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Q86VV4

- RNB3L_HUMAN

UniProt

Q86VV4 - RNB3L_HUMAN

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Protein

Ran-binding protein 3-like

Gene

RANBP3L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. intracellular transport Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ran-binding protein 3-like
Gene namesi
Name:RANBP3L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:26353. RANBP3L.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400660.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Ran-binding protein 3-likePRO_0000312749Add
BLAST

Proteomic databases

PaxDbiQ86VV4.
PRIDEiQ86VV4.

PTM databases

PhosphoSiteiQ86VV4.

Expressioni

Gene expression databases

BgeeiQ86VV4.
CleanExiHS_RANBP3L.
ExpressionAtlasiQ86VV4. baseline and differential.
GenevestigatoriQ86VV4.

Organism-specific databases

HPAiHPA037471.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000296604.

Structurei

3D structure databases

ProteinModelPortaliQ86VV4.
SMRiQ86VV4. Positions 288-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini276 – 417142RanBD1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RanBD1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG294696.
GeneTreeiENSGT00530000063644.
HOGENOMiHOG000290662.
HOVERGENiHBG061383.
InParanoidiQ86VV4.
OMAiDCGTLQS.
OrthoDBiEOG7TJ3JQ.
PhylomeDBiQ86VV4.
TreeFamiTF313181.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR000156. Ran_bind_dom.
[Graphical view]
PfamiPF00638. Ran_BP1. 1 hit.
[Graphical view]
SMARTiSM00160. RanBD. 1 hit.
[Graphical view]
PROSITEiPS50196. RANBD1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86VV4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTIPRKGSS HLPGSLHTCK LKLQEDRRQQ EKSVIAQPIF VFEKGEQTFK
60 70 80 90 100
RPAEDTLYEA AEPECNGFPT KRVRSSSFTF HITDSQSQGV RKNNVFMTSA
110 120 130 140 150
LVQSSVDIKS AEQGPVKHSK HVIRPAILQL PQARSCAKVR KTFGHKALES
160 170 180 190 200
CKTKEKTNNK ISEGNSYLLS ENLSRARISV QLSTNQDFLG ATSVGCQPNE
210 220 230 240 250
DKCSFKSCSS NFVFGENMVE RVLGTQKLTQ PQLENDSYAK EKPFKSIPKF
260 270 280 290 300
PVNFLSSRTD SIKNTSLIES AAAFSSQPSR KCLLEKIDVI TGEETEHNVL
310 320 330 340 350
KINCKLFIFN KTTQSWIERG RGTLRLNDTA STDCGTLQSR LIMRNQGSLR
360 370 380 390 400
LILNSKLWAQ MKIQRANHKN VRITATDLED YSIKIFLIQA SAQDTAYLYA
410 420 430 440 450
AIHHRLVALQ SFNKQRDVNQ AESLSETAQQ LNCESCDENE DDFIQVTKNG
460
SDPSSWTHRQ SVACS
Length:465
Mass (Da):52,211
Last modified:January 11, 2011 - v2
Checksum:i3A47BE51C1D34A64
GO
Isoform 2 (identifier: Q86VV4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     302-321: INCKLFIFNKTTQSWIERGR → VCISCFTLSGSIYILGIKLT
     322-465: Missing.

Note: No experimental confirmation available.

Show »
Length:321
Mass (Da):35,676
Checksum:i7ECD5FE3E46A7639
GO
Isoform 3 (identifier: Q86VV4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-89: G → GVSTLSQKQMRCSSVTNLPTFPHSGP

Note: No experimental confirmation available.

Show »
Length:490
Mass (Da):54,896
Checksum:iC182AD65DD4168D7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti181 – 1811Q → R in BAH13852. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti70 – 701T → R.3 Publications
Corresponds to variant rs1035480 [ dbSNP | Ensembl ].
VAR_037557
Natural varianti111 – 1111A → D.
Corresponds to variant rs35433829 [ dbSNP | Ensembl ].
VAR_037558
Natural varianti271 – 2711A → V.
Corresponds to variant rs16902872 [ dbSNP | Ensembl ].
VAR_037559

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei89 – 891G → GVSTLSQKQMRCSSVTNLPT FPHSGP in isoform 3. 1 PublicationVSP_044463
Alternative sequencei302 – 32120INCKL…IERGR → VCISCFTLSGSIYILGIKLT in isoform 2. 1 PublicationVSP_029893Add
BLAST
Alternative sequencei322 – 465144Missing in isoform 2. 1 PublicationVSP_029894Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK058151 mRNA. Translation: BAB71689.1.
AK302947 mRNA. Translation: BAH13852.1.
AC008807 Genomic DNA. No translation available.
AC114277 Genomic DNA. No translation available.
CH471119 Genomic DNA. Translation: EAW55942.1.
CH471119 Genomic DNA. Translation: EAW55943.1.
BC047660 mRNA. Translation: AAH47660.1.
CCDSiCCDS3918.1. [Q86VV4-1]
CCDS54843.1. [Q86VV4-3]
RefSeqiNP_001154901.1. NM_001161429.1. [Q86VV4-3]
NP_659437.3. NM_145000.3. [Q86VV4-1]
UniGeneiHs.729817.

Genome annotation databases

EnsembliENST00000296604; ENSP00000296604; ENSG00000164188. [Q86VV4-1]
ENST00000502994; ENSP00000421853; ENSG00000164188. [Q86VV4-3]
ENST00000515759; ENSP00000421149; ENSG00000164188. [Q86VV4-2]
GeneIDi202151.
KEGGihsa:202151.
UCSCiuc003jkh.3. human. [Q86VV4-1]
uc011cow.2. human. [Q86VV4-3]

Polymorphism databases

DMDMi317373276.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK058151 mRNA. Translation: BAB71689.1 .
AK302947 mRNA. Translation: BAH13852.1 .
AC008807 Genomic DNA. No translation available.
AC114277 Genomic DNA. No translation available.
CH471119 Genomic DNA. Translation: EAW55942.1 .
CH471119 Genomic DNA. Translation: EAW55943.1 .
BC047660 mRNA. Translation: AAH47660.1 .
CCDSi CCDS3918.1. [Q86VV4-1 ]
CCDS54843.1. [Q86VV4-3 ]
RefSeqi NP_001154901.1. NM_001161429.1. [Q86VV4-3 ]
NP_659437.3. NM_145000.3. [Q86VV4-1 ]
UniGenei Hs.729817.

3D structure databases

ProteinModelPortali Q86VV4.
SMRi Q86VV4. Positions 288-411.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000296604.

PTM databases

PhosphoSitei Q86VV4.

Polymorphism databases

DMDMi 317373276.

Proteomic databases

PaxDbi Q86VV4.
PRIDEi Q86VV4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296604 ; ENSP00000296604 ; ENSG00000164188 . [Q86VV4-1 ]
ENST00000502994 ; ENSP00000421853 ; ENSG00000164188 . [Q86VV4-3 ]
ENST00000515759 ; ENSP00000421149 ; ENSG00000164188 . [Q86VV4-2 ]
GeneIDi 202151.
KEGGi hsa:202151.
UCSCi uc003jkh.3. human. [Q86VV4-1 ]
uc011cow.2. human. [Q86VV4-3 ]

Organism-specific databases

CTDi 202151.
GeneCardsi GC05M036286.
HGNCi HGNC:26353. RANBP3L.
HPAi HPA037471.
neXtProti NX_Q86VV4.
PharmGKBi PA162400660.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG294696.
GeneTreei ENSGT00530000063644.
HOGENOMi HOG000290662.
HOVERGENi HBG061383.
InParanoidi Q86VV4.
OMAi DCGTLQS.
OrthoDBi EOG7TJ3JQ.
PhylomeDBi Q86VV4.
TreeFami TF313181.

Miscellaneous databases

GenomeRNAii 202151.
NextBioi 90256.
PROi Q86VV4.

Gene expression databases

Bgeei Q86VV4.
CleanExi HS_RANBP3L.
ExpressionAtlasi Q86VV4. baseline and differential.
Genevestigatori Q86VV4.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR011993. PH_like_dom.
IPR000156. Ran_bind_dom.
[Graphical view ]
Pfami PF00638. Ran_BP1. 1 hit.
[Graphical view ]
SMARTi SM00160. RanBD. 1 hit.
[Graphical view ]
PROSITEi PS50196. RANBD1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT ARG-70.
    Tissue: Testis.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-70.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-70.
    Tissue: Brain.

Entry informationi

Entry nameiRNB3L_HUMAN
AccessioniPrimary (citable) accession number: Q86VV4
Secondary accession number(s): B7Z866, E9PGP9, Q96LK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3