Q86VW0 (SESD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SEC14 domain and spectrin repeat-containing protein 1

Alternative name(s):
Huntingtin-interacting protein-like protein
Protein Solo

Gene names

Name:	SESTD1
Synonyms:	SOLO

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	696 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1. Ref.5
Subunit structure	Interacts (via the spectrin 1 repeat) with TRPC4 and TRPC5 (via CIRB domain). Interacts with CTNNB1. Ref.5
Tissue specificity	Broad expression. High expression in thalamus and brain. Significantly expressed in vasculature. Ref.5
Miscellaneous	Called SOLO because the encoded protein is related to but shorter than DUO and TRIO.
Sequence similarities	Belongs to the SOLO family. Contains 1 CRAL-TRIO domain. Contains 3 spectrin repeats.
Sequence caution	The sequence BAB71618.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	phosphatidic acid binding Inferred from direct assay Ref.5. Source: UniProtKB phosphatidylinositol-3,4-bisphosphate binding Inferred from direct assay Ref.5. Source: UniProtKB phosphatidylinositol-3,5-bisphosphate binding Inferred from direct assay Ref.5. Source: UniProtKB phosphatidylinositol-3-phosphate binding Inferred from direct assay Ref.5. Source: UniProtKB phosphatidylinositol-4,5-bisphosphate binding Inferred from direct assay Ref.5. Source: UniProtKB phosphatidylinositol-4-phosphate binding Inferred from direct assay Ref.5. Source: UniProtKB phosphatidylinositol-5-phosphate binding Inferred from direct assay Ref.5. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 696	696	SEC14 domain and spectrin repeat-containing protein 1		PRO_0000309479
Regions
	Domain	1 – 153	153	CRAL-TRIO
	Repeat	275 – 378	104	Spectrin 1
	Repeat	381 – 494	114	Spectrin 2
	Repeat	500 – 602	103	Spectrin 3
Natural variations
	Natural variant	49	1	Y → F. Ref.3 Corresponds to variant rs17854501 [ dbSNP | Ensembl ].		VAR_036963
	Natural variant	563	1	V → A. Corresponds to variant rs1047994 [ dbSNP | Ensembl ].		VAR_051919
Experimental info
	Sequence conflict	508	1	Q → H in AAP47744. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q86VW0 [UniParc]. Last modified November 13, 2007. Version 2. Checksum: 5C5C80EB57A7303A	FASTA	696	79,348
	10 20 30 40 50 60 MEASVILPIL KKKLAFLSGG KDRRSGLILT IPLCLEQTNM DELSVTLDYL LSIPSEKCKA 70 80 90 100 110 120 RGFTVIVDGR KSQWNVVKTV VVMLQNVVPA EVSLVCVVKP DEFWDKKVTH FCFWKEKDRL 130 140 150 160 170 180 GFEVILVSAN KLTRYIEPCQ LTEDFGGSLT YDHMDWLNKR LVFEKFTKES TSLLDELALI 190 200 210 220 230 240 NNGSDKGNQQ EKERSVDLNF LPSVDPETVL QTGHELLSEL QQRRFNGSDG GVSWSPMDDE 250 260 270 280 290 300 LLAQPQVMKL LDSLREQYTR YQEVCRQRSK RTQLEEIQQK VMQVVNWLEG PGSEQLRAQW 310 320 330 340 350 360 GIGDSIRASQ ALQQKHEEIE SQHSEWFAVY VELNQQIAAL LNAGDEEDLV ELKSLQQQLS 370 380 390 400 410 420 DVCYRQASQL EFRQNLLQAA LEFHGVAQDL SQQLDGLLGM LCVDVAPADG ASIQQTLKLL 430 440 450 460 470 480 EEKLKSVDVG LQGLREKGQG LLDQISNQAS WAYGKDVTIE NKENVDHIQG VMEDMQLRKQ 490 500 510 520 530 540 RCEDMVDVRR LKMLQMVQLF KCEEDAAQAV EWLSELLDAL LKTHIRLGDD AQETKVLLEK 550 560 570 580 590 600 HRKFVDVAQS TYDYGRQLLQ ATVVLCQSLR CTSRSSGDTL PRLNRVWKQF TIASEERVHR 610 620 630 640 650 660 LEMAIAFHSN AEKILQDCPE EPEAINDEEQ FDEIEAVGKS LLDRLTVPVV YPDGTEQYFG 670 680 690 SPSDMASTAE NIRDRMKLVN LKRQQLRHPE MVTTES

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Xu J., Xie Y., Mao Y. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-49. Tissue: Brain and Urinary bladder.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 462-696.
[5]	"The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5." Miehe S., Bieberstein A., Arnould I., Ihdene O., Rutten H., Strubing C. J. Biol. Chem. 285:12426-12434(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH TRPC4; TRPC5 AND CTNNB1, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY209190 mRNA. Translation: AAP47744.1. AC016755 Genomic DNA. Translation: AAY24323.1. AC093911 Genomic DNA. Translation: AAY24093.1. BC029744 mRNA. Translation: AAH29744.1. BC047578 mRNA. Translation: AAH47578.1. AK057944 mRNA. Translation: BAB71618.1. Different initiation.
IPI	IPI00329002.
PIR	T34530.
RefSeq	NP_835224.3. NM_178123.4.
UniGene	Hs.30977.
3D structure databases
ProteinModelPortal	Q86VW0.
SMR	Q86VW0. Positions 276-383.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86VW0. 1 interaction.
MINT	MINT-4875522.
STRING	9606.ENSP00000415332.
PTM databases
PhosphoSite	Q86VW0.
Polymorphism databases
DMDM	160358740.
Proteomic databases
PaxDb	Q86VW0.
PRIDE	Q86VW0.
Protocols and materials databases
DNASU	91404.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000428443; ENSP00000415332; ENSG00000187231.
GeneID	91404.
KEGG	hsa:91404.
UCSC	uc002uni.4. human.
Organism-specific databases
CTD	91404.
GeneCards	GC02M179966.
H-InvDB	HIX0002639.
HGNC	HGNC:18379. SESTD1.
neXtProt	NX_Q86VW0.
PharmGKB	PA38534.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG149526.
HOGENOM	HOG000072717.
HOVERGEN	HBG104429.
InParanoid	Q86VW0.
OMA	CPMEEEL.
OrthoDB	EOG47M1XG.
Gene expression databases
ArrayExpress	Q86VW0.
Bgee	Q86VW0.
CleanEx	HS_SESTD1.
Genevestigator	Q86VW0.
Family and domain databases
InterPro	IPR001251. CRAL-TRIO_dom. IPR018159. Spectrin/alpha-actinin. [Graphical view]
SMART	SM00150. SPEC. 2 hits. [Graphical view]
PROSITE	PS50191. CRAL_TRIO. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	91404.
NextBio	77223.

Entry information

Entry name

SESD1_HUMAN

Accession

Primary (citable) accession number: Q86VW0
Secondary accession number(s): Q53R38 , Q53SP3, Q5GM69, Q8N6M1, Q96LQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	May 1, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.