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Protein

Ran-binding protein 3-like

Gene

RANBP3L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. intracellular transport Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ran-binding protein 3-like
Gene namesi
Name:RANBP3L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:26353. RANBP3L.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400660.

Polymorphism and mutation databases

BioMutaiRANBP3L.
DMDMi317373276.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Ran-binding protein 3-likePRO_0000312749Add
BLAST

Proteomic databases

PaxDbiQ86VV4.
PRIDEiQ86VV4.

PTM databases

PhosphoSiteiQ86VV4.

Expressioni

Gene expression databases

BgeeiQ86VV4.
CleanExiHS_RANBP3L.
ExpressionAtlasiQ86VV4. baseline and differential.
GenevestigatoriQ86VV4.

Organism-specific databases

HPAiHPA037471.
HPA037472.
HPA061526.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000296604.

Structurei

3D structure databases

ProteinModelPortaliQ86VV4.
SMRiQ86VV4. Positions 288-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini276 – 417142RanBD1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RanBD1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG294696.
GeneTreeiENSGT00530000063644.
HOGENOMiHOG000290662.
HOVERGENiHBG061383.
InParanoidiQ86VV4.
OMAiDCGTLQS.
OrthoDBiEOG7TJ3JQ.
PhylomeDBiQ86VV4.
TreeFamiTF313181.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR000156. Ran_bind_dom.
[Graphical view]
PfamiPF00638. Ran_BP1. 1 hit.
[Graphical view]
SMARTiSM00160. RanBD. 1 hit.
[Graphical view]
PROSITEiPS50196. RANBD1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86VV4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTIPRKGSS HLPGSLHTCK LKLQEDRRQQ EKSVIAQPIF VFEKGEQTFK
60 70 80 90 100
RPAEDTLYEA AEPECNGFPT KRVRSSSFTF HITDSQSQGV RKNNVFMTSA
110 120 130 140 150
LVQSSVDIKS AEQGPVKHSK HVIRPAILQL PQARSCAKVR KTFGHKALES
160 170 180 190 200
CKTKEKTNNK ISEGNSYLLS ENLSRARISV QLSTNQDFLG ATSVGCQPNE
210 220 230 240 250
DKCSFKSCSS NFVFGENMVE RVLGTQKLTQ PQLENDSYAK EKPFKSIPKF
260 270 280 290 300
PVNFLSSRTD SIKNTSLIES AAAFSSQPSR KCLLEKIDVI TGEETEHNVL
310 320 330 340 350
KINCKLFIFN KTTQSWIERG RGTLRLNDTA STDCGTLQSR LIMRNQGSLR
360 370 380 390 400
LILNSKLWAQ MKIQRANHKN VRITATDLED YSIKIFLIQA SAQDTAYLYA
410 420 430 440 450
AIHHRLVALQ SFNKQRDVNQ AESLSETAQQ LNCESCDENE DDFIQVTKNG
460
SDPSSWTHRQ SVACS
Length:465
Mass (Da):52,211
Last modified:January 11, 2011 - v2
Checksum:i3A47BE51C1D34A64
GO
Isoform 2 (identifier: Q86VV4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     302-321: INCKLFIFNKTTQSWIERGR → VCISCFTLSGSIYILGIKLT
     322-465: Missing.

Note: No experimental confirmation available.

Show »
Length:321
Mass (Da):35,676
Checksum:i7ECD5FE3E46A7639
GO
Isoform 3 (identifier: Q86VV4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-89: G → GVSTLSQKQMRCSSVTNLPTFPHSGP

Note: No experimental confirmation available.

Show »
Length:490
Mass (Da):54,896
Checksum:iC182AD65DD4168D7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti181 – 1811Q → R in BAH13852 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti70 – 701T → R.3 Publications
Corresponds to variant rs1035480 [ dbSNP | Ensembl ].
VAR_037557
Natural varianti111 – 1111A → D.
Corresponds to variant rs35433829 [ dbSNP | Ensembl ].
VAR_037558
Natural varianti271 – 2711A → V.
Corresponds to variant rs16902872 [ dbSNP | Ensembl ].
VAR_037559

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei89 – 891G → GVSTLSQKQMRCSSVTNLPT FPHSGP in isoform 3. 1 PublicationVSP_044463
Alternative sequencei302 – 32120INCKL…IERGR → VCISCFTLSGSIYILGIKLT in isoform 2. 1 PublicationVSP_029893Add
BLAST
Alternative sequencei322 – 465144Missing in isoform 2. 1 PublicationVSP_029894Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058151 mRNA. Translation: BAB71689.1.
AK302947 mRNA. Translation: BAH13852.1.
AC008807 Genomic DNA. No translation available.
AC114277 Genomic DNA. No translation available.
CH471119 Genomic DNA. Translation: EAW55942.1.
CH471119 Genomic DNA. Translation: EAW55943.1.
BC047660 mRNA. Translation: AAH47660.1.
CCDSiCCDS3918.1. [Q86VV4-1]
CCDS54843.1. [Q86VV4-3]
RefSeqiNP_001154901.1. NM_001161429.1. [Q86VV4-3]
NP_659437.3. NM_145000.3. [Q86VV4-1]
UniGeneiHs.729817.

Genome annotation databases

EnsembliENST00000296604; ENSP00000296604; ENSG00000164188. [Q86VV4-1]
ENST00000502994; ENSP00000421853; ENSG00000164188. [Q86VV4-3]
ENST00000515759; ENSP00000421149; ENSG00000164188. [Q86VV4-2]
GeneIDi202151.
KEGGihsa:202151.
UCSCiuc003jkh.3. human. [Q86VV4-1]
uc011cow.2. human. [Q86VV4-3]

Polymorphism and mutation databases

BioMutaiRANBP3L.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058151 mRNA. Translation: BAB71689.1.
AK302947 mRNA. Translation: BAH13852.1.
AC008807 Genomic DNA. No translation available.
AC114277 Genomic DNA. No translation available.
CH471119 Genomic DNA. Translation: EAW55942.1.
CH471119 Genomic DNA. Translation: EAW55943.1.
BC047660 mRNA. Translation: AAH47660.1.
CCDSiCCDS3918.1. [Q86VV4-1]
CCDS54843.1. [Q86VV4-3]
RefSeqiNP_001154901.1. NM_001161429.1. [Q86VV4-3]
NP_659437.3. NM_145000.3. [Q86VV4-1]
UniGeneiHs.729817.

3D structure databases

ProteinModelPortaliQ86VV4.
SMRiQ86VV4. Positions 288-411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000296604.

PTM databases

PhosphoSiteiQ86VV4.

Polymorphism and mutation databases

BioMutaiRANBP3L.
DMDMi317373276.

Proteomic databases

PaxDbiQ86VV4.
PRIDEiQ86VV4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296604; ENSP00000296604; ENSG00000164188. [Q86VV4-1]
ENST00000502994; ENSP00000421853; ENSG00000164188. [Q86VV4-3]
ENST00000515759; ENSP00000421149; ENSG00000164188. [Q86VV4-2]
GeneIDi202151.
KEGGihsa:202151.
UCSCiuc003jkh.3. human. [Q86VV4-1]
uc011cow.2. human. [Q86VV4-3]

Organism-specific databases

CTDi202151.
GeneCardsiGC05M036286.
HGNCiHGNC:26353. RANBP3L.
HPAiHPA037471.
HPA037472.
HPA061526.
neXtProtiNX_Q86VV4.
PharmGKBiPA162400660.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG294696.
GeneTreeiENSGT00530000063644.
HOGENOMiHOG000290662.
HOVERGENiHBG061383.
InParanoidiQ86VV4.
OMAiDCGTLQS.
OrthoDBiEOG7TJ3JQ.
PhylomeDBiQ86VV4.
TreeFamiTF313181.

Miscellaneous databases

ChiTaRSiRANBP3L. human.
GenomeRNAii202151.
NextBioi90256.
PROiQ86VV4.

Gene expression databases

BgeeiQ86VV4.
CleanExiHS_RANBP3L.
ExpressionAtlasiQ86VV4. baseline and differential.
GenevestigatoriQ86VV4.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR000156. Ran_bind_dom.
[Graphical view]
PfamiPF00638. Ran_BP1. 1 hit.
[Graphical view]
SMARTiSM00160. RanBD. 1 hit.
[Graphical view]
PROSITEiPS50196. RANBD1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT ARG-70.
    Tissue: Testis.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-70.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-70.
    Tissue: Brain.

Entry informationi

Entry nameiRNB3L_HUMAN
AccessioniPrimary (citable) accession number: Q86VV4
Secondary accession number(s): B7Z866, E9PGP9, Q96LK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 11, 2011
Last modified: April 29, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.