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Protein

Thioredoxin domain-containing protein 2

Gene

TXNDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 2
Alternative name(s):
Spermatid-specific thioredoxin-1
Short name:
Sptrx-1
Gene namesi
Name:TXNDC2
Synonyms:SPTRX, SPTRX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:16470. TXNDC2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • mitochondrion Source: GO_Central
  • nucleolus Source: HPA
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168454.
PharmGKBiPA38147.

Polymorphism and mutation databases

BioMutaiTXNDC2.
DMDMi313104290.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001201531 – 553Thioredoxin domain-containing protein 2Add BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei362PhosphoserineBy similarity1
Modified residuei392PhosphoserineBy similarity1
Disulfide bondi480 ↔ 483Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ86VQ3.
PaxDbiQ86VQ3.
PeptideAtlasiQ86VQ3.
PRIDEiQ86VQ3.

PTM databases

iPTMnetiQ86VQ3.
PhosphoSitePlusiQ86VQ3.

Expressioni

Tissue specificityi

Testis-specific. Only expressed during spermiogenesis, prominently in round and elongating spermatids.1 Publication

Gene expression databases

BgeeiENSG00000168454.
CleanExiHS_TXNDC2.
ExpressionAtlasiQ86VQ3. baseline and differential.
GenevisibleiQ86VQ3. HS.

Organism-specific databases

HPAiCAB016414.
HPA018817.

Interactioni

Protein-protein interaction databases

BioGridi123944. 2 interactors.
IntActiQ86VQ3. 2 interactors.
MINTiMINT-3057977.
STRINGi9606.ENSP00000304908.

Structurei

3D structure databases

ProteinModelPortaliQ86VQ3.
SMRiQ86VQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati113 – 1271Add BLAST15
Repeati128 – 1422Add BLAST15
Repeati143 – 1573Add BLAST15
Repeati158 – 1724Add BLAST15
Repeati173 – 1875Add BLAST15
Repeati188 – 2026Add BLAST15
Repeati203 – 2177Add BLAST15
Repeati218 – 2328Add BLAST15
Repeati233 – 2479Add BLAST15
Repeati248 – 26210Add BLAST15
Repeati263 – 27711Add BLAST15
Repeati278 – 29212Add BLAST15
Repeati293 – 30713Add BLAST15
Repeati308 – 32214Add BLAST15
Repeati323 – 33715Add BLAST15
Repeati338 – 35216Add BLAST15
Repeati353 – 36717Add BLAST15
Repeati368 – 38218Add BLAST15
Repeati383 – 39719Add BLAST15
Repeati398 – 41220Add BLAST15
Repeati413 – 42721Add BLAST15
Repeati428 – 44222Add BLAST15
Domaini429 – 553ThioredoxinPROSITE-ProRule annotationAdd BLAST125

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 44222 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-IAdd BLAST330

Sequence similaritiesi

Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Repeat

Phylogenomic databases

eggNOGiKOG0907. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00530000063008.
HOGENOMiHOG000154719.
HOVERGENiHBG087115.
InParanoidiQ86VQ3.
OMAiIEEAMHV.
OrthoDBiEOG091G01FG.
PhylomeDBiQ86VQ3.
TreeFamiTF106377.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86VQ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDVDKELGME SVKAGASGKP EMRLGTQEET SEGDANESSL LVLSSNVPLL
60 70 80 90 100
ALEFLEIAQA KEKAFLPMVS HTFHMRTEES DASQEGDDLP KSSANTSHPK
110 120 130 140 150
QDDSPKSSEE TIQPKEGDIP KAPEETIQSK KEDLPKSSEK AIQPKESNIP
160 170 180 190 200
KSSAKPIQPK LGNIPKASVK PSQPKEGDIP KAPEETIQSK KEDLPKSSEE
210 220 230 240 250
AIQPKEGDIP KSSAKPIQPK LGNIAKTSVK PSQPKESDIP KSPEETIQPK
260 270 280 290 300
EGDIPKSSAK PIQPKLGNIP KASVKPSQPK EGDISKSPEE AIQPKEGDLP
310 320 330 340 350
KSLEEAIQPK EGDIPKSPEE AIQPKEGDIP KSLEEAIQPK EGDIPKSPEE
360 370 380 390 400
TIQPKKGDIP KSPEEAIQPK EGDIPKSPKQ AIQPKEGDIP KSLEEAIPPK
410 420 430 440 450
EIDIPKSPEE TIQPKEDDSP KSLEEATPSK EGDILKPEEE TMEFPEGDKV
460 470 480 490 500
KVILSKEDFE ASLKEAGERL VAVDFSATWC GPCRTIRPFF HALSVKHEDV
510 520 530 540 550
VFLEVDADNC EEVVRECAIM CVPTFQFYKK EEKVDELCGA LKEKLEAVIA

ELK
Length:553
Mass (Da):60,404
Last modified:November 30, 2010 - v4
Checksum:i74EE3210BA5EBCF1
GO
Isoform 2 (identifier: Q86VQ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.

