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Q86VR2

- F134C_HUMAN

UniProt

Q86VR2 - F134C_HUMAN

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Protein
Protein FAM134C
Gene
FAM134C
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM134C
Gene namesi
Name:FAM134C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:27258. FAM134C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei81 – 10121Helical; Reviewed prediction
Add
BLAST
Transmembranei164 – 18421Helical; Reviewed prediction
Add
BLAST
Transmembranei187 – 20721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162386207.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 466465Protein FAM134C
PRO_0000288469Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine3 Publications
Modified residuei10 – 101Phosphothreonine1 Publication
Modified residuei26 – 261Phosphoserine1 Publication
Modified residuei258 – 2581Phosphoserine4 Publications
Modified residuei260 – 2601Phosphoserine4 Publications
Modified residuei283 – 2831Phosphothreonine1 Publication
Modified residuei285 – 2851Phosphoserine1 Publication
Modified residuei288 – 2881Phosphoserine By similarity
Modified residuei303 – 3031Phosphoserine By similarity
Modified residuei307 – 3071Phosphothreonine2 Publications
Modified residuei310 – 3101Phosphothreonine1 Publication
Modified residuei313 – 3131Phosphoserine2 Publications
Modified residuei320 – 3201Phosphoserine3 Publications
Modified residuei360 – 3601Phosphoserine1 Publication
Modified residuei440 – 4401Phosphothreonine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ86VR2.
PaxDbiQ86VR2.
PeptideAtlasiQ86VR2.
PRIDEiQ86VR2.

PTM databases

PhosphoSiteiQ86VR2.

Expressioni

Gene expression databases

ArrayExpressiQ86VR2.
BgeeiQ86VR2.
CleanExiHS_FAM134C.
GenevestigatoriQ86VR2.

Organism-specific databases

HPAiHPA016492.

Interactioni

Protein-protein interaction databases

BioGridi127817. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ86VR2.

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM134 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26663.
HOGENOMiHOG000050246.
HOVERGENiHBG096339.
InParanoidiQ86VR2.
OMAiFCLLSCG.
PhylomeDBiQ86VR2.
TreeFamiTF329111.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86VR2-1 [UniParc]FASTAAdd to Basket

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MAEAEGVPTT PGPASGSTFR GRRDVSGSWE RDQQVEAAQR ALVEVLGPYE    50
PLLSRVQAAL VWERPARSAL WCLGLNAAFW FFALTSLRLV FLLAFGLMII 100
VCIDQWKNKI WPEIKVPRPD ALDNESWGFV HPRLLSVPEL CHHVAEVWVS 150
GTIFIRNVLL FKKQNPGKFC LLSCGILTFL AVLGRYVPGL LLSYLMLVTV 200
MMWPLAVYHR LWDRAYVRLK PALQRLDFSV RGYMMSKQRE RQLRRRALHP 250
ERAMDNHSDS EEELAAFCPQ LDDSTVAREL AITDSEHSDA EVSCTDNGTF 300
NLSRGQTPLT EGSEDLDGHS DPEESFARDL PDFPSINMDP AGLDDEDDTS 350
IGMPSLMYRS PPGAEEPQAP PASRDEAALP ELLLGALPVG SNLTSNLASL 400
VSQGMIQLAL SGASQPGPSG APAQRATRGF LRSPSSDLDT DAEGDDFELL 450
DQSELSQLDP ASSRSH 466
Length:466
Mass (Da):51,396
Last modified:June 1, 2003 - v1
Checksum:iF9D468353C13A14B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC049370 mRNA. Translation: AAH49370.1.
CCDSiCCDS11432.1.
RefSeqiNP_835227.1. NM_178126.3.
UniGeneiHs.632262.

Genome annotation databases

EnsembliENST00000309428; ENSP00000309432; ENSG00000141699.
GeneIDi162427.
KEGGihsa:162427.
UCSCiuc002ial.2. human.

Polymorphism databases

DMDMi74727607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC049370 mRNA. Translation: AAH49370.1 .
CCDSi CCDS11432.1.
RefSeqi NP_835227.1. NM_178126.3.
UniGenei Hs.632262.

3D structure databases

ProteinModelPortali Q86VR2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127817. 3 interactions.

PTM databases

PhosphoSitei Q86VR2.

Polymorphism databases

DMDMi 74727607.

Proteomic databases

MaxQBi Q86VR2.
PaxDbi Q86VR2.
PeptideAtlasi Q86VR2.
PRIDEi Q86VR2.

Protocols and materials databases

DNASUi 162427.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309428 ; ENSP00000309432 ; ENSG00000141699 .
GeneIDi 162427.
KEGGi hsa:162427.
UCSCi uc002ial.2. human.

Organism-specific databases

CTDi 162427.
GeneCardsi GC17M040731.
H-InvDB HIX0020377.
HGNCi HGNC:27258. FAM134C.
HPAi HPA016492.
neXtProti NX_Q86VR2.
PharmGKBi PA162386207.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG26663.
HOGENOMi HOG000050246.
HOVERGENi HBG096339.
InParanoidi Q86VR2.
OMAi FCLLSCG.
PhylomeDBi Q86VR2.
TreeFami TF329111.

Miscellaneous databases

ChiTaRSi FAM134C. human.
GeneWikii FAM134C.
GenomeRNAii 162427.
NextBioi 88169.
PROi Q86VR2.

Gene expression databases

ArrayExpressi Q86VR2.
Bgeei Q86VR2.
CleanExi HS_FAM134C.
Genevestigatori Q86VR2.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258; SER-260; THR-283; SER-285; THR-307; THR-310; SER-313; SER-320; SER-360 AND THR-440, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  3. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258; SER-260; THR-307; SER-313; SER-320 AND THR-440, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-10; SER-258 AND SER-260, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-258; SER-260 AND SER-320, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiF134C_HUMAN
AccessioniPrimary (citable) accession number: Q86VR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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