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Protein

Four-jointed box protein 1

Gene

FJX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as an inhibitor of dendrite extension and branching.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Four-jointed box protein 1
Alternative name(s):
Four-jointed protein homolog
Gene namesi
Name:FJX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:17166. FJX1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi24147.
OpenTargetsiENSG00000179431.
PharmGKBiPA28151.

Polymorphism and mutation databases

BioMutaiFJX1.
DMDMi74727610.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000033304525 – 437Four-jointed box protein 1Add BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi248N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Glycosylated.By similarity
Undergoes proteolytic cleavage.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86VR8.
PeptideAtlasiQ86VR8.
PRIDEiQ86VR8.

Expressioni

Gene expression databases

BgeeiENSG00000179431.
CleanExiHS_FJX1.
GenevisibleiQ86VR8. HS.

Organism-specific databases

HPAiHPA059220.

Interactioni

Protein-protein interaction databases

BioGridi117297. 2 interactors.
IntActiQ86VR8. 2 interactors.
STRINGi9606.ENSP00000400223.

Structurei

3D structure databases

ProteinModelPortaliQ86VR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi31 – 67Pro-richAdd BLAST37

Sequence similaritiesi

Belongs to the FJX1/FJ family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHNI. Eukaryota.
ENOG410XSE2. LUCA.
GeneTreeiENSGT00390000016768.
HOGENOMiHOG000112598.
HOVERGENiHBG098046.
InParanoidiQ86VR8.
KOiK16674.
OMAiMERDTNN.
OrthoDBiEOG091G0L1D.
PhylomeDBiQ86VR8.
TreeFamiTF324767.

Family and domain databases

InterProiIPR024868. FJX1/FJ.
[Graphical view]
PANTHERiPTHR13147. PTHR13147. 1 hit.
PRINTSiPR02072. 4JOINTEDBOX1.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86VR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRMRGAAA TAGLWLLALG SLLALWGGLL PPRTELPASR PPEDRLPRRP
60 70 80 90 100
ARSGGPAPAP RFPLPPPLAW DARGGSLKTF RALLTLAAGA DGPPRQSRSE
110 120 130 140 150
PRWHVSARQP RPEESAAVHG GVFWSRGLEE QVPPGFSEAQ AAAWLEAARG
160 170 180 190 200
ARMVALERGG CGRSSNRLAR FADGTRACVR YGINPEQIQG EALSYYLARL
210 220 230 240 250
LGLQRHVPPL ALARVEARGA QWAQVQEELR AAHWTEGSVV SLTRWLPNLT
260 270 280 290 300
DVVVPAPWRS EDGRLRPLRD AGGELANLSQ AELVDLVQWT DLILFDYLTA
310 320 330 340 350
NFDRLVSNLF SLQWDPRVMQ RATSNLHRGP GGALVFLDNE AGLVHGYRVA
360 370 380 390 400
GMWDKYNEPL LQSVCVFRER TARRVLELHR GQDAAARLLR LYRRHEPRFP
410 420 430
ELAALADPHA QLLQRRLDFL AKHILHCKAK YGRRSGT
Length:437
Mass (Da):48,507
Last modified:June 1, 2003 - v1
Checksum:i3E2B8D3977722639
GO

Sequence cautioni

The sequence CAB53246 differs from that shown. Reason: Frameshift at position 436.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58P → R in CAB53246 (PubMed:10568747).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043117153M → L.Corresponds to variant rs12792700dbSNPEnsembl.1
Natural variantiVAR_062233415R → H.Corresponds to variant rs12286850dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245599 mRNA. Translation: CAB53246.1. Frameshift.
AK315015 mRNA. Translation: BAG37506.1.
CH471064 Genomic DNA. Translation: EAW68138.1.
BC049171 mRNA. Translation: AAH49171.1.
BC071898 mRNA. Translation: AAH71898.1.
CCDSiCCDS44570.1.
RefSeqiNP_055159.2. NM_014344.3.
UniGeneiHs.39384.

Genome annotation databases

EnsembliENST00000317811; ENSP00000400223; ENSG00000179431.
GeneIDi24147.
KEGGihsa:24147.
UCSCiuc001mwh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245599 mRNA. Translation: CAB53246.1. Frameshift.
AK315015 mRNA. Translation: BAG37506.1.
CH471064 Genomic DNA. Translation: EAW68138.1.
BC049171 mRNA. Translation: AAH49171.1.
BC071898 mRNA. Translation: AAH71898.1.
CCDSiCCDS44570.1.
RefSeqiNP_055159.2. NM_014344.3.
UniGeneiHs.39384.

3D structure databases

ProteinModelPortaliQ86VR8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117297. 2 interactors.
IntActiQ86VR8. 2 interactors.
STRINGi9606.ENSP00000400223.

Polymorphism and mutation databases

BioMutaiFJX1.
DMDMi74727610.

Proteomic databases

PaxDbiQ86VR8.
PeptideAtlasiQ86VR8.
PRIDEiQ86VR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317811; ENSP00000400223; ENSG00000179431.
GeneIDi24147.
KEGGihsa:24147.
UCSCiuc001mwh.4. human.

Organism-specific databases

CTDi24147.
DisGeNETi24147.
GeneCardsiFJX1.
HGNCiHGNC:17166. FJX1.
HPAiHPA059220.
MIMi612206. gene.
neXtProtiNX_Q86VR8.
OpenTargetsiENSG00000179431.
PharmGKBiPA28151.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHNI. Eukaryota.
ENOG410XSE2. LUCA.
GeneTreeiENSGT00390000016768.
HOGENOMiHOG000112598.
HOVERGENiHBG098046.
InParanoidiQ86VR8.
KOiK16674.
OMAiMERDTNN.
OrthoDBiEOG091G0L1D.
PhylomeDBiQ86VR8.
TreeFamiTF324767.

Miscellaneous databases

ChiTaRSiFJX1. human.
GenomeRNAii24147.
PROiQ86VR8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179431.
CleanExiHS_FJX1.
GenevisibleiQ86VR8. HS.

Family and domain databases

InterProiIPR024868. FJX1/FJ.
[Graphical view]
PANTHERiPTHR13147. PTHR13147. 1 hit.
PRINTSiPR02072. 4JOINTEDBOX1.
ProtoNetiSearch...

Entry informationi

Entry nameiFJX1_HUMAN
AccessioniPrimary (citable) accession number: Q86VR8
Secondary accession number(s): B2RCA9, Q9UGK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.