Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tax1-binding protein 1

Gene

TAX1BP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri725 – 754UBZ-type 1Add BLAST30
Zinc fingeri755 – 789UBZ-type 2Add BLAST35

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5357905. Regulation of TNFR1 signaling.
R-HSA-936440. Negative regulators of RIG-I/MDA5 signaling.
SIGNORiQ86VP1.

Names & Taxonomyi

Protein namesi
Recommended name:
Tax1-binding protein 1
Alternative name(s):
TRAF6-binding protein
Gene namesi
Name:TAX1BP1
Synonyms:T6BP
ORF Names:PRO0105
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:11575. TAX1BP1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi771Q → A: Normal affinity for ubiquitin. 1 Publication1
Mutagenesisi774E → A: Reduced affinity for ubiquitin. 1 Publication1
Mutagenesisi775R → A: Normal affinity for ubiquitin. 1 Publication1
Mutagenesisi777V → S: Reduced affinity for ubiquitin. 1 Publication1
Mutagenesisi778Q → A: Reduced affinity for ubiquitin. 1 Publication1
Mutagenesisi781F → A: Reduced affinity for ubiquitin. 1 Publication1

Organism-specific databases

DisGeNETi8887.
OpenTargetsiENSG00000106052.
PharmGKBiPA36339.

Polymorphism and mutation databases

BioMutaiTAX1BP1.
DMDMi97202549.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345541 – 789Tax1-binding protein 1Add BLAST789

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphoserineBy similarity1
Modified residuei138PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei593Phosphoserine; by IKKA1 Publication1
Modified residuei609PhosphoserineBy similarity1
Modified residuei666Phosphoserine; by IKKACombined sources1 Publication1

Post-translational modificationi

Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86VP1.
MaxQBiQ86VP1.
PaxDbiQ86VP1.
PeptideAtlasiQ86VP1.
PRIDEiQ86VP1.

PTM databases

iPTMnetiQ86VP1.
PhosphoSitePlusiQ86VP1.

Expressioni

Tissue specificityi

Expressed in all tissues tested.

Gene expression databases

BgeeiENSG00000106052.
CleanExiHS_TAX1BP1.
ExpressionAtlasiQ86VP1. baseline and differential.
GenevisibleiQ86VP1. HS.

Organism-specific databases

HPAiHPA024432.

Interactioni

Subunit structurei

Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13. Interacts with the HTLV-1 protein Tax-1.4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114405. 69 interactors.
DIPiDIP-33010N.
IntActiQ86VP1. 83 interactors.
MINTiMINT-200894.
STRINGi9606.ENSP00000379612.

Structurei

Secondary structure

1789
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi16 – 21Combined sources6
Beta strandi24 – 26Combined sources3
Beta strandi32 – 38Combined sources7
Beta strandi49 – 54Combined sources6
Helixi60 – 62Combined sources3
Beta strandi63 – 68Combined sources6
Beta strandi81 – 87Combined sources7
Helixi89 – 91Combined sources3
Beta strandi100 – 105Combined sources6
Beta strandi111 – 114Combined sources4
Beta strandi118 – 121Combined sources4
Beta strandi727 – 729Combined sources3
Beta strandi731 – 734Combined sources4
Helixi743 – 751Combined sources9
Beta strandi754 – 756Combined sources3
Turni758 – 760Combined sources3
Helixi770 – 778Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M7QNMR-A725-789[»]
4BMJX-ray2.75A/B/C/D/E/F/G/H/I/J/K725-789[»]
4NLHX-ray1.90A/B15-147[»]
4Z4KX-ray2.80A/B725-781[»]
4Z4MX-ray2.15A/B755-781[»]
5AASNMR-A722-784[»]
ProteinModelPortaliQ86VP1.
SMRiQ86VP1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni320 – 420OligomerizationAdd BLAST101

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili144 – 599Sequence analysisAdd BLAST456

Domaini

The C-terminal UBZ-type zinc fingers function as ubiquitin-binding domains.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri725 – 754UBZ-type 1Add BLAST30
Zinc fingeri755 – 789UBZ-type 2Add BLAST35

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGMS. Eukaryota.
ENOG410XQDF. LUCA.
GeneTreeiENSGT00530000063216.
HOGENOMiHOG000271638.
HOVERGENiHBG053034.
InParanoidiQ86VP1.
PhylomeDBiQ86VP1.
TreeFamiTF329501.

Family and domain databases

InterProiView protein in InterPro
IPR012852. CALCOCO1-like.
PfamiView protein in Pfam
PF07888. CALCOCO1. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86VP1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV
60 70 80 90 100
GIFKVGWSTA RDYYTFLWSP MPEHYVEGST VNCVLAFQGY YLPNDDGEFY
110 120 130 140 150
QFCYVTHKGE IRGASTPFQF RASSPVEELL TMEDEGNSDM LVVTTKAGLL
160 170 180 190 200
ELKIEKTMKE KEELLKLIAV LEKETAQLRE QVGRMERELN HEKERCDQLQ
210 220 230 240 250
AEQKGLTEVT QSLKMENEEF KKRFSDATSK AHQLEEDIVS VTHKAIEKET
260 270 280 290 300
ELDSLKDKLK KAQHEREQLE CQLKTEKDEK ELYKVHLKNT EIENTKLMSE
310 320 330 340 350
VQTLKNLDGN KESVITHFKE EIGRLQLCLA EKENLQRTFL LTTSSKEDTC
360 370 380 390 400
FLKEQLRKAE EQVQATRQEV VFLAKELSDA VNVRDRTMAD LHTARLENEK
410 420 430 440 450
VKKQLADAVA ELKLNAMKKD QDKTDTLEHE LRREVEDLKL RLQMAADHYK
460 470 480 490 500
EKFKECQRLQ KQINKLSDQS ANNNNVFTKK TGNQQKVNDA SVNTDPATSA
510 520 530 540 550
STVDVKPSPS AAEADFDIVT KGQVCEMTKE IADKTEKYNK CKQLLQDEKA
560 570 580 590 600
KCNKYADELA KMELKWKEQV KIAENVKLEL AEVQDNYKEL KRSLENPAER
610 620 630 640 650
KMEGQNSQSP QCFKTCSEQN GYVLTLSNAQ PVLQYGNPYA SQETRDGADG
660 670 680 690 700
AFYPDEIQRP PVRVPSWGLE DNVVCSQPAR NFSRPDGLED SEDSKEDENV
710 720 730 740 750
PTAPDPPSQH LRGHGTGFCF DSSFDVHKKC PLCELMFPPN YDQSKFEEHV
760 770 780
ESHWKVCPMC SEQFPPDYDQ QVFERHVQTH FDQNVLNFD
Length:789
Mass (Da):90,877
Last modified:May 16, 2006 - v2
Checksum:iDE8460DAA6712125
GO
Isoform 2 (identifier: Q86VP1-2) [UniParc]FASTAAdd to basket
Also known as: TXBP151-L

The sequence of this isoform differs from the canonical sequence as follows:
     604-645: Missing.

Show »
Length:747
Mass (Da):86,257
Checksum:i93EEDFF29106CE1C
GO
Isoform 3 (identifier: Q86VP1-3) [UniParc]FASTAAdd to basket
Also known as: TXBP151-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: Missing.
     604-645: Missing.

Show »
Length:563
Mass (Da):65,112
Checksum:iEFA52B16B4408B9C
GO
Isoform 4 (identifier: Q86VP1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.
     604-645: Missing.

Note: No experimental confirmation available.
Show »
Length:590
Mass (Da):68,277
Checksum:iF65F3BC653A80234
GO

Sequence cautioni

The sequence AAC13359 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti199L → P in BAG59309 (PubMed:14702039).Curated1
Sequence conflicti233 – 234QL → HV in AAA75595 (PubMed:10435631).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05141558S → N. Corresponds to variant dbSNP:rs7809260Ensembl.1
Natural variantiVAR_026286307L → I1 PublicationCorresponds to variant dbSNP:rs11540483Ensembl.1
Natural variantiVAR_035665457Q → R in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0183541 – 184Missing in isoform 3. CuratedAdd BLAST184
Alternative sequenceiVSP_0459211 – 157Missing in isoform 4. 1 PublicationAdd BLAST157
Alternative sequenceiVSP_018355604 – 645Missing in isoform 2, isoform 3 and isoform 4. 5 PublicationsAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33821 mRNA. Translation: AAA75595.2.
AF268075 mRNA. Translation: AAG03025.1.
AL136586 mRNA. Translation: CAB66521.1.
AF090891 mRNA. Translation: AAF24016.1.
CR457056 mRNA. Translation: CAG33337.1.
AK296720 mRNA. Translation: BAG59309.1.
AK314292 mRNA. Translation: BAG36949.1.
CR533556 mRNA. Translation: CAG38587.1.
AC004549 Genomic DNA. Translation: AAC13359.2. Sequence problems.
AC005091 Genomic DNA. Translation: AAD15412.1.
CH236948 Genomic DNA. Translation: EAL24213.1.
CH471073 Genomic DNA. Translation: EAW93901.1.
CH471073 Genomic DNA. Translation: EAW93904.1.
BC050358 mRNA. Translation: AAH50358.1.
CCDSiCCDS43561.1. [Q86VP1-2]
CCDS5415.1. [Q86VP1-1]
CCDS56471.1. [Q86VP1-4]
PIRiG02043.
RefSeqiNP_001073333.1. NM_001079864.2. [Q86VP1-2]
NP_001193830.1. NM_001206901.1. [Q86VP1-2]
NP_001193831.1. NM_001206902.1. [Q86VP1-4]
NP_006015.4. NM_006024.6. [Q86VP1-1]
UniGeneiHs.34576.

Genome annotation databases

EnsembliENST00000265393; ENSP00000265393; ENSG00000106052. [Q86VP1-2]
ENST00000396319; ENSP00000379612; ENSG00000106052. [Q86VP1-1]
ENST00000433216; ENSP00000391907; ENSG00000106052. [Q86VP1-4]
ENST00000543117; ENSP00000444811; ENSG00000106052. [Q86VP1-2]
GeneIDi8887.
KEGGihsa:8887.
UCSCiuc003szk.4. human. [Q86VP1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33821 mRNA. Translation: AAA75595.2.
AF268075 mRNA. Translation: AAG03025.1.
AL136586 mRNA. Translation: CAB66521.1.
AF090891 mRNA. Translation: AAF24016.1.
CR457056 mRNA. Translation: CAG33337.1.
AK296720 mRNA. Translation: BAG59309.1.
AK314292 mRNA. Translation: BAG36949.1.
CR533556 mRNA. Translation: CAG38587.1.
AC004549 Genomic DNA. Translation: AAC13359.2. Sequence problems.
AC005091 Genomic DNA. Translation: AAD15412.1.
CH236948 Genomic DNA. Translation: EAL24213.1.
CH471073 Genomic DNA. Translation: EAW93901.1.
CH471073 Genomic DNA. Translation: EAW93904.1.
BC050358 mRNA. Translation: AAH50358.1.
CCDSiCCDS43561.1. [Q86VP1-2]
CCDS5415.1. [Q86VP1-1]
CCDS56471.1. [Q86VP1-4]
PIRiG02043.
RefSeqiNP_001073333.1. NM_001079864.2. [Q86VP1-2]
NP_001193830.1. NM_001206901.1. [Q86VP1-2]
NP_001193831.1. NM_001206902.1. [Q86VP1-4]
NP_006015.4. NM_006024.6. [Q86VP1-1]
UniGeneiHs.34576.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M7QNMR-A725-789[»]
4BMJX-ray2.75A/B/C/D/E/F/G/H/I/J/K725-789[»]
4NLHX-ray1.90A/B15-147[»]
4Z4KX-ray2.80A/B725-781[»]
4Z4MX-ray2.15A/B755-781[»]
5AASNMR-A722-784[»]
ProteinModelPortaliQ86VP1.
SMRiQ86VP1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114405. 69 interactors.
DIPiDIP-33010N.
IntActiQ86VP1. 83 interactors.
MINTiMINT-200894.
STRINGi9606.ENSP00000379612.

PTM databases

iPTMnetiQ86VP1.
PhosphoSitePlusiQ86VP1.

Polymorphism and mutation databases

BioMutaiTAX1BP1.
DMDMi97202549.

Proteomic databases

EPDiQ86VP1.
MaxQBiQ86VP1.
PaxDbiQ86VP1.
PeptideAtlasiQ86VP1.
PRIDEiQ86VP1.

Protocols and materials databases

DNASUi8887.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265393; ENSP00000265393; ENSG00000106052. [Q86VP1-2]
ENST00000396319; ENSP00000379612; ENSG00000106052. [Q86VP1-1]
ENST00000433216; ENSP00000391907; ENSG00000106052. [Q86VP1-4]
ENST00000543117; ENSP00000444811; ENSG00000106052. [Q86VP1-2]
GeneIDi8887.
KEGGihsa:8887.
UCSCiuc003szk.4. human. [Q86VP1-1]

Organism-specific databases

CTDi8887.
DisGeNETi8887.
GeneCardsiTAX1BP1.
HGNCiHGNC:11575. TAX1BP1.
HPAiHPA024432.
MIMi605326. gene.
neXtProtiNX_Q86VP1.
OpenTargetsiENSG00000106052.
PharmGKBiPA36339.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGMS. Eukaryota.
ENOG410XQDF. LUCA.
GeneTreeiENSGT00530000063216.
HOGENOMiHOG000271638.
HOVERGENiHBG053034.
InParanoidiQ86VP1.
PhylomeDBiQ86VP1.
TreeFamiTF329501.

Enzyme and pathway databases

ReactomeiR-HSA-5357905. Regulation of TNFR1 signaling.
R-HSA-936440. Negative regulators of RIG-I/MDA5 signaling.
SIGNORiQ86VP1.

Miscellaneous databases

ChiTaRSiTAX1BP1. human.
GeneWikiiTAX1BP1.
GenomeRNAii8887.
PROiQ86VP1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106052.
CleanExiHS_TAX1BP1.
ExpressionAtlasiQ86VP1. baseline and differential.
GenevisibleiQ86VP1. HS.

Family and domain databases

InterProiView protein in InterPro
IPR012852. CALCOCO1-like.
PfamiView protein in Pfam
PF07888. CALCOCO1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTAXB1_HUMAN
AccessioniPrimary (citable) accession number: Q86VP1
Secondary accession number(s): A4D196
, B4DKU7, E7ENV2, O60398, O95770, Q13311, Q9BQG5, Q9UI88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: February 15, 2017
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.