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Q86VP1

- TAXB1_HUMAN

UniProt

Q86VP1 - TAXB1_HUMAN

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Protein

Tax1-binding protein 1

Gene

TAX1BP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.2 Publications

GO - Molecular functioni

  1. kinase binding Source: BHF-UCL

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. innate immune response Source: Reactome
  3. negative regulation of apoptotic process Source: ProtInc
  4. negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  5. negative regulation of type I interferon production Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiREACT_25271. Negative regulators of RIG-I/MDA5 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tax1-binding protein 1
Alternative name(s):
TRAF6-binding protein
Gene namesi
Name:TAX1BP1
Synonyms:T6BP
ORF Names:PRO0105
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:11575. TAX1BP1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36339.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 789789Tax1-binding protein 1PRO_0000234554Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei225 – 2251Phosphoserine1 Publication
Modified residuei593 – 5931Phosphoserine; by IKKA1 Publication
Modified residuei666 – 6661Phosphoserine; by IKKA1 Publication

Post-translational modificationi

Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ86VP1.
PaxDbiQ86VP1.
PRIDEiQ86VP1.

PTM databases

PhosphoSiteiQ86VP1.

Expressioni

Tissue specificityi

Expressed in all tissues tested.

Gene expression databases

BgeeiQ86VP1.
CleanExiHS_TAX1BP1.
ExpressionAtlasiQ86VP1. baseline and differential.
GenevestigatoriQ86VP1.

Organism-specific databases

HPAiHPA024432.

Interactioni

Subunit structurei

Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13. Interacts with the HTLV-1 protein Tax-1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CHUKO151112EBI-529518,EBI-81249
RALBP1Q153113EBI-529518,EBI-749285
RNF11Q9Y3C52EBI-529518,EBI-396669
STARD13Q9Y3M82EBI-529518,EBI-465487
TRAF6Q9Y4K38EBI-529518,EBI-359276
UBCP0CG485EBI-529518,EBI-3390054

Protein-protein interaction databases

BioGridi114405. 31 interactions.
DIPiDIP-33010N.
IntActiQ86VP1. 23 interactions.
MINTiMINT-200894.
STRINGi9606.ENSP00000379612.

Structurei

Secondary structure

1
789
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi727 – 7293Combined sources
Beta strandi731 – 7344Combined sources
Helixi743 – 7519Combined sources
Beta strandi754 – 7563Combined sources
Turni758 – 7603Combined sources
Helixi770 – 78213Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2M7QNMR-A725-789[»]
4BMJX-ray2.75A/B/C/D/E/F/G/H/I/J/K725-789[»]
ProteinModelPortaliQ86VP1.
SMRiQ86VP1. Positions 15-121, 725-789.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni320 – 420101OligomerizationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili144 – 599456Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG135564.
GeneTreeiENSGT00530000063216.
HOGENOMiHOG000271638.
HOVERGENiHBG053034.
InParanoidiQ86VP1.
OrthoDBiEOG7RRF8H.
PhylomeDBiQ86VP1.
TreeFamiTF329501.

Family and domain databases

InterProiIPR012852. CoCoA.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF07888. CALCOCO1. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86VP1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV
60 70 80 90 100
GIFKVGWSTA RDYYTFLWSP MPEHYVEGST VNCVLAFQGY YLPNDDGEFY
110 120 130 140 150
QFCYVTHKGE IRGASTPFQF RASSPVEELL TMEDEGNSDM LVVTTKAGLL
160 170 180 190 200
ELKIEKTMKE KEELLKLIAV LEKETAQLRE QVGRMERELN HEKERCDQLQ
210 220 230 240 250
AEQKGLTEVT QSLKMENEEF KKRFSDATSK AHQLEEDIVS VTHKAIEKET
260 270 280 290 300
ELDSLKDKLK KAQHEREQLE CQLKTEKDEK ELYKVHLKNT EIENTKLMSE
310 320 330 340 350
VQTLKNLDGN KESVITHFKE EIGRLQLCLA EKENLQRTFL LTTSSKEDTC
360 370 380 390 400
FLKEQLRKAE EQVQATRQEV VFLAKELSDA VNVRDRTMAD LHTARLENEK
410 420 430 440 450
VKKQLADAVA ELKLNAMKKD QDKTDTLEHE LRREVEDLKL RLQMAADHYK
460 470 480 490 500
EKFKECQRLQ KQINKLSDQS ANNNNVFTKK TGNQQKVNDA SVNTDPATSA
510 520 530 540 550
STVDVKPSPS AAEADFDIVT KGQVCEMTKE IADKTEKYNK CKQLLQDEKA
560 570 580 590 600
KCNKYADELA KMELKWKEQV KIAENVKLEL AEVQDNYKEL KRSLENPAER
610 620 630 640 650
KMEGQNSQSP QCFKTCSEQN GYVLTLSNAQ PVLQYGNPYA SQETRDGADG
660 670 680 690 700
AFYPDEIQRP PVRVPSWGLE DNVVCSQPAR NFSRPDGLED SEDSKEDENV
710 720 730 740 750
PTAPDPPSQH LRGHGTGFCF DSSFDVHKKC PLCELMFPPN YDQSKFEEHV
760 770 780
ESHWKVCPMC SEQFPPDYDQ QVFERHVQTH FDQNVLNFD
Length:789
Mass (Da):90,877
Last modified:May 16, 2006 - v2
Checksum:iDE8460DAA6712125
GO
Isoform 2 (identifier: Q86VP1-2) [UniParc]FASTAAdd to Basket

