Q86VP1 (TAXB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tax1-binding protein 1

Alternative name(s):
TRAF6-binding protein

Gene names

Name:	TAX1BP1
Synonyms:	T6BP
ORF Names:	PRO0105

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	789 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. Ref.1 Ref.2
Subunit structure	Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13. Interacts with the HTLV-1 protein Tax-1. Ref.1 Ref.2 Ref.9 Ref.10
Tissue specificity	Expressed in all tissues tested.
Post-translational modification	Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation. Ref.13
Sequence caution	The sequence AAC13359.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Apoptosis
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW innate immune response Traceable author statement. Source: Reactome negative regulation of NF-kappaB transcription factor activity Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of apoptotic process Traceable author statement Ref.1. Source: ProtInc negative regulation of type I interferon production Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome
Molecular_function	kinase binding Inferred from sequence or structural similarity. Source: BHF-UCL zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CHUK	O15111	2	EBI-529518,EBI-81249
STARD13	Q9Y3M8	2	EBI-529518,EBI-465487
TRAF6	Q9Y4K3	3	EBI-529518,EBI-359276

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86VP1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86VP1-2)

Also known as: TXBP151-L;

The sequence of this isoform differs from the canonical sequence as follows:
     604-645: Missing.

Isoform 3 (identifier: Q86VP1-3)

Also known as: TXBP151-S;

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: Missing.
     604-645: Missing.

Isoform 4 (identifier: Q86VP1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.
     604-645: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 789	789	Tax1-binding protein 1		PRO_0000234554
Regions
	Region	320 – 420	101	Oligomerization
	Coiled coil	144 – 599	456	Potential
Amino acid modifications
	Modified residue	225	1	Phosphoserine Ref.11
	Modified residue	593	1	Phosphoserine; by IKKA Ref.13
	Modified residue	666	1	Phosphoserine; by IKKA Ref.13
Natural variations
	Alternative sequence	1 – 184	184	Missing in isoform 3.		VSP_018354
	Alternative sequence	1 – 157	157	Missing in isoform 4.		VSP_045921
	Alternative sequence	604 – 645	42	Missing in isoform 2, isoform 3 and isoform 4.		VSP_018355
	Natural variant	58	1	S → N. Corresponds to variant rs7809260 [ dbSNP | Ensembl ].		VAR_051415
	Natural variant	307	1	L → I. Ref.8 Corresponds to variant rs11540483 [ dbSNP | Ensembl ].		VAR_026286
	Natural variant	457	1	Q → R in a breast cancer sample; somatic mutation. Ref.12		VAR_035665
Experimental info
	Sequence conflict	199	1	L → P in BAG59309. Ref.5
	Sequence conflict	233 – 234	2	QL → HV in AAA75595. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 16, 2006. Version 2. Checksum: DE8460DAA6712125	FASTA	789	90,877
	10 20 30 40 50 60 MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV GIFKVGWSTA 70 80 90 100 110 120 RDYYTFLWSP MPEHYVEGST VNCVLAFQGY YLPNDDGEFY QFCYVTHKGE IRGASTPFQF 130 140 150 160 170 180 RASSPVEELL TMEDEGNSDM LVVTTKAGLL ELKIEKTMKE KEELLKLIAV LEKETAQLRE 190 200 210 220 230 240 QVGRMERELN HEKERCDQLQ AEQKGLTEVT QSLKMENEEF KKRFSDATSK AHQLEEDIVS 250 260 270 280 290 300 VTHKAIEKET ELDSLKDKLK KAQHEREQLE CQLKTEKDEK ELYKVHLKNT EIENTKLMSE 310 320 330 340 350 360 VQTLKNLDGN KESVITHFKE EIGRLQLCLA EKENLQRTFL LTTSSKEDTC FLKEQLRKAE 370 380 390 400 410 420 EQVQATRQEV VFLAKELSDA VNVRDRTMAD LHTARLENEK VKKQLADAVA ELKLNAMKKD 430 440 450 460 470 480 QDKTDTLEHE LRREVEDLKL RLQMAADHYK EKFKECQRLQ KQINKLSDQS ANNNNVFTKK 490 500 510 520 530 540 TGNQQKVNDA SVNTDPATSA STVDVKPSPS AAEADFDIVT KGQVCEMTKE IADKTEKYNK 550 560 570 580 590 600 CKQLLQDEKA KCNKYADELA KMELKWKEQV KIAENVKLEL AEVQDNYKEL KRSLENPAER 610 620 630 640 650 660 KMEGQNSQSP QCFKTCSEQN GYVLTLSNAQ PVLQYGNPYA SQETRDGADG AFYPDEIQRP 670 680 690 700 710 720 PVRVPSWGLE DNVVCSQPAR NFSRPDGLED SEDSKEDENV PTAPDPPSQH LRGHGTGFCF 730 740 750 760 770 780 DSSFDVHKKC PLCELMFPPN YDQSKFEEHV ESHWKVCPMC SEQFPPDYDQ QVFERHVQTH FDQNVLNFD
	Isoform 2 (TXBP151-L) [UniParc]. Checksum: 93EEDFF29106CE1C	FASTA	747	86,257
	10 20 30 40 50 60 MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV GIFKVGWSTA 70 80 90 100 110 120 RDYYTFLWSP MPEHYVEGST VNCVLAFQGY YLPNDDGEFY QFCYVTHKGE IRGASTPFQF 130 140 150 160 170 180 RASSPVEELL TMEDEGNSDM LVVTTKAGLL ELKIEKTMKE KEELLKLIAV LEKETAQLRE 190 200 210 220 230 240 QVGRMERELN HEKERCDQLQ AEQKGLTEVT QSLKMENEEF KKRFSDATSK AHQLEEDIVS 250 260 270 280 290 300 VTHKAIEKET ELDSLKDKLK KAQHEREQLE CQLKTEKDEK ELYKVHLKNT EIENTKLMSE 310 320 330 340 350 360 VQTLKNLDGN KESVITHFKE EIGRLQLCLA EKENLQRTFL LTTSSKEDTC FLKEQLRKAE 370 380 390 400 410 420 EQVQATRQEV VFLAKELSDA VNVRDRTMAD LHTARLENEK VKKQLADAVA ELKLNAMKKD 430 440 450 460 470 480 QDKTDTLEHE LRREVEDLKL RLQMAADHYK EKFKECQRLQ KQINKLSDQS ANNNNVFTKK 490 500 510 520 530 540 TGNQQKVNDA SVNTDPATSA STVDVKPSPS AAEADFDIVT KGQVCEMTKE IADKTEKYNK 550 560 570 580 590 600 CKQLLQDEKA KCNKYADELA KMELKWKEQV KIAENVKLEL AEVQDNYKEL KRSLENPAER 610 620 630 640 650 660 KMEDGADGAF YPDEIQRPPV RVPSWGLEDN VVCSQPARNF SRPDGLEDSE DSKEDENVPT 670 680 690 700 710 720 APDPPSQHLR GHGTGFCFDS SFDVHKKCPL CELMFPPNYD QSKFEEHVES HWKVCPMCSE 730 740 QFPPDYDQQV FERHVQTHFD QNVLNFD
	Isoform 3 (TXBP151-S) [UniParc]. Checksum: EFA52B16B4408B9C	FASTA	563	65,112
	10 20 30 40 50 60 MERELNHEKE RCDQLQAEQK GLTEVTQSLK MENEEFKKRF SDATSKAHQL EEDIVSVTHK 70 80 90 100 110 120 AIEKETELDS LKDKLKKAQH EREQLECQLK TEKDEKELYK VHLKNTEIEN TKLMSEVQTL 130 140 150 160 170 180 KNLDGNKESV ITHFKEEIGR LQLCLAEKEN LQRTFLLTTS SKEDTCFLKE QLRKAEEQVQ 190 200 210 220 230 240 ATRQEVVFLA KELSDAVNVR DRTMADLHTA RLENEKVKKQ LADAVAELKL NAMKKDQDKT 250 260 270 280 290 300 DTLEHELRRE VEDLKLRLQM AADHYKEKFK ECQRLQKQIN KLSDQSANNN NVFTKKTGNQ 310 320 330 340 350 360 QKVNDASVNT DPATSASTVD VKPSPSAAEA DFDIVTKGQV CEMTKEIADK TEKYNKCKQL 370 380 390 400 410 420 LQDEKAKCNK YADELAKMEL KWKEQVKIAE NVKLELAEVQ DNYKELKRSL ENPAERKMED 430 440 450 460 470 480 GADGAFYPDE IQRPPVRVPS WGLEDNVVCS QPARNFSRPD GLEDSEDSKE DENVPTAPDP 490 500 510 520 530 540 PSQHLRGHGT GFCFDSSFDV HKKCPLCELM FPPNYDQSKF EEHVESHWKV CPMCSEQFPP 550 560 DYDQQVFERH VQTHFDQNVL NFD
	Isoform 4 [UniParc]. Checksum: F65F3BC653A80234	FASTA	590	68,277
	10 20 30 40 50 60 MKEKEELLKL IAVLEKETAQ LREQVGRMER ELNHEKERCD QLQAEQKGLT EVTQSLKMEN 70 80 90 100 110 120 EEFKKRFSDA TSKAHQLEED IVSVTHKAIE KETELDSLKD KLKKAQHERE QLECQLKTEK 130 140 150 160 170 180 DEKELYKVHL KNTEIENTKL MSEVQTLKNL DGNKESVITH FKEEIGRLQL CLAEKENLQR 190 200 210 220 230 240 TFLLTTSSKE DTCFLKEQLR KAEEQVQATR QEVVFLAKEL SDAVNVRDRT MADLHTARLE 250 260 270 280 290 300 NEKVKKQLAD AVAELKLNAM KKDQDKTDTL EHELRREVED LKLRLQMAAD HYKEKFKECQ 310 320 330 340 350 360 RLQKQINKLS DQSANNNNVF TKKTGNQQKV NDASVNTDPA TSASTVDVKP SPSAAEADFD 370 380 390 400 410 420 IVTKGQVCEM TKEIADKTEK YNKCKQLLQD EKAKCNKYAD ELAKMELKWK EQVKIAENVK 430 440 450 460 470 480 LELAEVQDNY KELKRSLENP AERKMEDGAD GAFYPDEIQR PPVRVPSWGL EDNVVCSQPA 490 500 510 520 530 540 RNFSRPDGLE DSEDSKEDEN VPTAPDPPSQ HLRGHGTGFC FDSSFDVHKK CPLCELMFPP 550 560 570 580 590 NYDQSKFEEH VESHWKVCPM CSEQFPPDYD QQVFERHVQT HFDQNVLNFD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases." de Valck D., Jin D.-Y., Heyninck K., van de Craen M., Contreras R., Fiers W., Jeang K.-T., Beyaert R. Oncogene 18:4182-4190(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH TNFAIP3 AND HTLV-1 PROTEIN TAX-1, ALTERNATIVE SPLICING (ISOFORM 3). Tissue: Cervix carcinoma.
[2]	"T6BP, a TRAF6-interacting protein involved in IL-1 signaling." Ling L., Goeddel D.V. Proc. Natl. Acad. Sci. U.S.A. 97:9567-9572(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH TRAF6, SUBUNIT.
[3]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Amygdala.
[4]	"Functional prediction of the coding sequences of 50 new genes deduced by analysis of cDNA clones from human fetal liver." Yu Y., Zhang C., Luo L., Ouyang S., Zhang S., Li W., Wu J., Zhou S., Liu M., He F. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Fetal liver.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Tongue.
[6]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[7]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-307. Tissue: Skin.
[9]	"Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins." Nagaraja G.M., Kandpal R.P. Biochem. Biophys. Res. Commun. 313:654-665(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH STARD13.
[10]	"Protein profile of tax-associated complexes." Wu K., Bottazzi M.E., de la Fuente C., Deng L., Gitlin S.D., Maddukuri A., Dadgar S., Li H., Vertes A., Pumfery A., Kashanchi F. J. Biol. Chem. 279:495-508(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH HTLV-1 PROTEIN TAX-1.
[11]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-457.
[13]	"The kinase IKKalpha inhibits activation of the transcription factor NF-kappaB by phosphorylating the regulatory molecule TAX1BP1." Shembade N., Pujari R., Harhaj N.S., Abbott D.W., Harhaj E.W. Nat. Immunol. 12:834-843(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT SER-593 AND SER-666 BY CHUK/IKKA.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U33821 mRNA. Translation: AAA75595.2. AF268075 mRNA. Translation: AAG03025.1. AL136586 mRNA. Translation: CAB66521.1. AF090891 mRNA. Translation: AAF24016.1. CR457056 mRNA. Translation: CAG33337.1. AK296720 mRNA. Translation: BAG59309.1. CR533556 mRNA. Translation: CAG38587.1. AC004549 Genomic DNA. Translation: AAC13359.2. Sequence problems. AC005091 Genomic DNA. Translation: AAD15412.1. BC050358 mRNA. Translation: AAH50358.1.
IPI	IPI00106559. IPI00657950. IPI00747530.
PIR	G02043.
RefSeq	NP_001073333.1. NM_001079864.2. NP_001193830.1. NM_001206901.1. NP_001193831.1. NM_001206902.1. NP_006015.4. NM_006024.6.
UniGene	Hs.34576.
3D structure databases
ProteinModelPortal	Q86VP1.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-33010N.
IntAct	Q86VP1. 18 interactions.
MINT	MINT-200894.
STRING	9606.ENSP00000379612.
PTM databases
PhosphoSite	Q86VP1.
Polymorphism databases
DMDM	97202549.
Proteomic databases
PaxDb	Q86VP1.
PRIDE	Q86VP1.
Protocols and materials databases
DNASU	8887.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000265393; ENSP00000265393; ENSG00000106052. ENST00000396319; ENSP00000379612; ENSG00000106052. ENST00000433216; ENSP00000391907; ENSG00000106052. ENST00000543117; ENSP00000444811; ENSG00000106052.
GeneID	8887.
KEGG	hsa:8887.
UCSC	uc003szk.3. human. uc003szl.3. human.
Organism-specific databases
CTD	8887.
GeneCards	GC07P027746.
HGNC	HGNC:11575. TAX1BP1.
HPA	HPA024432.
MIM	605326. gene.
neXtProt	NX_Q86VP1.
PharmGKB	PA36339.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG135564.
HOGENOM	HOG000271638.
HOVERGEN	HBG053034.
PhylomeDB	Q86VP1.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q86VP1.
Bgee	Q86VP1.
CleanEx	HS_TAX1BP1.
Genevestigator	Q86VP1.
GermOnline	ENSG00000106052. Homo sapiens.
Family and domain databases
InterPro	IPR012852. CoCoA. IPR015880. Znf_C2H2-like. [Graphical view]
Pfam	PF07888. CALCOCO1. 1 hit. [Graphical view]
SMART	SM00355. ZnF_C2H2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TAX1BP1. human.
GenomeRNAi	8887.
NextBio	33373.
SOURCE	Search...

Entry information

Entry name

TAXB1_HUMAN

Accession

Primary (citable) accession number: Q86VP1
Secondary accession number(s): B4DKU7 , E7ENV2, O60398, O95770, Q13311, Q9BQG5, Q9UI88

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	May 16, 2006
Last modified:	May 1, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.