Q86VM9 (ZCH18_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger CCCH domain-containing protein 18

Alternative name(s):
Nuclear protein NHN1

Gene names

Name:	ZC3H18
Synonyms:	NHN1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	953 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 1 C3H1-type zinc finger.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	nucleus Inferred from direct assay. Source: HPA
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86VM9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86VM9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     228-228: M → MKDVVTPLSTLLPPISNSIPFRGQV
     412-469: NRQRERERERERDRERERRQRERERERERERDKERQRRKEEWERERAKRDEKDRQHRD → RE
     683-953: TLSGSGSGSG...RKRAKIPGKA → LIKEAGSAMN...PARCLGGRSC

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 953	953	Zinc finger CCCH domain-containing protein 18		PRO_0000311242
Regions
	Zinc finger	219 – 245	27	C3H1-type
	Coiled coil	105 – 134	30	Potential
	Coiled coil	399 – 464	66	Potential
	Coiled coil	921 – 950	30	Potential
	Compositional bias	201 – 204	4	Poly-Asp
	Compositional bias	259 – 296	38	Pro-rich
	Compositional bias	532 – 746	215	Ser-rich
Amino acid modifications
	Modified residue	46	1	Phosphoserine Ref.4 Ref.9 Ref.11 Ref.12 Ref.14
	Modified residue	67	1	Phosphoserine Ref.4 Ref.11 Ref.14
	Modified residue	74	1	Phosphoserine Ref.4 Ref.11
	Modified residue	78	1	Phosphoserine Ref.4 Ref.11
	Modified residue	83	1	Phosphoserine Ref.4
	Modified residue	95	1	Phosphoserine Ref.11
	Modified residue	109	1	Phosphothreonine Ref.11
	Modified residue	110	1	Phosphoserine Ref.11
	Modified residue	487	1	Phosphoserine Ref.4 Ref.7
	Modified residue	532	1	Phosphoserine Ref.4 Ref.5 Ref.10 Ref.11 Ref.12
	Modified residue	534	1	Phosphoserine Ref.4 Ref.5 Ref.6 Ref.8 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14
	Modified residue	599	1	Phosphoserine Ref.4
	Modified residue	601	1	Phosphoserine Ref.4
	Modified residue	603	1	Phosphoserine Ref.4
	Modified residue	604	1	Phosphoserine Ref.4
	Modified residue	605	1	Phosphoserine Ref.4
	Modified residue	607	1	Phosphoserine Ref.4
	Modified residue	609	1	Phosphoserine Ref.4
	Modified residue	611	1	Phosphothreonine Ref.4
	Modified residue	613	1	Phosphoserine Ref.4
	Modified residue	677	1	Phosphothreonine Ref.4
	Modified residue	842	1	Phosphoserine Ref.4
	Modified residue	852	1	Phosphoserine By similarity
	Modified residue	857	1	Phosphoserine Ref.4
	Modified residue	868	1	Phosphoserine Ref.4 Ref.6 Ref.10 Ref.13
	Modified residue	893	1	Phosphoserine Ref.4
Natural variations
	Alternative sequence	228	1	M → MKDVVTPLSTLLPPISNSIP FRGQV in isoform 2.		VSP_029453
	Alternative sequence	412 – 469	58	NRQRE…RQHRD → RE in isoform 2.		VSP_029454
	Alternative sequence	683 – 953	271	TLSGS…IPGKA → LIKEAGSAMNHQTRTGRALL QPSGPTHPQTEVLGTGSQVG DWAPRSQSGREARTPKPLQP RLTGSASCHPSPRAPARSRA CPAKPRIPAPPAPNQGRPAR CLGGRSC in isoform 2.		VSP_029455
