SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q86VQ3

- TXND2_HUMAN

UniProt

Q86VQ3 - TXND2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Thioredoxin domain-containing protein 2

Gene
TXNDC2, SPTRX, SPTRX1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.

GO - Molecular functioni

  1. nutrient reservoir activity Source: InterPro
  2. protein disulfide isomerase activity Source: Ensembl
  3. protein disulfide oxidoreductase activity Source: InterPro
  4. thioredoxin-disulfide reductase activity Source: UniProtKB

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. cell redox homeostasis Source: UniProtKB
  3. glycerol ether metabolic process Source: InterPro
  4. multicellular organismal development Source: UniProtKB-KW
  5. oxidation-reduction process Source: GOC
  6. spermatogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 2
Alternative name(s):
Spermatid-specific thioredoxin-1
Short name:
Sptrx-1
Gene namesi
Name:TXNDC2
Synonyms:SPTRX, SPTRX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:16470. TXNDC2.

Subcellular locationi

Cytoplasm
Note: In ejaculated spermatozoa, it localizes in the caudal region of the head to the end of the principal piece.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. motile cilium Source: Ensembl
  3. nucleolus Source: HPA
  4. nucleus Source: HPA
  5. outer dense fiber Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38147.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Thioredoxin domain-containing protein 2PRO_0000120153Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi480 ↔ 483Redox-active By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ86VQ3.
PRIDEiQ86VQ3.

PTM databases

PhosphoSiteiQ86VQ3.

Expressioni

Tissue specificityi

Testis-specific. Only expressed during spermiogenesis, prominently in round and elongating spermatids.1 Publication

Gene expression databases

ArrayExpressiQ86VQ3.
BgeeiQ86VQ3.
CleanExiHS_TXNDC2.
GenevestigatoriQ86VQ3.

Organism-specific databases

HPAiCAB016414.
HPA018817.

Interactioni

Protein-protein interaction databases

BioGridi123944. 2 interactions.
IntActiQ86VQ3. 1 interaction.
MINTiMINT-3057977.
STRINGi9606.ENSP00000304908.

Structurei

3D structure databases

ProteinModelPortaliQ86VQ3.
SMRiQ86VQ3. Positions 450-552.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati113 – 127151Add
BLAST
Repeati128 – 142152Add
BLAST
Repeati143 – 157153Add
BLAST
Repeati158 – 172154Add
BLAST
Repeati173 – 187155Add
BLAST
Repeati188 – 202156Add
BLAST
Repeati203 – 217157Add
BLAST
Repeati218 – 232158Add
BLAST
Repeati233 – 247159Add
BLAST
Repeati248 – 2621510Add
BLAST
Repeati263 – 2771511Add
BLAST
Repeati278 – 2921512Add
BLAST
Repeati293 – 3071513Add
BLAST
Repeati308 – 3221514Add
BLAST
Repeati323 – 3371515Add
BLAST
Repeati338 – 3521516Add
BLAST
Repeati353 – 3671517Add
BLAST
Repeati368 – 3821518Add
BLAST
Repeati383 – 3971519Add
BLAST
Repeati398 – 4121520Add
BLAST
Repeati413 – 4271521Add
BLAST
Repeati428 – 4421522Add
BLAST
Domaini429 – 553125ThioredoxinAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni113 – 44233022 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-IAdd
BLAST

Sequence similaritiesi

Contains 1 thioredoxin domain.

