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Protein

Glucocorticoid-induced transcript 1 protein

Gene

GLCCI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Glucocorticoid-induced transcript 1 protein
Gene namesi
Name:GLCCI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:18713. GLCCI1.

Pathology & Biotechi

Organism-specific databases

MalaCardsiGLCCI1.
MIMi614400. phenotype.
PharmGKBiPA38657.

Polymorphism and mutation databases

BioMutaiGLCCI1.
DMDMi74727602.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 547547Glucocorticoid-induced transcript 1 proteinPRO_0000256128Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei105 – 1051PhosphoserineCombined sources
Modified residuei107 – 1071PhosphoserineBy similarity
Modified residuei108 – 1081PhosphoserineCombined sources
Modified residuei110 – 1101PhosphothreonineBy similarity
Modified residuei172 – 1721PhosphoserineCombined sources
Modified residuei175 – 1751PhosphothreonineCombined sources
Modified residuei177 – 1771PhosphothreonineCombined sources
Modified residuei223 – 2231PhosphoserineCombined sources
Modified residuei258 – 2581PhosphoserineCombined sources
Modified residuei266 – 2661PhosphothreonineCombined sources
Modified residuei303 – 3031PhosphoserineCombined sources
Modified residuei345 – 3451PhosphoserineCombined sources
Modified residuei350 – 3501PhosphothreonineBy similarity
Modified residuei394 – 3941PhosphoserineBy similarity
Modified residuei398 – 3981PhosphoserineCombined sources
Modified residuei412 – 4121PhosphoserineBy similarity
Modified residuei480 – 4801PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86VQ1.
MaxQBiQ86VQ1.
PaxDbiQ86VQ1.
PRIDEiQ86VQ1.

PTM databases

iPTMnetiQ86VQ1.
PhosphoSiteiQ86VQ1.

Expressioni

Tissue specificityi

Predominantly expressed in lung, spleen, thymus and testis and, at lower levels, in brain, bone marrow, peripheral leukocytes, skin and trachea.2 Publications

Gene expression databases

BgeeiQ86VQ1.
CleanExiHS_GLCCI1.
ExpressionAtlasiQ86VQ1. baseline and differential.
GenevisibleiQ86VQ1. HS.

Organism-specific databases

HPAiHPA001674.
HPA005987.

Interactioni

Protein-protein interaction databases

BioGridi125239. 8 interactions.
IntActiQ86VQ1. 5 interactions.
STRINGi9606.ENSP00000223145.

Structurei

3D structure databases

ProteinModelPortaliQ86VQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili225 – 25430Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 139Poly-Ser
Compositional biasi38 – 5013Poly-GlyAdd
BLAST
Compositional biasi86 – 905Poly-Ala
Compositional biasi113 – 1186Poly-Ala
Compositional biasi525 – 5284Poly-Gln

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEAU. Eukaryota.
ENOG4111PY2. LUCA.
GeneTreeiENSGT00390000005655.
HOGENOMiHOG000252927.
HOVERGENiHBG079782.
InParanoidiQ86VQ1.
OMAiDRPKSQQ.
OrthoDBiEOG74XS6S.
PhylomeDBiQ86VQ1.
TreeFamiTF333159.

Family and domain databases

InterProiIPR026639. Glcci1.
IPR026642. Glcci1/FAM117.
[Graphical view]
PANTHERiPTHR14972. PTHR14972. 1 hit.
PTHR14972:SF3. PTHR14972:SF3. 1 hit.
PfamiPF15388. FAM117. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86VQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTASSSSSS SSSQTPHPPS QRMRRSAAGS PPAVAAAGSG NGAGGGGGVG
60 70 80 90 100
CAPAAGAGRL LQPIRATVPY QLLRGSQHSP TRPPVAAAAA SLGSLPGPGA
110 120 130 140 150
ARGPSPSSPT PPAAAAPAEQ APRAKGRPRR SPESHRRSSS PERRSPGSPV
160 170 180 190 200
CRADKAKSQQ VRTSSTIRRT SSLDTITGPY LTGQWPRDPH VHYPSCMKDK
210 220 230 240 250
ATQTPSCWAE EGAEKRSHQR SASWGSADQL KEQIAKLRQQ LQRSKQSSRH
260 270 280 290 300
SKEKDRQSPL HGNHITISHT QATGSRSVPM PLSNISVPKS SVSRVPCNVE
310 320 330 340 350
GISPELEKVF IKENNGKEEV SKPLDIPDGR RAPLPAHYRS SSTRSIDTQT
360 370 380 390 400
PSVQERSSSC SSHSPCVSPF CPPESQDGSP CSTEDLLYDR DKDSGSSSPL
410 420 430 440 450
PKYASSPKPN NSYMFKREPP EGCERVKVFE EMASRQPISA PLFSCPDKNK
460 470 480 490 500
VNFIPTGSAF CPVKLLGPLL PASDLMLKNS PNSGQSSALA TLTVEQLSSR
510 520 530 540
VSFTSLSDDT STAGSMEASV QQPSQQQQLL QELQGEDHIS AQNYVII
Length:547
Mass (Da):58,024
Last modified:June 1, 2003 - v1
Checksum:i51B6AF7788E8800D
GO

Polymorphismi

Polymorphisms dbSNP:rs37972 and dbSNP:rs37973, located in GLCCI1 promoter region, are associated with a decreased response to glucorticoid treatment [MIMi:614400] in asthma patients (PubMed:21991891), as well as in chronic obstructive pulmonary disease patients (PubMed:22187997). The mean increase in forced expiratory volume in 1 second in glucorticoid treated subjects who are homozygous for the mutant (G) rs37973 allele is only about one-third of that seen in similarly treated subjects who are homozygous for the wild-type allele (A) (PubMed:21991891). These polymorphisms affect GLCCI1 transcription level.2 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236948 Genomic DNA. Translation: EAL24302.1.
CH471073 Genomic DNA. Translation: EAW93607.1.
BC011254 mRNA. Translation: AAH11254.1.
BC050291 mRNA. Translation: AAH50291.1.
CCDSiCCDS34601.1.
RefSeqiNP_612435.1. NM_138426.3.
UniGeneiHs.131673.

Genome annotation databases

EnsembliENST00000223145; ENSP00000223145; ENSG00000106415.
GeneIDi113263.
KEGGihsa:113263.
UCSCiuc003srk.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236948 Genomic DNA. Translation: EAL24302.1.
CH471073 Genomic DNA. Translation: EAW93607.1.
BC011254 mRNA. Translation: AAH11254.1.
BC050291 mRNA. Translation: AAH50291.1.
CCDSiCCDS34601.1.
RefSeqiNP_612435.1. NM_138426.3.
UniGeneiHs.131673.

3D structure databases

ProteinModelPortaliQ86VQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125239. 8 interactions.
IntActiQ86VQ1. 5 interactions.
STRINGi9606.ENSP00000223145.

PTM databases

iPTMnetiQ86VQ1.
PhosphoSiteiQ86VQ1.

Polymorphism and mutation databases

BioMutaiGLCCI1.
DMDMi74727602.

Proteomic databases

EPDiQ86VQ1.
MaxQBiQ86VQ1.
PaxDbiQ86VQ1.
PRIDEiQ86VQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223145; ENSP00000223145; ENSG00000106415.
GeneIDi113263.
KEGGihsa:113263.
UCSCiuc003srk.5. human.

Organism-specific databases

CTDi113263.
GeneCardsiGLCCI1.
HGNCiHGNC:18713. GLCCI1.
HPAiHPA001674.
HPA005987.
MalaCardsiGLCCI1.
MIMi614283. gene.
614400. phenotype.
neXtProtiNX_Q86VQ1.
PharmGKBiPA38657.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEAU. Eukaryota.
ENOG4111PY2. LUCA.
GeneTreeiENSGT00390000005655.
HOGENOMiHOG000252927.
HOVERGENiHBG079782.
InParanoidiQ86VQ1.
OMAiDRPKSQQ.
OrthoDBiEOG74XS6S.
PhylomeDBiQ86VQ1.
TreeFamiTF333159.

Miscellaneous databases

ChiTaRSiGLCCI1. human.
GeneWikiiGLCCI1.
GenomeRNAii113263.
PROiQ86VQ1.
SOURCEiSearch...

Gene expression databases

BgeeiQ86VQ1.
CleanExiHS_GLCCI1.
ExpressionAtlasiQ86VQ1. baseline and differential.
GenevisibleiQ86VQ1. HS.

Family and domain databases

InterProiIPR026639. Glcci1.
IPR026642. Glcci1/FAM117.
[Graphical view]
PANTHERiPTHR14972. PTHR14972. 1 hit.
PTHR14972:SF3. PTHR14972:SF3. 1 hit.
PfamiPF15388. FAM117. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix and Testis.
  4. "Two genes, three messengers: hybrid transcript between a gene expressed at specific stages of T-cell and sperm maturation and an unrelated adjacent gene."
    Miazek A., Malissen B.
    Immunogenetics 54:681-692(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-303 AND SER-345, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105; SER-108; SER-172; THR-175 AND SER-345, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-177, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223; SER-258; SER-398 AND SER-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: INVOLVEMENT IN ASTHMA RESPONSE TO GLUCOCORTICOID TREATMENT, TISSUE SPECIFICITY.
  13. Cited for: INVOLVEMENT IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE RESPONSE TO GLUCOCORTICOID TREATMENT.
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223; SER-258 AND SER-398, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-266 AND SER-345, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiGLCI1_HUMAN
AccessioniPrimary (citable) accession number: Q86VQ1
Secondary accession number(s): A4D103, Q96FD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.