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Q86VQ3

- TXND2_HUMAN

UniProt

Q86VQ3 - TXND2_HUMAN

Protein

Thioredoxin domain-containing protein 2

Gene

TXNDC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 4 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.

    GO - Molecular functioni

    1. nutrient reservoir activity Source: InterPro
    2. protein disulfide isomerase activity Source: Ensembl
    3. protein disulfide oxidoreductase activity Source: InterPro
    4. thioredoxin-disulfide reductase activity Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. cell redox homeostasis Source: UniProtKB
    3. glycerol ether metabolic process Source: InterPro
    4. multicellular organismal development Source: UniProtKB-KW
    5. oxidation-reduction process Source: GOC
    6. spermatogenesis Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thioredoxin domain-containing protein 2
    Alternative name(s):
    Spermatid-specific thioredoxin-1
    Short name:
    Sptrx-1
    Gene namesi
    Name:TXNDC2
    Synonyms:SPTRX, SPTRX1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:16470. TXNDC2.

    Subcellular locationi

    Cytoplasm 1 Publication
    Note: In ejaculated spermatozoa, it localizes in the caudal region of the head to the end of the principal piece.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. motile cilium Source: Ensembl
    3. nucleolus Source: HPA
    4. nucleus Source: HPA
    5. outer dense fiber Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38147.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 553553Thioredoxin domain-containing protein 2PRO_0000120153Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi480 ↔ 483Redox-activePROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ86VQ3.
    PRIDEiQ86VQ3.

    PTM databases

    PhosphoSiteiQ86VQ3.

    Expressioni

    Tissue specificityi

    Testis-specific. Only expressed during spermiogenesis, prominently in round and elongating spermatids.1 Publication

    Gene expression databases

    ArrayExpressiQ86VQ3.
    BgeeiQ86VQ3.
    CleanExiHS_TXNDC2.
    GenevestigatoriQ86VQ3.

    Organism-specific databases

    HPAiCAB016414.
    HPA018817.

    Interactioni

    Protein-protein interaction databases

    BioGridi123944. 2 interactions.
    IntActiQ86VQ3. 1 interaction.
    MINTiMINT-3057977.
    STRINGi9606.ENSP00000304908.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86VQ3.
    SMRiQ86VQ3. Positions 450-552.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati113 – 127151Add
    BLAST
    Repeati128 – 142152Add
    BLAST
    Repeati143 – 157153Add
    BLAST
    Repeati158 – 172154Add
    BLAST
    Repeati173 – 187155Add
    BLAST
    Repeati188 – 202156Add
    BLAST
    Repeati203 – 217157Add
    BLAST
    Repeati218 – 232158Add
    BLAST
    Repeati233 – 247159Add
    BLAST
    Repeati248 – 2621510Add
    BLAST
    Repeati263 – 2771511Add
    BLAST
    Repeati278 – 2921512Add
    BLAST
    Repeati293 – 3071513Add
    BLAST
    Repeati308 – 3221514Add
    BLAST
    Repeati323 – 3371515Add
    BLAST
    Repeati338 – 3521516Add
    BLAST
    Repeati353 – 3671517Add
    BLAST
    Repeati368 – 3821518Add
    BLAST
    Repeati383 – 3971519Add
    BLAST
    Repeati398 – 4121520Add
    BLAST
    Repeati413 – 4271521Add
    BLAST
    Repeati428 – 4421522Add
    BLAST
    Domaini429 – 553125ThioredoxinPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni113 – 44233022 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-IAdd
    BLAST

    Sequence similaritiesi

    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Repeat

    Phylogenomic databases

    eggNOGiCOG0526.
    HOGENOMiHOG000154719.
    HOVERGENiHBG087115.
    InParanoidiQ86VQ3.
    OMAiKTIPPKQ.
    OrthoDBiEOG7H4DX9.
    PhylomeDBiQ86VQ3.
    TreeFamiTF106377.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR001419. Glutenin.
    IPR005746. Thioredoxin.
    IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PANTHERiPTHR10438. PTHR10438. 1 hit.
    PfamiPF03157. Glutenin_hmw. 1 hit.
    PF00085. Thioredoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86VQ3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDVDKELGME SVKAGASGKP EMRLGTQEET SEGDANESSL LVLSSNVPLL    50
    ALEFLEIAQA KEKAFLPMVS HTFHMRTEES DASQEGDDLP KSSANTSHPK 100
    QDDSPKSSEE TIQPKEGDIP KAPEETIQSK KEDLPKSSEK AIQPKESNIP 150
    KSSAKPIQPK LGNIPKASVK PSQPKEGDIP KAPEETIQSK KEDLPKSSEE 200
    AIQPKEGDIP KSSAKPIQPK LGNIAKTSVK PSQPKESDIP KSPEETIQPK 250
    EGDIPKSSAK PIQPKLGNIP KASVKPSQPK EGDISKSPEE AIQPKEGDLP 300
    KSLEEAIQPK EGDIPKSPEE AIQPKEGDIP KSLEEAIQPK EGDIPKSPEE 350
    TIQPKKGDIP KSPEEAIQPK EGDIPKSPKQ AIQPKEGDIP KSLEEAIPPK 400
    EIDIPKSPEE TIQPKEDDSP KSLEEATPSK EGDILKPEEE TMEFPEGDKV 450
    KVILSKEDFE ASLKEAGERL VAVDFSATWC GPCRTIRPFF HALSVKHEDV 500
    VFLEVDADNC EEVVRECAIM CVPTFQFYKK EEKVDELCGA LKEKLEAVIA 550
    ELK 553
    Length:553
    Mass (Da):60,404
    Last modified:November 30, 2010 - v4
    Checksum:i74EE3210BA5EBCF1
    GO
    Isoform 2 (identifier: Q86VQ3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-67: Missing.

    Show »
    Length:486
    Mass (Da):53,271
    Checksum:iC9C7056E2E8D4BAF
    GO
    Isoform 3 (identifier: Q86VQ3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         304-318: Missing.

    Show »
    Length:538
    Mass (Da):58,784
    Checksum:i2A675984F81D0834
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti225 – 2251A → P.
    Corresponds to variant rs11662946 [ dbSNP | Ensembl ].
    VAR_057351
    Natural varianti314 – 3141I → L.
    Corresponds to variant rs2240909 [ dbSNP | Ensembl ].
    VAR_057352
    Natural varianti341 – 3411E → K.3 Publications
    Corresponds to variant rs11081510 [ dbSNP | Ensembl ].
    VAR_022762
    Natural varianti357 – 3571G → D.2 Publications
    Corresponds to variant rs2240906 [ dbSNP | Ensembl ].
    VAR_022763
    Natural varianti461 – 4611A → T.1 Publication
    Corresponds to variant rs17732496 [ dbSNP | Ensembl ].
    VAR_022764
    Natural varianti487 – 4871R → T.1 Publication
    Corresponds to variant rs17805544 [ dbSNP | Ensembl ].
    VAR_022765

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6767Missing in isoform 2. 2 PublicationsVSP_014328Add
    BLAST
    Alternative sequencei304 – 31815Missing in isoform 3. 1 PublicationVSP_053684Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF080095 mRNA. Translation: AAK94950.1.
    EF560747 mRNA. Translation: ABQ59057.1.
    AK097656 mRNA. Translation: BAC05133.1.
    AC006238 Genomic DNA. No translation available.
    BC050132 mRNA. Translation: AAH50132.1.
    AL136742 mRNA. Translation: CAB66676.2.
    CCDSiCCDS11846.1. [Q86VQ3-2]
    CCDS42414.1. [Q86VQ3-1]
    RefSeqiNP_001091999.1. NM_001098529.1. [Q86VQ3-1]
    NP_115619.4. NM_032243.5. [Q86VQ3-2]
    UniGeneiHs.98712.

    Genome annotation databases

    EnsembliENST00000306084; ENSP00000304908; ENSG00000168454. [Q86VQ3-1]
    ENST00000357775; ENSP00000350419; ENSG00000168454. [Q86VQ3-2]
    GeneIDi84203.
    KEGGihsa:84203.
    UCSCiuc002koh.4. human. [Q86VQ3-1]

    Polymorphism databases

    DMDMi313104290.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF080095 mRNA. Translation: AAK94950.1 .
    EF560747 mRNA. Translation: ABQ59057.1 .
    AK097656 mRNA. Translation: BAC05133.1 .
    AC006238 Genomic DNA. No translation available.
    BC050132 mRNA. Translation: AAH50132.1 .
    AL136742 mRNA. Translation: CAB66676.2 .
    CCDSi CCDS11846.1. [Q86VQ3-2 ]
    CCDS42414.1. [Q86VQ3-1 ]
    RefSeqi NP_001091999.1. NM_001098529.1. [Q86VQ3-1 ]
    NP_115619.4. NM_032243.5. [Q86VQ3-2 ]
    UniGenei Hs.98712.

    3D structure databases

    ProteinModelPortali Q86VQ3.
    SMRi Q86VQ3. Positions 450-552.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123944. 2 interactions.
    IntActi Q86VQ3. 1 interaction.
    MINTi MINT-3057977.
    STRINGi 9606.ENSP00000304908.

    PTM databases

    PhosphoSitei Q86VQ3.

    Polymorphism databases

    DMDMi 313104290.

    Proteomic databases

    PaxDbi Q86VQ3.
    PRIDEi Q86VQ3.

    Protocols and materials databases

    DNASUi 84203.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306084 ; ENSP00000304908 ; ENSG00000168454 . [Q86VQ3-1 ]
    ENST00000357775 ; ENSP00000350419 ; ENSG00000168454 . [Q86VQ3-2 ]
    GeneIDi 84203.
    KEGGi hsa:84203.
    UCSCi uc002koh.4. human. [Q86VQ3-1 ]

    Organism-specific databases

    CTDi 84203.
    GeneCardsi GC18P009875.
    HGNCi HGNC:16470. TXNDC2.
    HPAi CAB016414.
    HPA018817.
    neXtProti NX_Q86VQ3.
    PharmGKBi PA38147.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0526.
    HOGENOMi HOG000154719.
    HOVERGENi HBG087115.
    InParanoidi Q86VQ3.
    OMAi KTIPPKQ.
    OrthoDBi EOG7H4DX9.
    PhylomeDBi Q86VQ3.
    TreeFami TF106377.

    Miscellaneous databases

    GeneWikii TXNDC2.
    GenomeRNAii 84203.
    NextBioi 35462341.
    PROi Q86VQ3.

    Gene expression databases

    ArrayExpressi Q86VQ3.
    Bgeei Q86VQ3.
    CleanExi HS_TXNDC2.
    Genevestigatori Q86VQ3.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR001419. Glutenin.
    IPR005746. Thioredoxin.
    IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    PANTHERi PTHR10438. PTHR10438. 1 hit.
    Pfami PF03157. Glutenin_hmw. 1 hit.
    PF00085. Thioredoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of Sptrx, a novel member of the thioredoxin family specifically expressed in human spermatozoa."
      Miranda-Vizuete A., Ljung J., Damdimopoulos A.E., Gustafsson J.-A., Oko R., Pelto-Huikko M., Spyrou G.
      J. Biol. Chem. 276:31567-31574(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ENZYME ACTIVITY IN VITRO.
    2. Schupp I.
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT LYS-341.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS LYS-341; ASP-357 AND THR-487.
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS LYS-341 AND ASP-357.
      Tissue: Brain.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 393-553, VARIANT THR-461.
      Tissue: Testis.
    7. "Human spermatid-specific thioredoxin-1 (Sptrx-1) is a two-domain protein with oxidizing activity."
      Jimenez A., Johansson C., Ljung J., Sagemark J., Berndt K.D., Ren B., Tibbelin G., Ladenstein R., Kieselbach T., Holmgren A., Gustafsson J.-A., Miranda-Vizuete A.
      FEBS Lett. 530:79-84(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME ACTIVITY IN VITRO.

    Entry informationi

    Entry nameiTXND2_HUMAN
    AccessioniPrimary (citable) accession number: Q86VQ3
    Secondary accession number(s): A5YM73
    , Q8N7U4, Q96RX3, Q9H0L8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 112 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3