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Q86VR2

- F134C_HUMAN

UniProt

Q86VR2 - F134C_HUMAN

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Protein

Protein FAM134C

Gene

FAM134C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM134C
Gene namesi
Name:FAM134C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:27258. FAM134C.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162386207.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 466465Protein FAM134CPRO_0000288469Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine3 Publications
Modified residuei10 – 101Phosphothreonine1 Publication
Modified residuei26 – 261Phosphoserine1 Publication
Modified residuei258 – 2581Phosphoserine4 Publications
Modified residuei260 – 2601Phosphoserine4 Publications
Modified residuei283 – 2831Phosphothreonine1 Publication
Modified residuei285 – 2851Phosphoserine1 Publication
Modified residuei288 – 2881PhosphoserineBy similarity
Modified residuei303 – 3031PhosphoserineBy similarity
Modified residuei307 – 3071Phosphothreonine2 Publications
Modified residuei310 – 3101Phosphothreonine1 Publication
Modified residuei313 – 3131Phosphoserine2 Publications
Modified residuei320 – 3201Phosphoserine3 Publications
Modified residuei360 – 3601Phosphoserine1 Publication
Modified residuei440 – 4401Phosphothreonine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ86VR2.
PaxDbiQ86VR2.
PeptideAtlasiQ86VR2.
PRIDEiQ86VR2.

PTM databases

PhosphoSiteiQ86VR2.

Expressioni

Gene expression databases

BgeeiQ86VR2.
CleanExiHS_FAM134C.
ExpressionAtlasiQ86VR2. baseline and differential.
GenevestigatoriQ86VR2.

Organism-specific databases

HPAiHPA016492.

Interactioni

Protein-protein interaction databases

BioGridi127817. 37 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ86VR2.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei81 – 10121HelicalSequence AnalysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence AnalysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM134 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26663.
GeneTreeiENSGT00530000063240.
HOGENOMiHOG000050246.
HOVERGENiHBG096339.
InParanoidiQ86VR2.
OMAiFCLLSCG.
PhylomeDBiQ86VR2.
TreeFamiTF329111.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86VR2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAEGVPTT PGPASGSTFR GRRDVSGSWE RDQQVEAAQR ALVEVLGPYE
60 70 80 90 100
PLLSRVQAAL VWERPARSAL WCLGLNAAFW FFALTSLRLV FLLAFGLMII
110 120 130 140 150
VCIDQWKNKI WPEIKVPRPD ALDNESWGFV HPRLLSVPEL CHHVAEVWVS
160 170 180 190 200
GTIFIRNVLL FKKQNPGKFC LLSCGILTFL AVLGRYVPGL LLSYLMLVTV
210 220 230 240 250
MMWPLAVYHR LWDRAYVRLK PALQRLDFSV RGYMMSKQRE RQLRRRALHP
260 270 280 290 300
ERAMDNHSDS EEELAAFCPQ LDDSTVAREL AITDSEHSDA EVSCTDNGTF
310 320 330 340 350
NLSRGQTPLT EGSEDLDGHS DPEESFARDL PDFPSINMDP AGLDDEDDTS
360 370 380 390 400
IGMPSLMYRS PPGAEEPQAP PASRDEAALP ELLLGALPVG SNLTSNLASL
410 420 430 440 450
VSQGMIQLAL SGASQPGPSG APAQRATRGF LRSPSSDLDT DAEGDDFELL
460
DQSELSQLDP ASSRSH
Length:466
Mass (Da):51,396
Last modified:June 1, 2003 - v1
Checksum:iF9D468353C13A14B
GO
Isoform 2 (identifier: Q86VR2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-195: Missing.

Note: No experimental confirmation available

Show »
Length:271
Mass (Da):29,582
Checksum:i7361F5A0294F76BC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 195195Missing in isoform 2. 1 PublicationVSP_056991Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK091125 mRNA. Translation: BAG52287.1.
AK294791 mRNA. Translation: BAG57914.1.
AC067852 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60851.1.
BC049370 mRNA. Translation: AAH49370.1.
CCDSiCCDS11432.1.
RefSeqiNP_835227.1. NM_178126.3.
UniGeneiHs.632262.

Genome annotation databases

EnsembliENST00000309428; ENSP00000309432; ENSG00000141699.
GeneIDi162427.
KEGGihsa:162427.
UCSCiuc002ial.2. human.

Polymorphism databases

DMDMi74727607.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK091125 mRNA. Translation: BAG52287.1 .
AK294791 mRNA. Translation: BAG57914.1 .
AC067852 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60851.1 .
BC049370 mRNA. Translation: AAH49370.1 .
CCDSi CCDS11432.1.
RefSeqi NP_835227.1. NM_178126.3.
UniGenei Hs.632262.

3D structure databases

ProteinModelPortali Q86VR2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127817. 37 interactions.

PTM databases

PhosphoSitei Q86VR2.

Polymorphism databases

DMDMi 74727607.

Proteomic databases

MaxQBi Q86VR2.
PaxDbi Q86VR2.
PeptideAtlasi Q86VR2.
PRIDEi Q86VR2.

Protocols and materials databases

DNASUi 162427.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309428 ; ENSP00000309432 ; ENSG00000141699 .
GeneIDi 162427.
KEGGi hsa:162427.
UCSCi uc002ial.2. human.

Organism-specific databases

CTDi 162427.
GeneCardsi GC17M040731.
H-InvDB HIX0020377.
HGNCi HGNC:27258. FAM134C.
HPAi HPA016492.
neXtProti NX_Q86VR2.
PharmGKBi PA162386207.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG26663.
GeneTreei ENSGT00530000063240.
HOGENOMi HOG000050246.
HOVERGENi HBG096339.
InParanoidi Q86VR2.
OMAi FCLLSCG.
PhylomeDBi Q86VR2.
TreeFami TF329111.

Miscellaneous databases

ChiTaRSi FAM134C. human.
GeneWikii FAM134C.
GenomeRNAii 162427.
NextBioi 88169.
PROi Q86VR2.

Gene expression databases

Bgeei Q86VR2.
CleanExi HS_FAM134C.
ExpressionAtlasi Q86VR2. baseline and differential.
Genevestigatori Q86VR2.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain and Tongue.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258; SER-260; THR-283; SER-285; THR-307; THR-310; SER-313; SER-320; SER-360 AND THR-440, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258; SER-260; THR-307; SER-313; SER-320 AND THR-440, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-10; SER-258 AND SER-260, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-258; SER-260 AND SER-320, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiF134C_HUMAN
AccessioniPrimary (citable) accession number: Q86VR2
Secondary accession number(s): B3KR75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3