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Protein

Ran-binding protein 3-like

Gene

RANBP3L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner.By similarity1 Publication

GO - Molecular functioni

  • Ran GTPase binding Source: GO_Central
  • SMAD binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ran-binding protein 3-like
Gene namesi
Name:RANBP3L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164188.8
HGNCiHGNC:26353 RANBP3L
MIMi616391 gene
neXtProtiNX_Q86VV4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164188
PharmGKBiPA162400660

Polymorphism and mutation databases

BioMutaiRANBP3L
DMDMi317373276

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003127491 – 465Ran-binding protein 3-likeAdd BLAST465

Proteomic databases

PeptideAtlasiQ86VV4
PRIDEiQ86VV4

PTM databases

iPTMnetiQ86VV4
PhosphoSitePlusiQ86VV4

Expressioni

Gene expression databases

BgeeiENSG00000164188
CleanExiHS_RANBP3L
ExpressionAtlasiQ86VV4 baseline and differential
GenevisibleiQ86VV4 HS

Organism-specific databases

HPAiHPA037471
HPA037472
HPA061526

Interactioni

Subunit structurei

Interacts with SMAD1, SMAD5 and SMAD8; the interaction (with SMAD at least) increases when SMAD1 is not phosphorylated and mediates SMAD1 nuclear export.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIP6Q156544EBI-12028066,EBI-742327

GO - Molecular functioni

  • Ran GTPase binding Source: GO_Central
  • SMAD binding Source: UniProtKB

Protein-protein interaction databases

BioGridi128419, 2 interactors
IntActiQ86VV4, 6 interactors

Structurei

3D structure databases

ProteinModelPortaliQ86VV4
SMRiQ86VV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini276 – 417RanBD1PROSITE-ProRule annotationAdd BLAST142

Phylogenomic databases

GeneTreeiENSGT00530000063644
HOGENOMiHOG000290662
HOVERGENiHBG061383
InParanoidiQ86VV4
OMAiYLYAAIH
OrthoDBiEOG091G076E
PhylomeDBiQ86VV4
TreeFamiTF313181

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR000156 Ran_bind_dom
PfamiView protein in Pfam
PF00638 Ran_BP1, 1 hit
SMARTiView protein in SMART
SM00160 RanBD, 1 hit
PROSITEiView protein in PROSITE
PS50196 RANBD1, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86VV4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTIPRKGSS HLPGSLHTCK LKLQEDRRQQ EKSVIAQPIF VFEKGEQTFK
60 70 80 90 100
RPAEDTLYEA AEPECNGFPT KRVRSSSFTF HITDSQSQGV RKNNVFMTSA
110 120 130 140 150
LVQSSVDIKS AEQGPVKHSK HVIRPAILQL PQARSCAKVR KTFGHKALES
160 170 180 190 200
CKTKEKTNNK ISEGNSYLLS ENLSRARISV QLSTNQDFLG ATSVGCQPNE
210 220 230 240 250
DKCSFKSCSS NFVFGENMVE RVLGTQKLTQ PQLENDSYAK EKPFKSIPKF
260 270 280 290 300
PVNFLSSRTD SIKNTSLIES AAAFSSQPSR KCLLEKIDVI TGEETEHNVL
310 320 330 340 350
KINCKLFIFN KTTQSWIERG RGTLRLNDTA STDCGTLQSR LIMRNQGSLR
360 370 380 390 400
LILNSKLWAQ MKIQRANHKN VRITATDLED YSIKIFLIQA SAQDTAYLYA
410 420 430 440 450
AIHHRLVALQ SFNKQRDVNQ AESLSETAQQ LNCESCDENE DDFIQVTKNG
460
SDPSSWTHRQ SVACS
Length:465
Mass (Da):52,211
Last modified:January 11, 2011 - v2
Checksum:i3A47BE51C1D34A64
GO
Isoform 2 (identifier: Q86VV4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     302-321: INCKLFIFNKTTQSWIERGR → VCISCFTLSGSIYILGIKLT
     322-465: Missing.

Note: No experimental confirmation available.
Show »
Length:321
Mass (Da):35,676
Checksum:i7ECD5FE3E46A7639
GO
Isoform 3 (identifier: Q86VV4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-89: G → GVSTLSQKQMRCSSVTNLPTFPHSGP

Note: No experimental confirmation available.
Show »
Length:490
Mass (Da):54,896
Checksum:iC182AD65DD4168D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181Q → R in BAH13852 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03755770T → R3 PublicationsCorresponds to variant dbSNP:rs1035480Ensembl.1
Natural variantiVAR_037558111A → D. Corresponds to variant dbSNP:rs35433829Ensembl.1
Natural variantiVAR_037559271A → V. Corresponds to variant dbSNP:rs16902872Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04446389G → GVSTLSQKQMRCSSVTNLPT FPHSGP in isoform 3. 1 Publication1
Alternative sequenceiVSP_029893302 – 321INCKL…IERGR → VCISCFTLSGSIYILGIKLT in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_029894322 – 465Missing in isoform 2. 1 PublicationAdd BLAST144

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058151 mRNA Translation: BAB71689.1
AK302947 mRNA Translation: BAH13852.1
AC008807 Genomic DNA No translation available.
AC114277 Genomic DNA No translation available.
CH471119 Genomic DNA Translation: EAW55942.1
CH471119 Genomic DNA Translation: EAW55943.1
BC047660 mRNA Translation: AAH47660.1
CCDSiCCDS3918.1 [Q86VV4-1]
CCDS54843.1 [Q86VV4-3]
RefSeqiNP_001154901.1, NM_001161429.2 [Q86VV4-3]
NP_001310202.1, NM_001323273.1
NP_001310203.1, NM_001323274.1
NP_001310204.1, NM_001323275.1
NP_001310205.1, NM_001323276.1
NP_001310206.1, NM_001323277.1
NP_001310207.1, NM_001323278.1
NP_001310208.1, NM_001323279.1
NP_001310209.1, NM_001323280.1
NP_659437.3, NM_145000.4 [Q86VV4-1]
UniGeneiHs.199777
Hs.729817

Genome annotation databases

EnsembliENST00000296604; ENSP00000296604; ENSG00000164188 [Q86VV4-1]
ENST00000502994; ENSP00000421853; ENSG00000164188 [Q86VV4-3]
ENST00000515759; ENSP00000421149; ENSG00000164188 [Q86VV4-2]
GeneIDi202151
KEGGihsa:202151
UCSCiuc003jkh.4 human [Q86VV4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRNB3L_HUMAN
AccessioniPrimary (citable) accession number: Q86VV4
Secondary accession number(s): B7Z866, E9PGP9, Q96LK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 11, 2011
Last modified: April 25, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health