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Q86VV4 (RNB3L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ran-binding protein 3-like
Gene names
Name:RANBP3L
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 RanBD1 domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processintracellular transport

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86VV4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86VV4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     302-321: INCKLFIFNKTTQSWIERGR → VCISCFTLSGSIYILGIKLT
     322-465: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q86VV4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     89-89: G → GVSTLSQKQMRCSSVTNLPTFPHSGP
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 465465Ran-binding protein 3-like
PRO_0000312749

Regions

Domain276 – 417142RanBD1

Natural variations

Alternative sequence891G → GVSTLSQKQMRCSSVTNLPT FPHSGP in isoform 3.
VSP_044463
Alternative sequence302 – 32120INCKL…IERGR → VCISCFTLSGSIYILGIKLT in isoform 2.
VSP_029893
Alternative sequence322 – 465144Missing in isoform 2.
VSP_029894
Natural variant701T → R. Ref.1 Ref.2 Ref.4
Corresponds to variant rs1035480 [ dbSNP | Ensembl ].
VAR_037557
Natural variant1111A → D.
Corresponds to variant rs35433829 [ dbSNP | Ensembl ].
VAR_037558
Natural variant2711A → V.
Corresponds to variant rs16902872 [ dbSNP | Ensembl ].
VAR_037559

Experimental info

Sequence conflict1811Q → R in BAH13852. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 11, 2011. Version 2.
Checksum: 3A47BE51C1D34A64

FASTA46552,211
        10         20         30         40         50         60 
MTTIPRKGSS HLPGSLHTCK LKLQEDRRQQ EKSVIAQPIF VFEKGEQTFK RPAEDTLYEA 

        70         80         90        100        110        120 
AEPECNGFPT KRVRSSSFTF HITDSQSQGV RKNNVFMTSA LVQSSVDIKS AEQGPVKHSK 

       130        140        150        160        170        180 
HVIRPAILQL PQARSCAKVR KTFGHKALES CKTKEKTNNK ISEGNSYLLS ENLSRARISV 

       190        200        210        220        230        240 
QLSTNQDFLG ATSVGCQPNE DKCSFKSCSS NFVFGENMVE RVLGTQKLTQ PQLENDSYAK 

       250        260        270        280        290        300 
EKPFKSIPKF PVNFLSSRTD SIKNTSLIES AAAFSSQPSR KCLLEKIDVI TGEETEHNVL 

       310        320        330        340        350        360 
KINCKLFIFN KTTQSWIERG RGTLRLNDTA STDCGTLQSR LIMRNQGSLR LILNSKLWAQ 

       370        380        390        400        410        420 
MKIQRANHKN VRITATDLED YSIKIFLIQA SAQDTAYLYA AIHHRLVALQ SFNKQRDVNQ 

       430        440        450        460 
AESLSETAQQ LNCESCDENE DDFIQVTKNG SDPSSWTHRQ SVACS 

« Hide

Isoform 2 [UniParc].

Checksum: 7ECD5FE3E46A7639
Show »

FASTA32135,676
Isoform 3 [UniParc].

Checksum: C182AD65DD4168D7
Show »

FASTA49054,896

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT ARG-70.
Tissue: Testis.
[2]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-70.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-70.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK058151 mRNA. Translation: BAB71689.1.
AK302947 mRNA. Translation: BAH13852.1.
AC008807 Genomic DNA. No translation available.
AC114277 Genomic DNA. No translation available.
CH471119 Genomic DNA. Translation: EAW55942.1.
CH471119 Genomic DNA. Translation: EAW55943.1.
BC047660 mRNA. Translation: AAH47660.1.
RefSeqNP_001154901.1. NM_001161429.1.
NP_659437.3. NM_145000.3.
UniGeneHs.729817.

3D structure databases

ProteinModelPortalQ86VV4.
SMRQ86VV4. Positions 288-411.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000296604.

PTM databases

PhosphoSiteQ86VV4.

Polymorphism databases

DMDM317373276.

Proteomic databases

PaxDbQ86VV4.
PRIDEQ86VV4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296604; ENSP00000296604; ENSG00000164188. [Q86VV4-1]
ENST00000502994; ENSP00000421853; ENSG00000164188. [Q86VV4-3]
ENST00000515759; ENSP00000421149; ENSG00000164188. [Q86VV4-2]
GeneID202151.
KEGGhsa:202151.
UCSCuc003jkh.3. human. [Q86VV4-1]
uc011cow.2. human. [Q86VV4-3]

Organism-specific databases

CTD202151.
GeneCardsGC05M036286.
HGNCHGNC:26353. RANBP3L.
HPAHPA037471.
neXtProtNX_Q86VV4.
PharmGKBPA162400660.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG294696.
HOGENOMHOG000290662.
HOVERGENHBG061383.
InParanoidQ86VV4.
OMAYLYAAIH.
OrthoDBEOG7TJ3JQ.
PhylomeDBQ86VV4.
TreeFamTF313181.

Gene expression databases

ArrayExpressQ86VV4.
BgeeQ86VV4.
CleanExHS_RANBP3L.
GenevestigatorQ86VV4.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR011993. PH_like_dom.
IPR000156. Ran_bind_dom.
[Graphical view]
PfamPF00638. Ran_BP1. 1 hit.
[Graphical view]
SMARTSM00160. RanBD. 1 hit.
[Graphical view]
PROSITEPS50196. RANBD1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi202151.
NextBio90256.
PROQ86VV4.

Entry information

Entry nameRNB3L_HUMAN
AccessionPrimary (citable) accession number: Q86VV4
Secondary accession number(s): B7Z866, E9PGP9, Q96LK2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 11, 2011
Last modified: April 16, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM