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Q86VP1 (TAXB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tax1-binding protein 1
Alternative name(s):
TRAF6-binding protein
Gene names
Name:TAX1BP1
Synonyms:T6BP
ORF Names:PRO0105
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length789 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. Ref.1 Ref.2

Subunit structure

Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13. Interacts with the HTLV-1 protein Tax-1. Ref.1 Ref.2 Ref.9 Ref.10

Tissue specificity

Expressed in all tissues tested.

Post-translational modification

Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation. Ref.13

Sequence caution

The sequence AAC13359.2 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86VP1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86VP1-2)

Also known as: TXBP151-L;

The sequence of this isoform differs from the canonical sequence as follows:
     604-645: Missing.
Isoform 3 (identifier: Q86VP1-3)

Also known as: TXBP151-S;

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: Missing.
     604-645: Missing.
Isoform 4 (identifier: Q86VP1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.
     604-645: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 789789Tax1-binding protein 1
PRO_0000234554

Regions

Region320 – 420101Oligomerization
Coiled coil144 – 599456 Potential

Amino acid modifications

Modified residue2251Phosphoserine Ref.11
Modified residue5931Phosphoserine; by IKKA Ref.13
Modified residue6661Phosphoserine; by IKKA Ref.13

Natural variations

Alternative sequence1 – 184184Missing in isoform 3.
VSP_018354
Alternative sequence1 – 157157Missing in isoform 4.
VSP_045921
Alternative sequence604 – 64542Missing in isoform 2, isoform 3 and isoform 4.
VSP_018355
Natural variant581S → N.
Corresponds to variant rs7809260 [ dbSNP | Ensembl ].
VAR_051415
Natural variant3071L → I. Ref.8
Corresponds to variant rs11540483 [ dbSNP | Ensembl ].
VAR_026286
Natural variant4571Q → R in a breast cancer sample; somatic mutation. Ref.12
VAR_035665

Experimental info

Sequence conflict1991L → P in BAG59309. Ref.5
Sequence conflict233 – 2342QL → HV in AAA75595. Ref.1

Secondary structure

............. 789
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 16, 2006. Version 2.
Checksum: DE8460DAA6712125

FASTA78990,877
        10         20         30         40         50         60 
MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV GIFKVGWSTA 

        70         80         90        100        110        120 
RDYYTFLWSP MPEHYVEGST VNCVLAFQGY YLPNDDGEFY QFCYVTHKGE IRGASTPFQF 

       130        140        150        160        170        180 
RASSPVEELL TMEDEGNSDM LVVTTKAGLL ELKIEKTMKE KEELLKLIAV LEKETAQLRE 

       190        200        210        220        230        240 
QVGRMERELN HEKERCDQLQ AEQKGLTEVT QSLKMENEEF KKRFSDATSK AHQLEEDIVS 

       250        260        270        280        290        300 
VTHKAIEKET ELDSLKDKLK KAQHEREQLE CQLKTEKDEK ELYKVHLKNT EIENTKLMSE 

       310        320        330        340        350        360 
VQTLKNLDGN KESVITHFKE EIGRLQLCLA EKENLQRTFL LTTSSKEDTC FLKEQLRKAE 

       370        380        390        400        410        420 
EQVQATRQEV VFLAKELSDA VNVRDRTMAD LHTARLENEK VKKQLADAVA ELKLNAMKKD 

       430        440        450        460        470        480 
QDKTDTLEHE LRREVEDLKL RLQMAADHYK EKFKECQRLQ KQINKLSDQS ANNNNVFTKK 

       490        500        510        520        530        540 
TGNQQKVNDA SVNTDPATSA STVDVKPSPS AAEADFDIVT KGQVCEMTKE IADKTEKYNK 

       550        560        570        580        590        600 
CKQLLQDEKA KCNKYADELA KMELKWKEQV KIAENVKLEL AEVQDNYKEL KRSLENPAER 

       610        620        630        640        650        660 
KMEGQNSQSP QCFKTCSEQN GYVLTLSNAQ PVLQYGNPYA SQETRDGADG AFYPDEIQRP 

       670        680        690        700        710        720 
PVRVPSWGLE DNVVCSQPAR NFSRPDGLED SEDSKEDENV PTAPDPPSQH LRGHGTGFCF 

       730        740        750        760        770        780 
DSSFDVHKKC PLCELMFPPN YDQSKFEEHV ESHWKVCPMC SEQFPPDYDQ QVFERHVQTH 


FDQNVLNFD 

« Hide

Isoform 2 (TXBP151-L) [UniParc].

Checksum: 93EEDFF29106CE1C
Show »

FASTA74786,257
Isoform 3 (TXBP151-S) [UniParc].

Checksum: EFA52B16B4408B9C
Show »

FASTA56365,112
Isoform 4 [UniParc].

Checksum: F65F3BC653A80234
Show »

FASTA59068,277

References

« Hide 'large scale' references
[1]"The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases."
de Valck D., Jin D.-Y., Heyninck K., van de Craen M., Contreras R., Fiers W., Jeang K.-T., Beyaert R.
Oncogene 18:4182-4190(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH TNFAIP3 AND HTLV-1 PROTEIN TAX-1, ALTERNATIVE SPLICING (ISOFORM 3).
Tissue: Cervix carcinoma.
[2]"T6BP, a TRAF6-interacting protein involved in IL-1 signaling."
Ling L., Goeddel D.V.
Proc. Natl. Acad. Sci. U.S.A. 97:9567-9572(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH TRAF6, SUBUNIT.
[3]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Amygdala.
[4]"Functional prediction of the coding sequences of 50 new genes deduced by analysis of cDNA clones from human fetal liver."
Yu Y., Zhang C., Luo L., Ouyang S., Zhang S., Li W., Wu J., Zhou S., Liu M., He F.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Fetal liver.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Tongue.
[6]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[7]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-307.
Tissue: Skin.
[9]"Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins."
Nagaraja G.M., Kandpal R.P.
Biochem. Biophys. Res. Commun. 313:654-665(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH STARD13.
[10]"Protein profile of tax-associated complexes."
Wu K., Bottazzi M.E., de la Fuente C., Deng L., Gitlin S.D., Maddukuri A., Dadgar S., Li H., Vertes A., Pumfery A., Kashanchi F.
J. Biol. Chem. 279:495-508(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH HTLV-1 PROTEIN TAX-1.
[11]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-457.
[13]"The kinase IKKalpha inhibits activation of the transcription factor NF-kappaB by phosphorylating the regulatory molecule TAX1BP1."
Shembade N., Pujari R., Harhaj N.S., Abbott D.W., Harhaj E.W.
Nat. Immunol. 12:834-843(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-593 AND SER-666 BY CHUK/IKKA.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U33821 mRNA. Translation: AAA75595.2.
AF268075 mRNA. Translation: AAG03025.1.
AL136586 mRNA. Translation: CAB66521.1.
AF090891 mRNA. Translation: AAF24016.1.
CR457056 mRNA. Translation: CAG33337.1.
AK296720 mRNA. Translation: BAG59309.1.
CR533556 mRNA. Translation: CAG38587.1.
AC004549 Genomic DNA. Translation: AAC13359.2. Sequence problems.
AC005091 Genomic DNA. Translation: AAD15412.1.
BC050358 mRNA. Translation: AAH50358.1.
CCDSCCDS43561.1. [Q86VP1-2]
CCDS5415.1. [Q86VP1-1]
CCDS56471.1. [Q86VP1-4]
PIRG02043.
RefSeqNP_001073333.1. NM_001079864.2. [Q86VP1-2]
NP_001193830.1. NM_001206901.1. [Q86VP1-2]
NP_001193831.1. NM_001206902.1. [Q86VP1-4]
NP_006015.4. NM_006024.6. [Q86VP1-1]
UniGeneHs.34576.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2M7QNMR-A725-789[»]
4BMJX-ray2.75A/B/C/D/E/F/G/H/I/J/K725-789[»]
ProteinModelPortalQ86VP1.
SMRQ86VP1. Positions 15-121, 725-789.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114405. 21 interactions.
DIPDIP-33010N.
IntActQ86VP1. 22 interactions.
MINTMINT-200894.
STRING9606.ENSP00000379612.

PTM databases

PhosphoSiteQ86VP1.

Polymorphism databases

DMDM97202549.

Proteomic databases

MaxQBQ86VP1.
PaxDbQ86VP1.
PRIDEQ86VP1.

Protocols and materials databases

DNASU8887.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000265393; ENSP00000265393; ENSG00000106052. [Q86VP1-2]
ENST00000396319; ENSP00000379612; ENSG00000106052. [Q86VP1-1]
ENST00000433216; ENSP00000391907; ENSG00000106052. [Q86VP1-4]
ENST00000543117; ENSP00000444811; ENSG00000106052. [Q86VP1-2]
GeneID8887.
KEGGhsa:8887.
UCSCuc003szk.3. human. [Q86VP1-2]
uc003szl.3. human. [Q86VP1-1]

Organism-specific databases

CTD8887.
GeneCardsGC07P027746.
HGNCHGNC:11575. TAX1BP1.
HPAHPA024432.
MIM605326. gene.
neXtProtNX_Q86VP1.
PharmGKBPA36339.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG135564.
HOGENOMHOG000271638.
HOVERGENHBG053034.
OrthoDBEOG7RRF8H.
PhylomeDBQ86VP1.
TreeFamTF329501.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressQ86VP1.
BgeeQ86VP1.
CleanExHS_TAX1BP1.
GenevestigatorQ86VP1.

Family and domain databases

InterProIPR012852. CoCoA.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamPF07888. CALCOCO1. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTAX1BP1. human.
GeneWikiTAX1BP1.
GenomeRNAi8887.
NextBio33373.
PROQ86VP1.
SOURCESearch...

Entry information

Entry nameTAXB1_HUMAN
AccessionPrimary (citable) accession number: Q86VP1
Secondary accession number(s): B4DKU7 expand/collapse secondary AC list , E7ENV2, O60398, O95770, Q13311, Q9BQG5, Q9UI88
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: July 9, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM