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Protein

Catechol O-methyltransferase domain-containing protein 1

Gene

COMTD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Putative O-methyltransferase.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei108S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1
Binding sitei116S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1
Binding sitei134S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1
Binding sitei135S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei163S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei185S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1
Binding sitei187S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1
Binding sitei194S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Catechol O-methyltransferase domain-containing protein 1 (EC:2.1.1.-)
Gene namesi
Name:COMTD1
ORF Names:UNQ766/PRO1558
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:26309. COMTD1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165644.
PharmGKBiPA134961676.

Polymorphism and mutation databases

BioMutaiCOMTD1.
DMDMi74750472.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002332891 – 262Catechol O-methyltransferase domain-containing protein 1Add BLAST262

Proteomic databases

EPDiQ86VU5.
MaxQBiQ86VU5.
PaxDbiQ86VU5.
PeptideAtlasiQ86VU5.
PRIDEiQ86VU5.

PTM databases

PhosphoSitePlusiQ86VU5.
SwissPalmiQ86VU5.

Expressioni

Gene expression databases

BgeeiENSG00000165644.
CleanExiHS_COMTD1.
ExpressionAtlasiQ86VU5. baseline and differential.
GenevisibleiQ86VU5. HS.

Organism-specific databases

HPAiHPA042165.

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN1Q9UMX0-23EBI-2836030,EBI-10173939

Protein-protein interaction databases

BioGridi125625. 61 interactors.
IntActiQ86VU5. 3 interactors.
STRINGi9606.ENSP00000361616.

Structurei

Secondary structure

1262
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi53 – 60Combined sources8
Helixi67 – 77Combined sources11
Helixi82 – 84Combined sources3
Helixi88 – 100Combined sources13
Beta strandi105 – 109Combined sources5
Helixi115 – 122Combined sources8
Beta strandi129 – 135Combined sources7
Helixi138 – 149Combined sources12
Turni153 – 155Combined sources3
Beta strandi156 – 161Combined sources6
Helixi163 – 172Combined sources10
Beta strandi179 – 184Combined sources6
Helixi191 – 201Combined sources11
Beta strandi202 – 211Combined sources10
Helixi215 – 220Combined sources6
Helixi227 – 241Combined sources15
Beta strandi245 – 250Combined sources6
Beta strandi256 – 261Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AVDX-ray1.70A/B36-262[»]
ProteinModelPortaliQ86VU5.
SMRiQ86VU5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ86VU5.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 111S-adenosyl-L-methionine binding2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1663. Eukaryota.
COG4122. LUCA.
GeneTreeiENSGT00390000004409.
HOGENOMiHOG000016839.
HOVERGENiHBG081259.
InParanoidiQ86VU5.
OMAiYWQRAGV.
OrthoDBiEOG091G0JQB.
PhylomeDBiQ86VU5.
TreeFamiTF312986.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002935. O-MeTrfase_3.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01596. Methyltransf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51682. SAM_OMT_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86VU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQPVPRLSV PAALALGSAA LGAAFATGLF LGRRCPPWRG RREQCLLPPE
60 70 80 90 100
DSRLWQYLLS RSMREHPALR SLRLLTLEQP QGDSMMTCEQ AQLLANLARL
110 120 130 140 150
IQAKKALDLG TFTGYSALAL ALALPADGRV VTCEVDAQPP ELGRPLWRQA
160 170 180 190 200
EAEHKIDLRL KPALETLDEL LAAGEAGTFD VAVVDADKEN CSAYYERCLQ
210 220 230 240 250
LLRPGGILAV LRVLWRGKVL QPPKGDVAAE CVRNLNERIR RDVRVYISLL
260
PLGDGLTLAF KI
Length:262
Mass (Da):28,809
Last modified:June 1, 2003 - v1
Checksum:i6A422F32D6FBE128
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84S → Y in BAB85077 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358476 mRNA. Translation: AAQ88840.1.
AK074421 mRNA. Translation: BAB85077.1.
AL390034 Genomic DNA. Translation: CAH73105.1.
BC023663 mRNA. Translation: AAH23663.1.
BC047774 mRNA. Translation: AAH47774.1.
CCDSiCCDS7349.1.
RefSeqiNP_653190.2. NM_144589.2.
UniGeneiHs.355333.

Genome annotation databases

EnsembliENST00000372538; ENSP00000361616; ENSG00000165644.
GeneIDi118881.
KEGGihsa:118881.
UCSCiuc001jxb.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358476 mRNA. Translation: AAQ88840.1.
AK074421 mRNA. Translation: BAB85077.1.
AL390034 Genomic DNA. Translation: CAH73105.1.
BC023663 mRNA. Translation: AAH23663.1.
BC047774 mRNA. Translation: AAH47774.1.
CCDSiCCDS7349.1.
RefSeqiNP_653190.2. NM_144589.2.
UniGeneiHs.355333.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AVDX-ray1.70A/B36-262[»]
ProteinModelPortaliQ86VU5.
SMRiQ86VU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125625. 61 interactors.
IntActiQ86VU5. 3 interactors.
STRINGi9606.ENSP00000361616.

PTM databases

PhosphoSitePlusiQ86VU5.
SwissPalmiQ86VU5.

Polymorphism and mutation databases

BioMutaiCOMTD1.
DMDMi74750472.

Proteomic databases

EPDiQ86VU5.
MaxQBiQ86VU5.
PaxDbiQ86VU5.
PeptideAtlasiQ86VU5.
PRIDEiQ86VU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372538; ENSP00000361616; ENSG00000165644.
GeneIDi118881.
KEGGihsa:118881.
UCSCiuc001jxb.4. human.

Organism-specific databases

CTDi118881.
GeneCardsiCOMTD1.
HGNCiHGNC:26309. COMTD1.
HPAiHPA042165.
neXtProtiNX_Q86VU5.
OpenTargetsiENSG00000165644.
PharmGKBiPA134961676.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1663. Eukaryota.
COG4122. LUCA.
GeneTreeiENSGT00390000004409.
HOGENOMiHOG000016839.
HOVERGENiHBG081259.
InParanoidiQ86VU5.
OMAiYWQRAGV.
OrthoDBiEOG091G0JQB.
PhylomeDBiQ86VU5.
TreeFamiTF312986.

Miscellaneous databases

ChiTaRSiCOMTD1. human.
EvolutionaryTraceiQ86VU5.
GenomeRNAii118881.
PROiQ86VU5.

Gene expression databases

BgeeiENSG00000165644.
CleanExiHS_COMTD1.
ExpressionAtlasiQ86VU5. baseline and differential.
GenevisibleiQ86VU5. HS.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002935. O-MeTrfase_3.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01596. Methyltransf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51682. SAM_OMT_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCMTD1_HUMAN
AccessioniPrimary (citable) accession number: Q86VU5
Secondary accession number(s): Q8TE79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.