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Q86VV4

- RNB3L_HUMAN

UniProt

Q86VV4 - RNB3L_HUMAN

Protein

Ran-binding protein 3-like

Gene

RANBP3L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. intracellular transport Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ran-binding protein 3-like
    Gene namesi
    Name:RANBP3L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:26353. RANBP3L.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162400660.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 465465Ran-binding protein 3-likePRO_0000312749Add
    BLAST

    Proteomic databases

    PaxDbiQ86VV4.
    PRIDEiQ86VV4.

    PTM databases

    PhosphoSiteiQ86VV4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ86VV4.
    BgeeiQ86VV4.
    CleanExiHS_RANBP3L.
    GenevestigatoriQ86VV4.

    Organism-specific databases

    HPAiHPA037471.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000296604.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86VV4.
    SMRiQ86VV4. Positions 288-411.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini276 – 417142RanBD1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RanBD1 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG294696.
    HOGENOMiHOG000290662.
    HOVERGENiHBG061383.
    InParanoidiQ86VV4.
    OMAiDCGTLQS.
    OrthoDBiEOG7TJ3JQ.
    PhylomeDBiQ86VV4.
    TreeFamiTF313181.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR011993. PH_like_dom.
    IPR000156. Ran_bind_dom.
    [Graphical view]
    PfamiPF00638. Ran_BP1. 1 hit.
    [Graphical view]
    SMARTiSM00160. RanBD. 1 hit.
    [Graphical view]
    PROSITEiPS50196. RANBD1. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86VV4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTTIPRKGSS HLPGSLHTCK LKLQEDRRQQ EKSVIAQPIF VFEKGEQTFK    50
    RPAEDTLYEA AEPECNGFPT KRVRSSSFTF HITDSQSQGV RKNNVFMTSA 100
    LVQSSVDIKS AEQGPVKHSK HVIRPAILQL PQARSCAKVR KTFGHKALES 150
    CKTKEKTNNK ISEGNSYLLS ENLSRARISV QLSTNQDFLG ATSVGCQPNE 200
    DKCSFKSCSS NFVFGENMVE RVLGTQKLTQ PQLENDSYAK EKPFKSIPKF 250
    PVNFLSSRTD SIKNTSLIES AAAFSSQPSR KCLLEKIDVI TGEETEHNVL 300
    KINCKLFIFN KTTQSWIERG RGTLRLNDTA STDCGTLQSR LIMRNQGSLR 350
    LILNSKLWAQ MKIQRANHKN VRITATDLED YSIKIFLIQA SAQDTAYLYA 400
    AIHHRLVALQ SFNKQRDVNQ AESLSETAQQ LNCESCDENE DDFIQVTKNG 450
    SDPSSWTHRQ SVACS 465
    Length:465
    Mass (Da):52,211
    Last modified:January 11, 2011 - v2
    Checksum:i3A47BE51C1D34A64
    GO
    Isoform 2 (identifier: Q86VV4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         302-321: INCKLFIFNKTTQSWIERGR → VCISCFTLSGSIYILGIKLT
         322-465: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:321
    Mass (Da):35,676
    Checksum:i7ECD5FE3E46A7639
    GO
    Isoform 3 (identifier: Q86VV4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         89-89: G → GVSTLSQKQMRCSSVTNLPTFPHSGP

    Note: No experimental confirmation available.

    Show »
    Length:490
    Mass (Da):54,896
    Checksum:iC182AD65DD4168D7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti181 – 1811Q → R in BAH13852. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti70 – 701T → R.3 Publications
    Corresponds to variant rs1035480 [ dbSNP | Ensembl ].
    VAR_037557
    Natural varianti111 – 1111A → D.
    Corresponds to variant rs35433829 [ dbSNP | Ensembl ].
    VAR_037558
    Natural varianti271 – 2711A → V.
    Corresponds to variant rs16902872 [ dbSNP | Ensembl ].
    VAR_037559

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei89 – 891G → GVSTLSQKQMRCSSVTNLPT FPHSGP in isoform 3. 1 PublicationVSP_044463
    Alternative sequencei302 – 32120INCKL…IERGR → VCISCFTLSGSIYILGIKLT in isoform 2. 1 PublicationVSP_029893Add
    BLAST
    Alternative sequencei322 – 465144Missing in isoform 2. 1 PublicationVSP_029894Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK058151 mRNA. Translation: BAB71689.1.
    AK302947 mRNA. Translation: BAH13852.1.
    AC008807 Genomic DNA. No translation available.
    AC114277 Genomic DNA. No translation available.
    CH471119 Genomic DNA. Translation: EAW55942.1.
    CH471119 Genomic DNA. Translation: EAW55943.1.
    BC047660 mRNA. Translation: AAH47660.1.
    CCDSiCCDS3918.1. [Q86VV4-1]
    CCDS54843.1. [Q86VV4-3]
    RefSeqiNP_001154901.1. NM_001161429.1. [Q86VV4-3]
    NP_659437.3. NM_145000.3. [Q86VV4-1]
    UniGeneiHs.729817.

    Genome annotation databases

    EnsembliENST00000296604; ENSP00000296604; ENSG00000164188. [Q86VV4-1]
    ENST00000502994; ENSP00000421853; ENSG00000164188. [Q86VV4-3]
    ENST00000515759; ENSP00000421149; ENSG00000164188. [Q86VV4-2]
    GeneIDi202151.
    KEGGihsa:202151.
    UCSCiuc003jkh.3. human. [Q86VV4-1]
    uc011cow.2. human. [Q86VV4-3]

    Polymorphism databases

    DMDMi317373276.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK058151 mRNA. Translation: BAB71689.1 .
    AK302947 mRNA. Translation: BAH13852.1 .
    AC008807 Genomic DNA. No translation available.
    AC114277 Genomic DNA. No translation available.
    CH471119 Genomic DNA. Translation: EAW55942.1 .
    CH471119 Genomic DNA. Translation: EAW55943.1 .
    BC047660 mRNA. Translation: AAH47660.1 .
    CCDSi CCDS3918.1. [Q86VV4-1 ]
    CCDS54843.1. [Q86VV4-3 ]
    RefSeqi NP_001154901.1. NM_001161429.1. [Q86VV4-3 ]
    NP_659437.3. NM_145000.3. [Q86VV4-1 ]
    UniGenei Hs.729817.

    3D structure databases

    ProteinModelPortali Q86VV4.
    SMRi Q86VV4. Positions 288-411.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000296604.

    PTM databases

    PhosphoSitei Q86VV4.

    Polymorphism databases

    DMDMi 317373276.

    Proteomic databases

    PaxDbi Q86VV4.
    PRIDEi Q86VV4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296604 ; ENSP00000296604 ; ENSG00000164188 . [Q86VV4-1 ]
    ENST00000502994 ; ENSP00000421853 ; ENSG00000164188 . [Q86VV4-3 ]
    ENST00000515759 ; ENSP00000421149 ; ENSG00000164188 . [Q86VV4-2 ]
    GeneIDi 202151.
    KEGGi hsa:202151.
    UCSCi uc003jkh.3. human. [Q86VV4-1 ]
    uc011cow.2. human. [Q86VV4-3 ]

    Organism-specific databases

    CTDi 202151.
    GeneCardsi GC05M036286.
    HGNCi HGNC:26353. RANBP3L.
    HPAi HPA037471.
    neXtProti NX_Q86VV4.
    PharmGKBi PA162400660.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG294696.
    HOGENOMi HOG000290662.
    HOVERGENi HBG061383.
    InParanoidi Q86VV4.
    OMAi DCGTLQS.
    OrthoDBi EOG7TJ3JQ.
    PhylomeDBi Q86VV4.
    TreeFami TF313181.

    Miscellaneous databases

    GenomeRNAii 202151.
    NextBioi 90256.
    PROi Q86VV4.

    Gene expression databases

    ArrayExpressi Q86VV4.
    Bgeei Q86VV4.
    CleanExi HS_RANBP3L.
    Genevestigatori Q86VV4.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR011993. PH_like_dom.
    IPR000156. Ran_bind_dom.
    [Graphical view ]
    Pfami PF00638. Ran_BP1. 1 hit.
    [Graphical view ]
    SMARTi SM00160. RanBD. 1 hit.
    [Graphical view ]
    PROSITEi PS50196. RANBD1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT ARG-70.
      Tissue: Testis.
    2. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-70.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-70.
      Tissue: Brain.

    Entry informationi

    Entry nameiRNB3L_HUMAN
    AccessioniPrimary (citable) accession number: Q86VV4
    Secondary accession number(s): B7Z866, E9PGP9, Q96LK2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3