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Q86VP1

- TAXB1_HUMAN

UniProt

Q86VP1 - TAXB1_HUMAN

Protein

Tax1-binding protein 1

Gene

TAX1BP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (16 May 2006)
      Previous versions | rss
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    Functioni

    Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.2 Publications

    GO - Molecular functioni

    1. kinase binding Source: BHF-UCL
    2. protein binding Source: IntAct

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. innate immune response Source: Reactome
    3. negative regulation of apoptotic process Source: ProtInc
    4. negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
    5. negative regulation of type I interferon production Source: Reactome

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    ReactomeiREACT_25271. Negative regulators of RIG-I/MDA5 signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tax1-binding protein 1
    Alternative name(s):
    TRAF6-binding protein
    Gene namesi
    Name:TAX1BP1
    Synonyms:T6BP
    ORF Names:PRO0105
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:11575. TAX1BP1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36339.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 789789Tax1-binding protein 1PRO_0000234554Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei225 – 2251Phosphoserine1 Publication
    Modified residuei593 – 5931Phosphoserine; by IKKA1 Publication
    Modified residuei666 – 6661Phosphoserine; by IKKA1 Publication

    Post-translational modificationi

    Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation.2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ86VP1.
    PaxDbiQ86VP1.
    PRIDEiQ86VP1.

    PTM databases

    PhosphoSiteiQ86VP1.

    Expressioni

    Tissue specificityi

    Expressed in all tissues tested.

    Gene expression databases

    ArrayExpressiQ86VP1.
    BgeeiQ86VP1.
    CleanExiHS_TAX1BP1.
    GenevestigatoriQ86VP1.

    Organism-specific databases

    HPAiHPA024432.

    Interactioni

    Subunit structurei

    Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13. Interacts with the HTLV-1 protein Tax-1.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CHUKO151112EBI-529518,EBI-81249
    RALBP1Q153113EBI-529518,EBI-749285
    RNF11Q9Y3C52EBI-529518,EBI-396669
    STARD13Q9Y3M82EBI-529518,EBI-465487
    TRAF6Q9Y4K38EBI-529518,EBI-359276
    UBCP0CG485EBI-529518,EBI-3390054

    Protein-protein interaction databases

    BioGridi114405. 21 interactions.
    DIPiDIP-33010N.
    IntActiQ86VP1. 23 interactions.
    MINTiMINT-200894.
    STRINGi9606.ENSP00000379612.

    Structurei

    Secondary structure

    1
    789
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi727 – 7293
    Beta strandi731 – 7344
    Helixi743 – 7519
    Beta strandi754 – 7563
    Turni758 – 7603
    Helixi770 – 78213

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2M7QNMR-A725-789[»]
    4BMJX-ray2.75A/B/C/D/E/F/G/H/I/J/K725-789[»]
    ProteinModelPortaliQ86VP1.
    SMRiQ86VP1. Positions 15-121, 725-789.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni320 – 420101OligomerizationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili144 – 599456Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG135564.
    HOGENOMiHOG000271638.
    HOVERGENiHBG053034.
    OrthoDBiEOG7RRF8H.
    PhylomeDBiQ86VP1.
    TreeFamiTF329501.

    Family and domain databases

    InterProiIPR012852. CoCoA.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    PfamiPF07888. CALCOCO1. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 2 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86VP1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV    50
    GIFKVGWSTA RDYYTFLWSP MPEHYVEGST VNCVLAFQGY YLPNDDGEFY 100
    QFCYVTHKGE IRGASTPFQF RASSPVEELL TMEDEGNSDM LVVTTKAGLL 150
    ELKIEKTMKE KEELLKLIAV LEKETAQLRE QVGRMERELN HEKERCDQLQ 200
    AEQKGLTEVT QSLKMENEEF KKRFSDATSK AHQLEEDIVS VTHKAIEKET 250
    ELDSLKDKLK KAQHEREQLE CQLKTEKDEK ELYKVHLKNT EIENTKLMSE 300
    VQTLKNLDGN KESVITHFKE EIGRLQLCLA EKENLQRTFL LTTSSKEDTC 350
    FLKEQLRKAE EQVQATRQEV VFLAKELSDA VNVRDRTMAD LHTARLENEK 400
    VKKQLADAVA ELKLNAMKKD QDKTDTLEHE LRREVEDLKL RLQMAADHYK 450
    EKFKECQRLQ KQINKLSDQS ANNNNVFTKK TGNQQKVNDA SVNTDPATSA 500
    STVDVKPSPS AAEADFDIVT KGQVCEMTKE IADKTEKYNK CKQLLQDEKA 550
    KCNKYADELA KMELKWKEQV KIAENVKLEL AEVQDNYKEL KRSLENPAER 600
    KMEGQNSQSP QCFKTCSEQN GYVLTLSNAQ PVLQYGNPYA SQETRDGADG 650
    AFYPDEIQRP PVRVPSWGLE DNVVCSQPAR NFSRPDGLED SEDSKEDENV 700
    PTAPDPPSQH LRGHGTGFCF DSSFDVHKKC PLCELMFPPN YDQSKFEEHV 750
    ESHWKVCPMC SEQFPPDYDQ QVFERHVQTH FDQNVLNFD 789
    Length:789
    Mass (Da):90,877
    Last modified:May 16, 2006 - v2
    Checksum:iDE8460DAA6712125
    GO
    Isoform 2 (identifier: Q86VP1-2) [UniParc]FASTAAdd to Basket

    Also known as: TXBP151-L

    The sequence of this isoform differs from the canonical sequence as follows:
         604-645: Missing.

    Show »
    Length:747
    Mass (Da):86,257
    Checksum:i93EEDFF29106CE1C
    GO
    Isoform 3 (identifier: Q86VP1-3) [UniParc]FASTAAdd to Basket

    Also known as: TXBP151-S

    The sequence of this isoform differs from the canonical sequence as follows:
         1-184: Missing.
         604-645: Missing.

    Show »
    Length:563
    Mass (Da):65,112
    Checksum:iEFA52B16B4408B9C
    GO
    Isoform 4 (identifier: Q86VP1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-157: Missing.
         604-645: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:590
    Mass (Da):68,277
    Checksum:iF65F3BC653A80234
    GO

    Sequence cautioni

    The sequence AAC13359.2 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti199 – 1991L → P in BAG59309. (PubMed:14702039)Curated
    Sequence conflicti233 – 2342QL → HV in AAA75595. (PubMed:10435631)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti58 – 581S → N.
    Corresponds to variant rs7809260 [ dbSNP | Ensembl ].
    VAR_051415
    Natural varianti307 – 3071L → I.1 Publication
    Corresponds to variant rs11540483 [ dbSNP | Ensembl ].
    VAR_026286
    Natural varianti457 – 4571Q → R in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035665

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 184184Missing in isoform 3. CuratedVSP_018354Add
    BLAST
    Alternative sequencei1 – 157157Missing in isoform 4. 1 PublicationVSP_045921Add
    BLAST
    Alternative sequencei604 – 64542Missing in isoform 2, isoform 3 and isoform 4. 5 PublicationsVSP_018355Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33821 mRNA. Translation: AAA75595.2.
    AF268075 mRNA. Translation: AAG03025.1.
    AL136586 mRNA. Translation: CAB66521.1.
    AF090891 mRNA. Translation: AAF24016.1.
    CR457056 mRNA. Translation: CAG33337.1.
    AK296720 mRNA. Translation: BAG59309.1.
    CR533556 mRNA. Translation: CAG38587.1.
    AC004549 Genomic DNA. Translation: AAC13359.2. Sequence problems.
    AC005091 Genomic DNA. Translation: AAD15412.1.
    BC050358 mRNA. Translation: AAH50358.1.
    CCDSiCCDS43561.1. [Q86VP1-2]
    CCDS5415.1. [Q86VP1-1]
    CCDS56471.1. [Q86VP1-4]
    PIRiG02043.
    RefSeqiNP_001073333.1. NM_001079864.2. [Q86VP1-2]
    NP_001193830.1. NM_001206901.1. [Q86VP1-2]
    NP_001193831.1. NM_001206902.1. [Q86VP1-4]
    NP_006015.4. NM_006024.6. [Q86VP1-1]
    UniGeneiHs.34576.

    Genome annotation databases

    EnsembliENST00000265393; ENSP00000265393; ENSG00000106052. [Q86VP1-2]
    ENST00000396319; ENSP00000379612; ENSG00000106052. [Q86VP1-1]
    ENST00000433216; ENSP00000391907; ENSG00000106052. [Q86VP1-4]
    ENST00000543117; ENSP00000444811; ENSG00000106052. [Q86VP1-2]
    GeneIDi8887.
    KEGGihsa:8887.
    UCSCiuc003szk.3. human. [Q86VP1-2]
    uc003szl.3. human. [Q86VP1-1]

    Polymorphism databases

    DMDMi97202549.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33821 mRNA. Translation: AAA75595.2 .
    AF268075 mRNA. Translation: AAG03025.1 .
    AL136586 mRNA. Translation: CAB66521.1 .
    AF090891 mRNA. Translation: AAF24016.1 .
    CR457056 mRNA. Translation: CAG33337.1 .
    AK296720 mRNA. Translation: BAG59309.1 .
    CR533556 mRNA. Translation: CAG38587.1 .
    AC004549 Genomic DNA. Translation: AAC13359.2 . Sequence problems.
    AC005091 Genomic DNA. Translation: AAD15412.1 .
    BC050358 mRNA. Translation: AAH50358.1 .
    CCDSi CCDS43561.1. [Q86VP1-2 ]
    CCDS5415.1. [Q86VP1-1 ]
    CCDS56471.1. [Q86VP1-4 ]
    PIRi G02043.
    RefSeqi NP_001073333.1. NM_001079864.2. [Q86VP1-2 ]
    NP_001193830.1. NM_001206901.1. [Q86VP1-2 ]
    NP_001193831.1. NM_001206902.1. [Q86VP1-4 ]
    NP_006015.4. NM_006024.6. [Q86VP1-1 ]
    UniGenei Hs.34576.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2M7Q NMR - A 725-789 [» ]
    4BMJ X-ray 2.75 A/B/C/D/E/F/G/H/I/J/K 725-789 [» ]
    ProteinModelPortali Q86VP1.
    SMRi Q86VP1. Positions 15-121, 725-789.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114405. 21 interactions.
    DIPi DIP-33010N.
    IntActi Q86VP1. 23 interactions.
    MINTi MINT-200894.
    STRINGi 9606.ENSP00000379612.

    PTM databases

    PhosphoSitei Q86VP1.

    Polymorphism databases

    DMDMi 97202549.

    Proteomic databases

    MaxQBi Q86VP1.
    PaxDbi Q86VP1.
    PRIDEi Q86VP1.

    Protocols and materials databases

    DNASUi 8887.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265393 ; ENSP00000265393 ; ENSG00000106052 . [Q86VP1-2 ]
    ENST00000396319 ; ENSP00000379612 ; ENSG00000106052 . [Q86VP1-1 ]
    ENST00000433216 ; ENSP00000391907 ; ENSG00000106052 . [Q86VP1-4 ]
    ENST00000543117 ; ENSP00000444811 ; ENSG00000106052 . [Q86VP1-2 ]
    GeneIDi 8887.
    KEGGi hsa:8887.
    UCSCi uc003szk.3. human. [Q86VP1-2 ]
    uc003szl.3. human. [Q86VP1-1 ]

    Organism-specific databases

    CTDi 8887.
    GeneCardsi GC07P027746.
    HGNCi HGNC:11575. TAX1BP1.
    HPAi HPA024432.
    MIMi 605326. gene.
    neXtProti NX_Q86VP1.
    PharmGKBi PA36339.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG135564.
    HOGENOMi HOG000271638.
    HOVERGENi HBG053034.
    OrthoDBi EOG7RRF8H.
    PhylomeDBi Q86VP1.
    TreeFami TF329501.

    Enzyme and pathway databases

    Reactomei REACT_25271. Negative regulators of RIG-I/MDA5 signaling.

    Miscellaneous databases

    ChiTaRSi TAX1BP1. human.
    GeneWikii TAX1BP1.
    GenomeRNAii 8887.
    NextBioi 33373.
    PROi Q86VP1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86VP1.
    Bgeei Q86VP1.
    CleanExi HS_TAX1BP1.
    Genevestigatori Q86VP1.

    Family and domain databases

    InterProi IPR012852. CoCoA.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    Pfami PF07888. CALCOCO1. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases."
      de Valck D., Jin D.-Y., Heyninck K., van de Craen M., Contreras R., Fiers W., Jeang K.-T., Beyaert R.
      Oncogene 18:4182-4190(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH TNFAIP3 AND HTLV-1 PROTEIN TAX-1, ALTERNATIVE SPLICING (ISOFORM 3).
      Tissue: Cervix carcinoma.
    2. "T6BP, a TRAF6-interacting protein involved in IL-1 signaling."
      Ling L., Goeddel D.V.
      Proc. Natl. Acad. Sci. U.S.A. 97:9567-9572(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH TRAF6, SUBUNIT.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Amygdala.
    4. "Functional prediction of the coding sequences of 50 new genes deduced by analysis of cDNA clones from human fetal liver."
      Yu Y., Zhang C., Luo L., Ouyang S., Zhang S., Li W., Wu J., Zhou S., Liu M., He F.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Fetal liver.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Tongue.
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    7. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-307.
      Tissue: Skin.
    9. "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins."
      Nagaraja G.M., Kandpal R.P.
      Biochem. Biophys. Res. Commun. 313:654-665(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH STARD13.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH HTLV-1 PROTEIN TAX-1.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-457.
    13. "The kinase IKKalpha inhibits activation of the transcription factor NF-kappaB by phosphorylating the regulatory molecule TAX1BP1."
      Shembade N., Pujari R., Harhaj N.S., Abbott D.W., Harhaj E.W.
      Nat. Immunol. 12:834-843(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-593 AND SER-666 BY CHUK/IKKA.

    Entry informationi

    Entry nameiTAXB1_HUMAN
    AccessioniPrimary (citable) accession number: Q86VP1
    Secondary accession number(s): B4DKU7
    , E7ENV2, O60398, O95770, Q13311, Q9BQG5, Q9UI88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3