Keywords - Domaini

Redox-active center, Repeat

Phylogenomic databases

eggNOGiCOG0526.
HOGENOMiHOG000154719.
HOVERGENiHBG087115.
InParanoidiQ86VQ3.
OMAiKTIPPKQ.
OrthoDBiEOG7H4DX9.
PhylomeDBiQ86VQ3.
TreeFamiTF106377.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR001419. Glutenin.
IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF03157. Glutenin_hmw. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86VQ3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDVDKELGME SVKAGASGKP EMRLGTQEET SEGDANESSL LVLSSNVPLL    50
ALEFLEIAQA KEKAFLPMVS HTFHMRTEES DASQEGDDLP KSSANTSHPK 100
QDDSPKSSEE TIQPKEGDIP KAPEETIQSK KEDLPKSSEK AIQPKESNIP 150
KSSAKPIQPK LGNIPKASVK PSQPKEGDIP KAPEETIQSK KEDLPKSSEE 200
AIQPKEGDIP KSSAKPIQPK LGNIAKTSVK PSQPKESDIP KSPEETIQPK 250
EGDIPKSSAK PIQPKLGNIP KASVKPSQPK EGDISKSPEE AIQPKEGDLP 300
KSLEEAIQPK EGDIPKSPEE AIQPKEGDIP KSLEEAIQPK EGDIPKSPEE 350
TIQPKKGDIP KSPEEAIQPK EGDIPKSPKQ AIQPKEGDIP KSLEEAIPPK 400
EIDIPKSPEE TIQPKEDDSP KSLEEATPSK EGDILKPEEE TMEFPEGDKV 450
KVILSKEDFE ASLKEAGERL VAVDFSATWC GPCRTIRPFF HALSVKHEDV 500
VFLEVDADNC EEVVRECAIM CVPTFQFYKK EEKVDELCGA LKEKLEAVIA 550
ELK 553
Length:553
Mass (Da):60,404
Last modified:November 30, 2010 - v4
Checksum:i74EE3210BA5EBCF1
GO
Isoform 2 (identifier: Q86VQ3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.

Show »
Length:486
Mass (Da):53,271
Checksum:iC9C7056E2E8D4BAF
GO
Isoform 3 (identifier: Q86VQ3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     304-318: Missing.

Show »
Length:538
Mass (Da):58,784
Checksum:i2A675984F81D0834
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti225 – 2251A → P.
Corresponds to variant rs11662946 [ dbSNP | Ensembl ].
VAR_057351
Natural varianti314 – 3141I → L.
Corresponds to variant rs2240909 [ dbSNP | Ensembl ].
VAR_057352
Natural varianti341 – 3411E → K.3 Publications
Corresponds to variant rs11081510 [ dbSNP | Ensembl ].
VAR_022762
Natural varianti357 – 3571G → D.2 Publications
Corresponds to variant rs2240906 [ dbSNP | Ensembl ].
VAR_022763
Natural varianti461 – 4611A → T.1 Publication
Corresponds to variant rs17732496 [ dbSNP | Ensembl ].
VAR_022764
Natural varianti487 – 4871R → T.1 Publication
Corresponds to variant rs17805544 [ dbSNP | Ensembl ].
VAR_022765

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6767Missing in isoform 2. VSP_014328Add
BLAST
Alternative sequencei304 – 31815Missing in isoform 3. VSP_053684Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF080095 mRNA. Translation: AAK94950.1.
EF560747 mRNA. Translation: ABQ59057.1.
AK097656 mRNA. Translation: BAC05133.1.
AC006238 Genomic DNA. No translation available.
BC050132 mRNA. Translation: AAH50132.1.
AL136742 mRNA. Translation: CAB66676.2.
CCDSiCCDS11846.1. [Q86VQ3-2]
CCDS42414.1. [Q86VQ3-1]
RefSeqiNP_001091999.1. NM_001098529.1. [Q86VQ3-1]
NP_115619.4. NM_032243.5. [Q86VQ3-2]
UniGeneiHs.98712.