Also known as: TXBP151-L

The sequence of this isoform differs from the canonical sequence as follows:
     604-645: Missing.

Show »
Length:747
Mass (Da):86,257
Checksum:i93EEDFF29106CE1C
GO
Isoform 3 (identifier: Q86VP1-3) [UniParc]FASTAAdd to Basket

Also known as: TXBP151-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: Missing.
     604-645: Missing.

Show »
Length:563
Mass (Da):65,112
Checksum:iEFA52B16B4408B9C
GO
Isoform 4 (identifier: Q86VP1-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.
     604-645: Missing.

Note: No experimental confirmation available.

Show »
Length:590
Mass (Da):68,277
Checksum:iF65F3BC653A80234
GO

Sequence cautioni

The sequence AAC13359.2 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti199 – 1991L → P in BAG59309. (PubMed:14702039)Curated
Sequence conflicti233 – 2342QL → HV in AAA75595. (PubMed:10435631)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti58 – 581S → N.
Corresponds to variant rs7809260 [ dbSNP | Ensembl ].
VAR_051415
Natural varianti307 – 3071L → I.1 Publication
Corresponds to variant rs11540483 [ dbSNP | Ensembl ].
VAR_026286
Natural varianti457 – 4571Q → R in a breast cancer sample; somatic mutation. 1 Publication
VAR_035665

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 184184Missing in isoform 3. CuratedVSP_018354Add
BLAST
Alternative sequencei1 – 157157Missing in isoform 4. 1 PublicationVSP_045921Add
BLAST
Alternative sequencei604 – 64542Missing in isoform 2, isoform 3 and isoform 4. 5 PublicationsVSP_018355Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33821 mRNA. Translation: AAA75595.2.
AF268075 mRNA. Translation: AAG03025.1.
AL136586 mRNA. Translation: CAB66521.1.
AF090891 mRNA. Translation: AAF24016.1.
CR457056 mRNA. Translation: CAG33337.1.
AK296720 mRNA. Translation: BAG59309.1.
CR533556 mRNA. Translation: CAG38587.1.
AC004549 Genomic DNA. Translation: AAC13359.2. Sequence problems.
AC005091 Genomic DNA. Translation: AAD15412.1.
BC050358 mRNA. Translation: AAH50358.1.
CCDSiCCDS43561.1. [Q86VP1-2]
CCDS5415.1. [Q86VP1-1]
CCDS56471.1. [Q86VP1-4]
PIRiG02043.
RefSeqiNP_001073333.1. NM_001079864.2. [Q86VP1-2]
NP_001193830.1. NM_001206901.1. [Q86VP1-2]
NP_001193831.1. NM_001206902.1. [Q86VP1-4]
NP_006015.4. NM_006024.6. [Q86VP1-1]
UniGeneiHs.34576.

Genome annotation databases

EnsembliENST00000265393; ENSP00000265393; ENSG00000106052. [Q86VP1-2]
ENST00000396319; ENSP00000379612; ENSG00000106052. [Q86VP1-1]
ENST00000433216; ENSP00000391907; ENSG00000106052. [Q86VP1-4]
ENST00000543117; ENSP00000444811; ENSG00000106052. [Q86VP1-2]
GeneIDi8887.
KEGGihsa:8887.
UCSCiuc003szk.3. human. [Q86VP1-2]
uc003szl.3. human. [Q86VP1-1]

