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Protein

Glucocorticoid-induced transcript 1 protein

Gene

GLCCI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Glucocorticoid-induced transcript 1 protein
Gene namesi
Name:GLCCI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:18713. GLCCI1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi113263.
MalaCardsiGLCCI1.
MIMi614400. phenotype.
OpenTargetsiENSG00000106415.
PharmGKBiPA38657.

Polymorphism and mutation databases

BioMutaiGLCCI1.
DMDMi74727602.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002561281 – 547Glucocorticoid-induced transcript 1 proteinAdd BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1
Modified residuei107PhosphoserineBy similarity1
Modified residuei108PhosphoserineCombined sources1
Modified residuei110PhosphothreonineBy similarity1
Modified residuei171PhosphoserineCombined sources1
Modified residuei172PhosphoserineCombined sources1
Modified residuei175PhosphothreonineCombined sources1
Modified residuei177PhosphothreonineCombined sources1
Modified residuei223PhosphoserineCombined sources1
Modified residuei258PhosphoserineCombined sources1
Modified residuei266PhosphothreonineCombined sources1
Modified residuei303PhosphoserineCombined sources1
Modified residuei343PhosphothreonineCombined sources1
Modified residuei345PhosphoserineCombined sources1
Modified residuei350PhosphothreonineBy similarity1
Modified residuei394PhosphoserineBy similarity1
Modified residuei398PhosphoserineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei412PhosphoserineBy similarity1
Modified residuei480PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86VQ1.
MaxQBiQ86VQ1.
PaxDbiQ86VQ1.
PeptideAtlasiQ86VQ1.
PRIDEiQ86VQ1.

PTM databases

iPTMnetiQ86VQ1.
PhosphoSitePlusiQ86VQ1.

Expressioni

Tissue specificityi

Predominantly expressed in lung, spleen, thymus and testis and, at lower levels, in brain, bone marrow, peripheral leukocytes, skin and trachea.2 Publications

Gene expression databases

BgeeiENSG00000106415.
CleanExiHS_GLCCI1.
ExpressionAtlasiQ86VQ1. baseline and differential.
GenevisibleiQ86VQ1. HS.

Organism-specific databases

HPAiHPA001674.
HPA005987.

Interactioni

Protein-protein interaction databases

BioGridi125239. 8 interactors.
IntActiQ86VQ1. 6 interactors.
STRINGi9606.ENSP00000223145.

Structurei

3D structure databases

ProteinModelPortaliQ86VQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili225 – 254Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 13Poly-Ser9
Compositional biasi38 – 50Poly-GlyAdd BLAST13
Compositional biasi86 – 90Poly-Ala5
Compositional biasi113 – 118Poly-Ala6
Compositional biasi525 – 528Poly-Gln4

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEAU. Eukaryota.
ENOG4111PY2. LUCA.
GeneTreeiENSGT00390000005655.
HOGENOMiHOG000252927.
HOVERGENiHBG079782.
InParanoidiQ86VQ1.
OMAiDRPKSQQ.
OrthoDBiEOG091G0B78.
PhylomeDBiQ86VQ1.
TreeFamiTF333159.

Family and domain databases

InterProiIPR026639. Glcci1.
IPR026642. Glcci1/FAM117.
[Graphical view]
PANTHERiPTHR14972. PTHR14972. 1 hit.
PTHR14972:SF3. PTHR14972:SF3. 1 hit.
PfamiPF15388. FAM117. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86VQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTASSSSSS SSSQTPHPPS QRMRRSAAGS PPAVAAAGSG NGAGGGGGVG
60 70 80 90 100
CAPAAGAGRL LQPIRATVPY QLLRGSQHSP TRPPVAAAAA SLGSLPGPGA
110 120 130 140 150
ARGPSPSSPT PPAAAAPAEQ APRAKGRPRR SPESHRRSSS PERRSPGSPV
160 170 180 190 200
CRADKAKSQQ VRTSSTIRRT SSLDTITGPY LTGQWPRDPH VHYPSCMKDK
210 220 230 240 250
ATQTPSCWAE EGAEKRSHQR SASWGSADQL KEQIAKLRQQ LQRSKQSSRH
260 270 280 290 300
SKEKDRQSPL HGNHITISHT QATGSRSVPM PLSNISVPKS SVSRVPCNVE
310 320 330 340 350
GISPELEKVF IKENNGKEEV SKPLDIPDGR RAPLPAHYRS SSTRSIDTQT
360 370 380 390 400
PSVQERSSSC SSHSPCVSPF CPPESQDGSP CSTEDLLYDR DKDSGSSSPL
410 420 430 440 450
PKYASSPKPN NSYMFKREPP EGCERVKVFE EMASRQPISA PLFSCPDKNK
460 470 480 490 500
VNFIPTGSAF CPVKLLGPLL PASDLMLKNS PNSGQSSALA TLTVEQLSSR
510 520 530 540
VSFTSLSDDT STAGSMEASV QQPSQQQQLL QELQGEDHIS AQNYVII
Length:547
Mass (Da):58,024
Last modified:June 1, 2003 - v1
Checksum:i51B6AF7788E8800D
GO

Polymorphismi

Polymorphisms dbSNP:rs37972 and dbSNP:rs37973, located in GLCCI1 promoter region, are associated with a decreased response to glucorticoid treatment [MIMi:614400] in asthma patients (PubMed:21991891), as well as in chronic obstructive pulmonary disease patients (PubMed:22187997). The mean increase in forced expiratory volume in 1 second in glucorticoid treated subjects who are homozygous for the mutant (G) rs37973 allele is only about one-third of that seen in similarly treated subjects who are homozygous for the wild-type allele (A) (PubMed:21991891). These polymorphisms affect GLCCI1 transcription level.2 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236948 Genomic DNA. Translation: EAL24302.1.
CH471073 Genomic DNA. Translation: EAW93607.1.
BC011254 mRNA. Translation: AAH11254.1.
BC050291 mRNA. Translation: AAH50291.1.
CCDSiCCDS34601.1.
RefSeqiNP_612435.1. NM_138426.3.
UniGeneiHs.131673.

Genome annotation databases

EnsembliENST00000223145; ENSP00000223145; ENSG00000106415.
GeneIDi113263.
KEGGihsa:113263.
UCSCiuc003srk.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236948 Genomic DNA. Translation: EAL24302.1.
CH471073 Genomic DNA. Translation: EAW93607.1.
BC011254 mRNA. Translation: AAH11254.1.
BC050291 mRNA. Translation: AAH50291.1.
CCDSiCCDS34601.1.
RefSeqiNP_612435.1. NM_138426.3.
UniGeneiHs.131673.

3D structure databases

ProteinModelPortaliQ86VQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125239. 8 interactors.
IntActiQ86VQ1. 6 interactors.
STRINGi9606.ENSP00000223145.

PTM databases

iPTMnetiQ86VQ1.
PhosphoSitePlusiQ86VQ1.

Polymorphism and mutation databases

BioMutaiGLCCI1.
DMDMi74727602.

Proteomic databases

EPDiQ86VQ1.
MaxQBiQ86VQ1.
PaxDbiQ86VQ1.
PeptideAtlasiQ86VQ1.
PRIDEiQ86VQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223145; ENSP00000223145; ENSG00000106415.
GeneIDi113263.
KEGGihsa:113263.
UCSCiuc003srk.5. human.

Organism-specific databases

CTDi113263.
DisGeNETi113263.
GeneCardsiGLCCI1.
HGNCiHGNC:18713. GLCCI1.
HPAiHPA001674.
HPA005987.
MalaCardsiGLCCI1.
MIMi614283. gene.
614400. phenotype.
neXtProtiNX_Q86VQ1.
OpenTargetsiENSG00000106415.
PharmGKBiPA38657.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEAU. Eukaryota.
ENOG4111PY2. LUCA.
GeneTreeiENSGT00390000005655.
HOGENOMiHOG000252927.
HOVERGENiHBG079782.
InParanoidiQ86VQ1.
OMAiDRPKSQQ.
OrthoDBiEOG091G0B78.
PhylomeDBiQ86VQ1.
TreeFamiTF333159.

Miscellaneous databases

ChiTaRSiGLCCI1. human.
GeneWikiiGLCCI1.
GenomeRNAii113263.
PROiQ86VQ1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106415.
CleanExiHS_GLCCI1.
ExpressionAtlasiQ86VQ1. baseline and differential.
GenevisibleiQ86VQ1. HS.

Family and domain databases

InterProiIPR026639. Glcci1.
IPR026642. Glcci1/FAM117.
[Graphical view]
PANTHERiPTHR14972. PTHR14972. 1 hit.
PTHR14972:SF3. PTHR14972:SF3. 1 hit.
PfamiPF15388. FAM117. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLCI1_HUMAN
AccessioniPrimary (citable) accession number: Q86VQ1
Secondary accession number(s): A4D103, Q96FD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.