Show »
Length:486
Mass (Da):53,271
Checksum:iC9C7056E2E8D4BAF
GO
Isoform 3 (identifier: Q86VQ3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     304-318: Missing.

Show »
Length:538
Mass (Da):58,784
Checksum:i2A675984F81D0834
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057351225A → P.Corresponds to variant rs11662946dbSNPEnsembl.1
Natural variantiVAR_057352314I → L.Corresponds to variant rs2240909dbSNPEnsembl.1
Natural variantiVAR_022762341E → K.3 PublicationsCorresponds to variant rs11081510dbSNPEnsembl.1
Natural variantiVAR_022763357G → D.2 PublicationsCorresponds to variant rs2240906dbSNPEnsembl.1
Natural variantiVAR_022764461A → T.1 PublicationCorresponds to variant rs17732496dbSNPEnsembl.1
Natural variantiVAR_022765487R → T.1 PublicationCorresponds to variant rs17805544dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0143281 – 67Missing in isoform 2. 2 PublicationsAdd BLAST67
Alternative sequenceiVSP_053684304 – 318Missing in isoform 3. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080095 mRNA. Translation: AAK94950.1.
EF560747 mRNA. Translation: ABQ59057.1.
AK097656 mRNA. Translation: BAC05133.1.
AC006238 Genomic DNA. No translation available.
BC050132 mRNA. Translation: AAH50132.1.
AL136742 mRNA. Translation: CAB66676.2.
CCDSiCCDS11846.1. [Q86VQ3-2]
CCDS42414.1. [Q86VQ3-1]
RefSeqiNP_001091999.1. NM_001098529.1. [Q86VQ3-1]
NP_115619.4. NM_032243.5. [Q86VQ3-2]
XP_016881530.1. XM_017026041.1. [Q86VQ3-2]
UniGeneiHs.98712.

Genome annotation databases

EnsembliENST00000306084; ENSP00000304908; ENSG00000168454. [Q86VQ3-1]
ENST00000357775; ENSP00000350419; ENSG00000168454. [Q86VQ3-2]
ENST00000611534; ENSP00000483261; ENSG00000168454. [Q86VQ3-3]
GeneIDi84203.
KEGGihsa:84203.
UCSCiuc002koh.5. human. [Q86VQ3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080095 mRNA. Translation: AAK94950.1.
EF560747 mRNA. Translation: ABQ59057.1.
AK097656 mRNA. Translation: BAC05133.1.
AC006238 Genomic DNA. No translation available.
BC050132 mRNA. Translation: AAH50132.1.
AL136742 mRNA. Translation: CAB66676.2.
CCDSiCCDS11846.1. [Q86VQ3-2]
CCDS42414.1. [Q86VQ3-1]
RefSeqiNP_001091999.1. NM_001098529.1. [Q86VQ3-1]
NP_115619.4. NM_032243.5. [Q86VQ3-2]
XP_016881530.1. XM_017026041.1. [Q86VQ3-2]
UniGeneiHs.98712.

3D structure databases

ProteinModelPortaliQ86VQ3.
SMRiQ86VQ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123944. 2 interactors.
IntActiQ86VQ3. 2 interactors.
MINTiMINT-3057977.
STRINGi9606.ENSP00000304908.

PTM databases

iPTMnetiQ86VQ3.
PhosphoSitePlusiQ86VQ3.

Polymorphism and mutation databases

BioMutaiTXNDC2.
DMDMi313104290.

Proteomic databases

MaxQBiQ86VQ3.
PaxDbiQ86VQ3.
PeptideAtlasiQ86VQ3.
PRIDEiQ86VQ3.

Protocols and materials databases

DNASUi84203.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306084; ENSP00000304908; ENSG00000168454. [Q86VQ3-1]
ENST00000357775; ENSP00000350419; ENSG00000168454. [Q86VQ3-2]
ENST00000611534; ENSP00000483261; ENSG00000168454. [Q86VQ3-3]
GeneIDi84203.
KEGGihsa:84203.
UCSCiuc002koh.5. human. [Q86VQ3-1]

Organism-specific databases

CTDi84203.
GeneCardsiTXNDC2.
HGNCiHGNC:16470. TXNDC2.
HPAiCAB016414.
HPA018817.
neXtProtiNX_Q86VQ3.
OpenTargetsiENSG00000168454.
PharmGKBiPA38147.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0907. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00530000063008.
HOGENOMiHOG000154719.
HOVERGENiHBG087115.
InParanoidiQ86VQ3.
OMAiIEEAMHV.
OrthoDBiEOG091G01FG.
PhylomeDBiQ86VQ3.
TreeFamiTF106377.

Miscellaneous databases

GeneWikiiTXNDC2.
GenomeRNAii84203.
PROiQ86VQ3.

Gene expression databases

BgeeiENSG00000168454.
CleanExiHS_TXNDC2.
ExpressionAtlasiQ86VQ3. baseline and differential.
GenevisibleiQ86VQ3. HS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTXND2_HUMAN
AccessioniPrimary (citable) accession number: Q86VQ3
Secondary accession number(s): A5YM73
, Q8N7U4, Q96RX3, Q9H0L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 132 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.