Polymorphism databases

DMDMi97202549.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33821 mRNA. Translation: AAA75595.2 .
AF268075 mRNA. Translation: AAG03025.1 .
AL136586 mRNA. Translation: CAB66521.1 .
AF090891 mRNA. Translation: AAF24016.1 .
CR457056 mRNA. Translation: CAG33337.1 .
AK296720 mRNA. Translation: BAG59309.1 .
CR533556 mRNA. Translation: CAG38587.1 .
AC004549 Genomic DNA. Translation: AAC13359.2 . Sequence problems.
AC005091 Genomic DNA. Translation: AAD15412.1 .
BC050358 mRNA. Translation: AAH50358.1 .
CCDSi CCDS43561.1. [Q86VP1-2 ]
CCDS5415.1. [Q86VP1-1 ]
CCDS56471.1. [Q86VP1-4 ]
PIRi G02043.
RefSeqi NP_001073333.1. NM_001079864.2. [Q86VP1-2 ]
NP_001193830.1. NM_001206901.1. [Q86VP1-2 ]
NP_001193831.1. NM_001206902.1. [Q86VP1-4 ]
NP_006015.4. NM_006024.6. [Q86VP1-1 ]
UniGenei Hs.34576.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2M7Q NMR - A 725-789 [» ]
4BMJ X-ray 2.75 A/B/C/D/E/F/G/H/I/J/K 725-789 [» ]
ProteinModelPortali Q86VP1.
SMRi Q86VP1. Positions 15-121, 725-789.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114405. 31 interactions.
DIPi DIP-33010N.
IntActi Q86VP1. 23 interactions.
MINTi MINT-200894.
STRINGi 9606.ENSP00000379612.

PTM databases

PhosphoSitei Q86VP1.

Polymorphism databases

DMDMi 97202549.

Proteomic databases

MaxQBi Q86VP1.
PaxDbi Q86VP1.
PRIDEi Q86VP1.

Protocols and materials databases

DNASUi 8887.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265393 ; ENSP00000265393 ; ENSG00000106052 . [Q86VP1-2 ]
ENST00000396319 ; ENSP00000379612 ; ENSG00000106052 . [Q86VP1-1 ]
ENST00000433216 ; ENSP00000391907 ; ENSG00000106052 . [Q86VP1-4 ]
ENST00000543117 ; ENSP00000444811 ; ENSG00000106052 . [Q86VP1-2 ]
GeneIDi 8887.
KEGGi hsa:8887.
UCSCi uc003szk.3. human. [Q86VP1-2 ]
uc003szl.3. human. [Q86VP1-1 ]

Organism-specific databases

CTDi 8887.
GeneCardsi GC07P027746.
HGNCi HGNC:11575. TAX1BP1.
HPAi HPA024432.
MIMi 605326. gene.
neXtProti NX_Q86VP1.
PharmGKBi PA36339.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG135564.
GeneTreei ENSGT00530000063216.
HOGENOMi HOG000271638.
HOVERGENi HBG053034.
InParanoidi Q86VP1.
OrthoDBi EOG7RRF8H.
PhylomeDBi Q86VP1.
TreeFami TF329501.

Enzyme and pathway databases

Reactomei REACT_25271. Negative regulators of RIG-I/MDA5 signaling.

Miscellaneous databases

ChiTaRSi TAX1BP1. human.
GeneWikii TAX1BP1.
GenomeRNAii 8887.
NextBioi 33373.
PROi Q86VP1.
SOURCEi Search...

Gene expression databases

Bgeei Q86VP1.
CleanExi HS_TAX1BP1.
ExpressionAtlasi Q86VP1. baseline and differential.
Genevestigatori Q86VP1.

Family and domain databases

InterProi IPR012852. CoCoA.
IPR015880. Znf_C2H2-like.
[Graphical view ]
Pfami PF07888. CALCOCO1. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases."
    de Valck D., Jin D.-Y., Heyninck K., van de Craen M., Contreras R., Fiers W., Jeang K.-T., Beyaert R.
    Oncogene 18:4182-4190(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH TNFAIP3 AND HTLV-1 PROTEIN TAX-1, ALTERNATIVE SPLICING (ISOFORM 3).
    Tissue: Cervix carcinoma.
  2. "T6BP, a TRAF6-interacting protein involved in IL-1 signaling."
    Ling L., Goeddel D.V.
    Proc. Natl. Acad. Sci. U.S.A. 97:9567-9572(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH TRAF6, SUBUNIT.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  4. "Functional prediction of the coding sequences of 50 new genes deduced by analysis of cDNA clones from human fetal liver."
    Yu Y., Zhang C., Luo L., Ouyang S., Zhang S., Li W., Wu J., Zhou S., Liu M., He F.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Fetal liver.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Tongue.
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  7. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-307.
    Tissue: Skin.
  9. "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins."
    Nagaraja G.M., Kandpal R.P.
    Biochem. Biophys. Res. Commun. 313:654-665(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH STARD13.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH HTLV-1 PROTEIN TAX-1.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-457.
  13. "The kinase IKKalpha inhibits activation of the transcription factor NF-kappaB by phosphorylating the regulatory molecule TAX1BP1."
    Shembade N., Pujari R., Harhaj N.S., Abbott D.W., Harhaj E.W.
    Nat. Immunol. 12:834-843(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-593 AND SER-666 BY CHUK/IKKA.

Entry informationi

Entry nameiTAXB1_HUMAN
AccessioniPrimary (citable) accession number: Q86VP1
Secondary accession number(s): B4DKU7
, E7ENV2, O60398, O95770, Q13311, Q9BQG5, Q9UI88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: November 26, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

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