum:i5C5C80EB57A7303A
    GO

    Sequence cautioni

    The sequence BAB71618.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti508 – 5081Q → H in AAP47744. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti49 – 491Y → F.1 Publication
    Corresponds to variant rs17854501 [ dbSNP | Ensembl ].
    VAR_036963
    Natural varianti563 – 5631V → A.
    Corresponds to variant rs1047994 [ dbSNP | Ensembl ].
    VAR_051919

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY209190 mRNA. Translation: AAP47744.1.
    AC016755 Genomic DNA. Translation: AAY24323.1.
    AC093911 Genomic DNA. Translation: AAY24093.1.
    BC029744 mRNA. Translation: AAH29744.1.
    BC047578 mRNA. Translation: AAH47578.1.
    AK057944 mRNA. Translation: BAB71618.1. Different initiation.
    CCDSiCCDS33338.1.
    PIRiT34530.
    RefSeqiNP_835224.3. NM_178123.4.
    UniGeneiHs.30977.

    Genome annotation databases

    EnsembliENST00000428443; ENSP00000415332; ENSG00000187231.
    GeneIDi91404.
    KEGGihsa:91404.
    UCSCiuc002uni.4. human.

    Polymorphism databases

    DMDMi160358740.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY209190 mRNA. Translation: AAP47744.1 .
    AC016755 Genomic DNA. Translation: AAY24323.1 .
    AC093911 Genomic DNA. Translation: AAY24093.1 .
    BC029744 mRNA. Translation: AAH29744.1 .
    BC047578 mRNA. Translation: AAH47578.1 .
    AK057944 mRNA. Translation: BAB71618.1 . Different initiation.
    CCDSi CCDS33338.1.
    PIRi T34530.
    RefSeqi NP_835224.3. NM_178123.4.
    UniGenei Hs.30977.

    3D structure databases

    ProteinModelPortali Q86VW0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124826. 1 interaction.
    IntActi Q86VW0. 4 interactions.
    MINTi MINT-4875522.
    STRINGi 9606.ENSP00000415332.

    PTM databases

    PhosphoSitei Q86VW0.

    Polymorphism databases

    DMDMi 160358740.

    Proteomic databases

    MaxQBi Q86VW0.
    PaxDbi Q86VW0.
    PRIDEi Q86VW0.

    Protocols and materials databases

    DNASUi 91404.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000428443 ; ENSP00000415332 ; ENSG00000187231 .
    GeneIDi 91404.
    KEGGi hsa:91404.
    UCSCi uc002uni.4. human.

    Organism-specific databases

    CTDi 91404.
    GeneCardsi GC02M179966.
    H-InvDB HIX0002639.
    HGNCi HGNC:18379. SESTD1.
    neXtProti NX_Q86VW0.
    PharmGKBi PA38534.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149526.
    HOGENOMi HOG000072717.
    HOVERGENi HBG104429.
    InParanoidi Q86VW0.
    OMAi CPMEEEL.
    OrthoDBi EOG7D59MS.
    PhylomeDBi Q86VW0.
    TreeFami TF332003.

    Miscellaneous databases

    GeneWikii SESTD1.
    GenomeRNAii 91404.
    NextBioi 77223.
    PROi Q86VW0.

    Gene expression databases

    ArrayExpressi Q86VW0.
    Bgeei Q86VW0.
    CleanExi HS_SESTD1.
    Genevestigatori Q86VW0.

    Family and domain databases

    InterProi IPR001251. CRAL-TRIO_dom.
    IPR018159. Spectrin/alpha-actinin.
    [Graphical view ]
    Pfami PF13716. CRAL_TRIO_2. 1 hit.
    [Graphical view ]
    SMARTi SM00150. SPEC. 2 hits.
    [Graphical view ]
    PROSITEi PS50191. CRAL_TRIO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Xu J., Xie Y., Mao Y.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-49.
      Tissue: Brain and Urinary bladder.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 462-696.
    5. "The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5."
      Miehe S., Bieberstein A., Arnould I., Ihdene O., Rutten H., Strubing C.
      J. Biol. Chem. 285:12426-12434(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TRPC4; TRPC5 AND CTNNB1, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiSESD1_HUMAN
    AccessioniPrimary (citable) accession number: Q86VW0
    Secondary accession number(s): Q53R38
    , Q53SP3, Q5GM69, Q8N6M1, Q96LQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Called SOLO because the encoded protein is related to but shorter than DUO and TRIO.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3