ID   RNB3L_HUMAN             Reviewed;         465 AA.
AC   Q86VV4; B7Z866; E9PGP9; Q96LK2;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 2.
DT   24-JAN-2024, entry version 153.
DE   RecName: Full=Ran-binding protein 3-like;
GN   Name=RANBP3L;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND VARIANT
RP   ARG-70.
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-70.
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-70.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   INTERACTION WITH SMAD1; SMAD5 AND SMAD8, AND SUBCELLULAR LOCATION.
RX   PubMed=25755279; DOI=10.1128/mcb.00121-15;
RA   Chen F., Lin X., Xu P., Zhang Z., Chen Y., Wang C., Han J., Zhao B.,
RA   Xiao M., Feng X.H.;
RT   "Nuclear export of Smads by RanBP3L regulates bone morphogenetic protein
RT   signaling and mesenchymal stem cell differentiation.";
RL   Mol. Cell. Biol. 35:1700-1711(2015).
CC   -!- FUNCTION: Nuclear export factor for BMP-specific SMAD1/5/8 that plays a
CC       critical role in terminating BMP signaling and regulating mesenchymal
CC       stem cell differentiation by blocking osteoblast differentiation to
CC       promote myogenic differention. Directly recognizes dephosphorylated
CC       SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner.
CC       {ECO:0000250|UniProtKB:Q6PDH4, ECO:0000269|PubMed:25755279}.
CC   -!- SUBUNIT: Interacts with SMAD1, SMAD5 and SMAD8; the interaction (with
CC       SMAD at least) increases when SMAD1 is not phosphorylated and mediates
CC       SMAD1 nuclear export. {ECO:0000250|UniProtKB:Q6PDH4,
CC       ECO:0000269|PubMed:25755279}.
CC   -!- INTERACTION:
CC       Q86VV4; Q08379: GOLGA2; NbExp=3; IntAct=EBI-12028066, EBI-618309;
CC       Q86VV4; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-12028066, EBI-5916454;
CC       Q86VV4; Q5T7B8-2: KIF24; NbExp=3; IntAct=EBI-12028066, EBI-10213781;
CC       Q86VV4; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-12028066, EBI-10172526;
CC       Q86VV4; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-12028066, EBI-11522433;
CC       Q86VV4; Q15654: TRIP6; NbExp=3; IntAct=EBI-12028066, EBI-742327;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:25755279}. Cytoplasm
CC       {ECO:0000305|PubMed:25755279}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q86VV4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q86VV4-2; Sequence=VSP_029893, VSP_029894;
CC       Name=3;
CC         IsoId=Q86VV4-3; Sequence=VSP_044463;
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DR   EMBL; AK058151; BAB71689.1; -; mRNA.
DR   EMBL; AK302947; BAH13852.1; -; mRNA.
DR   EMBL; AC008807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC114277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471119; EAW55942.1; -; Genomic_DNA.
DR   EMBL; CH471119; EAW55943.1; -; Genomic_DNA.
DR   EMBL; BC047660; AAH47660.1; -; mRNA.
DR   CCDS; CCDS3918.1; -. [Q86VV4-1]
DR   CCDS; CCDS54843.1; -. [Q86VV4-3]
DR   RefSeq; NP_001154901.1; NM_001161429.2. [Q86VV4-3]
DR   RefSeq; NP_001310202.1; NM_001323273.1.
DR   RefSeq; NP_001310203.1; NM_001323274.1.
DR   RefSeq; NP_001310204.1; NM_001323275.1.
DR   RefSeq; NP_001310205.1; NM_001323276.1.
DR   RefSeq; NP_001310206.1; NM_001323277.1.
DR   RefSeq; NP_001310207.1; NM_001323278.1.
DR   RefSeq; NP_001310208.1; NM_001323279.1.
DR   RefSeq; NP_001310209.1; NM_001323280.1.
DR   RefSeq; NP_659437.3; NM_145000.4. [Q86VV4-1]
DR   AlphaFoldDB; Q86VV4; -.
DR   SMR; Q86VV4; -.
DR   BioGRID; 128419; 11.
DR   IntAct; Q86VV4; 8.
DR   STRING; 9606.ENSP00000421853; -.
DR   iPTMnet; Q86VV4; -.
DR   PhosphoSitePlus; Q86VV4; -.
DR   BioMuta; RANBP3L; -.
DR   DMDM; 317373276; -.
DR   MassIVE; Q86VV4; -.
DR   PaxDb; 9606-ENSP00000421853; -.
DR   PeptideAtlas; Q86VV4; -.
DR   ProteomicsDB; 20364; -.
DR   ProteomicsDB; 70072; -. [Q86VV4-1]
DR   ProteomicsDB; 70073; -. [Q86VV4-2]
DR   Antibodypedia; 43549; 122 antibodies from 19 providers.
DR   DNASU; 202151; -.
DR   Ensembl; ENST00000296604.8; ENSP00000296604.3; ENSG00000164188.9. [Q86VV4-1]
DR   Ensembl; ENST00000502994.5; ENSP00000421853.1; ENSG00000164188.9. [Q86VV4-3]
DR   Ensembl; ENST00000515759.5; ENSP00000421149.1; ENSG00000164188.9. [Q86VV4-2]
DR   GeneID; 202151; -.
DR   KEGG; hsa:202151; -.
DR   MANE-Select; ENST00000296604.8; ENSP00000296604.3; NM_145000.5; NP_659437.3.
DR   UCSC; uc003jkh.4; human. [Q86VV4-1]
DR   AGR; HGNC:26353; -.
DR   CTD; 202151; -.
DR   DisGeNET; 202151; -.
DR   GeneCards; RANBP3L; -.
DR   HGNC; HGNC:26353; RANBP3L.
DR   HPA; ENSG00000164188; Tissue enhanced (brain, kidney).
DR   MIM; 616391; gene.
DR   neXtProt; NX_Q86VV4; -.
DR   OpenTargets; ENSG00000164188; -.
DR   PharmGKB; PA162400660; -.
DR   VEuPathDB; HostDB:ENSG00000164188; -.
DR   eggNOG; KOG0866; Eukaryota.
DR   GeneTree; ENSGT00940000161387; -.
DR   HOGENOM; CLU_046714_0_0_1; -.
DR   InParanoid; Q86VV4; -.
DR   OMA; HSRLIMR; -.
DR   OrthoDB; 2906517at2759; -.
DR   PhylomeDB; Q86VV4; -.
DR   TreeFam; TF313181; -.
DR   PathwayCommons; Q86VV4; -.
DR   SignaLink; Q86VV4; -.
DR   BioGRID-ORCS; 202151; 8 hits in 1141 CRISPR screens.
DR   GenomeRNAi; 202151; -.
DR   Pharos; Q86VV4; Tdark.
DR   PRO; PR:Q86VV4; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q86VV4; Protein.
DR   Bgee; ENSG00000164188; Expressed in metanephros cortex and 96 other cell types or tissues.
DR   ExpressionAtlas; Q86VV4; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR   GO; GO:0046332; F:SMAD binding; IPI:UniProtKB.
DR   GO; GO:1901706; P:mesenchymal cell differentiation involved in bone development; ISS:UniProtKB.
DR   GO; GO:0045668; P:negative regulation of osteoblast differentiation; ISS:UniProtKB.
DR   GO; GO:0045663; P:positive regulation of myoblast differentiation; ISS:UniProtKB.
DR   GO; GO:0006611; P:protein export from nucleus; IBA:GO_Central.
DR   CDD; cd13180; RanBD_RanBP3; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR000156; Ran_bind_dom.
DR   InterPro; IPR045255; RanBP1-like.
DR   PANTHER; PTHR23138; RAN BINDING PROTEIN; 1.
DR   PANTHER; PTHR23138:SF88; RAN-BINDING PROTEIN 3-LIKE; 1.
DR   Pfam; PF00638; Ran_BP1; 1.
DR   SMART; SM00160; RanBD; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50196; RANBD1; 1.
DR   Genevisible; Q86VV4; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..465
FT                   /note="Ran-binding protein 3-like"
FT                   /id="PRO_0000312749"
FT   DOMAIN          276..417
FT                   /note="RanBD1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00164"
FT   VAR_SEQ         89
FT                   /note="G -> GVSTLSQKQMRCSSVTNLPTFPHSGP (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_044463"
FT   VAR_SEQ         302..321
FT                   /note="INCKLFIFNKTTQSWIERGR -> VCISCFTLSGSIYILGIKLT (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_029893"
FT   VAR_SEQ         322..465
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_029894"
FT   VARIANT         70
FT                   /note="T -> R (in dbSNP:rs1035480)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:15372022, ECO:0000269|PubMed:15489334"
FT                   /id="VAR_037557"
FT   VARIANT         111
FT                   /note="A -> D (in dbSNP:rs35433829)"
FT                   /id="VAR_037558"
FT   VARIANT         271
FT                   /note="A -> V (in dbSNP:rs16902872)"
FT                   /id="VAR_037559"
FT   CONFLICT        181
FT                   /note="Q -> R (in Ref. 1; BAH13852)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   465 AA;  52211 MW;  3A47BE51C1D34A64 CRC64;
     MTTIPRKGSS HLPGSLHTCK LKLQEDRRQQ EKSVIAQPIF VFEKGEQTFK RPAEDTLYEA
     AEPECNGFPT KRVRSSSFTF HITDSQSQGV RKNNVFMTSA LVQSSVDIKS AEQGPVKHSK
     HVIRPAILQL PQARSCAKVR KTFGHKALES CKTKEKTNNK ISEGNSYLLS ENLSRARISV
     QLSTNQDFLG ATSVGCQPNE DKCSFKSCSS NFVFGENMVE RVLGTQKLTQ PQLENDSYAK
     EKPFKSIPKF PVNFLSSRTD SIKNTSLIES AAAFSSQPSR KCLLEKIDVI TGEETEHNVL
     KINCKLFIFN KTTQSWIERG RGTLRLNDTA STDCGTLQSR LIMRNQGSLR LILNSKLWAQ
     MKIQRANHKN VRITATDLED YSIKIFLIQA SAQDTAYLYA AIHHRLVALQ SFNKQRDVNQ
     AESLSETAQQ LNCESCDENE DDFIQVTKNG SDPSSWTHRQ SVACS
//