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Protein

Ran-binding protein 3-like

Gene

RANBP3L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner.By similarity1 Publication

GO - Molecular functioni

  • Ran GTPase binding Source: GO_Central
  • SMAD binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ran-binding protein 3-like
Gene namesi
Name:RANBP3L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164188.8.
HGNCiHGNC:26353. RANBP3L.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164188.
PharmGKBiPA162400660.

Polymorphism and mutation databases

BioMutaiRANBP3L.
DMDMi317373276.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003127491 – 465Ran-binding protein 3-likeAdd BLAST465

Proteomic databases

PeptideAtlasiQ86VV4.
PRIDEiQ86VV4.

PTM databases

iPTMnetiQ86VV4.
PhosphoSitePlusiQ86VV4.

Expressioni

Gene expression databases

BgeeiENSG00000164188.
CleanExiHS_RANBP3L.
ExpressionAtlasiQ86VV4. baseline and differential.
GenevisibleiQ86VV4. HS.

Organism-specific databases

HPAiHPA037471.
HPA037472.
HPA061526.

Interactioni

Subunit structurei

Interacts with SMAD1, SMAD5 and SMAD8; the interaction (with SMAD at least) increases when SMAD1 is not phosphorylated and mediates SMAD1 nuclear export.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIP6Q156544EBI-12028066,EBI-742327

GO - Molecular functioni

  • Ran GTPase binding Source: GO_Central
  • SMAD binding Source: UniProtKB

Protein-protein interaction databases

BioGridi128419. 2 interactors.
IntActiQ86VV4. 6 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ86VV4.
SMRiQ86VV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini276 – 417RanBD1PROSITE-ProRule annotationAdd BLAST142

Phylogenomic databases

GeneTreeiENSGT00530000063644.
HOGENOMiHOG000290662.
HOVERGENiHBG061383.
InParanoidiQ86VV4.
OMAiYLYAAIH.
OrthoDBiEOG091G076E.
PhylomeDBiQ86VV4.
TreeFamiTF313181.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR011993. PH-like_dom_sf.
IPR000156. Ran_bind_dom.
PfamiView protein in Pfam
PF00638. Ran_BP1. 1 hit.
SMARTiView protein in SMART
SM00160. RanBD. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS50196. RANBD1. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86VV4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTIPRKGSS HLPGSLHTCK LKLQEDRRQQ EKSVIAQPIF VFEKGEQTFK
60 70 80 90 100
RPAEDTLYEA AEPECNGFPT KRVRSSSFTF HITDSQSQGV RKNNVFMTSA
110 120 130 140 150
LVQSSVDIKS AEQGPVKHSK HVIRPAILQL PQARSCAKVR KTFGHKALES
160 170 180 190 200
CKTKEKTNNK ISEGNSYLLS ENLSRARISV QLSTNQDFLG ATSVGCQPNE
210 220 230 240 250
DKCSFKSCSS NFVFGENMVE RVLGTQKLTQ PQLENDSYAK EKPFKSIPKF
260 270 280 290 300
PVNFLSSRTD SIKNTSLIES AAAFSSQPSR KCLLEKIDVI TGEETEHNVL
310 320 330 340 350
KINCKLFIFN KTTQSWIERG RGTLRLNDTA STDCGTLQSR LIMRNQGSLR
360 370 380 390 400
LILNSKLWAQ MKIQRANHKN VRITATDLED YSIKIFLIQA SAQDTAYLYA
410 420 430 440 450
AIHHRLVALQ SFNKQRDVNQ AESLSETAQQ LNCESCDENE DDFIQVTKNG
460
SDPSSWTHRQ SVACS
Length:465
Mass (Da):52,211
Last modified:January 11, 2011 - v2
Checksum:i3A47BE51C1D34A64
GO
Isoform 2 (identifier: Q86VV4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     302-321: INCKLFIFNKTTQSWIERGR → VCISCFTLSGSIYILGIKLT
     322-465: Missing.

Note: No experimental confirmation available.
Show »
Length:321
Mass (Da):35,676
Checksum:i7ECD5FE3E46A7639
GO
Isoform 3 (identifier: Q86VV4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-89: G → GVSTLSQKQMRCSSVTNLPTFPHSGP

Note: No experimental confirmation available.
Show »
Length:490
Mass (Da):54,896
Checksum:iC182AD65DD4168D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181Q → R in BAH13852 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03755770T → R3 PublicationsCorresponds to variant dbSNP:rs1035480Ensembl.1
Natural variantiVAR_037558111A → D. Corresponds to variant dbSNP:rs35433829Ensembl.1
Natural variantiVAR_037559271A → V. Corresponds to variant dbSNP:rs16902872Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04446389G → GVSTLSQKQMRCSSVTNLPT FPHSGP in isoform 3. 1 Publication1
Alternative sequenceiVSP_029893302 – 321INCKL…IERGR → VCISCFTLSGSIYILGIKLT in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_029894322 – 465Missing in isoform 2. 1 PublicationAdd BLAST144

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058151 mRNA. Translation: BAB71689.1.
AK302947 mRNA. Translation: BAH13852.1.
AC008807 Genomic DNA. No translation available.
AC114277 Genomic DNA. No translation available.
CH471119 Genomic DNA. Translation: EAW55942.1.
CH471119 Genomic DNA. Translation: EAW55943.1.
BC047660 mRNA. Translation: AAH47660.1.
CCDSiCCDS3918.1. [Q86VV4-1]
CCDS54843.1. [Q86VV4-3]
RefSeqiNP_001154901.1. NM_001161429.2. [Q86VV4-3]
NP_001310202.1. NM_001323273.1.
NP_001310203.1. NM_001323274.1.
NP_001310204.1. NM_001323275.1.
NP_001310205.1. NM_001323276.1.
NP_001310206.1. NM_001323277.1.
NP_001310207.1. NM_001323278.1.
NP_001310208.1. NM_001323279.1.
NP_001310209.1. NM_001323280.1.
NP_659437.3. NM_145000.4. [Q86VV4-1]
UniGeneiHs.199777.
Hs.729817.

Genome annotation databases

EnsembliENST00000296604; ENSP00000296604; ENSG00000164188. [Q86VV4-1]
ENST00000502994; ENSP00000421853; ENSG00000164188. [Q86VV4-3]
ENST00000515759; ENSP00000421149; ENSG00000164188. [Q86VV4-2]
GeneIDi202151.
KEGGihsa:202151.
UCSCiuc003jkh.4. human. [Q86VV4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRNB3L_HUMAN
AccessioniPrimary (citable) accession number: Q86VV4
Secondary accession number(s): B7Z866, E9PGP9, Q96LK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 11, 2011
Last modified: November 22, 2017
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot