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Protein

IQ domain-containing protein H

Gene

IQCH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a regulatory role in spermatogenesis.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
IQ domain-containing protein H
Alternative name(s):
Testis development protein NYD-SP5
Gene namesi
Name:IQCH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:25721. IQCH.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671654.

Polymorphism and mutation databases

BioMutaiIQCH.
DMDMi269849608.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10271027IQ domain-containing protein HPRO_0000282565Add
BLAST

Proteomic databases

PaxDbiQ86VS3.
PRIDEiQ86VS3.

PTM databases

iPTMnetiQ86VS3.
PhosphoSiteiQ86VS3.

Expressioni

Tissue specificityi

Expressed in fetal and adult testis, in germ cells but not somatic cells.1 Publication

Gene expression databases

BgeeiQ86VS3.
CleanExiHS_IQCH.
ExpressionAtlasiQ86VS3. baseline and differential.
GenevisibleiQ86VS3. HS.

Organism-specific databases

HPAiHPA040845.

Interactioni

Protein-protein interaction databases

BioGridi122305. 2 interactions.
STRINGi9606.ENSP00000336861.

Structurei

3D structure databases

ProteinModelPortaliQ86VS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini369 – 39830IQPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJ65. Eukaryota.
ENOG410YTWX. LUCA.
GeneTreeiENSGT00390000008908.
HOGENOMiHOG000168550.
HOVERGENiHBG108009.
InParanoidiQ86VS3.
OMAiHCHKTRL.
OrthoDBiEOG75B84H.
PhylomeDBiQ86VS3.
TreeFamiTF328488.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
PROSITEiPS50096. IQ. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86VS3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQNTENHDP VGSILIQIHE DLYQLKEKLT KFSPEEKGET LDIQSLETAI
60 70 80 90 100
KRTEVGLRIH IEKYLNVVNQ NVLTTSVNDE SLYTPQASKW LLPTVIDQKS
110 120 130 140 150
FIFPQESEGT FWQPQRQHSS SLPVFPRAKI KVSKLIKGSN ISSLTVLPSS
160 170 180 190 200
HCTDPYFTPI PVLQADAHKG ILSMIERGLI PPTARITFQN PPITPRAAPL
210 220 230 240 250
HSFDEARKIP TVATFTIPRE PPPSPAEVKF FPKKQRSKGK SRRSRGHHDR
260 270 280 290 300
KAMKVKTPLR ALKSLWDYDF LIYDGVIDNT APDFLAFKEH FSLAWGGIFS
310 320 330 340 350
LLEHVEKFLR NYAIPEVKIK GNNLVALLPE FELTNKLTRY DLLSVLEDPA
360 370 380 390 400
HVQMLINLPG QRYKGQDGNS EAAMKIQATW KCYKARKFFL FYRQQKWASG
410 420 430 440 450
VIAIAWLLYC HKTRLKKILK ESRQRHLENF RIRAKHLAAN WNRIRTSRRT
460 470 480 490 500
IIHIPSLGYS QPVREHIADF NTQQNMQLGR LCDILDANVN VIYICSHHMN
510 520 530 540 550
DELVLYYKKI LSLHAAVKSG NLEDRSDLQD RFKIITPEAV NIFPKHHMCL
560 570 580 590 600
ATHLMYSPKA IKRIKNLIRG TEAYIVSGLL HRDDLAVADM LDIPILGSEP
610 620 630 640 650
ELAHLYSTKS GGKRVFDSAN VAVPPGIYDI YSQQQMIEQL SQLITDHLQI
660 670 680 690 700
QRWLFKMDSE FRGNGTAFCD IPSYLKCYKW VLKESSRYGL EDWRKKWAQE
710 720 730 740 750
PALVKISEEL AGILAQHAQP VNEKRFPTWR KFLQTFLSQG GVIEAFPPAD
760 770 780 790 800
NVTNLTVDML IEPNGKISVL STGDQLHAES PFISSGTTVP QTSVDPQVLT
810 820 830 840 850
YLCLQIGKAC RMRDVVGYFS IDLVTFIDPS TLEQQVWATG LNLAYSDQLA
860 870 880 890 900
LTQLTLYLTN GHLDCSLSTL EVPRFVPKER KKTKCMSALS MPMLATSRYA
910 920 930 940 950
VMTTQLRHSN LSLVFHYVFL QICRAHGIGY DVEERQGTVF ILYEHLKRHK
960 970 980 990 1000
LGMLTIGEDL QGVLMTFARH LFIIHQEISA PNMQGETNFK TTIADIETIL
1010 1020
RVTKENKMRF EEEQQSKDDK NLSKPKK
Length:1,027
Mass (Da):117,349
Last modified:November 24, 2009 - v2
Checksum:iB36D504EE4E303E6
GO
Isoform 2 (identifier: Q86VS3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-252: Missing.
     545-635: Missing.