Genome annotation databases

EnsembliENST00000306084; ENSP00000304908; ENSG00000168454. [Q86VQ3-1]
ENST00000357775; ENSP00000350419; ENSG00000168454. [Q86VQ3-2]
GeneIDi84203.
KEGGihsa:84203.
UCSCiuc002koh.4. human. [Q86VQ3-1]

Polymorphism databases

DMDMi313104290.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF080095 mRNA. Translation: AAK94950.1 .
EF560747 mRNA. Translation: ABQ59057.1 .
AK097656 mRNA. Translation: BAC05133.1 .
AC006238 Genomic DNA. No translation available.
BC050132 mRNA. Translation: AAH50132.1 .
AL136742 mRNA. Translation: CAB66676.2 .
CCDSi CCDS11846.1. [Q86VQ3-2 ]
CCDS42414.1. [Q86VQ3-1 ]
RefSeqi NP_001091999.1. NM_001098529.1. [Q86VQ3-1 ]
NP_115619.4. NM_032243.5. [Q86VQ3-2 ]
UniGenei Hs.98712.

3D structure databases

ProteinModelPortali Q86VQ3.
SMRi Q86VQ3. Positions 450-552.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123944. 2 interactions.
IntActi Q86VQ3. 1 interaction.
MINTi MINT-3057977.
STRINGi 9606.ENSP00000304908.

PTM databases

PhosphoSitei Q86VQ3.

Polymorphism databases

DMDMi 313104290.

Proteomic databases

PaxDbi Q86VQ3.
PRIDEi Q86VQ3.

Protocols and materials databases

DNASUi 84203.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306084 ; ENSP00000304908 ; ENSG00000168454 . [Q86VQ3-1 ]
ENST00000357775 ; ENSP00000350419 ; ENSG00000168454 . [Q86VQ3-2 ]
GeneIDi 84203.
KEGGi hsa:84203.
UCSCi uc002koh.4. human. [Q86VQ3-1 ]

Organism-specific databases

CTDi 84203.
GeneCardsi GC18P009875.
HGNCi HGNC:16470. TXNDC2.
HPAi CAB016414.
HPA018817.
neXtProti NX_Q86VQ3.
PharmGKBi PA38147.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0526.
HOGENOMi HOG000154719.
HOVERGENi HBG087115.
InParanoidi Q86VQ3.
OMAi KTIPPKQ.
OrthoDBi EOG7H4DX9.
PhylomeDBi Q86VQ3.
TreeFami TF106377.

Miscellaneous databases

GeneWikii TXNDC2.
GenomeRNAii 84203.
NextBioi 35462341.
PROi Q86VQ3.

Gene expression databases

ArrayExpressi Q86VQ3.
Bgeei Q86VQ3.
CleanExi HS_TXNDC2.
Genevestigatori Q86VQ3.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR001419. Glutenin.
IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view ]
PANTHERi PTHR10438. PTHR10438. 1 hit.
Pfami PF03157. Glutenin_hmw. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of Sptrx, a novel member of the thioredoxin family specifically expressed in human spermatozoa."
    Miranda-Vizuete A., Ljung J., Damdimopoulos A.E., Gustafsson J.-A., Oko R., Pelto-Huikko M., Spyrou G.
    J. Biol. Chem. 276:31567-31574(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ENZYME ACTIVITY IN VITRO.
  2. Schupp I.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT LYS-341.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS LYS-341; ASP-357 AND THR-487.
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS LYS-341 AND ASP-357.
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 393-553, VARIANT THR-461.
    Tissue: Testis.
  7. "Human spermatid-specific thioredoxin-1 (Sptrx-1) is a two-domain protein with oxidizing activity."
    Jimenez A., Johansson C., Ljung J., Sagemark J., Berndt K.D., Ren B., Tibbelin G., Ladenstein R., Kieselbach T., Holmgren A., Gustafsson J.-A., Miranda-Vizuete A.
    FEBS Lett. 530:79-84(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME ACTIVITY IN VITRO.

Entry informationi

Entry nameiTXND2_HUMAN
AccessioniPrimary (citable) accession number: Q86VQ3
Secondary accession number(s): A5YM73
, Q8N7U4, Q96RX3, Q9H0L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 111 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi