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Q86VR2

- F134C_HUMAN

UniProt

Q86VR2 - F134C_HUMAN

Protein

Protein FAM134C

Gene

FAM134C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM134C
    Gene namesi
    Name:FAM134C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:27258. FAM134C.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162386207.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 466465Protein FAM134CPRO_0000288469Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine3 Publications
    Modified residuei10 – 101Phosphothreonine1 Publication
    Modified residuei26 – 261Phosphoserine1 Publication
    Modified residuei258 – 2581Phosphoserine4 Publications
    Modified residuei260 – 2601Phosphoserine4 Publications
    Modified residuei283 – 2831Phosphothreonine1 Publication
    Modified residuei285 – 2851Phosphoserine1 Publication
    Modified residuei288 – 2881PhosphoserineBy similarity
    Modified residuei303 – 3031PhosphoserineBy similarity
    Modified residuei307 – 3071Phosphothreonine2 Publications
    Modified residuei310 – 3101Phosphothreonine1 Publication
    Modified residuei313 – 3131Phosphoserine2 Publications
    Modified residuei320 – 3201Phosphoserine3 Publications
    Modified residuei360 – 3601Phosphoserine1 Publication
    Modified residuei440 – 4401Phosphothreonine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ86VR2.
    PaxDbiQ86VR2.
    PeptideAtlasiQ86VR2.
    PRIDEiQ86VR2.

    PTM databases

    PhosphoSiteiQ86VR2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ86VR2.
    BgeeiQ86VR2.
    CleanExiHS_FAM134C.
    GenevestigatoriQ86VR2.

    Organism-specific databases

    HPAiHPA016492.

    Interactioni

    Protein-protein interaction databases

    BioGridi127817. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86VR2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei81 – 10121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei164 – 18421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FAM134 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG26663.
    HOGENOMiHOG000050246.
    HOVERGENiHBG096339.
    InParanoidiQ86VR2.
    OMAiFCLLSCG.
    PhylomeDBiQ86VR2.
    TreeFamiTF329111.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q86VR2-1 [UniParc]FASTAAdd to Basket

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    MAEAEGVPTT PGPASGSTFR GRRDVSGSWE RDQQVEAAQR ALVEVLGPYE    50
    PLLSRVQAAL VWERPARSAL WCLGLNAAFW FFALTSLRLV FLLAFGLMII 100
    VCIDQWKNKI WPEIKVPRPD ALDNESWGFV HPRLLSVPEL CHHVAEVWVS 150
    GTIFIRNVLL FKKQNPGKFC LLSCGILTFL AVLGRYVPGL LLSYLMLVTV 200
    MMWPLAVYHR LWDRAYVRLK PALQRLDFSV RGYMMSKQRE RQLRRRALHP 250
    ERAMDNHSDS EEELAAFCPQ LDDSTVAREL AITDSEHSDA EVSCTDNGTF 300
    NLSRGQTPLT EGSEDLDGHS DPEESFARDL PDFPSINMDP AGLDDEDDTS 350
    IGMPSLMYRS PPGAEEPQAP PASRDEAALP ELLLGALPVG SNLTSNLASL 400
    VSQGMIQLAL SGASQPGPSG APAQRATRGF LRSPSSDLDT DAEGDDFELL 450
    DQSELSQLDP ASSRSH 466
    Length:466
    Mass (Da):51,396
    Last modified:June 1, 2003 - v1
    Checksum:iF9D468353C13A14B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC049370 mRNA. Translation: AAH49370.1.
    CCDSiCCDS11432.1.
    RefSeqiNP_835227.1. NM_178126.3.
    UniGeneiHs.632262.

    Genome annotation databases

    EnsembliENST00000309428; ENSP00000309432; ENSG00000141699.
    GeneIDi162427.
    KEGGihsa:162427.
    UCSCiuc002ial.2. human.

    Polymorphism databases

    DMDMi74727607.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC049370 mRNA. Translation: AAH49370.1 .
    CCDSi CCDS11432.1.
    RefSeqi NP_835227.1. NM_178126.3.
    UniGenei Hs.632262.

    3D structure databases

    ProteinModelPortali Q86VR2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127817. 3 interactions.

    PTM databases

    PhosphoSitei Q86VR2.

    Polymorphism databases

    DMDMi 74727607.

    Proteomic databases

    MaxQBi Q86VR2.
    PaxDbi Q86VR2.
    PeptideAtlasi Q86VR2.
    PRIDEi Q86VR2.

    Protocols and materials databases

    DNASUi 162427.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309428 ; ENSP00000309432 ; ENSG00000141699 .
    GeneIDi 162427.
    KEGGi hsa:162427.
    UCSCi uc002ial.2. human.

    Organism-specific databases

    CTDi 162427.
    GeneCardsi GC17M040731.
    H-InvDB HIX0020377.
    HGNCi HGNC:27258. FAM134C.
    HPAi HPA016492.
    neXtProti NX_Q86VR2.
    PharmGKBi PA162386207.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26663.
    HOGENOMi HOG000050246.
    HOVERGENi HBG096339.
    InParanoidi Q86VR2.
    OMAi FCLLSCG.
    PhylomeDBi Q86VR2.
    TreeFami TF329111.

    Miscellaneous databases

    ChiTaRSi FAM134C. human.
    GeneWikii FAM134C.
    GenomeRNAii 162427.
    NextBioi 88169.
    PROi Q86VR2.

    Gene expression databases

    ArrayExpressi Q86VR2.
    Bgeei Q86VR2.
    CleanExi HS_FAM134C.
    Genevestigatori Q86VR2.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258; SER-260; THR-283; SER-285; THR-307; THR-310; SER-313; SER-320; SER-360 AND THR-440, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    3. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258; SER-260; THR-307; SER-313; SER-320 AND THR-440, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-10; SER-258 AND SER-260, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-258; SER-260 AND SER-320, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiF134C_HUMAN
    AccessioniPrimary (citable) accession number: Q86VR2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3