ID   LCA5_HUMAN              Reviewed;         697 AA.
AC   Q86VQ0; E1P542; Q9BWX7;
DT   02-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 2.
DT   24-JAN-2024, entry version 159.
DE   RecName: Full=Lebercilin {ECO:0000303|PubMed:17546029};
DE   AltName: Full=Leber congenital amaurosis 5 protein;
GN   Name=LCA5; Synonyms=C6orf152;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT SER-24.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-24.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   INVOLVEMENT IN LCA5.
RX   PubMed=18000884; DOI=10.1002/humu.9513;
RA   Gerber S., Hanein S., Perrault I., Delphin N., Aboussair N., Leowski C.,
RA   Dufier J.-L., Roche O., Munnich A., Kaplan J., Rozet J.-M.;
RT   "Mutations in LCA5 are an uncommon cause of Leber congenital amaurosis
RT   (LCA) type II.";
RL   Hum. Mutat. 28:1245-1245(2007).
RN   [5]
RP   SUBCELLULAR LOCATION, INVOLVEMENT IN LCA5, AND TISSUE SPECIFICITY.
RX   PubMed=17546029; DOI=10.1038/ng2066;
RA   den Hollander A.I., Koenekoop R.K., Mohamed M.D., Arts H.H., Boldt K.,
RA   Towns K.V., Sedmak T., Beer M., Nagel-Wolfrum K., McKibbin M.,
RA   Dharmaraj S., Lopez I., Ivings L., Williams G.A., Springell K., Woods C.G.,
RA   Jafri H., Rashid Y., Strom T.M., van der Zwaag B., Gosens I.,
RA   Kersten F.F.J., van Wijk E., Veltman J.A., Zonneveld M.N.,
RA   van Beersum S.E.C., Maumenee I.H., Wolfrum U., Cheetham M.E., Ueffing M.,
RA   Cremers F.P.M., Inglehearn C.F., Roepman R.;
RT   "Mutations in LCA5, encoding the ciliary protein lebercilin, cause Leber
RT   congenital amaurosis.";
RL   Nat. Genet. 39:889-895(2007).
RN   [6]
RP   INVOLVEMENT IN LCA5.
RX   PubMed=18334959;
RA   Ramprasad V.L., Soumittra N., Nancarrow D., Sen P., McKibbin M.,
RA   Williams G.A., Arokiasamy T., Lakshmipathy P., Inglehearn C.F.,
RA   Kumaramanickavel G.;
RT   "Identification of a novel splice-site mutation in the lebercilin (LCA5)
RT   gene causing Leber congenital amaurosis.";
RL   Mol. Vis. 14:481-486(2008).
RN   [7]
RP   INTERACTION WITH OFD1.
RX   PubMed=19800048; DOI=10.1016/j.ajhg.2009.09.002;
RA   Coene K.L., Roepman R., Doherty D., Afroze B., Kroes H.Y., Letteboer S.J.,
RA   Ngu L.H., Budny B., van Wijk E., Gorden N.T., Azhimi M.,
RA   Thauvin-Robinet C., Veltman J.A., Boink M., Kleefstra T., Cremers F.P.,
RA   van Bokhoven H., de Brouwer A.P.;
RT   "OFD1 is mutated in X-linked Joubert syndrome and interacts with LCA5-
RT   encoded lebercilin.";
RL   Am. J. Hum. Genet. 85:465-481(2009).
RN   [8]
RP   INTERACTION WITH NINL.
RX   PubMed=18826961; DOI=10.1093/hmg/ddn312;
RA   van Wijk E., Kersten F.F.J., Kartono A., Mans D.A., Brandwijk K.,
RA   Letteboer S.J.F., Peters T.A., Maerker T., Yan X., Cremers C.W.R.J.,
RA   Cremers F.P.M., Wolfrum U., Roepman R., Kremer H.;
RT   "Usher syndrome and Leber congenital amaurosis are molecularly linked via a
RT   novel isoform of the centrosomal ninein-like protein.";
RL   Hum. Mol. Genet. 18:51-64(2009).
RN   [9]
RP   INTERACTION WITH FAM161A.
RX   PubMed=22940612; DOI=10.1093/hmg/dds368;
RA   Di Gioia S.A., Letteboer S.J., Kostic C., Bandah-Rozenfeld D.,
RA   Hetterschijt L., Sharon D., Arsenijevic Y., Roepman R., Rivolta C.;
RT   "FAM161A, associated with retinitis pigmentosa, is a component of the
RT   cilia-basal body complex and interacts with proteins involved in
RT   ciliopathies.";
RL   Hum. Mol. Genet. 21:5174-5184(2012).
RN   [10]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [11]
RP   SUBCELLULAR LOCATION, AND INTERACTION WITH COMPONENTS OF THE IFT COMPLEX B.
RX   PubMed=21606596; DOI=10.1172/jci45627;
RA   Boldt K., Mans D.A., Won J., van Reeuwijk J., Vogt A., Kinkl N.,
RA   Letteboer S.J., Hicks W.L., Hurd R.E., Naggert J.K., Texier Y.,
RA   den Hollander A.I., Koenekoop R.K., Bennett J., Cremers F.P.,
RA   Gloeckner C.J., Nishina P.M., Roepman R., Ueffing M.;
RT   "Disruption of intraflagellar protein transport in photoreceptor cilia
RT   causes Leber congenital amaurosis in humans and mice.";
RL   J. Clin. Invest. 121:2169-2180(2011).
RN   [12]
RP   VARIANT LCA5 GLY-218.
RX   PubMed=28418496; DOI=10.1167/iovs.17-21424;
RA   Li L., Chen Y., Jiao X., Jin C., Jiang D., Tanwar M., Ma Z., Huang L.,
RA   Ma X., Sun W., Chen J., Ma Y., M'hamdi O., Govindarajan G., Cabrera P.E.,
RA   Li J., Gupta N., Naeem M.A., Khan S.N., Riazuddin S., Akram J.,
RA   Ayyagari R., Sieving P.A., Riazuddin S.A., Hejtmancik J.F.;
RT   "Homozygosity Mapping and Genetic Analysis of Autosomal Recessive Retinal
RT   Dystrophies in 144 Consanguineous Pakistani Families.";
RL   Invest. Ophthalmol. Vis. Sci. 58:2218-2238(2017).
CC   -!- FUNCTION: Involved in intraflagellar protein (IFT) transport in
CC       photoreceptor cilia. {ECO:0000250|UniProtKB:Q80ST9}.
CC   -!- SUBUNIT: Interacts with NINL (PubMed:18826961). Interacts with OFD1
CC       (PubMed:19800048). Interacts with FAM161A (PubMed:22940612). Interacts
CC       with components of the IFT complex B (PubMed:21606596).
CC       {ECO:0000269|PubMed:18826961, ECO:0000269|PubMed:19800048,
CC       ECO:0000269|PubMed:21606596, ECO:0000269|PubMed:22940612}.
CC   -!- INTERACTION:
CC       Q86VQ0; Q96CN9: GCC1; NbExp=3; IntAct=EBI-6658186, EBI-746252;
CC       Q86VQ0; Q9P2K3: RCOR3; NbExp=3; IntAct=EBI-6658186, EBI-743428;
CC       Q86VQ0; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-6658186, EBI-1504830;
CC       Q86VQ0; O43805: SSNA1; NbExp=3; IntAct=EBI-6658186, EBI-2515299;
CC       Q86VQ0; Q9UMX1: SUFU; NbExp=3; IntAct=EBI-6658186, EBI-740595;
CC       Q86VQ0; Q9UBB9: TFIP11; NbExp=4; IntAct=EBI-6658186, EBI-1105213;
CC       Q86VQ0; P40222: TXLNA; NbExp=3; IntAct=EBI-6658186, EBI-359793;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000269|PubMed:17546029}. Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000269|PubMed:17546029}. Cytoplasm, cytoskeleton, cilium basal
CC       body {ECO:0000269|PubMed:17546029}. Cytoplasm, cytoskeleton,
CC       microtubule organizing center, centrosome
CC       {ECO:0000269|PubMed:17546029}. Cell projection, cilium
CC       {ECO:0000269|PubMed:21606596}. Note=In non- ciliated cells, localizes
CC       to the centrosome and its associated microtubule array
CC       (PubMed:17546029). Colocalizes with IFT complex A and B proteins in the
CC       connecting cilium in primary cilia of hTERT-RPE1 cells
CC       (PubMed:21606596). {ECO:0000269|PubMed:17546029,
CC       ECO:0000269|PubMed:21606596}.
CC   -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:17546029}.
CC   -!- DISEASE: Leber congenital amaurosis 5 (LCA5) [MIM:604537]: A severe
CC       dystrophy of the retina, typically becoming evident in the first years
CC       of life. Visual function is usually poor and often accompanied by
CC       nystagmus, sluggish or near-absent pupillary responses, photophobia,
CC       high hyperopia and keratoconus. {ECO:0000269|PubMed:17546029,
CC       ECO:0000269|PubMed:18000884, ECO:0000269|PubMed:18334959,
CC       ECO:0000269|PubMed:28418496}. Note=The disease is caused by variants
CC       affecting the gene represented in this entry.
CC   -!- SIMILARITY: Belongs to the LCA5 family. {ECO:0000305}.
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DR   EMBL; AL391840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471051; EAW48705.1; -; Genomic_DNA.
DR   EMBL; CH471051; EAW48706.1; -; Genomic_DNA.
DR   EMBL; BC050327; AAH50327.1; -; mRNA.
DR   CCDS; CCDS4990.1; -.
DR   RefSeq; NP_001116241.1; NM_001122769.2.
DR   RefSeq; NP_859065.2; NM_181714.3.
DR   RefSeq; XP_005248722.1; XM_005248665.4.
DR   RefSeq; XP_011533806.1; XM_011535504.1.
DR   AlphaFoldDB; Q86VQ0; -.
DR   SMR; Q86VQ0; -.
DR   BioGRID; 127950; 126.
DR   IntAct; Q86VQ0; 120.
DR   MINT; Q86VQ0; -.
DR   STRING; 9606.ENSP00000376686; -.
DR   iPTMnet; Q86VQ0; -.
DR   PhosphoSitePlus; Q86VQ0; -.
DR   BioMuta; LCA5; -.
DR   DMDM; 71658798; -.
DR   EPD; Q86VQ0; -.
DR   jPOST; Q86VQ0; -.
DR   MassIVE; Q86VQ0; -.
DR   MaxQB; Q86VQ0; -.
DR   PaxDb; 9606-ENSP00000376686; -.
DR   PeptideAtlas; Q86VQ0; -.
DR   ProteomicsDB; 70054; -.
DR   Pumba; Q86VQ0; -.
DR   Antibodypedia; 31597; 157 antibodies from 24 providers.
DR   DNASU; 167691; -.
DR   Ensembl; ENST00000369846.9; ENSP00000358861.4; ENSG00000135338.14.
DR   Ensembl; ENST00000392959.5; ENSP00000376686.1; ENSG00000135338.14.
DR   GeneID; 167691; -.
DR   KEGG; hsa:167691; -.
DR   MANE-Select; ENST00000369846.9; ENSP00000358861.4; NM_001122769.3; NP_001116241.1.
DR   UCSC; uc003pix.4; human.
DR   AGR; HGNC:31923; -.
DR   CTD; 167691; -.
DR   DisGeNET; 167691; -.
DR   GeneCards; LCA5; -.
DR   HGNC; HGNC:31923; LCA5.
DR   HPA; ENSG00000135338; Low tissue specificity.
DR   MalaCards; LCA5; -.
DR   MIM; 604537; phenotype.
DR   MIM; 611408; gene.
DR   neXtProt; NX_Q86VQ0; -.
DR   OpenTargets; ENSG00000135338; -.
DR   Orphanet; 65; Leber congenital amaurosis.
DR   Orphanet; 364055; Severe early-childhood-onset retinal dystrophy.
DR   PharmGKB; PA142671563; -.
DR   VEuPathDB; HostDB:ENSG00000135338; -.
DR   eggNOG; ENOG502QQG3; Eukaryota.
DR   GeneTree; ENSGT00560000077266; -.
DR   HOGENOM; CLU_017042_0_0_1; -.
DR   InParanoid; Q86VQ0; -.
DR   OMA; SGKSNPF; -.
DR   OrthoDB; 2971757at2759; -.
DR   PhylomeDB; Q86VQ0; -.
DR   TreeFam; TF323306; -.
DR   PathwayCommons; Q86VQ0; -.
DR   SignaLink; Q86VQ0; -.
DR   BioGRID-ORCS; 167691; 7 hits in 1149 CRISPR screens.
DR   GeneWiki; LCA5; -.
DR   GenomeRNAi; 167691; -.
DR   Pharos; Q86VQ0; Tbio.
DR   PRO; PR:Q86VQ0; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q86VQ0; Protein.
DR   Bgee; ENSG00000135338; Expressed in mucosa of paranasal sinus and 149 other cell types or tissues.
DR   ExpressionAtlas; Q86VQ0; baseline and differential.
DR   GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR   GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; IDA:MGI.
DR   GO; GO:0032391; C:photoreceptor connecting cilium; IDA:UniProtKB.
DR   GO; GO:0044877; F:protein-containing complex binding; IDA:MGI.
DR   GO; GO:0042073; P:intraciliary transport; IBA:GO_Central.
DR   GO; GO:0045494; P:photoreceptor cell maintenance; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR026188; Lebercilin-like.
DR   InterPro; IPR028933; Lebercilin_dom.
DR   PANTHER; PTHR16650; C21ORF13-RELATED; 1.
DR   PANTHER; PTHR16650:SF10; LEBERCILIN; 1.
DR   Pfam; PF15619; Lebercilin; 1.
DR   Genevisible; Q86VQ0; HS.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Disease variant; Leber congenital amaurosis; Phosphoprotein;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..697
FT                   /note="Lebercilin"
FT                   /id="PRO_0000089546"
FT   REGION          1..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          412..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          522..548
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          606..697
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          103..297
FT                   /evidence="ECO:0000255"
FT   COILED          389..485
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        8..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..49
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        524..548
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        608..632
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        645..659
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        666..697
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         7
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q80ST9"
FT   MOD_RES         45
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   VARIANT         24
FT                   /note="L -> S (in dbSNP:rs2655655)"
FT                   /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT                   /id="VAR_023094"
FT   VARIANT         26
FT                   /note="D -> A (in dbSNP:rs34068461)"
FT                   /id="VAR_038989"
FT   VARIANT         66
FT                   /note="R -> Q (in dbSNP:rs35338066)"
FT                   /id="VAR_038990"
FT   VARIANT         218
FT                   /note="R -> G (in LCA5; uncertain significance)"
FT                   /evidence="ECO:0000269|PubMed:28418496"
FT                   /id="VAR_081583"
FT   VARIANT         546
FT                   /note="A -> P (in dbSNP:rs35415141)"
FT                   /id="VAR_038991"
FT   VARIANT         656
FT                   /note="G -> D (in dbSNP:rs1875845)"
FT                   /id="VAR_038992"
FT   CONFLICT        15
FT                   /note="K -> E (in Ref. 3; AAH50327)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        502
FT                   /note="P -> R (in Ref. 3; AAH50327)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        623
FT                   /note="D -> G (in Ref. 3; AAH50327)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   697 AA;  80554 MW;  A8F8AB1A565EB633 CRC64;
     MGERAGSPGT DQERKAGKHH YSYLSDFETP QSSGRSSLVS SSPASVRRKN PKRQTSDGQV
     HHQAPRKPSP KGLPNRKGVR VGFRSQSLNR EPLRKDTDLV TKRILSARLL KINELQNEVS
     ELQVKLAELL KENKSLKRLQ YRQEKALNKF EDAENEISQL IFRHNNEITA LKERLRKSQE
     KERATEKRVK DTESELFRTK FSLQKLKEIS EARHLPERDD LAKKLVSAEL KLDDTERRIK
     ELSKNLELST NSFQRQLLAE RKRAYEAHDE NKVLQKEVQR LYHKLKEKER ELDIKNIYSN
     RLPKSSPNKE KELALRKNAA CQSDFADLCT KGVQTMEDFK PEEYPLTPET IMCYENKWEE
     PGHLTLDLQS QKQDRHGEAG ILNPIMEREE KFVTDEELHV VKQEVEKLED EWEREELDKK
     QKEKASLLER EEKPEWETGR YQLGMYPIQN MDKLQGEEEE RLKREMLLAK LNEIDRELQD
     SRNLKYPVLP LLPDFESKLH SPERSPKTYR FSESSERLFN GHHLQDISFS TPKGEGQNSG
     NVRSPASPNE FAFGSYVPSF AKTSERSNPF SQKSSFLDFQ RNSMEKLSKD GVDLITRKEK
     KANLMEQLFG ASGSSTISSK SSDPNSVASS KGDIDPLNFL PGNKGSRDQE HDEDEGFFLS
     EGRSFNPNRH RLKHADDKPA VKAADSVEDE IEEVALR
//