Note: No experimental confirmation available.
Show »
Length:684
Mass (Da):78,870
Checksum:i08E301B6C5E803DF
GO
Isoform 3 (identifier: Q86VS3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: Missing.
     459-478: YSQPVREHIADFNTQQNMQL → ITLLPANLSATSITHHIMAP
     479-1027: Missing.

Note: No experimental confirmation available.
Show »
Length:305
Mass (Da):35,202
Checksum:iCEB9769DFB7FB70A
GO
Isoform 4 (identifier: Q86VS3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-248: Missing.
     249-250: DR → MT
     545-635: Missing.
     934-960: ERQGTVFILYEHLKRHKLGMLTIGEDL → NNRRGSPGGPHDLCSPSLHHPSRNIST
     961-1027: Missing.

Note: No experimental confirmation available.
Show »
Length:621
Mass (Da):71,182
Checksum:iE16F73A2B29B8763
GO
Isoform 5 (identifier: Q86VS3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-168: IKVSKLIKGS...PIPVLQADAH → RKIGLNVKIL...LPYINQRKAC
     169-1027: Missing.

Note: No experimental confirmation available.
Show »
Length:168
Mass (Da):19,245
Checksum:iAAC9494B3E43591C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331S → T in AAK27307 (PubMed:15897968).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti932 – 9321V → L.5 Publications
Corresponds to variant rs3985641 [ dbSNP | Ensembl ].
VAR_051077

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 252252Missing in isoform 2. 1 PublicationVSP_024188Add
BLAST
Alternative sequencei1 – 248248Missing in isoform 4. 1 PublicationVSP_024189Add
BLAST
Alternative sequencei1 – 173173Missing in isoform 3. 1 PublicationVSP_024190Add
BLAST
Alternative sequencei130 – 16839IKVSK…QADAH → RKIGLNVKILQDPENIHHRA AVNANYGISLPYINQRKAC in isoform 5. 1 PublicationVSP_045251Add
BLAST
Alternative sequencei169 – 1027859Missing in isoform 5. 1 PublicationVSP_045252Add
BLAST
Alternative sequencei249 – 2502DR → MT in isoform 4. 1 PublicationVSP_024191
Alternative sequencei459 – 47820YSQPV…QNMQL → ITLLPANLSATSITHHIMAP in isoform 3. 1 PublicationVSP_024192Add
BLAST
Alternative sequencei479 – 1027549Missing in isoform 3. 1 PublicationVSP_024193Add
BLAST
Alternative sequencei545 – 63591Missing in isoform 2 and isoform 4. 2 PublicationsVSP_024194Add
BLAST
Alternative sequencei934 – 96027ERQGT…IGEDL → NNRRGSPGGPHDLCSPSLHH PSRNIST in isoform 4. 1 PublicationVSP_024195Add
BLAST
Alternative sequencei961 – 102767Missing in isoform 4. 1 PublicationVSP_024196Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014282 mRNA. Translation: AAK27307.2.
AK022538 mRNA. Translation: BAB14087.1.
AK292478 mRNA. Translation: BAF85167.1.
AC012568 Genomic DNA. No translation available.
AC016355 Genomic DNA. No translation available.
AC106000 Genomic DNA. No translation available.
AC110292 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77796.1.
BC031041 mRNA. Translation: AAH31041.2.
BC039292 mRNA. Translation: AAH39292.1.
BC039463 mRNA. No translation available.
BC048964 mRNA. Translation: AAH48964.1.
AL133556 mRNA. Translation: CAB63711.1.
CCDSiCCDS10223.2. [Q86VS3-5]
CCDS32273.1. [Q86VS3-1]
CCDS61680.1. [Q86VS3-4]
CCDS61681.1. [Q86VS3-2]
CCDS76772.1. [Q86VS3-3]
PIRiT43438.
RefSeqiNP_001026885.1. NM_001031715.2.
NP_001271276.1. NM_001284347.1.
NP_001271277.1. NM_001284348.1.
NP_001271278.1. NM_001284349.1. [Q86VS3-3]
NP_073621.2. NM_022784.2. [Q86VS3-5]
UniGeneiHs.657894.