	Natural variant	368	1	A → T. Corresponds to variant rs34808360 [ dbSNP | Ensembl ].		VAR_037188
	Natural variant	440	1	R → H. Ref.3 Corresponds to variant rs17855686 [ dbSNP | Ensembl ].		VAR_037189
Experimental info
	Sequence conflict	251	1	Y → H in BAB71237. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 24, 2009. Version 2. Checksum: F12E87B342E1F892	FASTA	953	106,378
	10 20 30 40 50 60 MDVAESPERD PHSPEDEEQP QGLSDDDILR DSGSDQDLDG AGVRASDLED EESAARGPSQ 70 80 90 100 110 120 EEEDNHSDEE DRASEPKSQD QDSEVNELSR GPTSSPCEEE GDEGEEDRTS DLRDEASSVT 130 140 150 160 170 180 RELDEHELDY DEEVPEEPAP AVQEDEAEKA GAEDDEEKGE GTPREEGKAG VQSVGEKESL 190 200 210 220 230 240 EAAKEKKKED DDGEIDDGEI DDDDLEEGEV KDPSDRKVRP RPTCRFFMKG NCTWGMNCRF 250 260 270 280 290 300 IHPGVNDKGN YSLITKADPF PPNGAPPLGP HPLMPANPWG GPVVDEILPP PPPEPPTESA 310 320 330 340 350 360 WERGLRHAKE VLKKATIRKE QEPDFEEKRF TVTIGEDERE FDKENEVFRD WNSRIPRDVR 370 380 390 400 410 420 DTVLEPYADP YYDYEIERFW RGGQYENFRV QYTETEPYHN YRERERERER ENRQRERERE 430 440 450 460 470 480 RERDRERERR QRERERERER ERDKERQRRK EEWERERAKR DEKDRQHRDR DREKEREKEK 490 500 510 520 530 540 GKPKPRSPQP PSRQAEPPKK EAATTGPQVK RADEWKDPWR RSKSPKKKLG VSVSPSRARR 550 560 570 580 590 600 RRKTSASSAS ASNSSRSSSR SSSYSGSGSS RSRSRSSSYS SYSSRSSRHS SFSGSRSRSR 610 620 630 640 650 660 SFSSSPSPSP TPSPHRPSIR TKGEPAPPPG KAGEKSVKKP APPPAPPQAT KTTAPVPEPT 670 680 690 700 710 720 KPGDPREARR KERPARTPPR RRTLSGSGSG SGSSYSGSSS RSRSLSVSSV SSVSSATSSS 730 740 750 760 770 780 SSAHSVDSED MYADLASPVS SASSRSPAPA QTRKEKGKSK KEDGVKEEKR KRDSSTQPPK 790 800 810 820 830 840 SAKPPAGGKS SQQPSTPQQA PPGQPQQGTF VAHKEIKLTL LNKAADKGSR KRYEPSDKDR 850 860 870 880 890 900 QSPPPAKRPN TSPDRGSRDR KSGGRLGSPK PERQRGQNSK APAAPADRKR QLSPQSKSSS 910 920 930 940 950 KVTSVPGKAS DPGAASTKSG KASTLSRREE LLKQLKAVED AIARKRAKIP GKA
	Isoform 2 [UniParc]. Checksum: 883B3D5A20DCBC4F	FASTA	757	84,100
	10 20 30 40 50 60 MDVAESPERD PHSPEDEEQP QGLSDDDILR DSGSDQDLDG AGVRASDLED EESAARGPSQ 70 80 90 100 110 120 EEEDNHSDEE DRASEPKSQD QDSEVNELSR GPTSSPCEEE GDEGEEDRTS DLRDEASSVT 130 140 150 160 170 180 RELDEHELDY DEEVPEEPAP AVQEDEAEKA GAEDDEEKGE GTPREEGKAG VQSVGEKESL 190 200 210 220 230 240 EAAKEKKKED DDGEIDDGEI DDDDLEEGEV KDPSDRKVRP RPTCRFFMKD VVTPLSTLLP 250 260 270 280 290 300 PISNSIPFRG QVKGNCTWGM NCRFIHPGVN DKGNYSLITK ADPFPPNGAP PLGPHPLMPA 310 320 330 340 350 360 NPWGGPVVDE ILPPPPPEPP TESAWERGLR HAKEVLKKAT IRKEQEPDFE EKRFTVTIGE 370 380 390 400 410 420 DEREFDKENE VFRDWNSRIP RDVRDTVLEP YADPYYDYEI ERFWRGGQYE NFRVQYTETE 430 440 450 460 470 480 PYHNYRERER ERERERERDR EKEREKEKGK PKPRSPQPPS RQAEPPKKEA ATTGPQVKRA 490 500 510 520 530 540 DEWKDPWRRS KSPKKKLGVS VSPSRARRRR KTSASSASAS NSSRSSSRSS SYSGSGSSRS 550 560 570 580 590 600 RSRSSSYSSY SSRSSRHSSF SGSRSRSRSF SSSPSPSPTP SPHRPSIRTK GEPAPPPGKA 610 620 630 640 650 660 GEKSVKKPAP PPAPPQATKT TAPVPEPTKP GDPREARRKE RPARTPPRRR LIKEAGSAMN 670 680 690 700 710 720 HQTRTGRALL QPSGPTHPQT EVLGTGSQVG DWAPRSQSGR EARTPKPLQP RLTGSASCHP 730 740 750 SPRAPARSRA CPAKPRIPAP PAPNQGRPAR CLGGRSC

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-440. Tissue: Cervix and Testis.
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46; SER-67; SER-74; SER-78; SER-83; SER-487; SER-532; SER-534; SER-599; SER-601; SER-603; SER-604; SER-605; SER-607; SER-609; THR-611; SER-613; THR-677; SER-842; SER-857; SER-868 AND SER-893, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-532 AND SER-534, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-534 AND SER-868, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-487, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[8]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-534, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. J. Proteome Res. 7:5167-5176(2008) [PubMed: 19367720] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46, MASS SPECTROMETRY. Tissue: T-cell.
[10]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-532; SER-534 AND SER-868, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46; SER-67; SER-74; SER-78; SER-95; THR-109; SER-110; SER-532 AND SER-534, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46; SER-532 AND SER-534, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[13]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-534 AND SER-868, MASS SPECTROMETRY.
[14]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46; SER-67 AND SER-534, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[15]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK056632 mRNA. Translation: BAB71237.1. AC116552 Genomic DNA. No translation available. BC001584 mRNA. Translation: AAH01584.1. BC050463 mRNA. Translation: AAH50463.1.
IPI	IPI00293312. IPI00328929.
RefSeq	NP_653205.3. NM_144604.3.
UniGene	Hs.93670.
3D structure databases
ProteinModelPortal	Q86VM9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86VM9. 3 interactions.
PTM databases
PhosphoSite	Q86VM9.
Polymorphism databases
DMDM	269849528.
Proteomic databases
PRIDE	Q86VM9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000301011; ENSP00000301011; ENSG00000158545.
GeneID	124245.
KEGG	hsa:124245.
UCSC	uc002fky.1. human.
Organism-specific databases
CTD	124245.
GeneCards	GC16P088636.
H-InvDB	HIX0013334.
HGNC	HGNC:25091. ZC3H18.
HPA	HPA040847. HPA041327.
neXtProt	NX_Q86VM9.
PharmGKB	PA162409533.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10161.
GeneTree	ENSGT00580000081375.
HOVERGEN	HBG103346.
InParanoid	Q86VM9.
OrthoDB	EOG46T31J.
PhylomeDB	Q86VM9.
Gene expression databases
ArrayExpress	Q86VM9.
Bgee	Q86VM9.
CleanEx	HS_ZC3H18.
Genevestigator	Q86VM9.
Family and domain databases
InterPro	IPR000571. Znf_CCCH. [Graphical view]
KO	K13092.
SMART	SM00356. ZnF_C3H1. 1 hit. [Graphical view]
PROSITE	PS50103. ZF_C3H1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	81250.

Entry information

Entry name

ZCH18_HUMAN

Accession

Primary (citable) accession number: Q86VM9
Secondary accession number(s): Q96DG4, Q96MP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	November 24, 2009
Last modified:	January 25, 2012
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.