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Protein

Reticulophagy regulator 3

Gene

RETREG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates NRF1-enhanced neurite outgrowth.1 Publication

GO - Biological processi

  • positive regulation of neuron projection development Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulophagy regulator 3
Gene namesi
Name:RETREG3Imported
Synonyms:FAM134C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141699.10.
HGNCiHGNC:27258. RETREG3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000141699.
PharmGKBiPA162386207.

Polymorphism and mutation databases

BioMutaiFAM134C.
DMDMi74727607.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002884692 – 466Reticulophagy regulator 3Add BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei10PhosphothreonineCombined sources1
Modified residuei26PhosphoserineCombined sources1
Modified residuei258PhosphoserineCombined sources1
Modified residuei260PhosphoserineCombined sources1
Modified residuei283PhosphothreonineCombined sources1
Modified residuei285PhosphoserineCombined sources1
Modified residuei288PhosphoserineBy similarity1
Modified residuei293PhosphoserineBy similarity1
Modified residuei303PhosphoserineBy similarity1
Modified residuei307PhosphothreonineCombined sources1
Modified residuei310PhosphothreonineCombined sources1
Modified residuei313PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Modified residuei360PhosphoserineCombined sources1
Modified residuei440PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ86VR2.
MaxQBiQ86VR2.
PaxDbiQ86VR2.
PeptideAtlasiQ86VR2.
PRIDEiQ86VR2.

PTM databases

iPTMnetiQ86VR2.
PhosphoSitePlusiQ86VR2.
SwissPalmiQ86VR2.

Expressioni

Gene expression databases

BgeeiENSG00000141699.
CleanExiHS_FAM134C.
ExpressionAtlasiQ86VR2. baseline and differential.
GenevisibleiQ86VR2. HS.

Organism-specific databases

HPAiHPA016492.

Interactioni

Subunit structurei

Interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi127817. 70 interactors.
DIPiDIP-61578N.
IntActiQ86VR2. 35 interactors.
STRINGi9606.ENSP00000309432.

Structurei

3D structure databases

ProteinModelPortaliQ86VR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi445 – 450LIR motif1 Publication6

Domaini

The LIR motif interacts with ATG8 family proteins.1 Publication

Sequence similaritiesi

Belongs to the RETREG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHB8. Eukaryota.
ENOG4110GB7. LUCA.
GeneTreeiENSGT00530000063240.
HOGENOMiHOG000050246.
HOVERGENiHBG096339.
InParanoidiQ86VR2.
OMAiWPLAVYH.
OrthoDBiEOG091G08S3.
PhylomeDBiQ86VR2.
TreeFamiTF329111.

Family and domain databases

InterProiView protein in InterPro
IPR033361. RETREG3.
PANTHERiPTHR28659:SF1. PTHR28659:SF1. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86VR2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAEGVPTT PGPASGSTFR GRRDVSGSWE RDQQVEAAQR ALVEVLGPYE
60 70 80 90 100
PLLSRVQAAL VWERPARSAL WCLGLNAAFW FFALTSLRLV FLLAFGLMII
110 120 130 140 150
VCIDQWKNKI WPEIKVPRPD ALDNESWGFV HPRLLSVPEL CHHVAEVWVS
160 170 180 190 200
GTIFIRNVLL FKKQNPGKFC LLSCGILTFL AVLGRYVPGL LLSYLMLVTV
210 220 230 240 250
MMWPLAVYHR LWDRAYVRLK PALQRLDFSV RGYMMSKQRE RQLRRRALHP
260 270 280 290 300
ERAMDNHSDS EEELAAFCPQ LDDSTVAREL AITDSEHSDA EVSCTDNGTF
310 320 330 340 350
NLSRGQTPLT EGSEDLDGHS DPEESFARDL PDFPSINMDP AGLDDEDDTS
360 370 380 390 400
IGMPSLMYRS PPGAEEPQAP PASRDEAALP ELLLGALPVG SNLTSNLASL
410 420 430 440 450
VSQGMIQLAL SGASQPGPSG APAQRATRGF LRSPSSDLDT DAEGDDFELL
460
DQSELSQLDP ASSRSH
Length:466
Mass (Da):51,396
Last modified:June 1, 2003 - v1
Checksum:iF9D468353C13A14B
GO
Isoform 2 (identifier: Q86VR2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-195: Missing.

Note: No experimental confirmation available.
Show »
Length:271
Mass (Da):29,582
Checksum:i7361F5A0294F76BC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0569911 – 195Missing in isoform 2. 1 PublicationAdd BLAST195

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091125 mRNA. Translation: BAG52287.1.
AK294791 mRNA. Translation: BAG57914.1.
AC067852 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60851.1.
BC049370 mRNA. Translation: AAH49370.1.
CCDSiCCDS11432.1. [Q86VR2-1]
RefSeqiNP_835227.1. NM_178126.3. [Q86VR2-1]
UniGeneiHs.632262.

Genome annotation databases

EnsembliENST00000309428; ENSP00000309432; ENSG00000141699. [Q86VR2-1]
GeneIDi162427.
KEGGihsa:162427.
UCSCiuc060fkv.1. human. [Q86VR2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRETR3_HUMAN
AccessioniPrimary (citable) accession number: Q86VR2
Secondary accession number(s): B3KR75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families