Genome annotation databases

EnsembliENST00000335894; ENSP00000336861; ENSG00000103599. [Q86VS3-1]
ENST00000358767; ENSP00000351617; ENSG00000103599. [Q86VS3-4]
ENST00000512104; ENSP00000427323; ENSG00000103599. [Q86VS3-5]
ENST00000546225; ENSP00000444118; ENSG00000103599. [Q86VS3-2]
ENST00000629425; ENSP00000486970; ENSG00000103599. [Q86VS3-3]
GeneIDi64799.
KEGGihsa:64799.
UCSCiuc002aqm.4. human. [Q86VS3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014282 mRNA. Translation: AAK27307.2.
AK022538 mRNA. Translation: BAB14087.1.
AK292478 mRNA. Translation: BAF85167.1.
AC012568 Genomic DNA. No translation available.
AC016355 Genomic DNA. No translation available.
AC106000 Genomic DNA. No translation available.
AC110292 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77796.1.
BC031041 mRNA. Translation: AAH31041.2.
BC039292 mRNA. Translation: AAH39292.1.
BC039463 mRNA. No translation available.
BC048964 mRNA. Translation: AAH48964.1.
AL133556 mRNA. Translation: CAB63711.1.
CCDSiCCDS10223.2. [Q86VS3-5]
CCDS32273.1. [Q86VS3-1]
CCDS61680.1. [Q86VS3-4]
CCDS61681.1. [Q86VS3-2]
CCDS76772.1. [Q86VS3-3]
PIRiT43438.
RefSeqiNP_001026885.1. NM_001031715.2.
NP_001271276.1. NM_001284347.1.
NP_001271277.1. NM_001284348.1.
NP_001271278.1. NM_001284349.1. [Q86VS3-3]
NP_073621.2. NM_022784.2. [Q86VS3-5]
UniGeneiHs.657894.

3D structure databases

ProteinModelPortaliQ86VS3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122305. 2 interactions.
STRINGi9606.ENSP00000336861.

PTM databases

iPTMnetiQ86VS3.
PhosphoSiteiQ86VS3.

Polymorphism and mutation databases

BioMutaiIQCH.
DMDMi269849608.

Proteomic databases

PaxDbiQ86VS3.
PRIDEiQ86VS3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335894; ENSP00000336861; ENSG00000103599. [Q86VS3-1]
ENST00000358767; ENSP00000351617; ENSG00000103599. [Q86VS3-4]
ENST00000512104; ENSP00000427323; ENSG00000103599. [Q86VS3-5]
ENST00000546225; ENSP00000444118; ENSG00000103599. [Q86VS3-2]
ENST00000629425; ENSP00000486970; ENSG00000103599. [Q86VS3-3]
GeneIDi64799.
KEGGihsa:64799.
UCSCiuc002aqm.4. human. [Q86VS3-1]

Organism-specific databases

CTDi64799.
GeneCardsiIQCH.
H-InvDBHIX0026790.
HGNCiHGNC:25721. IQCH.
HPAiHPA040845.
MIMi612523. gene.
neXtProtiNX_Q86VS3.
PharmGKBiPA142671654.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ65. Eukaryota.
ENOG410YTWX. LUCA.
GeneTreeiENSGT00390000008908.
HOGENOMiHOG000168550.
HOVERGENiHBG108009.
InParanoidiQ86VS3.
OMAiHCHKTRL.
OrthoDBiEOG75B84H.
PhylomeDBiQ86VS3.
TreeFamiTF328488.

Miscellaneous databases

ChiTaRSiIQCH. human.
GenomeRNAii64799.
NextBioi66876.
PROiQ86VS3.
SOURCEiSearch...

Gene expression databases

BgeeiQ86VS3.
CleanExiHS_IQCH.
ExpressionAtlasiQ86VS3. baseline and differential.
GenevisibleiQ86VS3. HS.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
PROSITEiPS50096. IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel testis-specific gene and its potential roles in testis development/spermatogenesis."
    Yin L.L., Li J.M., Zhou Z.M., Sha J.H.
    Asian J. Androl. 7:127-137(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANT LEU-932.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT LEU-932.
    Tissue: Testis.
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-932.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 5), VARIANT LEU-932.
    Tissue: Medulla oblongata and Testis.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 810-1027 (ISOFORMS 1/2), VARIANT LEU-932.
    Tissue: Testis.

Entry informationi

Entry nameiIQCH_HUMAN
AccessioniPrimary (citable) accession number: Q86VS3
Secondary accession number(s): A8K8W3
, C9JPR6, D6RJ88, Q4G0S6, Q8NEH9, Q9BWX2, Q9H9Y1, Q9UF88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 24, 2009
Last modified: May 11, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.