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Q86VW0 (SESD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SEC14 domain and spectrin repeat-containing protein 1
Alternative name(s):
Huntingtin-interacting protein-like protein
Protein Solo
Gene names
Name:SESTD1
Synonyms:SOLO
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length696 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1. Ref.5

Subunit structure

Interacts (via the spectrin 1 repeat) with TRPC4 and TRPC5 (via CIRB domain). Interacts with CTNNB1. Ref.5

Tissue specificity

Broad expression. High expression in thalamus and brain. Significantly expressed in vasculature. Ref.5

Miscellaneous

Called SOLO because the encoded protein is related to but shorter than DUO and TRIO.

Sequence similarities

Belongs to the SOLO family.

Contains 1 CRAL-TRIO domain.

Contains 3 spectrin repeats.

Sequence caution

The sequence BAB71618.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 696696SEC14 domain and spectrin repeat-containing protein 1
PRO_0000309479

Regions

Domain1 – 153153CRAL-TRIO
Repeat275 – 378104Spectrin 1
Repeat381 – 494114Spectrin 2
Repeat500 – 602103Spectrin 3

Natural variations

Natural variant491Y → F. Ref.3
Corresponds to variant rs17854501 [ dbSNP | Ensembl ].
VAR_036963
Natural variant5631V → A.
Corresponds to variant rs1047994 [ dbSNP | Ensembl ].
VAR_051919

Experimental info

Sequence conflict5081Q → H in AAP47744. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q86VW0 [UniParc].

Last modified November 13, 2007. Version 2.
Checksum: 5C5C80EB57A7303A

FASTA69679,348
        10         20         30         40         50         60 
MEASVILPIL KKKLAFLSGG KDRRSGLILT IPLCLEQTNM DELSVTLDYL LSIPSEKCKA 

        70         80         90        100        110        120 
RGFTVIVDGR KSQWNVVKTV VVMLQNVVPA EVSLVCVVKP DEFWDKKVTH FCFWKEKDRL 

       130        140        150        160        170        180 
GFEVILVSAN KLTRYIEPCQ LTEDFGGSLT YDHMDWLNKR LVFEKFTKES TSLLDELALI 

       190        200        210        220        230        240 
NNGSDKGNQQ EKERSVDLNF LPSVDPETVL QTGHELLSEL QQRRFNGSDG GVSWSPMDDE 

       250        260        270        280        290        300 
LLAQPQVMKL LDSLREQYTR YQEVCRQRSK RTQLEEIQQK VMQVVNWLEG PGSEQLRAQW 

       310        320        330        340        350        360 
GIGDSIRASQ ALQQKHEEIE SQHSEWFAVY VELNQQIAAL LNAGDEEDLV ELKSLQQQLS 

       370        380        390        400        410        420 
DVCYRQASQL EFRQNLLQAA LEFHGVAQDL SQQLDGLLGM LCVDVAPADG ASIQQTLKLL 

       430        440        450        460        470        480 
EEKLKSVDVG LQGLREKGQG LLDQISNQAS WAYGKDVTIE NKENVDHIQG VMEDMQLRKQ 

       490        500        510        520        530        540 
RCEDMVDVRR LKMLQMVQLF KCEEDAAQAV EWLSELLDAL LKTHIRLGDD AQETKVLLEK 

       550        560        570        580        590        600 
HRKFVDVAQS TYDYGRQLLQ ATVVLCQSLR CTSRSSGDTL PRLNRVWKQF TIASEERVHR 

       610        620        630        640        650        660 
LEMAIAFHSN AEKILQDCPE EPEAINDEEQ FDEIEAVGKS LLDRLTVPVV YPDGTEQYFG 

       670        680        690 
SPSDMASTAE NIRDRMKLVN LKRQQLRHPE MVTTES 

« Hide

References

« Hide 'large scale' references
[1]Xu J., Xie Y., Mao Y.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-49.
Tissue: Brain and Urinary bladder.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 462-696.
[5]"The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5."
Miehe S., Bieberstein A., Arnould I., Ihdene O., Rutten H., Strubing C.
J. Biol. Chem. 285:12426-12434(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH TRPC4; TRPC5 AND CTNNB1, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY209190 mRNA. Translation: AAP47744.1.
AC016755 Genomic DNA. Translation: AAY24323.1.
AC093911 Genomic DNA. Translation: AAY24093.1.
BC029744 mRNA. Translation: AAH29744.1.
BC047578 mRNA. Translation: AAH47578.1.
AK057944 mRNA. Translation: BAB71618.1. Different initiation.
PIRT34530.
RefSeqNP_835224.3. NM_178123.4.
UniGeneHs.30977.

3D structure databases

ProteinModelPortalQ86VW0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124826. 1 interaction.
IntActQ86VW0. 3 interactions.
MINTMINT-4875522.
STRING9606.ENSP00000415332.

PTM databases

PhosphoSiteQ86VW0.

Polymorphism databases

DMDM160358740.

Proteomic databases

PaxDbQ86VW0.
PRIDEQ86VW0.

Protocols and materials databases

DNASU91404.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000428443; ENSP00000415332; ENSG00000187231.
GeneID91404.
KEGGhsa:91404.
UCSCuc002uni.4. human.

Organism-specific databases

CTD91404.
GeneCardsGC02M179966.
H-InvDBHIX0002639.
HGNCHGNC:18379. SESTD1.
neXtProtNX_Q86VW0.
PharmGKBPA38534.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG149526.
HOGENOMHOG000072717.
HOVERGENHBG104429.
InParanoidQ86VW0.
OMACPMEEEL.
OrthoDBEOG7D59MS.
PhylomeDBQ86VW0.
TreeFamTF332003.

Gene expression databases

ArrayExpressQ86VW0.
BgeeQ86VW0.
CleanExHS_SESTD1.
GenevestigatorQ86VW0.

Family and domain databases

InterProIPR001251. CRAL-TRIO_dom.
IPR018159. Spectrin/alpha-actinin.
[Graphical view]
PfamPF13716. CRAL_TRIO_2. 1 hit.
[Graphical view]
SMARTSM00150. SPEC. 2 hits.
[Graphical view]
PROSITEPS50191. CRAL_TRIO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSESTD1.
GenomeRNAi91404.
NextBio77223.
PROQ86VW0.

Entry information

Entry nameSESD1_HUMAN
AccessionPrimary (citable) accession number: Q86VW0
Secondary accession number(s): Q53R38 expand/collapse secondary AC list , Q53SP3, Q5GM69, Q8N6M1, Q96LQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: April 16, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM